Method for subtyping lymphoma types by means of expression profiling

ABSTRACT

The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.

BACKGROUND OF THE INVENTION

A variety of systems for identifying and classifying lymphomas have beenproposed over the last 25 years. In the 1980's, the Working Formulationwas introduced as a method of classifying lymphomas based onmorphological and clinical characteristics. In the 1990's, the RevisedEuropean-American Lymphoma (REAL) system was introduced in an attempt totake into account immunophenotypic and genetic characteristics inclassifying lymphomas (Harris 1994). The most recent standard, set forthby the World Health Organization (WHO), attempts to build on theseprevious systems (see, Swerdlow et al., eds., WHO Classification ofTumours of Haematopoietic and Lymphoid Tissues, 4th ed., InternationalAgency for Research on Cancer; World Health Organization (2008); andJaffe, E. S., Pathology & Genetics: Tumours of Haematopoietic andLymphoid Tissues, WHO Classification of Tumours, Pathology and Geneticsseries (2001)). The WHO classification of lymphomas is based on severalfactors, including tumor morphology, immunophenotype, recurrent geneticabnormalities, and clinical features.

Other diagnoses that have not been given WHO diagnostic numbers includeHIV-associated lymphoma, germinal center B cell-like subtype of diffuselarge B cell lymphoma, activated B cell-like subtype of diffuse largeB-cell lymphoma, follicular hyperplasia (non-malignant), and infectiousmononucleosis (non-malignant).

Although the WHO classification has proven useful in patient managementand treatment, patients assigned to the same WHO diagnostic categoryoften have noticeably different clinical outcomes. In many cases, thesedifferent outcomes appear to be due to molecular differences betweentumors that cannot be readily observed by analyzing tumor morphology.

Diffuse large B cell lymphoma (DLBCL) can be classified as the germinalcenter B cell (GCB) subtype or the activated B cell (ABC) subtype basedon the cell-of-origin (COO) distinction as molecularly describedpreviously by the Lymphoma/Leukemia Molecular Profiling Project (LLMPP)(see Alizadeh et al., Nature, 403: 503-511 (2000)). However, moreaccurate diagnostic assays are needed to qualify patients for clinicaltrials using targeted agents and to use as a predictive biomarker.

Therefore, more precise methods are needed for identifying andclassifying lymphomas based on their molecular characteristics. Theinvention provides such methods.

BRIEF SUMMARY OF THE INVENTION

The invention provides a method for selecting a treatment option for anactivated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject,a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL)subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkittlymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject. Themethod comprises: (a) isolating a gene expression product from a biopsysample from a lymphoma subject; (b) obtaining digital gene expressiondata from the isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature,and wherein the gene expression signature comprises at least one of thegenes listed in Table 2; (c) generating a weighted average of theexpression levels of genes from the gene expression signature to therebyobtain a gene expression signature value; (d) calculating a predictorscore based on the gene expression signature value; (e) classifying thesubject as belonging to one of the following groups based on thepredictor score of (d): (i) ABC DLBCL, (ii) GCB DLBCL, (iii) PMBL, (iv)BL, or (v) MCL; (f) selecting a treatment option for the subject basedon the subject's classification in (e); and (g) providing the treatmentoption to the subject.

The invention also provides a method for selecting a treatment optionfor a diffuse large B cell lymphoma (DLBCL) subject. The methodcomprises: (a) isolating a gene expression product from a biopsy samplefrom a DLBCL subject; (b) obtaining digital gene expression data fromthe isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature,and wherein the gene expression signature comprises at least one of thefollowing genes: ASB13 (GenBank Accession No. NM_024701.3), CCDC50(GenBank Accession No. NM_174908.3), CREB3L2 (GenBank Accession No.NM_194071.2), CYB5R2 (GenBank Accession No. NM_016229.3), IRF4 (GenBankAccession No. NM_002460.1), ISY1 (GenBank Accession No. NM_020701.2),ITPKB (GenBank Accession No. NM_002221.3), LIMD1 (GenBank Accession No.NM_014240.2), MAML3 (GenBank Accession No. NM_018717.4), MME (GenBankAccession No. NM_000902.2), MYBL1 (GenBank Accession No. XM_034274.14),PIM2 (GenBank Accession No. NM_006875.2), R3HDM1 (GenBank Accession No.NM_015361.2), RAB7L1 (GenBank Accession No. NM_001135664.1), S1PR2(GenBank Accession No. NM_004230.2), SERPINA9 (GenBank Accession No.NM_001042518.1), TNFRSF13B (GenBank Accession No. NM_012452.2), TRIM56(GenBank Accession No. NM_030961.1), UBXN4 (GenBank Accession No.NM_014607.3), and WDR55 (GenBank Accession No. NM_017706.4); (c)generating a weighted average of the expression levels of genes from thegene expression signature to thereby obtain a gene expression signaturevalue; (d) calculating a predictor score based on the gene expressionsignature value; (e) classifying the subject as belonging to one of thefollowing groups based on the predictor score of (d): (i) activated Bcell-like diffuse large B cell lymphoma (ABC DLBCL) or (ii) germinalcenter B cell-like diffuse large B cell lymphoma (GCB DLBCL); (f)selecting a treatment option for the subject based on the subject'sclassification in (e); and (g) providing the treatment option to thesubject.

The invention provides a method for selecting a germinal center Bcell-like diffuse large B cell lymphoma (GCB DLBCL) subject fortreatment with R-CHOP (rituxan, cyclophosphamide, hydroxydaunorubicin,oncovin (vincristine), and prednisone) therapy. The method comprises thesteps of: (a) isolating a gene expression product from a biopsy samplefrom a DLBCL subject; (b) obtaining digital gene expression data fromthe isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature,and wherein the gene expression signature comprises at least one of thefollowing genes: ASB13 (GenBank Accession No. NM_024701.3), CCDC50(GenBank Accession No. NM_174908.3), CREB3L2 (GenBank Accession No.NM_194071.2), CYB5R2 (GenBank Accession No. NM_016229.3), IRF4 (GenBankAccession No. NM_002460.1), ISY1 (GenBank Accession No. NM_020701.2),ITPKB (GenBank Accession No. NM_002221.3), LIMD1 (GenBank Accession No.NM_014240.2), MAML3 (GenBank Accession No. NM_018717.4), MME (GenBankAccession No. NM_000902.2), MYBL1 (GenBank Accession No. XM_034274.14),PIM2 (GenBank Accession No. NM_006875.2), R3HDM1 (GenBank Accession No.NM_015361.2), RAB7L1 (GenBank Accession No. NM_001135664.1), S1PR2(GenBank Accession No. NM_004230.2), SERPINA9 (GenBank Accession No.NM_001042518.1), TNFRSF13B (GenBank Accession No. NM_012452.2), TRIM56(GenBank Accession No. NM_030961.1), UBXN4 (GenBank Accession No.NM_014607.3), and WDR55 (GenBank Accession No. NM_017706.4); (c)generating a weighted average of the expression levels of genes from thegene expression signature to thereby obtain a gene expression signaturevalue; (d) calculating a predictor score based on the gene expressionsignature value; (e) classifying the subject as belonging to one of thefollowing groups based on the predictor score of (d): (i) activated Bcell-like diffuse large B cell lymphoma (ABC DLBCL) or (ii) germinalcenter B cell-like diffuse large B cell lymphoma (GCB DLBCL); (f)selecting a GCB DLBCL subject for R-CHOP therapy; and (g) providingR-CHOP therapy to the GCB DLBCL subject and providing a differenttherapy to an ABC DLBCL subject.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING(S)

The FIGURE is a diagram which illustrates the logic employed inclassifying a subject having (i) ABC DLBCL, (ii) GCB DLBCL, (iii) PMBL,(iv) BL, or (v) MCL based on the predictor models disclosed herein.

DETAILED DESCRIPTION OF THE INVENTION

Gene expression profiling of a cancer cell or biopsy reflects themolecular phenotype of a cancer at the time of diagnosis. As aconsequence, the detailed picture provided by the genomic expressionpattern provides a basis for a new systematic classification of cancersand more accurate predictors of survival and response to treatment. Theinvention discloses methods for identifying, diagnosing, and/orclassifying a lymphoma, lymphoid malignancy, or lymphoproliferativedisorder based on its gene expression patterns. The information obtainedusing these methods will be useful in evaluating the optimal therapeuticapproach to be employed with regards to a particular subject.

The term “lymphoproliferative disorder” as used herein refers to anytumor of lymphocytes, and may refer to both malignant and benign tumors.The terms “lymphoma” and “lymphoid malignancy” as used herein referspecifically to malignant tumors derived from lymphocytes andlymphoblasts. Examples of lymphomas include, but are not limited to,follicular lymphoma (FL), Burkitt lymphoma (BL), mantle cell lymphoma(MCL), follicular hyperplasia (FH), small cell lymphocytic lymphoma(SLL), mucosa-associated lymphoid tissue lymphoma (MALT), spleniclymphoma, multiple myeloma, lymphoplasmacytic lymphoma, post-transplantlymphoproliferative disorder (PTLD), lymphoblastic lymphoma, nodalmarginal zone lymphoma (NMZ), germinal center B cell-like diffuse largeB cell lymphoma (GCB), activated B cell-like diffuse large B celllymphoma (ABC), and primary mediastinal B cell lymphoma (PMBL).

The phrase “lymphoma type” (or simply “type”) as used herein refers to adiagnostic classification of a lymphoma. The phrase may refer to a broadlymphoma class (e.g., DLBCL, FL, MCL, etc.) or to a subtype or subgroupfalling within a broad lymphoma class (e.g., GCB DLBCL and ABC DLBCL).In one embodiment, the invention comprises selecting a treatment optionfor a subject having activated B cell-like diffuse large B cell lymphoma(ABC DLBCL), a germinal center B cell-like diffuse large B cell lymphoma(GCB DLBCL), primary mediastinal B cell lymphoma (PMBL), Burkittlymphoma (BL), or mantle cell lymphoma (MCL).

The inventive method comprises isolating a gene expression product froma subject, e.g., from a biopsy sample from a subject, such as from asnap-frozen biopsy sample from a subject or a formalin-fixed andparaffin-embedded (FFPE) biopsy sample from a subject. The term “geneexpression product,” as used herein, refers to any molecule that isproduced as a result of gene transcription. The gene expression productcan be, for example, total cellular mRNA, rRNA, cDNA obtained by reversetranscription of total cellular mRNA, or a protein. The gene expressionproduct can be obtained from the subject in any suitable manner. Forexample, one or more biopsy samples can be obtained from a patient thathas been diagnosed as having a particular lymphoma type, and the biopsysamples can be formalin-fixed and paraffin-embedded using protocols thatare known in the art or are commercially available (see, e.g., Keiman,J. (ed.), Histological and Histochemical Methods: Theory and Practice,4th edition, Cold Spring Harbor Laboratory Press (2008)). The geneexpression product can be extracted from an FFPE biopsy sample usingmethods that are known in the art or are commercially available (see,e.g., Huang et al., Cancer Epidemiol Biomarkers Prev., 19: 973-977(2010); QIAamp DNA FFPE Tissue Kit, RNAEASY™ FFPE Kit (Qiagen, Venlo,Netherlands); and MAGMAX™ FFPE DNA Isolation Kit (Life Technologies,Carlsbad, Calif.)).

The inventive method further comprises obtaining digital gene expressiondata from the isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature.The phrase “gene expression data” as used herein refers to informationregarding the relative or absolute level of expression of a gene or setof genes in a cell or group of cells. The level of expression of a genemay be determined based on the level of RNA, such as mRNA, encoded bythe gene. Alternatively, the level of expression may be determined basedon the level of a polypeptide or fragment thereof encoded by the gene.“Gene expression data” may be acquired for an individual cell, or for agroup of cells such as a tumor or biopsy sample. Any effective method ofquantifying the expression of at least one gene, gene set, or group ofgene sets may be used to acquire gene expression data for use in theinvention. For example, gene expression data may be measured orestimated using one or more microarrays. The microarrays may be of anyeffective type, including but not limited to nucleic acid based orantibody based. Gene expression may also be measured by a variety ofother techniques, including but not limited to PCR, quantitative RT-PCR,real-time PCR, RNA amplification, in situ hybridization,immunohistochemistry, immunocytochemistry, FACS, serial analysis of geneexpression (SAGE) (Velculescu et al., Science, 270: 484-487 (1995)),Northern blot hybridization, or western blot hybridization.

Nucleic acid microarrays generally comprise nucleic acid probes derivedfrom individual genes and placed in an ordered array on a support. Thissupport may be, for example, a glass slide, a nylon membrane, or asilicon wafer. Gene expression patterns in a sample are obtained byhybridizing the microarray with the gene expression product from thesample. This gene expression product may be, for example, total cellularmRNA, rRNA, or cDNA obtained by reverse transcription of total cellularmRNA. The gene expression product from a sample is labeled with aradioactive, fluorescent, or other label to allow for detection.Following hybridization, the microarray is washed, and hybridization ofgene expression product to each nucleic acid probe on the microarray isdetected and quantified using a detection device such as aphosphorimager or scanning confocal microscope.

The microarray can be a cDNA microarray or an oligonucleotidemicroarray. cDNA arrays consist of hundreds or thousands of cDNA probesimmobilized on a solid support, and are described in detail in, e.g.,Southern et al., Genomics, 13: 1008-1017 (1992); Southern et al., Nucl.Acids. Res., 22: 1368-1373 (1994); Gress et al., Oncogene, 13: 1819-1830(1996); Pietu et al., Genome Res., 6: 492-503 (1996); Schena et al.,Science, 270: 467-470 (1995); DeRisi et al., Nat. Genet., 14: 457-460(1996); Schena et al., Proc. Natl. Acad. Sci. USA, 93: 10614-10619(1996); Shalon et al., Genome Res., 6: 639-645 (1996); DeRisi et al.,Science, 278: 680-686 (1997); Heller et al., Proc. Natl. Acad. Sci. USA,94: 2150-2155 (1997); and Lashkari et al., Proc. Natl. Acad. Sci. USA,94: 13057-13062 (1997). Oligonucleotide arrays differ from cDNA arraysin that the probes are 20- to 25-mer oligonucleotides. Oligonucleotidearrays are generally produced by in situ oligonucleotide synthesis inconjunction with photolithographic masking techniques (see, e.g., Peaseet al., Proc. Natl. Acad. Sci. USA, 91: 5022-5026 (1994); Lipshutz etal., Biotechniques, 19: 442-447 (1995); Chee et al., Science, 274:610-14 (1996); Lockhart et al., Nat. Biotechnol., 14: 1675-1680 (1996);and Wodicka et al., Nat. Biotechnol., 15: 1359-1367 (1997)). The solidsupport for oligonucleotide arrays is typically a glass or siliconsurface.

Methods and techniques applicable to array synthesis and use have beendescribed in, for example, U.S. Pat. Nos. 5,143,854, 5,242,974,5,252,743, 5,324,633, 5,384,261, 5,424,186, 5,445,934, 5,451,683,5,482,867, 5,491,074, 5,527,681, 5,550,215, 5,571,639, 5,578,832,5,593,839, 5,599,695, 5,624,711, 5,631,734, 5,795,716, 5,831,070,5,837,832, 5,856,101, 5,858,659, 5,936,324, 5,968,740, 5,974,164,5,981,185, 5,981,956, 6,025,601, 6,033,860, 6,040,193, 6,090,555, and6,410,229, and U.S. Patent Application Publication 2003/0104411.Techniques for the synthesis of microarrays using mechanical synthesismethods are described in, for example, U.S. Pat. Nos. 5,384,261 and6,040,193. Microarrays may be nucleic acids on beads, gels, polymericsurfaces, fibers such as fiber optics, glass or any other appropriatesubstrate (see, e.g., U.S. Pat. Nos. 5,708,153, 5,770,358, 5,789,162,5,800,992, and 6,040,193.

Microarrays may be packaged in such a manner as to allow for diagnosticuse, or they can be an all-inclusive device (see, e.g., U.S. Pat. Nos.5,856,174 and 5,922,591). Microarrays directed to a variety of purposesare commercially available from Affymetrix (Affymetrix, Santa Clara,Calif.).

“Digital gene expression data,” as used herein, refers to geneexpression information that is based on the generation of sequence tags,as opposed to “analog gene expression data” which is based onhybridization to arrayed cDNA or oligonucleotide libraries as describedabove.

Digital gene expression data can be obtained and analyzed using avariety of methods known in the art, such as, for example, serialanalysis of gene expression (SAGE) (see, e.g., Velculescu et al.,Science, 270(5235): 484-487 (1995)), SuperSAGE (see e.g., Matsumura etal., Proc. Natl. Acad. Sci. USA, 100 (26): 15718-15723 (2003)), digitalnorthern analysis (see, e.g., Cao et al., Breast Cancer Research, 10:R91 (2008)), and RNA-seq (see, e.g., Mortazavi et al. Nat Methods,5(7):621-628 (2008)). In one embodiment, the digital gene expressiondata is obtained using the NCOUNTER™ gene expression assay availablefrom NanoString Technologies, Inc. The NCOUNTER™ assay can detect theexpression of up to 800 genes in a single reaction with high sensitivityand linearity across a broad range of expression levels. The NCOUNTER™assay is based on direct digital detection of mRNA molecules of interestusing target-specific, color-coded probe pairs, and does not require theconversion of mRNA to cDNA by reverse transcription or the amplificationof the resulting cDNA by PCR. Each target gene of interest is detectedusing a pair of reporter and capture probes carrying 35- to50-nucleotide target-specific sequences. In addition, each reporterprobe carries a unique color code at the 5′ end that enables themolecular barcoding of the genes of interest, while the capture probesall carry a biotin label at the 3′ end that provides a molecular handlefor attachment of target genes to facilitate downstream digitaldetection. After solution-phase hybridization between target mRNA andreporter-capture probe pairs, excess probes are removed and theprobe/target complexes are aligned and immobilized in an NCOUNTER™cartridge, which is then placed in a digital analyzer for imageacquisition and data processing. Hundreds of thousands of color codesdesignating mRNA targets of interest are directly imaged on the surfaceof the cartridge. The expression level of a gene is measured by countingthe number of times the color-coded barcode for that gene is detected,and the barcode counts are then tabulated. NANOSTRING™ technology andanalysis of digital gene expression data is described in detail in,e.g., Kulkarni, M. M., “Digital Multiplexed Gene Expression AnalysisUsing the NANOSTRING™ NCOUNTER™ System,” Current Protocols in MolecularBiology. 94: 25B.10.1-25B.10.17 (2011); Geiss et al., NatureBiotechnology, 26: 317-325 (2008); and U.S. Pat. No. 7,919,237.

The term “gene expression signature” or “signature” as used hereinrefers to a group of coordinately expressed genes. The genes making up aparticular signature may be expressed in a specific cell lineage, stageof differentiation, or during a particular biological response. Thegenes can reflect biological aspects of the tumors in which they areexpressed, such as the cell of origin of the cancer, the nature of thenon-malignant cells in the biopsy, and the oncogenic mechanismsresponsible for the cancer (see, e.g., Shaffer et al., Immunity, 15:375-385 (2001)). Examples of gene expression signatures include lymphnode (see Shaffer et al., supra), proliferation (see, e.g., Rosenwald etal., New Engl. J. Med., 346: 1937-1947 (2002)), MHC class II, ABC DLBCLhigh, B-cell differentiation, T-cell, macrophage, immune response-1,immune response-2, and germinal center B cell.

The invention provides gene expression signatures that can be used toclassify particular types of lymphoma and then select an appropriatetreatment option based on that classification. In this respect, theinvention provides a novel 800 gene array for the identification anddiagnosis various lymphoma types. The 800 gene array contains genespreviously identified as being differentially expressed between ABCDLBCL, GCB DLBCL, PMBL, BL, and MCL, shown to be associated withsurvival in DLBCL or MCL, or were known in the art to be of particularimportance in lymphoid biology. The genes and probe sequences thatcomprise the 800 gene array are set forth in Table 1.

TABLE 1 GenBank Capture Probe Reporter Probe Gene Accession No.Target Sequence Sequence Sequence DDX58 NM_014314.3 CTGGCATATTGACTGGTCATTCCTGTG TGATCTCCACTG GGACGTGGCAAAA TTCTGATTTGTTT GCTTTGAATGCACAAATCAGAACAC TGCCACGTCCAGT TCCAATATACAC AGGAATGACCCTCC CAATATGCCAGTTCTGTGCCGGG CGGCACAGAAGTG (SEQ ID NO: 2) AG (SEQ ID NO: 3)TATATTGGATGCAT TCAAAGCCAGTGG AGATCA (SEQ ID NO: 1) HLA-DQA1 NM_002122.3GGTGGCCTGAGTTC CAGTGCACCCTG TAGCGTTTAATC AGCAAATTTGGAG CGGGTCAAAACCATGATGTTCAAG GTTTTGACCCGCAG TCCAAATTTGCTG TTGTGTTTTGCC GGTGCACTGAGAAAACTCAGGCCAC ACAGCCATGTTT ACATGGCTGTGGCA C (SEQ ID NO: 5)CT (SEQ ID NO: 6) AAACACAACTTGA ACATCATGATTAAA CGCTA  (SEQ ID NO: 4)IFI16 NM_005531.1 ACGACTGAACACA TGGTGAGTTTCAG TACAGATCTCAAATCAACTGTGAGGA TTTATCTCCTTCC CTCCCCGGTATT AGGAGATAAACTG TCACAGTTGATTGCCCACTTTTCGG AAACTCACCAGCTT TGTTCAGTCGT TGCCAATTCAAA TGAATTGGCACCGA(SEQ ID NO: 8) GC (SEQ ID NO: 9) AAAGTGGGAATAC CGGGGAGTTGAGA TCTGTA (SEQ ID NO: 7) IFNAR1 NM_000629.2 CTAATCAGCTCTCA GACAGAGACCACAAGGGGTATCTG GTGATCAACCCACT CCATAACAAGAG AATACTGCTAGA CTTGTTATGGGTGGTGGGTTGATCACT CGAGAAGCCAG TCTCTGTCACTTTG GAGAGCTGATTA CCTGGCATTCAAAATGCCAGGCTGGC G (SEQ ID NO: 11) AGT  TTCTCGTCTAGCAG (SEQ ID NO: 12)TATTCAGATACCCC TT (SEQ ID NO: 10) IFNAR2 NM_000874.3 AAATACCACAAGAGTGTGCTTCTCCA TTCCCGCTGAAT TCATTTTGTGACCT CTCATCTGTGAGG CCTTCTAGGACGCACAGATGAGTGG TCACAAAATGAT GTGACATAGGCC AGAAGCACACACG CTTGTGGTATTTTCGT (SEQ ID NO: AGGCCTATGTCACC (SEQ ID NO: 14) 15) GTCCTAGAAGGATTCAGCGGGAACACA ACGTTG (SEQ ID NO: 13) IFNB1 NM_002176.2 ACAGACTTACAGGTGAGGCACAGGCT TAAACAGCATCT TACCTCCGAAACTG AGGAGATCTTCA GCTGGTTGAAGAAAGATCTCCTAGCC GTTTCGGAGGTA ATGCTTGAAGCA TGTGCCTCTGGGAC ACCTGTAAGTCTGATTGTCCAGTCC TGGACAATTGCTTC T (SEQ ID NO: 17) CA (SEQ ID NO:AAGCATTCTTCAAC 18) CAGCAGATGCTGTT TA (SEQ ID NO: 16) IL13 NM_002188.2TTTCTTTCTGATGTC CCTAACCCTCCTT TGAAGACGGGC AAAAATGTCTTGGG CCCGCCTACCCAAGCACAGGCTGA TAGGCGGGAAGGA AGACATTTTTGAC GGTCTAAGCTAA GGGTTAGGGAGGGATCAGAAAGAAA GGAATTTTACCC GTAAAATTCCTTAG (SEQ ID NO: 20) CTC (SEQ ID NO:CTTAGACCTCAGCC 21) TGTGCTGCCCGTCT TCA  (SEQ ID NO: 19) IRF3 NM_001571.4CTGCCCTCAACCGC CTTGCTCCGGTCC CCAACTCCTGAG AAAGAAGGGTTGC TCTGCTAAACGCTTCACAAACTCG GTTTAGCAGAGGAC AACCCTTCTTTGC TAGATTTTATGT CGGAGCAAGGACCGGTTGAG (SEQ ID GGGTCGTGAGGG CTCACGACCCACAT NO: 23) TC (SEQ ID NO:AAAATCTACGAGTT 24) TGTGAACTCAGGAG TTGG (SEQ ID NO: 22) IRF5 NM_002200.3GCCTGGCTCTCGGG GTTGGGAGAGTT CTTAGGCAATTC AAATTCAGCCATGA CTTTCCcTGCTCACTCCTATACAGC GCAGGGAAAGAAC TGGCTGAATTTCC TAGGCCCCAGG TCTCCCAACCCTGGCGAGAGCCAG (SEQ ID NO: 27) GGCCTAGCTGTATA (SEQ ID NO: 26) GGAGGAATTGCCTAAGGGTGGCCCACTC TTG  (SEQ ID NO: 25) IRF7 NM_001572.3 CGCAGCGTGAGGGGCAGAGGCTGAG TCCATAAGGAAG TGTGTCTTCCCTGG GCTGCTGCTATCC CACTCGATGTCGATAGCAGCAGCCTC AGGGAAGACACA TCATAGAGGCTG AGCCTCTGCCTGTCC (SEQ ID NO: 29) TTGGCGCTGGAC CAGCGCCAACAGC AG (SEQ ID NO:CTCTATGACGACAT 30) CGAGTGCTTCCTTA TGGA (SEQ ID NO: 28) RBCK1 NM_031229.2TACCAGCGATTTCT GCACTGCGGTTTT CAAAGAAGCAC AGACCTGGGCATCT CAGCAATGGAGACATCCCTTGCAA CCATTGCTGAAAAC TGCCCAGGTCTA TCTGGGGTCTTG CGCAGTGCCTTCAGGAAATCGC (SEQ CAATGGTAGCTG CTACCATTGCAAGA ID NO: 32) AAG (SEQ ID NO:CCCCAGATTGCAAG 33) GGATGGTGCTTCTT TG (SEQ ID NO: 31) RNF31 NM_017999.4ACCTCACCGATGAC GATGTCAAGGGT TTCTTATGGAAC ACACAGTTGCTCAG AGAGAAGTAGCTAACGCATAGGCA CTACTTCTCTACCC GAGCAACTGTGT TCTGGCTCTAGG TTGACATCCAGCTTGTCATCGGTGAG CTCTCGCGAAGC CGCGAGAGCCTAG (SEQ ID NO: 35) TG (SEQ ID NO:AGCCAGATGCCTAT 36) GCGTTGTTCCATAA GAA  (SEQ ID NO: 34) SHARPINNM_030974.3 TCTCAGAGCTCGGT CCGTCCGATGAC CCGTAAGAGGCA TTCCCGCCAGCCGTCCAGCGTTGCAC AGGCTGCGCTCA GCAACGCTGGGTCA GGCTGGCGGGAA GGCACACACAGTCGGACGGTGCCTG ACCG (SEQ ID NO: GCA (SEQ ID NO: TGTGTGCCTGAGCG 38) 39)CAGCCTTGCCTCTT ACGGGGTTCGGCA GGA  (SEQ ID NO: 37) TNIP2 NM_024309.3GTCACTTGTATGGT TATTCCATAGAAC AGCCGCAATACT CCCCAGGGTGGGA AGGATGGGGCTCCCATTTGACTGG GCCCCATCCTGTTC CCACCCTGGGGA TTCGAGGCAGAG TATGGAATAAAGCCCATACAAGTGA AGGCGACGCTT GTCGCCTCTCTGCC C (SEQ ID NO: 41)(SEQ ID NO: 42) TCGAACCAGTCAAA TGGAGTATTGCGGC TGCA (SEQ ID NO: 40)TRIM25 NM_005082.4 GTGAGTATGAGGA CCCAGAGTTGGA CTTCTTTTCATATATTTAGCCTCTTAT CTCATTTCACTAT TATAGGAAGCCT AGTGAAATGAGTCC AAGAGGCTAAATGACAGGAGCTCT AACTCTGGGCTTTG TCCTCATACTCAC CCTCTAAGCAAA CTTAGAGGAGAGCT(SEQ ID NO: 44) G (SEQ ID NO: 45) CCTGTCAGGCTTCC TATAATATGAAAAG AAG (SEQ ID NO: 43) A2LD1 NM_033110.2 AGCAAGGCACGAA TGACAATTATCAACTTTGCTGGGA GTACCAATTACTAC GATGGAGGTGGG AGCAGAAGCAA CCACCTCCATCTGATAGTAATTGGTAC GAGCCGTGCACC TAATTGTCAGCATC TTCGTGCCTTGCT GAGTTGAATCGAGATTCAACTCGGTG (SEQ ID NO: 47) TGC (SEQ ID NO: CACGGCTCTTGCTT 48)CTGCTTCCCAGCAA AGT  (SEQ ID NO: 46) ABCA12 NM_015657.3 TTTTCCTCTAACATGCAACCCCGACT GGTTATCAACAG CGAGCCTGAACCTA GTGAGATCTTTAG CAACTTTTGAGCAAGATCTCACAGTC GTTCAGGCTCGAT CATAGATCTTTG GGGGTTGCCCTGCA GTTAGAGGAAAATGACCCCATGCA TGGGGTCACAAAG (SEQ ID NO: 50) GG (SEQ ID NO: ATCTATGGCTCAAA51) AGTTGCTGTTGATA ACC  (SEQ ID NO: 49) ACPP NM_001099.2 CAGATGGCGCTAGCAAGAAGCATAG ACATCTCCACAA ATGTTTACAACGGA GGAGGAAGGAGT AGTACTCCCCCTCTCCTTCCTCCCTA CCGTTGTAAACAT TCTCAAAGTACA TGCTTCTTGCCACT CTAGCGCCATCTGATTCCGTCAAGT TGACGGAATTGTAC (SEQ ID NO: 53) GG (SEQ ID NO: TTTGAGAAGGGGG54) AGTACTTTGTGGAG ATGT (SEQ ID NO: 52) ACSL5 NM_016234.3 TCTGTGACACACCCTTTCTCTACATTC TCCATAAGGATG CAAAAGGCATTGGT CCTATCAGCACC ATCACCTTCAGGGCTGATAGGGAAT AATGCCTTTTGGG CTCGGGGTGAAG GTAGAGAAAGGCT GTGTGTCACAGACC (SEQ ID NO: TCACCCCGAGCCTG (SEQ ID NO: 56) 57) AAGGTGATCATCCTTATGGACCCCTTTG ATGA (SEQ ID NO: 55) ACTG2 NM_001615.3 GGGCCCTCCATTGTGAGAACCTGTTCT GGTTTTAATGTT CCACAGGAAGTGCT GACTTTAGAAGC TCATGACTGGTATCTAAAGTCAGAAC ACTTCCTGTGGAC ACAGAGTAGTCT AGGTTCTCCAAGGA AATGGAGGGCCGAGGGGATCCT TCCCCTCGAGACTA (SEQ ID NO: 59) TG (SEQ ID NO:CTCTGTTACCAGTC 60) ATGAAACATTAAA ACC  (SEQ ID NO: 58) ADAM12 NM_003474.4GTACTGATGTCTCC ACAGTGACCCAG CTGAGACTGACT CTCGCTCGAAATTA AATTACCGTGTAGCTGAATCAGAA CACGGTAATTCTGG ATTTCGAGCGAG TATCCCCGTACA GTCACTGTTACTACGGAGACATCAGT TGTCCATGGTAG CATGGACATGTACG AC  TA (SEQ ID NO:GGGATATTCTGATT (SEQ ID NO: 62) 63) CAGCAGTCAGTCTC AG (SEQ ID NO: 61)ADAM28 NM_014265.4 GCAGAGTGGATGA ACACATGGTATC CGTCCTTTCCAGCACACTCATTCCCT ATTTGCTTTGCAG GGCAAATTATCC GCAAAGCAAATGA GGAATGAGTGTGGACCCACCTTGA TACCATGTGTGGGA TCATCCACTCTGC CAGAACAACTTC AGTTGTTCTGTCAA(SEQ ID NO: 65) CC (SEQ ID NO: GGTGGGTCGGATA 66) ATTTGCCCTGGAAAGGACG (SEQ ID NO: 64) ADH1B NM_000668.4 ATAATCTTTAGTCA AGGGCAAGTAAAGAGACAGAGTTA TCGAATCCCAGTGG AGGGTCCCCTCC GAAGACTTCAAT AGGGGACCCTTTTAACTGGGATTCGA CACAATGGCCCA CTTGCCCTGAACAT TGACTAAAGATT GCATGTGTATGTACACATGCTGGGCC AT  TC (SEQ ID NO: ATTGTGATTGAAGT (SEQ ID NO: 68) 69)CTTCTAACTCTGTC TC (SEQ ID NO: 67) ADIPOQ NM_004797.2 GCTTTCTTCTCTACGAGGCTCTGAGT CTAACCGTACTG CATGACACCAACTG TAGTGGTGATCA AAAGCCTTTAATATCACCACTAACTC GTTGGTGTCATGG TGACTTTGGGGC AGAGCCTCCTCCAG TAGAGAAGAAAGTGTTTGGCCTGG GCCAAACAGCCCC (SEQ ID NO: 71) AG (SEQ ID NO: AAAGTCAATTAAA72) GGCTTTCAGTACGG TTAG (SEQ ID NO: 70) ADO NM_032804.5 AGGAACTTTAATGTCTGCCAGCAACA ATTAGATGAACC TCCCGACTCGGGTG CAGCTGGAATCA CAGGGCTCAGTCATTCCAGCTGTGTT CCCGAGTCGGGA ATTTTAGGGAGA GCTGGCAGTGTTGT ACATTAAAGTTCCGGGTTGAGACAA CTCAACCCTCTCCC T (SEQ ID NO: 74) CA (SEQ ID NO:TAAAATGACTGAGC 75) CCTGGGTTCATCTA AT (SEQ ID NO: 73) AHCYL2NM_001130723.2 CACGCATGATCACC AGAGGTAGAAGA CAGACTAGCTTT AAAACCTTCCCATCAGAGAATCAGGA GAGAGTATATGT CTGATTCTCTTCTTC TGGGAAGGTTTT GAAGACCAGGATACCTCTACCCTCT GGTGATCATGCG GAAGTTGGAGA CCAACTTCTCCTGG TG  GGGT (SEQ IDTCTTCACATATACT (SEQ ID NO: 77) NO: 78) CTCAAAGCTAGTCT G (SEQ ID NO: 76)AHR NM_001621.3 CTGCTACCACATCC GAGGGAACTAGG GAAGCAGGATA ACTCTAAGCAAGGATTGAGAGAGTC GAGATAAATAG ACTCTCTCAATCCT CTTGCTTAGAGTG ACTCATCTTGTTAGTTCCCTCCTGGC GATGTGGTAGCA GCATCATGGCAG TGCCATGATGCAACG (SEQ ID NO: 80) CCAG (SEQ ID AAGATGAGTCTATT NO: 81) TATCTCTATCCTGCTTC  (SEQ ID NO: 79) AICDA NM_020661.1 GCTGCATGAAAATT AAAGGATGCGCCTCCCAAAGTACG CAGTTCGTCTCTCC GAAGCTGTCTGG AAATGCGTCTCG AGACAGCTTCGGCGAGAGACGAACTG TAAGTCATCAAC CATCCTTTTGCCCC AATTTTCATGCAG CTCATACAGGGGTGTATGAGGTTGAT C (SEQ ID NO: 83) CA (SEQ ID NO: GACTTACGAGACGC 84)ATTTCGTACTTTGG GA (SEQ ID NO: 82) AKAP2 NM_001136562.2 GCTTGAGCCAGGGTTGAGAACTGCCTT TTCCTGCCCAGA GCACGCAGGAATCT TTTCCAGACAGAT GCGCGCGCCTCAGTCTGGAAAAAGG TCCTGCGTGCACC AACCTCCTCAG CAGTTCTCACTGAG CTGGCTCAAG(SEQ ID NO: 87) GAGGTTTGAGGCGC (SEQ ID NO: 86) GCGCTCTGGGCAGGAAGCCTCCCCAGCT TTC  (SEQ ID NO: 85) AKAP9 NM_005751.3 CTGGGAAGCAGCACATTTCTTCCAGC GCTTCAAATTCT TGAGATTGAAGAG TCTCTGTTTAGCT TGTAACTGCTGCCTAAACAGAGAGC CTTCAATCTCATG AGTCCTTCAGTC TGGAAGAAATGAG CTGCTTCCCAGCCATAGGTAACC GGTTACCTATGGGA (SEQ ID NO: 89) CT (SEQ ID NO: CTGAAGGACTGCA90) GCAGTTACAAGAAT TTGAAGC (SEQ ID NO: 88) AKR1C2 NM_001354.4ACATACTGCATCCT AATTCACATTGAT CAACCGTTTCTT ATAGTTATACCATC TTCAGAGTGGATACCTGTGGAAAA CACTCTGAAATCAA GGTATAACTATA GAAGTTTCTGTA TGTGAATTTAACTTGGATGCAGTATG TGGAACTGAAGT CAGTTCCATACAGA T (SEQ ID NO: 92)TA (SEQ ID NO: AACTTCTTTTCCAC 93) AGGTAAGAAACGG TTG  (SEQ ID NO: 91)ALOX5 NM_000698.2 GTCAAGATCAGCA TCCTGCCAGTGAT TCAACACAGGGTACACTATTTCTGAG TCATGACCCGCTC TGCAGCCATTCA CGGGTCATGAATCA AGAAATAGTGTTGGAACTGGTAGC CTGGCAGGAAGAC GCTGATCTTGAC CAAACATCAGGT CTGATGTTTGGCTA(SEQ ID NO: 95) CT (SEQ ID NO: CCAGTTCCTGAATG 96) GCTGCAACCCTGTGTTGA (SEQ ID NO: 94) AMIGO2 NM_001143668.1 TTTCGTGCGCTTGG ATCAGTCTTTCCCCCAGATGAAATC CTTTATTCATGAGG CGACCTGAGCCT CGTATTTGCATT CTCAGGTCGGGGACATGAATAAAGC ACCTGTCTTGCT AAGACTGATGGTCC CAAGCGCACGAA GTCACAGTGGACACTGTGACAGCAA A (SEQ ID NO: 98) C (SEQ ID NO: 99) GACAGGTAATGCAAATACGGATTTCAT CTGGG (SEQ ID NO: 97) ANKRD13A NM_033121.1 GCCAAACTGCGCGTCAGCTCATGTTTT CCGCCCAGTTGT CGATATCACATTGC CAAATCCCAGCA CTTCTCCCTTAATGGGATTTGAAAAC ATGTGATATCGA ATATAAAACTAC ATGAGCTGGATAA CGCGCAGTTTGGGCCTCCCTCTTA GAGGGAGGCGTAG C  TC (SEQ ID NO: TTTTATATTTAAGG(SEQ ID NO: 101) 102) GAGAAGACAACTG GGCGG (SEQ ID NO: 100) ANLNNM_018685.2 ATGACCTCTTCAGT CTTCTCCATATCT CTGTTCTTCGCT GATGTCCTAGAGGAAGTTCACCTTCCT GCTTTCTGCTAA AGGTGAACTAGAT CTAGGACATCAC TGCTTGATCCATATGGAGAAGAGCC TGAAGAGGTCAT CTCCTCTTGGCT AAGAGGAGATGGA (SEQ ID NO: 104)(SEQ ID NO: 105) TCAAGCATTAGCAG AAAGCAGCGAAGA ACAGGA (SEQ ID NO: 103)ANO3 NM_031418.2 ACGCTTACTCAAAG GGTTGACTGGAA TTGTCAGTGGAG AGCTTGAGCCAGTCGAGGGAAGTAGA ATTAAGGTTATA TACTTCCCTCTTCC CTGGCTCAAGCTC GATGTGGGAGCCAGTCAACCGAGAG TTTGAGTAAGCGT TGAGATTCACTC TGAATCTCAGGCTC (SEQ ID NO: 107)TC (SEQ ID NO: CCACATCTATAACC 108) TTAATCTCCACTGA CAA (SEQ ID NO: 106)ANTXR1 NM_018153.3 GATGGGGGTCCAG TCCAAAATGAAG CCACAAAGTAATCCTGCTACGGCGGA TACAGGTCAAAT AGATTTCATTCC TTTGACCTGTACTT CCGCCGTAGCAGAGTGGTGCAGCA CATTTTGGACAAAT GCTGGACCCCCA CACTTCCTGATT CAGGAAGTGTGCTGTC (SEQ ID NO: TG (SEQ ID NO: CACCACTGGAATGA 110) 111) AATCTATTACTTTGTGG (SEQ ID NO: 109) ANUBL1 NM_001128324.1 TGTACCTTGAAGCT CTAGTATTTATAGAATCCAAGTACT AGTTTTGGCTATGC GTCCGCCACGCA CTGCCATCTTCC GTGGCGGACCTATATAGCCAAAACTA TAAGTGGATCGT AATACTAGAAGAG GCTTCAAGGTAC CTGTAGGAACTCTTCCTACAGACGAT A (SEQ ID NO: 113) TT (SEQ ID NO: CCACTTAGGAAGAT 114)GGCAGAGTACTTGG ATT (SEQ ID NO: 112) APOL1 NM_003661.3 CCGCTTTGACCGGGCCACTTCTTTCCG AATTTGTCAAGG ATTACCAGCAGTAC TAGTCCATGGTAC CTTTTGATGACCCATGGACTACGGA TGCTGGTAATCCC AGGTCGTGGGCT AAGAAGTGGTGGA GGTCAAAG (SEQTGGGCTTGTGTC CACAAGCCCAAGC ID NO: 116) CA (SEQ ID NO: CCACGACCTGGTCA117) TCAAAAGCCTTGAC AAATT (SEQ ID NO: 115) ARID3A NM_005224.2AGAATTTAATAAAA ACCTGAGAAATT CTGATGGATTTC CAGGGGAAAACCA CAAGTGTTCCTTGTTTGCTGTTCTC AGGAACACTTGAAT GTTTTCCCCTGTT ACAATTCATCTC TTCTCAGGTTTTGGTTATTAAATTCT TCTGAATGTCCA ACATTCAGAGAGAT (SEQ ID NO: 119) AA (SEQ ID NO:GAATTGTGAGAAC 120) AGCAAAGAAATCC ATCAG (SEQ ID NO: 118) ARID3BNM_006465.2 GGGCCCATTTGAAG CCTGAGAAAGAC ATCCTCTGGGTG GTGTCTCAGACATTATACTGGCCAAA GGAAGAGTCCAT TGGCCAGTATGTCT TGTCTGAGACAC CCTTTGTGACCATTCTCAGGGGTTTG CTTCAAATGGGC AACC (SEQ ID GTCACAAAGGATG CC (SEQ ID NO:NO: 123) GACTCTTCCCACCC 122) AGAGGATGCAGGG AAAG (SEQ ID NO: 121) ARID5ANM_212481.1 CAGCAGGGCCTGG CCGCTGGCACCC TAGAAGCTGGAT CCTCTGGGTCTTCTACAAAGGACACA AGGAGCCGCTTG GTGTCCTTTGTGGG GAAGACCCAGAG TAGGCCTCAGGATGCCAGCGGCTGTC GCCAGG (SEQ ID CAG (SEQ ID NO: CTGAGGCCTACAAG NO: 125)126) CGGCTCCTATCCAG CTTCTACTGCAAGG GGA (SEQ ID NO: 124) ARL6IP1NM_015161.1 GACCATGATCGTTT GGACTTGTTGTCC AG GAAG CAATA CCCTTGCTGCGGTTCACCCAAGCAAC GTAAGGAAGTCA GCTTGGGTGGGACA CGCAGCAAGGGA CTATCAGGTAGGACAAGTCCACAACC AACGATCATGG TGAGAAGCAGGT TGCTTCTCACCTAC (SEQ ID NO: 128)TGT (SEQ ID NO: CTGATAGTGACTTC 129) CTTACTATTGCTTC CT  (SEQ ID NO: 127)ARNT2 NM_014862.3 CGGGCTCAAAGCTG CAAACAAAGTCA AAAGTCCAGTAG GATTAGAAAGGGGCAAGTGCCTCTCC TTCAAACAAGGT AGAGGCACTTGTGA CCTTTCTAATCCA GTGAGCGAGGACTTTGTTTGACTCT GCTTTGAGCCCG AGTGAGTCACAG GTGACTCACTTCCT (SEQ ID NO: 131)AGT (SEQ ID NO: CGCTCACACCTTGT 132) TTGAACTACTGGAC TTT (SEQ ID NO: 130)ARNTL NM_001178.4 GCCACGGTGGTGCT AAGTTAAGCTTG AGATTCCTATGAGGCTAGAGTGTATA GGTCCAAACGTA CATCGGAACCAA CGTTTGGACCCAAG TACACTCTAGCCATGAAGGCCCAGG CTTAACTTTTCCAA GCACCACCGTGG ATTCCACATTGG TGTGGAATCCTGGG(SEQ ID NO: 134) AA (SEQ ID NO: CCTTCATTGGTTCC 135) GATGTCATAGGAAT CT (SEQ ID NO: 133) ASB13 NM_024701.3 GGACACGTAGGCG CGGTTTGAATGGGAATGCCGAGCC GTACCACTAAGGTT CTCATTACCAAA ACGAGAATATAC TTGGTAATGAGCCAACCTTAGTGGTAC ACCTTGACACAC TTCAAACCGACAGC CGCCTACGTGTCC CTTCACACTGCTAGTGTGAAGGTGTG (SEQ ID NO: 137) GT (SEQ ID NO: TCAAGGTGTATATT 138)CTCGTGGCTCGGCA TTC (SEQ ID NO: 136) ASCL2 NM_005170.2 CGGGGGGCACCAATAGAAAATCCTCT CCTCCAGCAGCT CACTTGGAGATTTT CCCCTCCGGAAA CAAGTTAATGTGTCCGGAGGGGAGA AATCTCCAAGTGT TAGAAAATGGAT GGATTTTCTAAGGG TGGTGCCCC (SEQTCTCTGTGCCCT CACAGAGAATCCAT ID NO: 140) (SEQ ID NO: 141) TTTCTACACATTAACTTGAGCTGCTGGA GGGA (SEQ ID NO: 139) ASMTL- NR_026711.1 GGAAGTTCTCCTTCCCGAGAGCCGTC CATTCATGGGCA AS1 AAGTCTAACCTAAG ACAGTGTGGCCTT TCCACGGTGCCGGCCACACTGTGACG AGGTTAGACTTG AGGTCACGGAA GCTCTCGGGTCAGT AAG (SEQ ID NO:GGAACTGAC TCCTTCCGTGACCT 143) (SEQ ID NO: 144) CGGCACCGTGGATGCCCATGAATGCTGA TC  (SEQ ID NO: 142) ASPM NM_018136.4 CAGAGATGGTACAAAATGTGTTCTTG AGCCACGATAAG GGGCGTACAAGAC TATCATGAAGAG CAGACTGGAGGTCTTCATGATACAA TCTTGTACGCCCT GAAATCACAGCT GAACACATTTTTTG GTACCATCTCTGGCCTTTGTCTTC AAGACAAAGGCAG (SEQ ID NO: 146) AAA (SEQ ID NO:CTGTGATTTCCCTC 147) CAGTCTGCTTATCG TGGCT (SEQ ID NO: 145) ATF3NM_001674.2 TTTGATATACATGC GAGCCCGGACAA TATCTGTTGGAT TCAACCTTCATCGGTACACGTGGGCC AAAGAGGTTTCT CCCACGTGTATTGT GATGAAGGTTGA CTCATCTTCTGGCCGGGCTCAGAATG GCATGTATATCA AGTCCTCCCATT GGAGGACTCCAGA AA (SEQ ID NO:CT (SEQ ID NO: AGATGAGAGAAAC 149) 150) CTCTTTATCCAACA GATA (SEQ ID NO:148) ATM NM_000051.3 ACGCTAAGTCGCTG CGGAGCAAACGC CGGTCTCCGCGCGCCATTGGTGGACA GCCTGCGCCATGT TCAAAACACTGC TGGCGCAGGCGCGT CCACCAATGGCCCAAAACATTC TTGCTCCGACGGGC (SEQ ID NO: 152) GGCCCGT (SEQ CGAATGTTTTGGGGID NO: 153) CAGTGTTTTGAGCG CGGAGACCGCGTG ATA (SEQ ID NO: 151) ATOH8NM_032827.6 GGCATCCTGAGGA AGTTCTGGAAAA TTTGATCTCCAG ACTTGATAGACAAACACTGTCATTGTT GAATTCATAGTA CAATGACAGTGTTT TGTCTATCAAGTT CCATCTGAGATTTCCAGAACTGTGGG CCTCAGGATGCC AGACACGTACCC TACGTGTCTAATCT (SEQ ID NO: 155)AC (SEQ ID NO: CAGATGGTACTATG 156) AATTCCTGGAGATC AAA (SEQ ID NO: 154)ATP6V0E1 NM_003945.3 GACATGCTCTACAG AAGGCATTCTCTT ACAGGCAAGTCATGCTCAGTCTTTGA CTCGTGACCTCAA AGAAAAGTGGTC GGTCACGAGAAGA AGACTGAGCACTTGGTTTGGAGGT GAATGCCTTCTAGA GTAGAGCATGTC GATTTTGCATCT TGCAAAATCACCTC(SEQ ID NO: 158) AG (SEQ ID NO: CAAACCAGACCACT 159) TTTCTTGACTTGCCTGT (SEQ ID NO: 157) ATXN7L2 NM_153340.4 ATGTCCATCTTCGG ACAACCAAGTAGGAAAGCTTGAGG GCACTGCCCTGCCC AAGTCATCATGG CTTCACCACTTG ATGATGACTTCTACGCAGGGCAGTGC GCTGCAGTGGTT TTGGTTGTGTGTAA CCGAAGATGGAC ACAC (SEQ IDCCACTGCAGCCAAG AT (SEQ ID NO: NO: 162) TGGTGAAGCCTCAA 161)GCTTTCCAGAAGCA CT  (SEQ ID NO: 160) AUH NM_001698.2 GGTGGTCTTGAACTGAGGAAGCTGCT CTCCACCAGGAA GGCTTTAGCCTGTG ACTCGTATATCAC TAATCGCCAATTATATACGAGTAGCA AGGCTAAAGCCA TTGTTTCAACCA GCTTCCTCTGCAAA GTTCAAGACCACGGCCCATTTTTG AATGGGCCTGGTTG C  CA (SEQ ID NO: AAACAAAATTGGC(SEQ ID NO: 164) 165) GATTATTCCTGGTG GAG (SEQ ID NO: 163) AURKANM_198433.1 AGGCGCCCTGTAGG TGAGACCCTCTA CACTGAAGTTTC ATACTGCTTGTTACGCTGTAATAAGT TTATCAAATATC TTATTACAGCTAGA AACAAGCAGTAT CCCGCACTCTGGGGGTCTCACTCCAT CCTACAGGGCGC CCTGGGCAATGG TGCCCAGGCCAGA (SEQ ID NO: 167)AG (SEQ ID NO: GTGCGGGGATATTT 168) GATAAGAAACTTCA GTG (SEQ ID NO: 166)AUTS2 NM_001127231.1 CTTGTCCTTTCATTC TGTAGTGGTGTG TCTCTTCCCAAGAAAGAAGAGCAGA GGTGGCTGAGTC GTGCTGGCAGAG CTCAGCCACCCACA TGCTCTTCTTTGAATTGCGGTCATT CCACTACAGCTCAG ATGAAAGGACAA TTCTCGATCTGA ATCGAGAAAATGA G GC (SEQ ID NO: CCGCAATCTCTGCC (SEQ ID NO: 170) 171) AGCACCTTGGGAAGAGA (SEQ ID NO: 169) BANK1 NM_001083907.1 GGCAAATGAAATG TCTCCATGCCTGATCTTCAGAACTC GAAGGGGAAGGAA TCCATTCTGTTTT TCACTGCCAACC AACAGAATGGATCCCTTCCCCTTCCA TCTAGTGGGCTG AGGCATGGAGACC TTTCATTTGCC TGTTTGG (SEQ IDAAACACAGCCCACT (SEQ ID NO: 173) NO: 174) AGAGGTTGGCAGT GAGAGTTCTGAAGACCAGTAT (SEQ ID NO: 172) BASP1 NM_006317.3 GATCCGCGTCTGAA TGGCGGCAGTTTCCCCATTGCAGAA AGTGCAGTACATCG AGGTACAAACGA GAAAAGCTATTC TTTGTACCTGAAACTGTACTGCACTTT AACTCTCAGCGG TGCCGCCACATGCA CAGACGCGGATC TGGAGGAGTGCACTCCTCCACCGCTG (SEQ ID NO: 176) TG (SEQ ID NO: AGAGTTGAATAGCT 177)TTTCTTCTGCAATG GG  (SEQ ID NO: 175) BATF NM_006399.3 CACTGTGGGTTGCATTGAGCATCTTTC TATTTAGAAAAA GGCCCAATGCAGA TTAATACTCTTCT TAACCGTTCCCTAGAGTATTAAGAA GCATTGGGCCTG GCCCGCCTTGCT AGATGCTCAAGTCC CAACCCA (SEQ IDCTGTGCCATGGG CATGGCACAGAGC NO: 179) AC (SEQ ID NO: AAGGCGGGCAGGG 180)AACGGTTATTTTTC TAAATA (SEQ ID NO: 178) BATF3 NM_018664.2 CTGCTGTTATGCAGAGCATCTTTATTA AAGTGTATTGTG AGCCATTTCCTCTA TCCAAATTCTAGA CCTGTAAATTCCGAATTTGGATAATA GGAAATGGCTCT CAGAACTGGAG AAGATGCTTATTGT GCATAACAGCAGAAGGGAGAGAC CTCTCCCTTCTCCA (SEQ ID NO: 182) AATA (SEQ ID GTTCTGGGAATTTANO: 183) CAGGCACAATACA CTT (SEQ ID NO: 181) BCAT1 NM_005504.4CCGACGGAACAAT GGTACACTCTGC AGGTCTTTAGCC GAAGGATTGCAGT GGAGCATCCGTTTTAAAAGTCCCC AACGGATGCTCCGC ACTGCAATCCTTC ACCACCTCTTTT AGAGTGTACCGGAATTGTTCCGTCG GATCCTCCTTCT GAAGGAGGATCAA (SEQ ID NO: 185) CC (SEQ ID NO:AAGAGGTGGTGGG 186) GACTTTTAAGGCTA AAGACCT (SEQ ID NO: 184) BCL10NM_003921.2 TGAAAATACCATCT CTGGGTCCCCAG ACAAGTTCCTTC TCTCTTCAACTACAGTCTGGGAAGTG TTCTTCTAACTG CTTCCCAGACCTGG TAGTTGAAGAGA TAGATCTGGTGGGGACCCAGGGGCT AGATGGTATTTTC CAAAGGAGGAG CCTCCTTTGCCACC A CCC (SEQ ID NO: AGATCTACAGTTAG (SEQ ID NO: 188) 189) AAGAAGAAGGAACTTGT (SEQ ID NO: 187) BCL2A1 NM_004049.2 TCATGTGTCATAAC GGCAATGTGCTGCTGGTGGAGAGC TCAGTCAAGCTCAG AGAATGCTCACT AAAGTCTTGAGC TGAGCATTCTCAGCGAGCTTGACTGA TGGCTCACCTTG ACATTGCCTCAACA GTTATGACACAT AAGCTGTTGAGCTTCAAGGTGAGC GA (SEQ ID NO: (SEQ ID NO: 192) CAGCTCAAGACTTT 191)GCTCTCCACCAGGC AG  (SEQ ID NO: 190) BCL2L10 NM_020396.2 TTTTATCTGAATGCACACTGGCCAAA GAGCCATTTGCA ATACAAGGAGTCCT TCACCACCTCAG TTCTTGTCCTCAGAGGTGGTGATTTG GACTCCTTGTATG CACCTGAGTACT GCCAGTGTTTTAAC CATTCAGATAAATGTCACAAGTTA TTGTGACAAGTACT A  AA (SEQ ID NO: CAGGTGTGAGGAC(SEQ ID NO: 194) 195) AAGAATGCAAATG GCTC (SEQ ID NO: 193) BCL6NM_001706.2 GTTGTGGACACTTG ACCATCTCTGCTT TCAGCATCCGGC CCGGAAGTTTATTACACTGGCCTTAAT TGTTGAGGAACT AGGCCAGTGAAGC AAACTTCCGGCA CTTCACGAGGAGAGAGATGGTTTCTG AGTGTCCACAAC GCTTGATGGCAG CCATCAAGCCTCCT (SEQ ID NO: 197)AA (SEQ ID NO: CGTGAAGAGTTCCT 198) CAACAGCCGGATG CTGA (SEQ ID NO: 196)BEST3 NM_152439.2 TCTTGCAACTAAAG GATCAACACTGT GAGGCTGCACCA CCCGGAATGAAGGCTCTGATTCTACC AGAGCGGTATCG TAGAATCAGAGAC TTCATTCCGGGCT ATTCATTTCAGTAGTGTTGATCTGCA TTAGTTGCAAGA CATCAATGATTG ATCATTGATGACTG (SEQ ID NO: 200)CA (SEQ ID NO: AAATGAATCGATAC 201) CGCTCTTGGTGCAG CCTC (SEQ ID NO: 199)BIRC2 NM_001166.3 TGGGATCCACCTCT ATGTGCAAAACT GAGTAAGAACC AAGAATACGTCTCCGTTTCTCATTGGA ACTGAACAAGCT AATGAGAAACAGT GACGTATTCTTAG ACTATGTTCCAATTTGCACATTCATT AGGTGGATCCCA GGTGGGAGATA ATCTCCCACCTTGG (SEQ ID NO: 203)ATGA (SEQ ID AACATAGTAGCTTG NO: 204) TTCAGTGGTTCTTA CTC (SEQ ID NO: 202)BIRC3 NM_001165.3 GTGATGTTTCTCCT TCAACTGCAGAC ACCAGTGGTTTG GCCACCTGGAAACTTCAATGCTTTGT CAAGCATGGTTT AAAGCATTGAAGTC TTCCAGGTGGCA CCTGGATCTCACTGCAGTTGAAAAGC GGAGAAACATCA AGACGTTGGGCT CCAACGTCTGTGAG C TT (SEQ ID NO: ATCCAGGAAACCAT (SEQ ID NO: 206) 207) GCTTGCAAACCACTGGT (SEQ ID NO: 205) BIRC5 NM_001168.2 CCATTCTAAGTCAT TCTCCTCATCCACAGCAGTGGCAA TGGGGAAACGGGG CTGAAGTTCACCC AAGGAGTATCTG TGAACTTCAGGTGGCGTTTCCCCAATG CCAGACGCTTCC ATGAGGAGACAGA ACTTAGAATGG TATCACTCTATTATAGAGTGATAGG (SEQ ID NO: 209) CTG (SEQ ID NO: AAGCGTCTGGCAG 210)ATACTCCTTTTGCC ACTGCT (SEQ ID NO: 208) BMP7 NM_001719.1 GCTTCGTCAACCTCGTAGCGTGGGTG GCTTCCCCTTCT GTGGAACATGACA GAAGAATTCCTT GGGATCTTGGAAAGGAATTCTTCCAC GTCATGTTCCACG AGATCAAACCGG CCACGCTACCACCA AGGTTGACGAAGAACTCTCGATGG TCGAGAGTTCCGGT C  TG (SEQ ID NO: TTGATCTTTCCAAG(SEQ ID NO: 212) 213) ATCCCAGAAGGGG AAGC (SEQ ID NO: 211) BPGMNM_199186.1 TTTCCAGAGCTAGG AGTTACCTAGTTA GCTATGACATAA CTGTGGAGTAGAGTCCTATACAAACTC GCACTGAGGCAT TTGTATAGGTAACT TACTCCACAGCCT CCTAAAGCCTTAAGGTAACTTATTGT AGCTCTGGAAA TCTGGGCCACAA GGCCCAGATAAGG (SEQ ID NO: 215)TA (SEQ ID NO: CTTTAGGATGCCTC 216) AGTGCTTATGTCAT AGC (SEQ ID NO: 214)BPNT1 NM_006085.4 ACACTGTGTTGATG CTTTTGAGCAATA ACAATACCCAGGCGGTTGGTAGCCTC GAATATGCGGAG TCTCCTTCAGCA CGCATATTCTATTG GCTACCAACCGCATAACACGTCTG CTCAAAAGGCAGG ATCAACACAGTG ACTATCATTCCT AATGATAGTCAGAC T GC (SEQ ID NO: GTGTTATTGCTGAA (SEQ ID NO: 218) 219) GGAGACCTGGGTATTGT (SEQ ID NO: 217) BSPRY NM_017688.2 CACTGGCCTGGTGG GAATCAGCTGGACAAAATGCCCTC GCATGCTTACTCAC GGTCATCCAGGT TGCTTCTTCGGT CTGGATGACCTCCAGAGTAAGCATGC CCTCTCGAAAAT GCTGATTCAGAAGG CCAC (SEQ ID NO: CTCTTGCTCCTTCAGCAAGAGATTTTC 221) T (SEQ ID NO: GAGAGGACCGAAG 222) AAGCAGAGGGCATTTTG (SEQ ID NO: 220) BST2 NM_004335.2 TTCGTATGACTATT TACAGCGCTTATCCAGAATCACGAT GCAGAGTGCCCATG CCCGTCTTCCATG GATCAGGAGCAC GAAGACGGGGATAGGCACTCTG (SEQ CAGAATTCCTAT AGCGCTGTAAGCTT ID NO: 224) CCCCAGCAGAAGCTGCTGGGGATAGG CT (SEQ ID NO: AATTCTGGTGCTCC 225) TGATCATCGTGATTCTG (SEQ ID NO: 223) BTBD19 NM_001136537.1 TTTTTCCGCAGCAC CATCACTGTATCGGCACCGATGGGC TCCGAAGCCTTGTC CGGGTTGTTGAC AAATACCTCCTG AACAACCCGCGATAAGGCTTCGGAG CCGTTCTTGACC ACAGTGATGTTTGC TGCTGCGGAAAA AACCACGAAGCTTCGTGGTTGGTCA A  AAA (SEQ ID NO: AGAACGGCAGGAG (SEQ ID NO: 227) 228)GTATTTGCCCATCG GTGC (SEQ ID NO: 226) BTG1 NM_001731.2 CAACGTGCAAATGAGAGAAGTTCCT ACCTGATACAGT GTAGACAGCCGAA CCTTACAGCTGAT CATCATATTGTATCAGCTGTAAGGAG TCGGCTGTCTACC GTTTTTGGAAGG GAACTTCTCTTGGG ATTTGCACGTTGGCTCGTTCTGCC CAGAACGAGCCCTT (SEQ ID NO: 230) CA (SEQ ID NO:CCAAAAACTACAAT 231) ATGATGACTGTATC AGGT (SEQ ID NO: 229) BTG2NM_006763.2 TGCTCTCCTTGGGA CAAGGAATACAT ACAAGAATACCA TGATGGCTGGCTAGGCAAGGCTGACT AGTAGTCTTGCA TCAGCCTTGCATGT AGCCAGCCATCA GAACATGGGGCATTCCTTGGCTGAA TCCCAAGGAGAG ACTCTCCCATTC TGGGAGAGTGCCCC (SEQ ID NO: 233)AGC (SEQ ID NO: ATGTTCTGCAAGAC 234) TACTTGGTATTCTT GT  (SEQ ID NO: 232)BTK NM_000061.1 TGATCTGGTTCAGA GATACTGCCCATC CTCCAAAATTTG AATATCACCCTTGCGATCCAGAAGCA GCAGCCCATAGC TTCTGGATCGATGG AGGGTGATATTTC ATTTTTGGCTGTGCAGTATCTCTGCT TGAACCAGATCA CTGAGAGCAGCA GCTCTCAGACAGCC (SEQ ID NO: 236)GA (SEQ ID NO: AAAAATGCTATGG 237) GCTGCCAAATTTTG GAG (SEQ ID NO: 235)BUB1 NM_004336.2 CCCGGAAAATGTCC CCTTGTAGCTCTG CTCTTCTACCCATTCAGATGCTTGAA CATGTGGGCTTCA CTGTATGTATCT GCCCACATGCAGA AGCATCTGAAGGTTCCCATTCACC GCTACAAGGGCAA ACATTTTCCGGG AAGAGGGTCATT TGACCCTCTTGGTG(SEQ ID NO: 239) GC (SEQ ID NO: AATGGGAAAGATA 240) CATACAGTGGGTAGAAGAG (SEQ ID NO: 238) BUB1B NM_001211.4 GAGTCTTCTGTACC CCTTTGCTCTTTACCTTGAGAGCAC ACAACGAAGCACA GTTCAGCTAGTGT CTCCTACACGGA CTAGCTGAACTAAAGCTTCGTTGTGGT TGATTGGAGCTC GAGCAAAGGGAAA ACAGAAGACTC TTGCTGTCTTTTTAAGACAGCAAGAG (SEQ ID NO: 242) C (SEQ ID NO: CTCCAATCATCCGT 243)GTAGGAGGTGCTCT CAAGG (SEQ ID NO: 241) C10orf18 NM_017782.3 CCAGAAAATACCAACGATGGAGTTTT AGCTTAATGCTA CAGCGGCTCACAAT CAGGAAGATCAT GATCGGCTAACAGATCTTCCTGAAAA TGTGAGCCGCTGT TATTTAGGGCCT CTCCATCGTCAACT GGTATTTTCTGGGGGAGTCATAGT ATGACTCCCAGGCC (SEQ ID NO: 245) TG (SEQ ID NO:CTAAATATGTTAGC 246) CGATCTAGCATTAA GCT (SEQ ID NO: 244) C13orf18NM_025113.2 CCTCCCCATATCCT CAGATGGGAAGG GAAATGGTTCTT GAGACTGACAGTGCTCAAAAAAAGC CTACTGACTTGA CTTTTTTTGAGCCTT ACTGTCAGTCTCA ACAGCACCTTCACCCATCTGACATCT GGATATGGGGAG TCAGCAGCAGAT GCTGCTGATGAAGG G GT (SEQ ID NO: TGCTGTTCAAGTCA (SEQ ID NO: 248) 249) GTAGAAGAACCATT TC (SEQ ID NO: 247) C15orf41 NM_001130010.1 ATTAATGGCTCGGC TTTCCTCGTGTTCCTGAGAAGGGTC TTATACTGGAGAGG CTGTAGAAACCT CCGTAGCATACT TTTCTACAGGAACACTCCAGTATAAG ATTTATAATAGA CGAGGAAACTCCA CCGAGCCATTAA CTTGGAGGGTGGCCCTCCAAGTCTAT T  AG (SEQ ID NO: TATAAATAGTATGC (SEQ ID NO: 251) 252)TACGGGACCCTTCT CAG (SEQ ID NO: 250) C19orf26 NM_152769.2 CGGGGCAGGTACCTGGCATGGCGGC CTTCTTGACCTT GTTCTGCAGTTCCT GCAGGCGGGTGA GAAATAGGGGCTCACCCGCCTGCGCC GGAACTGCAGAA GGCCCCATCCAG GCCATGCCAGCCTG CGG (SEQ ID NO:GC (SEQ ID NO: GATGGGGCCAGCC 254) 255) CCTATTTCAAGGTC AAGAAGTGGAAGCTGGAG (SEQ ID NO: 253) C3orf37 NM_020187.2 CCAAGCTGCAGTTC CTCCATTACGGTAAAAACGACACA AATACTACCAACTG TCACTACGACAG GCGTCTTCCCTT TCGTAGTGATACCGTTGGTAGTATTGA TCCCAGAGGCAC TAATGGAGAAACG ACTGCAGCTTGG CTTAAATGACCGGTCATTTAAGGTGC (SEQ ID NO: 257) TTT (SEQ ID NO: CTCTGGGAAAGGG 258)AAGACGCTGTGTCG TTTT (SEQ ID NO: 256) C4orf31 NM_024574.3 TCCAGGCTTCTCGTGGACCCTGCCAA AGAAAAAAATC TCCTGGATATTGGT GATGCTAAGCAC CCTCCCCGTGGTGCTTAGCATCTTGG CAATATCCAGGA GTGGTGTGCGAA CAGGGTCCGGGGA ACGAGAAGCCTGATAGTCCACGTC CGTGGACTATTTCG GA (SEQ ID NO: CCC (SEQ ID NO:CACACCACACCACG 260) 261) GGGAGGGATTTTTT TCT (SEQ ID NO: 259) C5AR1NM_001736.2 TTGCCTGTCTTTCC GAGAAGAGTCCC GGGAGGGTGCTC CAGACTTGTCCCTCGCTGGAAAAGGA CCTAGAAGGAA CTTTTCCAGCGGGA GGGACAAGTCTG GTGTTCACCTTGCTCTTCTCATCCTTC GGAAAGACAGGC CAAATGAGGAA CTCATTTGCAAGGT AA (SEQ ID NO:GGAT (SEQ ID GAACACTTCCTTCT 263) NO: 264) AGGGAGCACCCTCCC (SEQ ID NO: 262) C5orf41 NM_153607.2 GCTCCTGTGTGTTC TCTGACAAAGGGTCACCATGATTT TTCTAAGACTCTGC ACCTCAGCCTGC GTGTGCTTGAAG AGGCTGAGGTCCCTAGAGTCTTAGAA TGGGTTTACTTG TTGTCAGACTGTGT GAACACACAGGA CTTTTTGGACACCCAAAAAGCAAGT GC (SEQ ID NO: AG (SEQ ID NO: AAACCCACTTCAAG 266) 267)CACACAAATCATGG TGA (SEQ ID NO: 265) C7orf68 NM_013332.1 CAACACAGAGCCCACATGCTTCTGGA TGTCTAGGTCAG ACCAAGGGCCTTCC TGGATGGTCTGG TGTTCCAAAATAAGACCATCCATCCA AAGGCCCTTGGT TGGCCAGTATGG GAAGCATGTGATA G  AAGGAGGTCTTAAGACCTCCTTCCAT (SEQ ID NO: 269) TC (SEQ ID NO: ACTGGCCATATTTT 270)GGAACACTGACCTA GACA (SEQ ID NO: 268) CA7 NM_005182.2 TCCCAGCCTGCAACTGAGGGACATGC CATTGAAGTCTA CACTGGAGCTTTCC AGGCCTCATAGG CCTGGACAGAGTTATGAGGCCTGCAT AAAGCTCCAGTG GGCCATTGTTGG GTCCCTCAGCATCA GTTG (SEQ ID NO:TGATGC (SEQ ID CCAACAATGGCCAC 272) NO: 273) TCTGTCCAGGTAGACTTCAATGACAGCG AT  (SEQ ID NO: 271) CACNA1D NM_000720.2 TATCGTGTGATTTGTTCTTCTCGTTTT TTGACATGGTTT CAAGATGACGAGC GTTTCCTCAGGCT CCAAGCAGGGCCTGAGGAAACAAA CGTCATCTTGCAA ACCATTTCTTTT ACGAGAAGAAGAA ATCACACGATAGAACACATCATC GATGATGTGTTCAA (SEQ ID NO: 275) TTC (SEQ ID NO:AAGAAATGGTGCC 276) CTGCTTGGAAACCA TGTCAA (SEQ ID NO: 274) CALD1NM_033138.2 GATTGACAGCAGA TTTTTGTTCCCTC TTCAGCAGGAAC CTGGAGCAGTATACAATTGCACTGGT AGGAAGATCCG CAGTGCAATTGAGG ATACTGCTCCAGT AGGCTGCCGGCTGAACAAAAAGCGC CTGCTGTCAATC TTGTAGGTTTTG AAAACCTACAAAG (SEQ ID NO: 278)CGC (SEQ ID NO: CCGGCAGCCTCGGA 279) TCTTCCTGTTCCTG CTGAA (SEQ ID NO:277) CAMK2B NM_001220.3 TCACCAGAAGCTGG AATGCTTCAGAA CTCCTCGGAGATAGAGAGAGGCTCG GGCGGCAGATCC GCTGTCGTGGAG GATCTGCCGCCTTC GAGCCTCTCTCTACGCACGATGTT TGAAGCATTCCAAC (SEQ ID NO: 281) GG (SEQ ID NO:ATCGTGCGTCTCCA 282) CGACAGCATCTCCG AGGAGGGCTTCCAC TAC (SEQ ID NO: 280)CAMKK1 NM_032294.2 GAGCCAGAAATCA TCTAACATCTTCA AAGGGTGCAACTGCGAGGAGCTCAA GGATCAGGTCCTT TGATGTCTGGCA GGACCTGATCCTGA GAGCTCCTCGCTGCCCCAATTCTCG AGATGTTAGACAA ATTTCTGG (SEQ TCTCGGGATTCT GAATCCCGAGACGID NO: 284) TG (SEQ ID NO: AGAATTGGGGTGCC 285) AGACATCAAGTTGCACCCTT (SEQ ID NO: 283) CARD11 NM_032415.2 TTGAAAATCGGCCC ATTCTCCCGCTCCCCGGCCTGGATG AAGAAGGAGCAGG AGTTCCAGAACC ATGGACTGCAGC TTCTGGAACTGGAGTGCTCCTTCTTGG TCCTGGTTTTTG CGGGAGAATGAAA GCCGATTTTCAA GTCTTCAGCATTTGCTGAAGACCAA (SEQ ID NO: 287) TC (SEQ ID NO: AAACCAGGAGCTG 288)CAGTCCATCATCCA GGCCGG (SEQ ID NO: 286) CAV1 NM_001753.3  AACCGCGACCCTAATCAAAGTCAATCT TCCAAATGCCGT ACACCTCAACGATG TGACCACGTCATC CAAAACTGTGTGACGTGGTCAAGATT GTTGAGGTGTTTA TCCCTTCTGGTT GACTTTGAAGATGT GGGTCGCGGTTCTGCAATCACAT GATTGCAGAACCA (SEQ ID NO: 290) CT (SEQ ID NO: GAAGGGACACACA291) GTTTTGACGGCATT TGGA (SEQ ID NO: 289) CAV2 NM_198212.1GCCTTTTGTAAAGA ATATTGTCTGCAC TCCTACGCTCGT CCTGCCTAATGGTT TGAAGGCAGAACACACAATGGAGC CTGCCTTCAGTGCA CATTAGGCAGGT AATGATAACATC GACAATATGGAAGCTTTACAAAAGG TGTCACACTCTT AGTGTGACAGATGT C  CC (SEQ ID NO:TATCATTGCTCCAT (SEQ ID NO: 293) 294) TGTGTACGAGCGTA GGA (SEQ ID NO: 292)CCDC50 NM_174908.3 AAACACTTTCCAGA TAGTAACTATCTG TAGATACAGCTTGTTCCCTGCAACCC CATAAGCACGGG CTTTCATCACTC GTGCTTATGCAGAT TTGCAGGGAACTTTGGCTTCATTC AGTTACTATTATGA CTGGAAAGTGTTT CTCCATCTTCAT AGATGGAGGAATG(SEQ ID NO: 296) AA (SEQ ID NO: AAGCCAAGAGTGA 297) TGAAAGAAGCTGTATCTA (SEQ ID NO: 295) CCDC75 NM_174931.2 ACTTGGCAAGAGTG TGATATTGAGAGCTTTCCGTTTTA GGGGTGGTATTGTT GAATTGGTTCAA ATGATGCCTCAT GAACCAATTCCTCTCAATACCACCCC GACCAATGCCAC CAATATCAAAACA CACTCTTGCCAAG TTTTCCCTGTTTGGGAAAAGTGGCA T  (SEQ ID NO: 300) TTGGTCATGAGGCA (SEQ ID NO: 299)TCATTAAAACGGAA AGCA (SEQ ID NO: 298) CCL17 NM_002987.2 GCCTGGAGTACTTCCCACGTCTTCAGC ACAGTTACAAAA AAGGGAGCCATTCC TTTCTAAGGGGA ACGATGGCATCCCCTTAGAAAGCTGA ATGGCTCCCTTGA CTGGAGCAGTCC AGACGTGGTACCA AGTACTC (SEQ IDTCAGATGTCTGG GACATCTGAGGACT NO: 302) TA (SEQ ID NO: GCTCCAGGGATGCC 303)ATCGTTTTTGTAAC TGT (SEQ ID NO: 301) CCNA2 NM_001237.2 CGGGACAAAGCTGCAGGGTATATCC GCTTTGAGGTAG GCCTGAATCATTAA AGTCTTTCGTATT GTCTGGTGAAGGTACGAAAGACTGG AATGATTCAGGC TCCATGAGACAA ATATACCCTGGAAA CAGCTTTGTCCCGGGCTTAAGACTT GTCTTAAGCCTTGT (SEQ ID NO: 305) TC (SEQ ID NO:CTCATGGACCTTCA 306) CCAGACCTACCTCA AAGC (SEQ ID NO: 304) CCNB1NM_031966.2 AACTTGAGGAAGA TTCCCGACCCAGT TGAACCTGTACT GCAAGCAGTCAGAAGGTATTTTGGTC AGCCAGTCAATT CCAAAATACCTACT TGACTGCTTGCTC AGGATGGCTCTCGGGTCGGGAAGTC TTCCTCAAGTT ATGTTTCCAGTG ACTGGAAACATGA (SEQ ID NO: 308)AC (SEQ ID NO: GAGCCATCCTAATT 309) GACTGGCTAGTACA GGTTCA (SEQ IDNO: 307) CCNB2 NM_004701.2 AGGTTGATGTTGAA AGTCAGCTCCATC GCTGCTGCTACCCAGCACACTTTAGC AAATACTTGGCT TTAGAAGGATGA CAAGTATTTGATGG AAAGTGTGCTGTTTAATGCACCATA AGCTGACTCTCATC CAACATCAACCT TCATAGTCGATG GACTATGATATGGT(SEQ ID NO: 311) AG (SEQ ID NO: GCATTATCATCCTT 312) CTAAGGTAGCAGCAGC (SEQ ID NO: 310) CCND1 NM_053056.2 TTGAACACTTCCTC GATCTGTTTGTTCTTCACATCTGTG TCCAAAATGCCAGA TCCTCCGCCTCTG GCACAGAGGGC GGCGGAGGAGAACGCATTTTGGAGA AACGAAGGTCTG AAACAGATCATCCG GGAAGTGTTCAA CGCGTGTTTGCGCAAACACGCGCAG (SEQ ID NO: 314) GAT (SEQ ID NO: ACCTTCGTTGCCCT 315)CTGTGCCACAGATG TGAA (SEQ ID NO: 313) CCND2 NM_001759.2 AGCCTGCATCCCTTTAAGGCACTTTAT AGGACAGGCAC CGCCTGCAGCCTAC TTCCCCAAAGTA CTGTCAAAAGACTTTGGGGAAATAAA GGCTGCAGGCGA ATTGGATACTGT GTGCCTTACTGACT AGGGATGCAGGCAATGGCTACAGT GTAGCCATTACAGT T  CAG (SEQ ID NO: ATCCAATGTCTTTT(SEQ ID NO: 317) 318) GACAGGTGCCTGTC CT  (SEQ ID NO: 316) CCND3NM_001760.2 GGCCAGCCATGTCT TGCAGGGAGGAG CCCAGCTAGAGT GCATTTCGGTGGCTGAGCTTGACTAG TGGGAAAGGCG AGTCAAGCTCCTCC CCACCGAAATGC CTGCTGGTCAGATCCCTGCATCTGAC AGACATGG (SEQ (SEQ ID NO: 321) CAGCAGCGCCTTTC ID NO: 320)CCAACTCTAGCTGG GGGTGGGCCAGGC TGA (SEQ ID NO: 319) CCR7 NM_001838.2TTCCGAAAACCAGG GAAGTCTCCCCA TCAGAGAGTTTG CCTTATCTCCAAGA CTATCTCTGGTCTTTTGACCAGCTG CCAGAGATAGTGG TGGAGATAAGGC ATGTCCGCTTTT GGAGACTTCTTGGCCTGGTTTTCGGAA CCTCACCAAGCC TTGGTGAGGAAAA (SEQ ID NO: 323) AA (SEQ ID NO:GCGGACATCAGCTG 324) GTCAAACAAACTCT CTGA (SEQ ID NO: 322) CD2 NM_001767.2TGGGTCTCACTACA AAGAAACTCCAG TATTTCACTTTTA AGCAGCCTATCTGC AGTCTCTTAAGCACTCACAGGATGG TTAAGAGACTCTGG GATAGGCTGCTT TGGGCAAGTGTC AGTTTCTTATGTGCGTAGTGAGACCC CACCAGGGCACA CCTGGTGGACACTT A (SEQ ID NO: 326)T (SEQ ID NO: GCCCACCATCCTGT 327) GAGTAAAAGTGAA ATA (SEQ ID NO: 325)CD200 NM_005944.5 CCCTCGGTCAGGGA CATTTGGGTGAG CTGATTCTTAGGTTGAAAATAGTACA ACAGAGTCACTG GTCTTTGATATG GTGACTCTGTCTCA TACTATTTTCAATGAGGATGCTGGT CCCAAATGGGACC CCCTGACCGAGG AACAGACGTGGT ACGTCTGTTACCAG G CC (SEQ ID NO: CATCCTCCATATCA (SEQ ID NO: 329) 330) AAGACCCTAAGAATCAG (SEQ ID NO: 328) CD22 NM_001771.2 TTTTCCAGAAGATG CCCCAAACTGGATTTGAGGATCAC AGGGGATTCATTAC TCAGCTCTGAGTA ATAGTCCACATT TCAGAGCTGATCCAATGAATCCCCTCA TTCTTGTGCCTG GTTTGGGGTCGGGG TCTTCTGGAAAA AGGCCGCTCCCCAGCGGCCTCAGGC (SEQ ID NO: 332) GA (SEQ ID NO: ACAAGAAAATGTG 333)GACTATGTGATCCT CAAA (SEQ ID NO: 331) CD247 NM_198053.1 TGGCAGGACAGGAAATGACGCAGCA AGAAAAAAAGC AAAACCCGTCAATG GTATCCTAGTACA AGAGCAGAGAGTACTAGGATACTGC TTGACGGGTTTTT CGTTTTCCATCC TGCGTCATTACAGG CCTGTCCTGCCAATGGCCTGTGCC GCACAGGCCATGG (SEQ ID NO: 335) CTGT (SEQ ID NO:ATGGAAAACGCTCT 336) CTGCTCTGCTTTTTT TCT (SEQ ID NO: 334) CD274NM_014143.2 TAGGAGATTAGATC CTGGGATGACCA CAGAATTACCAA CTGAGGAAAACCAATTCAGCTGTATG GTGAGTCCTTTC TACAGCTGAATTGG GTTTTCCTCAGGA ATTTGGAGGATGTCATCCCAGAACTA TCTAATCTCCTA TGCCAGAGGTAG CCTCTGGCACATCC (SEQ ID NO: 338)TT (SEQ ID NO: TCCAAATGAAAGG 339) ACTCACTTGGTAAT TCTG (SEQ ID NO: 337)CD3D NM_000732.4 TATCTACTGGATGA GAGAGAAACGTG TCACTTGCGAGA GTTCCGCTGGGAGACTATGTTCCATCT GAAGGGTAGCC TGGAACATAGCAC CCCAGCGGAACT AGTACCAGGCCAGTTTCTCTCTGGCC CATCCAGTAGAT (SEQ ID NO: 342) TGGTACTGGCTACC A CTTCTCTCGCAAGT (SEQ ID NO: 341) GAGCCCCTTCAAGA TAC (SEQ ID NO: 340) CD3ENM_000733.2 AAGTAACAGTCCCA ACTCTCCAGTGA CATTACCATCTT TGAAACAAAGATGGTGCCCGACTGC GCCCCCAAACGC CAGTCGGGCACTCA ATCTTTGTTTCAT CAACTGATAAGACTGGAGAGTTCTGG GGGACTGTTACTT GGCAGAGGCCC GCCTCTGCCTCTTA (SEQ ID NO: 344)AGA (SEQ ID NO: TCAGTTGGCGTTTG 345) GGGGCAAGATGGT AATG (SEQ ID NO: 343)CD3G NM_000073.2 AGAGCTTCAGACA GGCTGGTAGAGC ACTGGTTTCCTT AGCAGACTCTGTTGTGGTCATTGGGC GAAGGTGGCTGT CCCAATGACCAGCT AACAGAGTCTG ACTGGTCATCTTCTACCAGCCCCTCA (SEQ ID NO: 347) CTCGATCCTTGA AGGATCGAGAAGAGG (SEQ ID NO: TGACCAGTACAGCC 348) ACCTTCAAGGAAAC CAGT (SEQ ID NO: 346)CD40 NM_001250.4 CCCAGGAAGCCAT ACTATCACAAAC TATTTAGCCAGT ATACACAGATGCCCAATGCTGCAATG CTCCTGCTGATG ATTGCAGCATTGTT GGCATCTGTGTAT GACAGTTAAGCATGTGATAGTGAACA ATGGCTTCCTGGG GCTTCCAGTTGT ACTGGAAGCTGCTT(SEQ ID NO: 350) TC (SEQ ID NO: AACTGTCCATCAGC 351) AGGAGACTGGCTAAATA (SEQ ID NO: 349) CD44 NM_000610.3 GTGGGCAGAAGAA CTCCACAGCTCCACTGGCCTCTCCG AAAGCTAGTGATCA TTGCCACTGTTGA TTGAGTCCATT ACAGTGGCAATGGTCACTAGCTTTTT GGCTTTCTGTC AGCTGTGGAGGAC CTTCTGCCCAC (SEQ ID NO: 354)AGAAAGCCAAGTG (SEQ ID NO: 353) GACTCAACGGAGA GGCCAGCAAGTCTCAGGAAAT (SEQ ID NO: 352) CD47 NM_001777.3 GCCATATTGGTTAT AGTCCAACCACAAAATCAGAAGA TCAGGTGATAGCCT GCGAGGATATAG GGGCCATGCATT ATATCCTCGCTGTGGCTATCACCTGA GGTATACACGCC GTTGGACTGAGTCT ATAACCAATATG GCAATACAGAGCTGTATTGCGGCGT GC (SEQ ID NO: ACTC (SEQ ID NO: GTATACCAATGCAT 356) 357)GGCCCTCTTCTGAT TT  (SEQ ID NO: 355) CD5 NM_014207.2 CCAGAAGAAGCAGTGTTTTGGTTCAT GTTCTCAGCATG CGCCAGTGGATTGG TCCCGTTGGGCCA GGATCGGACGGTCCCAACGGGAATG ATCCACTGGCGCT TGCCGTGTGGTT AACCAAAACATGTC GCTTCTTCTGGGCGATGGAAAG TTTCCATCGCAACC (SEQ ID NO: 359) ACA (SEQ ID NO:ACACGGCAACCGTC 360) CGATCCCATGCTGA GAAC (SEQ ID NO: 358) CD58NM_001779.2 GTGCTTGAGTCTCT CCATTAGTCAATG CTCGATGGCTGT TCCATCTCCCACACCACAAGTTAGTG TGTAATGCTCTG TAACTTGTGCATTG TGGGAGATGGAA GTATCATGCATTACTAATGGAAGCAT GAGACTCAAGCA GGACTTCAATGC TGAAGTCCAATGCA C TT (SEQ ID NO: TGATACCAGAGCAT (SEQ ID NO: 362) 363) TACAACAGCCATCG AG (SEQ ID NO: 361) CD6 NM_006725.3 CGCTGGCAGCCAG CAGATTGTGCAA GAAGATTCTATAGGTCCTCTGCTCAG ACTCCGGGAAGC GTGACTGTCTGA CTTCCCGGAGTTTG TGAGCAGAGGACACACTTGCAGGG CACAATCTGTCCAC CCTGGCTGC (SEQ ACTTCGGGAGTG TCCCGAAGTCCCTGID NO: 365) GA (SEQ ID NO: CAAGTGTTCAGACA 366) GTCACTATAGAATCTTC (SEQ ID NO: 364) CD74 NM_001025159.1 TTCAGCCCCCAGCC TCATGGGATGAGTTGGTTTGTCTT CCTCCCCCATCTCC GTACAGGGTGGG GTCCAAGGGTGA CACCCTGTACCTCAAGATGGGGGAG CGAAAGAGCCA TCCCATGAGACCCT (SEQ ID NO: 368) GGCACCAGGGTCGGTGCCTGGCTCTT (SEQ ID NO: 369) TCGTCACCCTTGGA CAAGACAAACCAAGTC (SEQ ID NO: 367) CD79A NM_001783.3 AACGAGAAGCTCG AGGTTTTCATCTTCTCATACATGGA GGTTGGATGCCGGG CATATTCATCCCC GCAGTCGTCCAG GATGAATATGAAGGGCATCCAACCC GTTCAGGCCTTC ATGAAAACCTTTAT GAGCTTCTCGTT ATAA (SEQ IDGAAGGCCTGAACCT (SEQ ID NO: 371) NO: 372) GGACGACTGCTCCA TGTATGAGGACATCTCCC (SEQ ID NO: 370) CD79B NM_000626.2 TACCGGAATCCCAA CGTGGGCTCTGCCTCATGTAGCAGT AGGTAGTGCTTGTT AGATCCGCGAAC GCATTTTCACCG CGCGGATCTGGCAGAAGCACTACCTTT TGAAGCCCCGTT AGCCCACGTTTCAT GGGATTCCG (SEQ TCCTGGCTATGAAGCCAGGAAACGG ID NO: 374) AA (SEQ ID NO: GGCTTCACGGTGAA 375)AATGCACTGCTACA TGA (SEQ ID NO: 373) CD8A NM_001768.5 GCTCAGGGCTCTTTGGGGCCTCGGAA AAGTACTTGTTC CCTCCACACCATTC AGAAAGACCTGA CCTTGCCGTTGGAGGTCTTTCTTTCC ATGGTGTGGAGG AGACTCAAGCAC GAGGCCCCTGTCTC AAAGAGCCCTGACTCACCCTGAGA AGGGTGAGGTGCTT GC (SEQ ID NO: CA (SEQ ID NO: GAGTCTCCAACGGC377) 378) AAGGGAACAAGTA CTT (SEQ ID NO: 376) CD8B NM_004931.3CAGCTGAGTGTGGT TTCTTGGTGGGCT CCTGGGTAACCG TGATTTCCTTCCCA GGGCAGTGGTGGGCACACTCTCTT CCACTGCCCAGCCC GAAGGAAATCAA CTTGAGGGTGGA ACCAAGAAGTCCACCACACTCAG C (SEQ ID NO: CCCTCAAGAAGAG (SEQ ID NO: 380) 381)AGTGTGCCGGTTAC CCAGGCCAGAGAC CCAGA (SEQ ID NO: 379) CDC20 NM_001255.2GGAACATCAGAAA CCTCTACATCAAA ACCCTCTGGCGC GCCTGGGCTTTGAA ACCGTTCAGGTTCATTTTGTGGTTTT CCTGAACGGTTTTG AAAGCCCAGGCT CCACTGAGCCGA ATGTAGAGGAAGCTTCTGATGTTCC AGGATCTTGGCT CAAGATCCTTCGGC (SEQ ID NO: 383) T (SEQ ID NO:TCAGTGGAAAACC 384) ACAAAATGCGCCA GAGGGT (SEQ ID NO: 382) CDC25BNM_021873.2 CACCATACGAGCAC AATAGGAAAGAG TCCTGAGATGGG CTCCAGCCTGAACATAAGAGCTTCTGT CGTAAAGTCAAA GAAGCTCTTACTCT TCAGGCTGGAGG CAGACCAAGCACTTCCTATTTCAGTG TGCTCGTATGGTG ACAGGTAACACT TTACCTGTGTGCTT(SEQ ID NO: 386) GA (SEQ ID NO: GGTCTGTTTGACTT 387) TACGCCCATCTCAG GA (SEQ ID NO: 385) CDC25C NM_001790.2 CTCTCTGTGTGACA GGTTAGAATCTTCCACGGTTGGCAG TTACTATCACTCAG CTCCAGCATCTGA CGCACATACCTT ATGCTGGAGGAAGGTGATAGTAATG GGAAAAATCACC ATTCTAACCAGGGG TCACACAGAGAG AATCAGGTGCCCCACCTGATTGGTGA (SEQ ID NO: 389) CT (SEQ ID NO: TTTTTCCAAGGTAT 390)GTGCGCTGCCAACC GTG (SEQ ID NO: 388) CDCA3 NM_031299.4 AAGGAGCCATTCTTTGCTCGTCCTCCA AAGGGAAAGTG GGAACTGGACGAC GTTTTCAGAAGTC CTGATTTTCCTTTTCTGAAAACTGGA GTCCAGTTCCAA GTCATGGTCCTG GGACGAGCATGGG GAATGGCT (SEQGCCTTGCTCCCA AGCAAGGCCAGGA ID NO: 392) (SEQ ID NO: 393) CCATGACAAGGAAAATCAGCACTTTCC CTTGGT (SEQ ID NO: 391) CDCA5 NM_080668.3 TGCAGTCAGAAAGCTACAGCATGGG GAAAAAGGAAA CCCATCGTCTTAAA CCACGATCCTCTT TCCTAGGGCTCCGAGGATCGTGGCCC TAAGACGATGGG TGCGAGGTGATT ATGCTGTAGAGGTC CTTTCTGAC (SEQGGACAGCTGGG CCAGCTGTCCAATC ID NO: 395) ACCT (SEQ ID NO: ACCTCGCAGGAGCC396) CTAGGATTTCCTTT TTC (SEQ ID NO: 394) CDCA8 NM_018101.2TCCCTGTTTACTGA AGACATGGAAGT CCTACAGTTCCC AGACCAAATACTG TGTCTCCAAACCATTATCCAAATTT GTTTGGAGACAACT GTATTTGGTCTTC CCACTAACTAGG TCCATGTCTTGCTCAGTAAACAGGGA GAGGTAGAAGA TTCTACCTCCCTAG (SEQ ID NO: 398) GCA (SEQ ID NO:TTAGTGGAAATTTG 399) GATAAGGGAACTG TAGG (SEQ ID NO: 397) CDH11NM_001797.2 CAGGAAGCCAAAG TTATCGTTGACAT GATCACTCTCAC TCCCAGTGGCCATTCAAGGACCCTAA AGATGAAACCTT AGGGTCCTTGATGT TGGCCACTGGGA CATAAGGGGCACAACGATAATGCTC CTTTGGCTTCCTG GCAAACTTGGGA CCAAGTTTGCTGCC(SEQ ID NO: 401) GCA (SEQ ID NO: CCTTATGAAGGTTT 402) CATCTGTGAGAGTGATC (SEQ ID NO: 400) CDK1 NM_001786.2 CACATGAGGTAGTA CCCCAGCAATACAATATGGTGCCT ACACTCTGGTACAG TTCTGGAGATCTG ATACTCCAAATG ATCTCCAGAAGTATTACCAGAGTGTT TCAACTGGAGTT TGCTGGGGTCAGCT ACTACCTCATGTG GAGTAACGAGCTCGTTACTCAACTCC (SEQ ID NO: 404) GA (SEQ ID NO: AGTTGACATTTGGA 405)GTATAGGCACCATA TT  (SEQ ID NO: 403) CDK14 NM_012395.2 ATTACTCAGTGGACTGAGAGGCATGT GATTTCCTGTAT GGAGAAGTCTGTTT CTCTGTAACAAA GGGTGGCAAGGTGTTACAGAGACAT ACAGACTTCTCCG ATAGGTACTCAA GCCTCTCAGAAGGT TCCACTGAGTAATAACCTCCTGACC CAGGAGGTTTTGAG (SEQ ID NO: 407) TTC (SEQ ID NO:TACCTATCCTTGCC 408) ACCCATACAGGAA ATC (SEQ ID NO: 406) CDK4 NM_000075.2ACTTTTAACCCACA GAGTGCTGCAGA GCAGCCACTCCA CAAGCGAATCTCTG GCTCGAAAGGCATTGCTCACTCCG CCTTTCGAGCTCTG GAGATTCGCTTGT GATTACCTTCAT CAGCACTCTTATCTGTGGGTTAAAAG CCTTATGTAGAT ACATAAGGATGAA T (SEQ ID NO: 410)AA (SEQ ID NO: GGTAATCCGGAGTG 411) AGCAATGGAGTGG CTGC (SEQ ID NO: 409)CDK5RAP2 NM_001011649.1 AGCAACTGGAGCA CAAGGTCTTCCGC AGTGAAAATGATGGATGTGCTTTCAT AAATTCTGATATG TCTTCTTCCCGC ATCAGAATTTGCGG AAAGCACATCCTCTCCGAATTTCG AAGACCTTGGAGG GCTCCAGTTGCT CTGATCTGCTCC AGCAGATCAGCGA(SEQ ID NO: 413) TC (SEQ ID NO: AATTCGGAGGCGG 414) GAAGAAGAATCATTTTCACT (SEQ ID NO: 412) CDK6 NM_001259.5 GGGAAAGAAAAGT GCCTCTGCCCAACTCCTCTTCCCTC GCAATGATTCTGGA GCGCGTCTCAGTC CTCGAAGCGAAG CTGAGACGCGCTTGCAGAATCATTGC TCCTCAACACAG GGCAGAGGCTATGT ACTTTTCTTTC ACACGATTACATAATCGTGTCTGTGT (SEQ ID NO: 416) A (SEQ ID NO: TGAGGACTTCGCTT 417)CGAGGAGGGAAGA GGAG (SEQ ID NO: 415) CDKN3 NM_005192.3 TACCGAAAAACCTTAGACAAGATCTC CTCTGGTGATAT AATACACTGCTATG CCAAGTCCTCCAT TGTGTCAGACAGGAGGACTTGGGAG AGCAGTGTATTA GTATAGTAGGAG ATCTTGTCTTGTAG AGGTTTTTCGGTAACAAGCAGCTAC CTGCTTGTCTCCTA (SEQ ID NO: 419) A (SEQ ID NO:CTATACCTGTCTGA 420) CACAATATCACCAG AGC (SEQ ID NO: 418) CELSR1NM_014246.1 CCTGGGACCTTAAA CCCCACACCTCTG AGTCTCAGAGAG GCGTTGCAGGTTCCTCCAAATCAGGA TTAGAGAATTGG TGATTTGGACAGAG ACCTGCAACGCTT CAGGAGGTATGTGTGTGGGGCCTTCC TAAGGTCC (SEQ AACGGCCTGGAA AGGCCGTTACATAC ID NO: 422)GG (SEQ ID NO: CTCCTGCCAATTCT 423) CTAACTCTCTGAGA CT  (SEQ ID NO: 421)CENPA NM_001042426.1 CACTTTGAGCAGTT GAGGTCTATATG CACTCAGTTACAGCCTGGAAGGCTG ATGGAAATGCCC TGATGCTGCCAC GGCATTTCCATCAT AGCCTTCCAGGCTAATGGTGAGGC ATAGACCTCTGCCC AACTGCTCAAAG TACTCTGAAGGG TTCAGAGTAGCCTCTG (SEQ ID NO: CA (SEQ ID NO: ACCATTAGTGGCAG 425) 426) CATCATGTAACTGAGTG (SEQ ID NO: 424) CENPE NM_001813.2 GCACCAATCATCGA GCAAATATAGTACTTCTGAACCCA TTCTGCCATACAAG CCATTGTAGCCTT TCATGGTATATG GCTACAATGGTACTGTATGGCAGAAT TTTTTCCTGAAG ATATTTGCCTATGG CGATGATTGGTG CAGTCTGTCCATACAGACTGCTTCAG C  AG (SEQ ID NO: GAAAAACATATAC (SEQ ID NO: 428) 429)CATGATGGGTTCAG AAG (SEQ ID NO: 427) CENPF NM_016343.3 AGATAATGTGGCCACATCAAGAAATC ATGCTCAATGCT AGGTGAATGACAG TCTCCTTCCAGCT AGCTTTCTCCGACTGGAAGGAGAGA GTCATTCACCTTG TCTGATCCTACT TTTCTTGATGTGGA GCCACATTATCTCAGCTCATTTTC AAATGAGCTGAGT (SEQ ID NO: 431) CA (SEQ ID NO: AGGATCAGATCGG432) AGAAAGCTAGCATT GAGCAT (SEQ ID NO: 430) CENPN NM_018455.3CTCCCAGACTCCGT TATTGCGCCTCAG TCGGAGGTAGAT ACGCCTTCACGTCC CATGGAGGAGGATTTCCCAGTAGC TCCTCCATGCTGAG CGTGAAGGCGTA TTCTAACTCCTG GCGCAATACACCGCCGGAG (SEQ ID ACCCAGAAGCG TTCTGGGTCAGGAG NO: 434) GTG (SEQ ID NO:TTAGAAGCTACTGG 435) GAAAATCTACCTCC GA  (SEQ ID NO: 433) CENPVNM_181716.2 TTCATTGTTCCAGC ATGTGCTCAGCTC TCTTACAGAAGG TTCTCGCTTCAAGCCCTTCAGGAGCTT TATGCTGGGCTT TCCTGAAGGGAGCT GAAGCGAGAAGC TGTGAGTATTGAGAGCACATAACGA TGGAACAATGAA ACGTGTAAGTCG CTTACACGTTCAAT (SEQ ID NO: 437)TT (SEQ ID NO: ACTCACAAAGCCCA 438) GCATACCTTCTGTA AGA (SEQ ID NO: 436)CEP55 NM_018131.4 CTGCCCGCTCTGAT CCAGGCACGAAG TCCAAAGAAGCGAACAGTCCTTTTCC TGAGCGCCAGGG ATCGAAGAGAC CTGGCGCTCACTTC AAAAGGACTGTTAACGGTCTTGAG GTGCCTGGCACCCG ATCAGAGCGGG GCGCCCAGCCGG GCTGGGCGCCTCAA(SEQ ID NO: 440) GTG (SEQ ID NO: GACCGTTGTCTCTT 441) CGATCGCTTCTTTG GA (SEQ ID NO: 439) CFLAR NM_003879.3 CAAGACCCTTGTGA ACTTCAGCAGACGCAGCATCTCCT GCTTCCCTAGTCTA ATCCTACTCTTAG TCTCATCTGTAT AGAGTAGGATGTCTACTAGGGAAGCT CAAGTGCTTCTT GCTGAAGTCATCCA CACAAGGGTCTT CAACCTGATGGATCAGGTTGAAGAA G  TG (SEQ ID NO: GCACTTGATACAGA (SEQ ID NO: 443) 444)TGAGAAGGAGATG CTGC (SEQ ID NO: 442) CGNL1 NM_032866.3 TGAACCATGGAGCTTATTCCTGCTGCA CTTGATTTTTGG GTATTTCGGTGAAT CATGTTGATATTC GTATCATCACTTATCAACATGTGCAG ACCGAAATACAG GCGAGTCTCAGA CAGGAATATGGGG CTCCATGGTTCATGGACCCCA TCCATCTGAGACTC (SEQ ID NO: 446) (SEQ ID NO: 447)GCAAGTGATGATAC CCAAAAATCAAGG AGTT (SEQ ID NO: 445) CHD4 NM_001273.2AGAGGCATCTGTGA TGATCAATTCATA CACGATGAGGCA AATTCCATGTGCTG GGATGTCAGCAGGGCCCAATCAAT CTGACATCCTATGA CACATGGAATTTC AGAGCCCAAAAT ATTGATCACCATTGACAGATGCCTCT AGCCATGTCAAT ACATGGCTATTTTG (SEQ ID NO: 449) GG (SEQ ID NO:GGCTCTATTGATTG 450) GGCCTGCCTCATCG TG  (SEQ ID NO: 448) CHST5NM_012126.1 TAGGAGGCTGAGG TGCAACCTCCACC CACCCAAGCTAG TGGGAGAATCACTTTTTGGAGTCCAA GGTGCAGTGGCA GGACTCCAAAGGT GTGATTCTCCCAC TGATTTCAGCTTGGAGGTTGCAGTA (SEQ ID NO: 452) AC (SEQ ID NO: AGCTGAAATCATGC 453)CACTGCACCCTAGC TTGGGTGGCAAAGC AAAAC (SEQ ID NO: 451) CIITA NM_000246.3GCCTGAGCAAGGA ACCGATCACTTCA GGTCTTTTCTGA CATTTTCAAGCACA TCTGGTCCTATGTCTTTTCTGCCCA TAGGACCAGATGA GCTTGAAAATGT ACTTCTGCTGGC AGTGATCGGTGAGCCTTGCTCAGGC ATCTCCATACTC AGTATGGAGATGCC (SEQ ID NO: 455) TC (SEQ ID NO:AGCAGAAGTTGGG 456) CAGAAAAGTCAGA AAAGACC (SEQ ID NO: 454) CKS2NM_001827.1 AAACTCATCTGATG CTGTTGGACACC AGAATATGTGGT TCTGAAGAGGAGTAAGTCTCCTCCAC TCTGGCTCATGA GGAGGAGACTTGG TCCTCTTCAGACA ATCATGTAATGATGTCCAACAGAGTC TCAGATGAGTTT ACCCAGCCTAGA TAGGCTGGGTTCAT (SEQ ID NO: 458)CT (SEQ ID NO: TACATGATTCATGA 459) GCCAGAACCACAT ATTCT (SEQ ID NO: 457)CLIP2 NM_003388.4 GTCCCTGTTGGCTT ACGGCTGTTAAT GAAAGAGCTGTATCGGTAGCTCTCGC AGAACTGCATGC TTTGACCCTGGG ATGCAGTTCTATTA GAGAGCTACCGATTAGGCCACTAA ACAGCCGTCTAGAA AAGCCAACAGGG AGCATCGCTTCT GCGATGCTTTAGTGAC (SEQ ID NO: AG (SEQ ID NO: GCCTAACCCAGGGT 461) 462) CAAATACAGCTCTTTC  (SEQ ID NO: 460) CLMN NM_024734.3 TACTCAAAACTCAG AAGGACAAAACCCGGGCTAATGAT GCATGCAGCTGGAT CCACCTACGGAT CACTAACAATGC CCGTAGGTGGGGTTCCAGCTGCATGC TCCCTATCCAAC TTGTCCTTGTGTGC CTGAGTTTTGAGT CCAGCAAGGCACCTTGCTGGGTTGGA A  AC (SEQ ID NO: TAGGGAGCATTGTT (SEQ ID NO: 464) 465)AGTGATCATTAGCC CG  (SEQ ID NO: 463) CPA6 NM_001127445.1 GCAGACGATCACGATGAATACCACA GCTTCTTTTACA ACTCAAAAGAGCT GTCTATCCAAAC AACCACTGACAAGTTTGGATAGACTG AGCTCTTTTGAGT AAGGCAGGACC TGGTATTCATGCAA CGTGATCGTCTGCAATCCATTCTCT GAGAATGGATTGGT (SEQ ID NO: 467) TGC (SEQ ID NO:CCTGCCTTTTGTCA 468) GTGGTTTGTAAAAG AAGC (SEQ ID NO: 466) CPNE3NM_003909.2 GACTGCTCTCTGGT TATCAGCATCATA CTGCCACTGAGG CTGTGGGACTGGTCATCTTGAATGACC AGGTATCTGAGC ATTCAAGATTATGA AGTCCCACAGAC GCCAAAACCAATGCTGATAAGATGT CAGAGAGCAGTC AAGCTGGAAAC TTCCAGCTTTTGGT (SEQ ID NO: 470)ATCT (SEQ ID NO: TTTGGCGCTCAGAT 471) ACCTCCTCAGTGGC AG  (SEQ ID NO: 469)CR2 NM_001006658.1 GGTGTCAAGCAAAT TACACAGGTTGG TGTCCATTGTGGAATATGTGGGGGCC TAGTCGTGTCGGC ATCATAGGAAGT GACACGACTACCA CCCCACATATTATGCTGGACACTCG ACCTGTGTAAGTGT TTGCTTGACACC AGAGGGAAAAC TTTCCCTCTCGAGT(SEQ ID NO: 473) ACT (SEQ ID NO: GTCCAGCACTTCCT 474) ATGATCCACAATGGACA (SEQ ID NO: 472) CREB3L2 NM_194071.2 ATGCCTGAGGGGAT AAGATGGGGCAGAGAACTATGGAT CAGGCTTTTCTACT GTTTGCCTGGAGT GTGTGGGGAACC CCAGGCAAACCTGCAGAAAAGCCTGA AGGTTGTGGGAG CCCATCTTGTCGCT TCCCCT (SEQ ID GTCCTAAAAGCGTTTAGGACCTCCCA NO: 476) AC (SEQ ID NO: CAACCTGGTTCCCC 477)ACACATCCATAGTT CT  (SEQ ID NO: 475) CREBBP NM_004380.2 CACATTCGAGGCTCCTGACGACCCTA ACGACGGACAG ACAGGTGATTGTCG ACTGTGTGAGCG GGAGGATGGAGCTCACACAGTTAGG ACAATCACCTGT GAGTGGGCCAA GTCGTCAGTTGGTC GAGCCTCGAATGATGCAGTTTCAG TGAAACTGCATTTG TG (SEQ ID NO: ACCAA (SEQ ID GCCCACTCCTCCAT479) NO: 480) CCTCCCTGTCCGTC GT  (SEQ ID NO: 478) CSF2RA NM_006140.3AGAAGGAGGGAGA TGGGTTCCTGAGT AGTAATTGCGAG TCCGGTGTCCTTAT CTTGTATGTAATAACGTTAATCCTG TACATACAAGACTC AGGACACCGGAT ACAGGTTATCCA AGGAACCCATGTGCTCCCTCCTT GGTGACATCCCA GGATGTCACCTGGA (SEQ ID NO: 482) CA (SEQ ID NO:TAACCTGTCAGGAT 483) TAACGTCTCGCAAT TACT (SEQ ID NO: 481) CSTANM_005213.3 CTTCCCGGACAAAA TTGTCAACCTGGT ACACTTTGGGTA TGAGGACTTGGTACATCCAGTAAGTA CATGCTGCTAAA TTACTGGATACCAG CCAAGTCCTCATT AGCCCGTCAGCTGTTGACAAAAACA TTGTCCGGGAAG CGTCATCCTTGT AGGATGACGAGCT (SEQ ID NO: 485)TT (SEQ ID NO: GACGGGCTTTTAGC 486) AGCATGTACCCAAA GTGT (SEQ ID NO: 484)CTGF NM_001901.2 ACCACCCTGCCGGT TTCTTCATGACCT CTCCGGGACAGTGGAGTTCAAGTGCC CGCCGTCAGGGC TGTAATGGCAGG CTGACGGCGAGGTC ACTTGAACTCCACCACAGGTCTTGA ATGAAGAAGAACA CGG (SEQ ID NO: TGAACATCATGT TGATGTTCATCAAG488) TC (SEQ ID NO: ACCTGTGCCTGCCA 489) TTACAACTGTCCCG GAG (SEQ ID NO:487) CTH NM_001902.4 CTCGCCGTCGGCTC AAGGATCAGGCG ACCGAAGATATATACCTGCGTGCTTT AGAAGGAGCTAA ACCAGTCGAAGC AGCTCCTTCTCGCC AGCACGCAGGTACGGGTGTCCGGG TGATCCTTCTGTCT GAGCCGACGGCG GTTGGGAGAGAC CTCCCAACCCCGGAAG (SEQ ID NO: AG (SEQ ID NO: CACCCGGCTTCGAC 491) 492) TGGTTATATCTTCGGT  (SEQ ID NO: 490) CTHRC1 NM_138455.2 CTGTGGAAGGACTT AGCAACATCCACCCAGTAGAAGCA TGTGAAGGAATTGG TAATCCAGCACC TCTCCTTTTGGG TGCTGGATTAGTGGAATTCCTTCACAA TAATCTGAACAA ATGTTGCTATCTGG AGTCCTTCCACAG GTGCCAACCCAGGTTGGCACTTGTTC (SEQ ID NO: 494) AT (SEQ ID NO: AGATTACCCAAAA 495)GGAGATGCTTCTAC TGG (SEQ ID NO: 493) CTLA4 NM_005214.3 AGTCTGTGCGGCAACATCTAGGAAGG GATAGTGAGGTT CCTACATGATGGGG TCAACTCATTCCC CACTTGATTTCCAATGAGTTGACCTT CATCATGTAGGTT ACTGGAGGTGCC CCTAGATGATTCCA GCCGC (SEQ IDCGTGCAGATGGA TCTGCACGGGCACC NO: 497) AT (SEQ ID NO: TCCAGTGGAAATCA 498)AGTGAACCTCACTA TC  (SEQ ID NO: 496) CTNNA2 NM_004389.2 GAACCATGATTTTGCCTCTAATATTCC CTACACCTATGT CTAGAAATAGAAG ACCACTGGGCCTT ATTTGCCTCTAAGCCCAGTGGTGGA CTATTTCTAGCAA CTTTCACACGTT ATATTAGAGGGAA AATCATGGTTCGTCAGTTTCCTT GGAAACTGACAAC (SEQ ID NO: 500) C (SEQ ID NO: GTGTGAAAGTTAGA501) GGCAAATACATAG GTGTAGC (SEQ ID NO: 499) CTPS NM_001905.2CACCTTGTTTCTCA GGCAACGCGCTA GTCCATGTGGCA ACTACCTCGCATCA GCATCTGCAATGCACTTTATAACG TTGCAGATGCTAGC ATGCGAGGTAGT GTCTAGGTATCC GCGTTGCCTGTCGCTGAGAAACAAGG AAGGGAAAGCG TTTCCCTTGGATAC TG (SEQ ID NO: ACA (SEQ ID NO:CTAGACCGTTATAA 503) 504) AGTGTGCCACATGG AC (SEQ ID NO: 502) CTSHNM_148979.2 ACCCTGTGAGCTTT TCTATACATCATG TTTACTTTATCTG GCCTTTGAGGTGACAAGTCCTGAGTC GAGTTTTATGGC TCAGGACTTCATGA ACCTCAAAGGCA AGGAAGTACTGGTGTATAGAACGGGC AAGCTCACAGGG AGTAGATGCCCG ATCTACTCCAGTACT (SEQ ID NO: 506) T (SEQ ID NO: TTCCTGCCATAAAA 507) CTCCAGATAAAGTAAA (SEQ ID NO: 505) CTSK NM_000396.2 TCTCATTCCCGCAG CTACCTTCCCATTTGACAGGAGTAA TAATGACACCCTTT CTGGGATATAAA CATATCCTTTCTT ATATCCCAGAATGGGGGTGTCATTACT TCGATAGTCGAC GAAGGTAGAGCCC GCGGGAATGAGA AGAGTCTGGGGCCAGACTCTGTCGAC (SEQ ID NO: 509) T (SEQ ID NO: TATCGAAAGAAAG 510)GATATGTTACTCCT GTCA (SEQ ID NO: 508) CXCL10 NM_001565.1 GCAGAGGAACCTCAATCAGAATCGC GAGAGAGGTACT CAGTCTCAGCACCA AGTTTGATTCATG CCTTGAATGCCATGAATCAAACTGCG GTGCTGAGACTG CTTAGAGTCAGA ATTCTGATTTGCTG GAGGTTCCTCTGCAAGATAAGGCA CCTTATCTTTCTGA (SEQ ID NO: 512) GCA (SEQ ID NO:CTCTAAGTGGCATT 513) CAAGGAGTACCTCT CTC (SEQ ID NO: 511) CXCL12NM_199168.2 GGGCCTGAGGTTTG ATACCGTATGCTA GTTCCAACGTGC CCAGCATTTAGACCTAAATGCAGGGT ACAGGTACAGG CTGCATTTATAGCA CTAAATGCTGGC GCATGGATGAATTACGGTATGATATT AAACCTCAGGCC ATAAGCTGCAAT GCAGCTTATATTCAC (SEQ ID NO: 515) ATC (SEQ ID NO: TCCATGCCCTGTAC 516) CTGTGCACGTTGGAAC (SEQ ID NO: 514) CXCL9 NM_002416.1 CACCATCTCCCATG TCCTCTAGCGCTTGCTAACTGGGCA AAGAAAGGGAACG AGTACTTCACCGT CCAATCATGCTT GTGAAGTACTAAGCTCCCTTTCTTCAT CCACTAACCGAC GCTAGAGGAAGCA GGGAGATGGTG TTGGCTGCT (SEQGCCAAGTCGGTTAG (SEQ ID NO: 518) ID NO: 519) TGGAAGCATGATTGGTGCCCAGTTAGCC TCTG (SEQ ID NO: 517) CYB5R2 NM_016229.3  CCATGTCTTAGGGCTTTTTGCCAAGAG ATCATCACTGGA TTCCTGTAGGTAAC CTGGACATAGTT GACAGGGGTGTATATGTCCAGCTCTT ACCTACAGGAAG AGCCCTGACCAC GGCAAAAATCGAT CCCTAAGACATGCAATTCATTATC AATGAATTGGTGGT G (SEQ ID NO: 521) GA (SEQ ID NO:CAGGGCTTACACCC 522) CTGTCTCCAGTGAT GAT (SEQ ID NO: 520) CYP27A1NM_000784.3 TTTGCTACATCCTG GATGGATCGCTG TTCTGGAACATT TTCGAGAAACGCATCAGGCAGCCAAT AACCCGATGGAT TGGCTGCCTGCAGC GCGTTTCTCGAAC CTGACGAAGGTCGATCCATCCCCGAG AGGATGTAGCAA ACGGTGTCCTCG GACACCGTGACCTTA (SEQ ID NO: 524) GG (SEQ ID NO: CGTCAGATCCATCG 525) GGTTAATGTTCCAGAA (SEQ ID NO: 523) CYP2J2 NM_000775.2 GAAAAATGGATTG TTCTTTGCTCCTTTAAGCTCTTCTT ATTATGTCAAGTGG CCATGCCTGGCC TCCTAAACCAAA CCAGGCATGGAAGACTTGACATAATC GTTCCTTAGTGC GAGCAAAGAAGGT AATCCAT (SEQ ID TGTCAGAGTGAATCACTCTGACAGCA NO: 527) CC (SEQ ID NO: CTAAGGAACTTTGG 528) TTTAGGAAAGAAGAGCTTA (SEQ ID NO: 526) CYSLTR1 NM_006639.2.2 AAAGAAGCTTGCCTTAAAAGCACAGT ATTAATCCTTGT ATAGAGCAGGCAC CCATTCACAGAG TGGCGAGCTGCATCTGTGAATGGACT TGCCTGCTCTATA CAGTATCTTGAT GTGCTTTTACGACC GGCAAGCTTCTTTACCCTGTAGGGT CTACAGGGTATCAA (SEQ ID NO: 530) CG (SEQ ID NO:GATACTGTGCAGCT 531) CGCCAACAAGGATT AAT (SEQ ID NO: 529) DAZAP2NM_014764.3 ATGCCATTACTTCT GGCACCCTCCACT TTTGGGTTAGGT GCTTTCGTATCTCCTTTGCCTGAGGA TCGTGTATGCAG TCAGGCAAAAGTG GATACGAAAGCA AGACAACCTATGGAGGGTGCCTTATG GAAGTAATGGCA AGGAGGGCCCAT GGCCCTCCTCATAGT (SEQ ID NO: 533) AA (SEQ ID NO: GTTGTCTCTGCATA 534) CACGAACCTAACCCAAA (SEQ ID NO: 532) DCBLD1 NM_173674.1 CTCTTGTTGAACAC TGGGATCCACTCTCTGGATGGTCGC AAGTGAAGTAACC CAAAGCGGACGG TGCTCGCATAGG GTCCGCTTTGAGAGTTACTTCACTTGT TCAGCAAAAAAC TGGATCCCACATTT GTTCAACAAGAG CCCGGCCAGAAACTGGCCGGGGTTTT (SEQ ID NO: 536) TG (SEQ ID NO: TTGCTGACCTATGC 537)GAGCAGCGACCAT CCAG (SEQ ID NO: 535) DCLK3 NM_033403.1 GAAAAAGCCATGTGGTCATCTCTGAG CTTGTTCTCTTCT ATGTCTGGAGGCAG AGTCATCCTTCTG GGCCTCGTCTTGAAGGATGACTCTCA CCTCCAGACATA GGCTCCTTTTCT GAGATGACCAACCT CATGGCTTTTTCAGCTTTGCAGGT GCAAAGCTAGAAA (SEQ ID NO: 539) T (SEQ ID NO: AGGAGCCCAAGAC540) GAGGCCAGAAGAG AACAAG (SEQ ID NO: 538) DCTD NM_001012732.1GATCCGGCAGCCTC ATTTATTTGTCCT TGTTCAGATCAG TCTTCACTGCTACA TCCAGCACATGTTGTGTCTGCTCG TGTGCTGGAAGGAC AGCAGTGAAGAG TCCCCATTAAGA AAATAAATAATTGTAGGCTGCCGGAT ACACAACCACAA GGTTGTGTTCTTAA C (SEQ ID NO: 542)TT (SEQ ID NO: TGGGGACGAGCAG 543) ACACACTGATCTGA ACA (SEQ ID NO: 541)DDAH2 NM_013974.1 CGACAGGAGTGGG AGTTTTCTTGTTT CATCCACACAGA GGTGGCCGCTGGACTTCACCTGTCTC CTCCCCCTCCAA GACAGGTGAAGAA CAGCGGCCACCC CCGCTCGGATTTACAAGAAAACTAA C (SEQ ID NO: 545) CTT (SEQ ID NO: GAAATCCGAGCGG 546)TTGGAGGGGGAGT CTGTGTGGATGGGA TGGGGACG (SEQ ID NO: 544) DENND4ANM_005848.3 TGATTTTCCCTTTCC CAGTGGGCAGAG TCAATCCCTACT ACTGGCCATGCCCGAGGAACATACGG ATGAATGGACAT TATGTTCCTCTCTG GCATGGCCAGTG GGTGCACTCAAGCCCACTGGCTTTAG GAAAGGGAAAAT ACATCTGCTAAA CAGATGTCTTGAGT CA (SEQ ID NO:GC (SEQ ID NO: GCACCATGTCCATT 548) 549) CATAGTAGGGATTGA (SEQ ID NO: 547) DLC1 NM_182643.1 TGACCCACTGGATG TGCTGTGTTACGATCTTTTTCCATAC GGACAGCCTTTTAA TCATCAGAATTA TTGCCTGCAAGC TTCTGATGATCGTAAAAGGCTGTCCC TGTCAGCTACTA ACACAGCATGTCAT ATCCAGTGGGTC GTCCATGATGACCATGGACTAGTAGC A (SEQ ID NO: 551) A (SEQ ID NO: TGACAGCTTGCAGG 552)CAAGTATGGAAAA AGA (SEQ ID NO: 550) DLEU1 XR_001515.1 CATCGTGGTGCACGGCAAGAGGACTG TTCACTTCACCT GCTCTCCCTTTGCT CAACCGAAGAAG CCGCGGCTTTGCTCTTCGGTTGCAGT CAAAGGGAGAGC AAAAGCGCTACA CCTCTTGCTTCTTG CGTGCACCACGACGCACGCGCAAG CGCGTGCGTGTAGC TG (SEQ ID NO: AA (SEQ ID NO: GCTTTTGCAAAGCC554) 555) GCGGAGGTGAAGT GAA (SEQ ID NO: 553) DLGAP5 NM_014750.3CCTGCTTCGGAGTC AAAAGTAAAG AA GTGATGAAGACA GGCGGTGGTCGTCC CACTCGGTCTGGTCCTGAGCCACC AGACCGAGTGTTCT ACGACCACCGCC TTCTAGCGTGAA TTACTTTTTGTTTGGGACTCCGAAGCA ACCTCAACCAAA TTGAGGTTTCACGC GG (SEQ ID NO: CA (SEQ ID NO:TAGAAGGTGGCTCA 557) 558) GGATGTCTTCATCA C (SEQ ID NO: 556) DNAJA1NM_001539.2 CATCATCCCAGAGG TCACTGGCCCATT GTCCTTCACTCA TGGTGTTCAGTGTCAAGAGGTCTGAC TTCACTACTGCA AGACCTCTTAATGG ACTGAACACCAC CATTAAATGCCAGCCAGTGAATAAC CTCTGGGATGAT GCAGTGAGTGTT ACTCACTGCTGGCAG (SEQ ID NO: 560) AT (SEQ ID NO: TTTAATGTGCAGTA 561) GTGAATGAGTGAAGGAC (SEQ ID NO: 559) DNAJB12 NM_017626.4 TTTCTTCCATGTTTT ACCAGGGTACCTTGCGACTCTCCT AGAAAATGAGGCC TCCCCAAACAGG TATGCTGTCAGC TGTTTGGGGAAGGTCCTCATTTTCTAA TACAGCTAATGT ACCCTGGTGATGTT AACATGGAAGAA CTAGCAAAAACATTTGCTAGACATTA A (SEQ ID NO: 563) TC (SEQ ID NO: GCTGTAGCTGACAG 564)CATAAGGAGAGTC GCA (SEQ ID NO: 562) DNAJB9 NM_012328.1 GCCCGGATGCTGAATGTTTCATATGCT GCACTGTGTCCA GCAAAATTCAGAG TCTGCAATCTCTC AGTGTATCATACAGATTGCAGAAGC TGAATTTTGCTTC TCTTTTCGTCTAT ATATGAAACACTCT AGCATCCGGGCTAGCATCTGAGA CAGATGCTAATAGA (SEQ ID NO: 566) G (SEQ ID NO: CGAAAAGAGTATG567) ATACACTTGGACAC AGTGC (SEQ ID NO: 565) DNAJC10 NM_018981.1AGGAGATTGTTTGA CCAACATGCCAC AAGGTTATCCTG CTTCACAGACACGA TAAGCCTGAGTCGGTGGCACAGTC CTCAGGCTTAGTGG GTGTCTGTGAAGT CATCCATCCTAC CATGTTGGATGGTCCAAACAATCTCCT ATTAACAAGACC TTGTTAATGTAGGA (SEQ ID NO: 569)AT (SEQ ID NO: TGGATGGACTGTGC 570) CACCCAGGATAACC TT (SEQ ID NO: 568)DNMT3A NM_175630.1 TGGCAACAGCGGG CATTATCCCAGTC GCAGAAAACTACTTTCATAACGCCA TAGCAATCGTTG AGGCCCACAACC ACGATTGCTAGACT GCGTTATGAAAGAGCCACAGAAG GGGATAATGGCGG CCCGCTGTTG GCGATGGAGGG TCCCTCCATCGCCT(SEQ ID NO: 572) ACCGC (SEQ ID TCTGTGGCTGGTTG NO: 573) TGGGCCTTAGTTTTCTGC (SEQ ID NO: 571) DOCK10 NM_014689.1 CTGAGCTTAATCAG CAGTCTGATCATGATTGGCCCAGCA CTTTGCACAATGGA TCCACTTCTTCCA TTAACCTTCACG AGAAGTGGACATGTTGTGCAAAGCT CTGACACTTCCT ATCAGACTGCAGCT GATTAAGCTCAG CGCAGTTTGAGCCAAACTGCGAGGA (SEQ ID NO: 575) TG (SEQ ID NO: AGTGTCAGCGTGAA 576)GGTTAATGCTGGGC CAAT (SEQ ID NO: 574) DPY19L1 NM_015283.1 TTGTGGATTGTCCTGGGCACCAGAAA CTTGGGCTCTGG TCAGACCTTAGTCC CCATGCCTGAGG TAAGAAGGTAGTCAGGCATGGTTTC ACTAAGGTCTGA AAAGGGAACAG TGGTGCCCACTCCT AGGACAATCCACCGGCTTCCAGGA GGAAGCCGCTGTTC AA (SEQ ID NO: GT (SEQ ID NO:CCTTTCTACCTTCTT 578) 579) ACCAGAGCCCAAG GG (SEQ ID NO: 577) DPYSL3NM_001387.2 CCCTGGGCAGCCAG CACACCAGTTTTC CAGGAGATTACT CATTCATTGTAAGTAAAGAGGGAACT GTCTGTCCATAC TCCCTCTTTGAAAA TACAATGAATGC CCACCAGACACACTGGTGTGTGGGTG TGGCTGCCCAGG GAACTGAACACC TTCAGTTCTGTGTCG (SEQ ID NO: 581) CA (SEQ ID NO: TGGTGGGTATGGAC 582) AGACAGTAATCTCCTG (SEQ ID NO: 580) DRAM1 NM_018370.2 GTCTTTAGTGCTTG TGGCGACAATGCCAAAAGAGCGC GATTGGTGGGATGT CCATTCCGAAAC CCCCGTCATGAA TTCGGAATGGGCATATCCCACCAATCC CCACTGGCACAG TGTCGCCAATTTTC AAGCACTAAAGA CTAACTCCTGAAAGGAGTTAGCTGTG C (SEQ ID NO: 584) AAT (SEQ ID NO: CCAGTGGTTCATGA 585)CGGGGGCGCTCTTT TG (SEQ ID NO: 583) DTX1 NM_004416.2 TCTTCATCTCTCTGGGCCTGGAGATG GGTAGGGAGGA GACTCTGATCTCCT GGAAGGGAGAAG TGGGAGAACAGTCTCCCTTCCCATC GAGATCAGAGTC CGCCTTTATCTG TCCAGGCCTTCTGT CAGAGAGATGAAGGACAGACAGA CTGTCCCAGATAAA GA (SEQ ID NO: A (SEQ ID NO: GGCGCTGTTCTCCC587) 588) ATCCTCCCTACCCC AT (SEQ ID NO: 586) E2F2 NM_004091.2TCAGGGACCCTGTG CCTCAGAGCAGC TGACTTCAGAGA TAGGATCTCGTTTG CCACTCACCACATGGCACATGGCT TGGTGAGTGGGCTG AACGAGATCCTA AAATGGCAGCCC CTCTGAGGTCTCCACACAG (SEQ ID AGTGGAGA (SEQ CTGGGCTGCCATTT NO: 590) ID NO: 591)AGCCATGTGCCATC TCTGAAGTCAGAGG TG (SEQ ID NO: 589) E2F8 NM_024680.2CTCGTGCGCTTAGT AAGTTTTAATATC AGTTCCTCCCCA CCGGAGCCCTGATC CTGTTCGCAGATCAATCCCGATGGT TGCGAACAGGATAT AGGGCTCCGGAC TCAAGTAGTCCA TAAAACTTTTAGTATAAGCGCACGAG ATCAATTGTACT CAATTGATTGGACT (SEQ ID NO: 593) AA (SEQ ID NO:ACTTGAACCATCGG 594) GATTTGGGGAGGA ACT (SEQ ID NO: 592) EEPD1 NM_030636.2TGCTTTTTGCAACC CAGCTCACTTAA CAAGCCCGATTA AAAGCTGTGGACA GGAGGCTTTTCTGCGAACACAAAG GAAAAGCCTCCTTA TCCACAGCTTTGG GTCATCTGATTG AGTGAGCTGAGGGTTGCAAAAAGCA GATTTCCTGTCC GACAGGAAATCCA (SEQ ID NO: 596) CCT (SEQ ID NO:ATCAGATGACCTTT 597) GTGTTCGTAATCGG GCTTG (SEQ ID NO: 595) EFEMP2NM_016938.3 GTCTACCCCGGTGC TGCGAGTTTCCAG GGACCAGCATGG CTACAATGCCTTTCCACGGATCTGAA CGCTGACGTTGT AGATCCGTGCTGGA AGGCATTGTAGG TGATTTGCCTAAAACTCGCAGGGGG CACCGGGGTAGA TGTAAAAGTCCC ACTTTTACATTAGGC (SEQ ID NO: 599) CC (SEQ ID NO: CAAATCAACAACGT 600) CAGCGCCATGCTGGTCC (SEQ ID NO: 598) EGFL7 NM_016215.3 GCAGGGCCTTCCTC TCTGGGGAGCCTGATTCACAGAGA CTCTTCCTCCTCCC CCCGAGGAAGGG AGATCCCAGCCC CTTCCTCGGGAGGCGAGGAGGAAGAG ATCCCATGCCAG TCCCCAGACCCTGG GA (SEQ ID NO: GG (SEQ ID NO:CATGGGATGGGCTG 602) 603) GGATCTTCTCTGTG AATCCACCCCTGGCTA (SEQ ID NO: 601) EHD2 NM_014601.2 GACGACGAGGCCG TCGTCGTATTTGGGCTTGCCGTCGG AGTGGGTGGTGACC ACTTGTCCTTGGT CAGGCGCCAGGT AAGGACAAGTCCACACCACCCACTC TGTAGAAGATC AATACGACGAGAT GGC (SEQ ID NO: (SEQ ID NO: 606)CTTCTACAACCTGG 605) CGCCTGCCGACGGC AAGCTGAGCGGCTC CAAGG (SEQ ID NO: 604)EIF5AL1 NM_001099692.1 AGGGCCAGAAGCT AGTGTGGAAATG CAATAGCCATAGGTTCTTTCCCTTAA AGTTTGCCCTTTT ACAGGAAGGTAT AAGGGCAAACTCA AAGGGAAAGAACGCTATCTGTCAG TTTCCACACTATGG AGCTTCTGGCCCT AGTCCCCAT GGACTCTGACAGAT(SEQ ID NO: 608) (SEQ ID NO: 609) AGCATACCTTCCTG TCTATGGCTATTGGACCT (SEQ ID NO: 607) ELL2 NM_012081.5 AATCCCGCAACCGA TACATATGGTCCAACTGTATCTGAA AGCACAAAAGTTAT CCGGGTTTGATA ACAGCTTGAGGT CAAACCCGGTGGAACTTTTGTGCTTC GCTTTCCGAATT CCATATGTAGGGAA GGTTGCGGGATT TGCACTCTTTTCAAGAGTGCAAATTC (SEQ ID NO: 611) CC (SEQ ID NO: GGAAAGCACCTCA 612)AGCTGTTTCAGATA CAGT (SEQ ID NO: 610) EML1 NM_004434.2 CCGGAGACTACGAGACTTGCTTACAG GTGCAGGTATAG AATCCTCTACTGGG GCAGAGGGAACC GTAGCCCATTCATTCCCTCTGCCTGT CAGTAGAGGATT ATGTCTCTTGTA AAGCAAGTCGTAA TCGTAGTCTCCGGGTTTCCACACTT GTGTGGAAACTACA (SEQ ID NO: 614) AC (SEQ ID NO:AGAGACATTGAAT 615) GGGCTACCTATACC TGCAC (SEQ ID NO: 613) EMR1NM_001974.3 TTCAAAGACCACCA ATCTTCAGCTTGA AGCCGTCTTTCT GGCTCCCTTGACCATCTCAGAGGTGG TCTCTCCAGTCA CCTCTGAGATCAAG TCAAGGGAGCCT TTATGCCCCCAACTGAAGATGAATTC G (SEQ ID NO: 617) CGACTCGAGAAT TCGAGTCGTTGGGGTC (SEQ ID NO: GCATAATGACTGGA 618) GAGAAGAAAGACG GCT (SEQ ID NO: 616)ENO1 NM_001428.2 TTCTCGCCTCACTT GACACGAGGCTC ATTTTGAGCACA TCCACCAAGTGTCTACATGACTCTAG AAACCACCGGG AGAGTCATGTGAGC ACACTTGGTGGA GATCTAGCCTGTCTCGTGTCATCTCC AAGTGAGGCGAG GGCCACCCCGGA GGGGTGGCCACAG AA (SEQ ID NO:GAT (SEQ ID NO: GCTAGATCCCCGGT 620) 621) GGTTTTGTGCTCAA AAT (SEQ ID NO:619) ENPP3 NM_005021.2 CTTTTTATGAGCCA ACAAACAGAAAA TGAGGGCAGAATCCCATGCAGAGGA CTTTGACACCTCC ACAGTCAAGAG GGTGTCAAAGTTTT TCTGCATGGGATACTCTGTGGGCA CTGTTTGTGGCTTT GGCTCATAAAAA ATGGATTAGCAA GCTAATCCATTGCCG (SEQ ID NO: 623) AGCC (SEQ ID CACAGAGTCTCTTG NO: 624) ACTGTTTCTGCCCTCA (SEQ ID NO: 622) ENTPD1 NM_001776.4 TTCGAGTAACTTTA GACAGATTGACTCCCCGTTTCGGA GGAAAATGAGCTG GAGGAGTCCAGC AGGAACCTCAAA CTGGACTCCTCAGTAGCTCATTTTCCT CCCTGTCTTTTTC CAATCTGTCCTTTC AAAGTTACTCGA ATTGACTAGAAATAGTCAATGAAAA A (SEQ ID NO: 626) G (SEQ ID NO: AGACAGGGTTTGA 627)GGTTCCTTCCGAAA CGGGG (SEQ ID NO: 625) EP300 NM_001429.2 CCAGCCAGGCCCACATGCTATTTATC CCCATGTTGGGA ACAGAGCAGTCCTG AAACCTAATCCA GAAGTCAAGCCTGATTAGGTTTGATA GGACTGCTCTGTT GCCTGTGTCATT AATAGCATGGTCAA GGGCCTGGCTGGGGGCTTTTGAC AAGCCCAATGACA (SEQ ID NO: 629) (SEQ ID NO: 630)CAGGCAGGCTTGAC TTCTCCCAACATGG GGAT (SEQ ID NO: 628) EPHB1 NM_004441.3GCAGCGGCCGGGG ACGATAGAGATG GCTTATCGCTGT TCGTGTTCGTTGTG GCCACCAAGGACACACAGCCTCTT TCCTTGGTGGCCAT ACAACGAACACG TGCTATAAGCCC CTCTATCGTCTGTAACCCCGGCCGCT GTTTCCTGCTAC GCAGGAAACGGGC G (SEQ ID NO: 632)AG (SEQ ID NO: TTATAGCAAAGAG 633) GCTGTGTACAGCGA TAAGC (SEQ ID NO: 631)EPSTI1 NM_001002264.1 AGAGAAGCATTTA CTCAAGAACTCA AAACAGCACTTTGAGAGCATCAGCA GCGGTTTTGTATT GACAGGCACTTC ATACAAAACCGCTG GCTGATGCTCTCTTGTCTGGCGATT AGTTCTTGAGCAAA AAATGCTTCTCT CTGTGTTCAGTT CTGAACACAGAATC(SEQ ID NO: 635) TG (SEQ ID NO: GCCAGACAGAAGT 636) GCCTGTCAAAGTGCTGTTT (SEQ ID NO: 634) ERBB2IP NM_018695.2 CACAGAGACCCCTT TGCATTTGGACCAGTTCTCTCTGGT TCTGCACGAACATA TCTATGCTGTATG ATTTCATTAATA CAGCATAGATGGTCTTCGTGCAGAAA GAGGGTCGAGC CAAATGCATCAAG GGGGTCTCTGTG ACTCTGAGGTCTACCTCAGAGTGCTC (SEQ ID NO: 638) TGA (SEQ ID NO: GACCCTCTATTAAT 639)GAAATACCAGAGA GAAC (SEQ ID NO: 637) ERG NM_182918.3 GACCTCATCATTATTCTCTTACCTGAC CCTACCCAAAAT GTGGGGGCTTTGTT CCTGTGGAGAAC GCCTGCGTGATTCTCCACAGGGTCAG AAAGCCCCCACA TCTGATTGTGGC GTAAGAGATGGCCT TAATGATGAGGTAGCCAAGAAGG TCTTGGCTGCCACA C (SEQ ID NO: 641) CCA (SEQ ID NO:ATCAGAAATCACGC 642) AGGCATTTTGGGTA GG (SEQ ID NO: 640) ERN2 NM_033266.2ATCGAAGGACCAA GCTGGGTCAGAG TCATTAATCCCT TGTACGTCACAGAA AGAAAGGCCATTGTTGTTTTTGGG ATGGCCTTTCTCTC TCTGTGACGTACA TCCCCAAGATGT TGACCCAGCAGATGTTGGTCCTTCGAT ACAGGCTGCCAT GCAGCCTGTACATC (SEQ ID NO: 644)CT (SEQ ID NO: TTGGGGACCCAAA 645) AACAACAGGGATT AATGA (SEQ ID NO: 643)ERP29 NM_001034025.1 TAACCTGCTGGCTG TTTCCCACTACCC CAGGCATACTCATGAGTCCCTTGTGG CCTTATATTCCAC GGGCTCAGAATC AATATAAGGGGGT AAGGGACTCACAGTGGGTTAGTAC AGTGGGAAAAGTG GC (SEQ ID NO: CACT (SEQ ID NO:GTACTAACCCACGA 647) 648) TTCTGAGCCCTGAG TATGCCTGGACATT GATG (SEQ ID NO:646) ERP44 NM_015051.1 TGAGGAAGTATTAC GGGCTAGAGCCT CTTGTCCTCAGTTTAGCATTCATGCA AAGCCCAATATG GACTTCACAGTC TATTGGGCTTAGGC CATGAATGCTAACAGAGAAGACA TCTAGCCCTGCCAC GTAATACTTCCTC ATGATAGTGGCA TATCATTGTCTTCTA (SEQ ID NO: 650) (SEQ ID NO: 651) CTGGACTGTGAAGT CACTGAGGACAAGGAA (SEQ ID NO: 649) ESPL1 NM_012291.4 CAGGGACTTCACCT CAGCCTTGGGCAATTTACAACTGT CTACACTGTGGTGG AAGTCATAAACC CCACTAGTTGGG TTTATGACTTTGCCACCACAGTGTAG TCAGGTCAGCCA CAAGGCTGTCAGAT AGGTGAAGTCC AATCAACTATCTAGTTGATTTGGCTG (SEQ ID NO: 653) GA (SEQ ID NO: ACCTGACCCAACTA 654)GTGGACAGTTGTAA AT (SEQ ID NO: 652) ETV6 NM_001987.4 GTATGAATATGAAAGCTCTAATCCTAG ACAGTAAGAGA TCAGAGACCAGGG CAACATCATGCC CTGAGTTCTTGCCATGATGTTGCTAG CTGGTCTCTGATT ACTTGGGTGAAG GATTAGAGCCTCTC TCATATTCATACAGGCCAGACTGA AGTCTGGCCTCTTC (SEQ ID NO: 656) GAG (SEQ ID NO:ACCCAAGTGCAAG 657) AACTCAGTCTCTTA CTGT (SEQ ID NO: 655) EXO1 NM_003686.3GCCAGAGCCAGTG TTTCTCTTCTGGA GCTCATTGAGTT GGCTGAGCAAGAA TGCTTGCCGGCTTTGATCTGTAACC GCCGGCAAGCATCC CTTGCTCAGCCCA CCGGCTTGTTCT AGAAGAGAAAGCACTG (SEQ ID NO: CGGCATTATGAT TCATAATGCCGAGA 659) GC (SEQ ID NO:ACAAGCCGGGGTT 660) ACAGATCAAACTCA ATGAGC (SEQ ID NO: 658) FABP4NM_001442.2 GGTGGAATGCGTCA CTCTCTCATAAAC TAGAGTTCAATG TGAAAGGCGTCACTTCTCGTGGAAGT CGAACTTCAGTC TCCACGAGAGTTTA GACGCCTTTCATG CAGGTCAACGTCTGAGAGAGCATAA ACGCATTCCACC CCTTGGCTTATG GCCAAGGGACGTT (SEQ ID NO: 662)(SEQ ID NO: 663) GACCTGGACTGAA GTTCGCATTGAACT CTACA (SEQ ID NO: 661)FAM108C1 NM_021214.1 TCTGACATTCATGC AATACCGAGAAC CAAATGGATTGAAGGACTTGCCCTGT ATTGGTGGCAAC ACCCATGTATCC TGCCACCAATGTTC AGGGCAAGTCCTAGTGGCAGAAA TCGGTATTTCACAT GCATGAATGTCA GAGAGCTGCATG GCAGCTCTCTTTCTGA (SEQ ID NO: TGA (SEQ ID NO: GCCACTGGATACAT 665) 666) GGGTTCAATCCATTTG (SEQ ID NO: 664) FAM159A NM_001042693.1 ACAGCTACATGTGG TACGGACAGGCCTAGCAGAGCACA TGGCTCAGCATTGG TATGAGAGCGCC CAGGCGGTAACA CGCTCTCATAGGCCAATGCTGAGCCA ATGAAGGCGAG TGTCCGTAGCAGCA CCAC (SEQ ID NO: AAGAACCACTGCGTGGTTCTTCTCGC 668) TGC (SEQ ID NO: CTTCATTGTTACCG 669) CCTGTGTGCTCTGCTA (SEQ ID NO: 667) FAM171B NM_177454.3 CTTTTCTCCACACC GGCAAAGTAGCTCTCGATTTACTG GGAACAATTACATA GACTTAGCAGTA GTTCCATCAATT CTGCTAAGTCAGCTTGTAATTGTTCCG GGCCATAGACTA ACTTTGCCAAGAAA GTGTGGAGAAAA ACTGTCCCTTTCGGGACAGTTAGTCT G (SEQ ID NO: 671) TT (SEQ ID NO: ATGGCCAATTGATG 672)GAACCAGTAAATC GAG (SEQ ID NO: 670) FAM189A1 NM_015307.1 CAGTGAACTCTCTGACTGCTCAGTTCA TCTTTAGGTGAC GTTTTATCTGGCGT AGGTGCTGCACG GTAAGTGTCGCCGCAGCACCTTGAAC CCAGATAAAACC TGTTGCTGTATT TGAGCAGTGTTGCA AGAGAGTTCACTCACATTTGTGCA CAAATGTGAATACA G (SEQ ID NO: 674) AC (SEQ ID NO:GCAACAGGCGACA 675) CTTACGTCACCTAA AGA (SEQ ID NO: 673) FAM46CNM_017709.3 TTGGAATGGGTCTA ATACGGGTCCTTT AGATGTGGATAG CAGTGTATCATGAGGAGGGTTGGCTC GTCATGCTTCCT CCAACCCTCAAAGG ATGATACACTGT GTAGCGTTTTCCACCCGTATTACAGT AGACCCATTCCA AACGTGGCACTG GCCACGTTGGAAAA (SEQ ID NO: 677) TA (SEQ ID NO: ACGCTACAGGAAG 678) CATGACCTATCCACATCT (SEQ ID NO: 676) FAM69A NM_001006605.3 GTGCCAGAGACAA GACTCACAGTGATCTGATCACAGC ACCTGAAAGAACTT CGATCCTTAATAA TAGTTCTACAAT ATTAAGGATCGTCAGTTCTTTCAGGTT CTGTGCCATAGA CTGTGAGTCTGATT TGTCTCTGGCAC CACAGTCCAAATTGGACTGTGTCTAT (SEQ ID NO: 680) CA (SEQ ID NO: GGCACAGATTGTAG 681)AACTAGCTGTGATC AGA (SEQ ID NO: 679) FAM83D NM_030919.2 CAC GTTGATTGATGATGTAAAACTGT TTGGCCAGACAG GCATCCGCGTGGCA AGGAGCCTGTTG AATTACCAAGTTACAGGCTCCTACAG CCACGCGGATGC ACTGCTGTTTAA TTTTACATGGACGG CATCAATCAACGTTTGCCATCCGT ATGGCAAATTAAAC TG (SEQ ID NO: CC (SEQ ID NO: AGCAGTAACTTGGT683) 684) AATTCTGTCTGGCC AA (SEQ ID NO: 682) FAP NM_004460.2GCATTGGAAGCTAT CCTTAGATGGCA TACTTGGCGTAG CCTCCAAGCAAGA AGTAACACACTTTCGCTGAAACTT AGTGTGTTACTTGC CTTGCTTGGAGG GCTGTGTAATAT CATCTAAGGAAAGATAGCTTCCAATG TGGCACCTTTCT AAAGGTGCCAATAT C (SEQ ID NO: 686)TT (SEQ ID NO: TACACAGCAAGTTT 687) CAGCGACTACGCCA AGTA (SEQ ID NO: 685)FAR2 NM_018099.3 TCTTTCAGGAGCTA GCTGCAATTGTG CAGAAAGCCTGT TAAAAGAAAGGGAGACATGATTCCTC GGCCCCCGTGAT GGAATCATGTCCAC CCTTTCTTTTATA GAGAATGGACTTAATTGCAGCTTTCT GCTCCTGAAAGA GCCGCCATAGAA ATGGCGGCAAGTCC (SEQ ID NO: 689)A (SEQ ID NO: ATTCTCATCACGGG 690) GGCCACAGGCTTTC TGG (SEQ ID NO: 688)FARP1 NM_005766.2 TCATGGTACGTAGT TGCAGGAGGATA AGACAGGCACG CCCCGGCACCTGTCTAGGAATAACGA ATATATACTACT GTTATTCCTATATC CAGGTGCCGGGG AGAGAATGCGCCTCCTGCAACTGTG ACTACGTACCAT AGTTTCAAACCA GTTTGAAACTGCGC GA (SEQ ID NO:CAGT (SEQ ID ATTCTCTAGTAGTA 692) NO: 693) TATATCGTGCCTGTCT (SEQ ID NO: 691) FAS NM_000043.3 CACCGGGGCTTTTC TGTGTCACTCTTGTCACTCGTAAAC GTGAGCTCGTCTCT CGCGAGATCAGA CGCTTCCCTCAC GATCTCGCGCAAGAGACGAGCTCACG TCCCCAGAAGCG GTGACACACAGGT AAAAGCCCCGG TCTTTGAACACCGTTCAAAGACGCTT (SEQ ID NO: 695) TG (SEQ ID NO: CTGGGGAGTGAGG 696)GAAGCGGTTTACGA GTGA (SEQ ID NO: 694) FBP2 NM_003837.2 AGATGAGGTGAAGTGTTGATCACCAG TTATTCTCTTCTG AAACTGGATGTGCT GGAATTGGATAG AGACCAGGACGATCCAATTCCCTGG CACATCCAGTTTC CAGGTACTATAG TGATCAACATGGTC TTCACCT (SEQ IDGAGGATTGGACC CAATCCTCCTATAG NO: 698) A (SEQ ID NO: TACCTGCGTCCTGG 699)TCTCAGAAGAGAAT AAG (SEQ ID NO: 697) FBXL13 NM_145032.3 ACGATGCGACTCCTAAACTAAGATTC CCAAGTTCAGGT GCCGAGGCACTTCC TGTAAGTTGTGG ACTGTAAGCCTTACAACTTACAGAAT AAGTGCCTCGGC TGTCTGTGAACC CTTAGTTTGGCTTA AGGAGTCGCATCGTCTGCAATAAG TTGCAGACGGTTCA GT (SEQ ID NO: CC (SEQ ID NO: CAGACAAAGGCTT701) 702) ACAGTACCTGAACT TGG (SEQ ID NO: 700) FBX010 NM_012166.2TCAGCTCCACAGCC TCCCTGAAAAAC AATCTTTATAGA CATAGCAAGAAGA ATTGCCCACTTTCCTTCGAGTGACT AAGTGGGCAATGTT TTCTTGCTATGGG GGAAACCCACCA TTTCAGGGAGAAGCTGTGGAG (SEQ GCTTCTATCCCT GGATAGAAGCTGG ID NO: 704) TC (SEQ ID NO:TGGGTTTCCAGTCA 705) CTCGAAGTCTATAA AGATT (SEQ ID NO: 703) FBX011NM_018693.2 TGCAGATATGGTTG ATGGACTATTTTG TGTGGGACACGC CAGAAGAATCAGGTGCACCAGGACC TGTTCTTTTCGG TCCTGGTGCACAAA TGATTCTTCTGCA CAAAAGAGTTTTATAGTCCATACCAA ACCATATCTGCA TCTACGAAGTTG CTTCGTAGAAAAAC (SEQ ID NO: 707)GT (SEQ ID NO: TCTTTTGCCGAAAA 708) GAACAGCGTGTCCC ACA (SEQ ID NO: 706)FBXO36 NM_174899.4 AGCAAAGACTATTA CTAAAGATTACCT CAGGTTTTGTTGCCAGTTACTGGTCA GAGACCGGGTGA ATCGATACTCAC CCCGGTCTCAGGTA CCAGTAACTGGTTCCTTAGAGAGA ATCTTTAGATGGTG AATAGTCTTTGCT TCTTCCACCAT GAAGATCTCTCTAA(SEQ ID NO: 710) (SEQ ID NO: 711) GGAGTGAGTATCG ATCAACAAAACCTGGAG (SEQ ID NO: 709) FBXO41 NM_001080410.1 TTTGTTCTCTCCTCG GCAAAAGCTCCCCCCTAGCTGTAT GGGATGAGCTCTGC TACTCAGCAGCA GGTCACCAAAAA TGCTGAGTAGGGAGAGCTCATCCCC AATCCATGCATA GCTTTTGCTTGCTG GAGGAGAGAACA GAGCCTCCCAGCGGAGGCTCTATGCA AA (SEQ ID NO: AA (SEQ ID NO: TGGATTTTTTTG GT 713) 714)GACCATACAGCTAG GG (SEQ ID NO: 712) FCER2 NM_002002.4 AACTTGGAAAGCCGTGGACTGGGAT AATCTCTGCTGT ACCACGGTGACCA TTCTGCGCCATCT TCAGCTCGAAGTGATGGCGCAGAAA GGTCACCGTG TCCTCCAGTTCC TCCCAGTCCACGCA (SEQ ID NO: 716)TGTGAAATCTGC GATTTCACAGGAAC (SEQ ID NO: 717) TGGAGGAACTTCGAGCTGAACAGCAGA GATTGA (SEQ ID NO: 715) FCN2 NM_015837.2 ACCAGGACAATGATCCCTGAAACATC TAGCGACCATTC TCTTAACACCGGAA ACAGCACAATTT AGGTTTGACACAATTGTGCTGTGATG CCGGTGTTAAGA TGGCAGTTTTTG TTTCAGGGAGCTTG TCATTGTCCTGGTTACCACCAAGC GTGGTACAAAAACT (SEQ ID NO: 719) (SEQ ID NO: 720)GCCATGTGTCAAAC CTGAATGGTCGCTA CCT (SEQ ID NO: 718) FEZ1 NM_005103.3TAAACGTGTATAGC GACCCCGCGCGC TGCCCCATCATG TTAACCTGGATTAA TTGCTCGTGTTTACATCCAATGATT ACACGAGCAAGCG ATCCAGGTTAAG ACTAGCACTAGA CGCGGGGTCCTTTGCTATACACGTTTA AGCCAACGGCA CCGTTGGCTTCTAG (SEQ ID NO: 722)AAG (SEQ ID NO: TGCTAGTAATCATT 723) GGATGCATGATGG GGCA (SEQ ID NO: 721)FGL2 NM_006682.2 CAATTCAGCAGGAT TCCTTGAGGTTTT CAGCCTGCAGCTCGAGGAGGTGTTCA GGACTTCTTTGAA TGCAGTCTTGGC AAGAAGTCCAAAA CACCTCCTCGATCAAGATTTCTTTA CCTCAAGGAAATCG CTGCTGAATTG GACTATTTACGA TAAATAGTCTAAAG(SEQ ID NO: 725) TT (SEQ ID NO: AAATCTTGCCAAGA 726) CTGCAAGCTGCAGGCTG (SEQ ID NO: 724) FKBP11 NM_016594.2 AAAGCAGGTGATTC CCACACACATGTTTCCATAGGCCA CAGGTCTGGAGCA CGAGAAGACTCT AGTGAGAAGGA GAGTCTTCTCGACAGCTCCAGACCTG ATGATTGCCCTT TGTGTGTGGGAGAG GAATCACCTG CGCTTCTCTCAAGCGAAGGGCAA (SEQ ID NO: 728) (SEQ ID NO: 729) TCATTCCTTCTCACTTGGCCTATGGAAA ACGG (SEQ ID NO: 727) FKBP2 NM_057092.2 CCACGGCCACGGGCTTGACCCCGATC CCCTTTGCGCGA GGCCGAGGGCAAA TGCAGCTTCCTTT TTTGATGGGACAAGGAAGCTGCAGA TGCCCTCGG (SEQ GTGGTCCACCCG TCGGGGTCAAGAA ID NO: 731)CTT (SEQ ID NO: GCGGGTGGACCACT 732) GTCCCATCAAATCG CGCAAAGGGGATGTCCTGCA (SEQ ID NO: 730) FLJ42418 NM_001001695.1 TCCCATTCTTACTGCTGCTCTAGCTCC TCTTGCTGGCAA GCTGAAATTCAAAG ATTTATCAGCTTT GTCTTAATGTAACTGATAAATGGAGC GAATTTCAGCCA GACCCTCAACTC TAGAGCAGATAGCT GTAAGAATGGGAATTTTCCCAGCT GGGAAAATGAGTT (SEQ ID NO: 734) AT (SEQ ID NO:GAGGGTCTTACATT 735) AAGACTTGCCAGCA AGA (SEQ ID NO: 733) FLNA NM_001456.3CCCTCAGGAGCCCT TTATCTTGGTCAA CGTCAATCAG GT GGAGGAGTGCTAT TTTCTGTGACATAAAACGCCATTCT GTCACAGAAATTGA GCACTCCTCCAG CCCGAGGGATGA CCAAGATAAGTATGGGCTCCTGAG AGCGCACAGCAT CTGTGCGCTTCATC (SEQ ID NO: 737) AC (SEQ ID NO:CCTCGGGAGAATG 738) GCGTTTACCTGATT GACG (SEQ ID NO: 736) FN1 NM_212482.1GGGAATGGACATG AACAATGCACTG TCTTCATGAC GC CATTGCCTACTCGC ATCTCGAAGCTGTTGTGGAATGTG AGCTTCGAGATCAG CGAGTAGGCAAT TCGTTCACATTG TGCATTGTTGATGAGCATGTCCATTCC TAAGTGATGTCA CATCACTTACAATG C (SEQ ID NO: 740)TC (SEQ ID NO: TGAACGACACATTC 741) CACAAGCGTCATGA AGA (SEQ ID NO: 739)FNBP1 NM_015033.2 CATGACCTCCAAAC GCCCACGCTTTAG GTGGGAGGTTGCCCAAAATCCACTGC GCTCCTGAAGCA TGAAATCCTCCG TTCAGGAGCCTAAA GTGGATTTTGGGTGTGTTGCACCCA GCGTGGGCTTTCTC TTGGAGGTCATG GCTTGAGAGAAA TCAAGCTGGGTGCA(SEQ ID NO: 743) (SEQ ID NO: 744) ACACCGGAGGATTT CAGCAACCTCCCACCT (SEQ ID NO: 742) FNDC1 NM_032532.2 GATTATAAGCAGAT GGAATCAGGTTCCATCTCTTTCAC CGCTAACAGGCGTG TCAATCAGCACA CCTGTGAAATAC TGCTGATTGAGAACCGCCTGTTAGCG GGACTGCAAATT CTGATTCCAGACAC ATCTGCTTATAAT CATACACAGTGTTGTGTATGAATTTG C (SEQ ID NO: 746) CT (SEQ ID NO: CAGTCCGTATTTCA 747)CAGGGTGAAAGAG ATG (SEQ ID NO: 745) FOXM1 NM_021953.2 AAGTCTTTTGTATTCATCCATCCTCCC GAGAAACATCTA GGGTCAGGAGTTG ACCCCAAATTCA ATAGCGCACATCAATTTGGGGTGGGA ACTCCTGACCCA TGGGCACCCACA GGATGGATGCAACT ATACAAAAGACTCTCTGCTTCAGT GAAGCAGAGTGTG T (SEQ ID NO: 749) TG (SEQ ID NO:GGTGCCCAGATGTG 750) CGCTATTAGATGTT TCTC (SEQ ID NO: 748) FOXO1NM_002015.3 TCTCATCACCAACA GGTGCCAGGTGA AAACTGGTGTTT TCATTAACTGTTTCGGACTGGGTCGA GGTGGCGCAAAC GACCCAGTCCTCAC AACAGTTAATGA GAGTAGCACGGCCTGGCACCATGATG TGTTGGTGATGA GTCTGCTGCATC CAGCAGACGCCGT GA (SEQ ID NO:AT (SEQ ID NO: GCTACTCGTTTGCG 752) 753) CCACCAAACACCA GTTT (SEQ ID NO:751) FOXP1 NM_001012505.1 TGCTAGCCAAAAG GCATAATGCCAC GCCATAAAAAGCGCTTCCCTCTGTGT AGGACTGCAACA CTGGGGTCACTG GTTGCAGTCCTGTG CACAGAGGGAAGGGAGGGGGCAT GCATTATGCATGCC CCTTTTGGCTAGC (SEQ ID NO: 756) CCCTCCCAGTGACCA (SEQ ID NO: 755) CCAGGCTTTTTATG GCTGTGAGACACGT TAA (SEQ ID NO: 754)FSCN1 NM_003088.2 CCCTGCCCTCTTGT TCAGAAGAAAGA CCTTAGCCGCTT CTGCCACGGGGCGGGTGCCAGACTC CCAGAGAAATA AGTCTGGCACCTCT GCCCCGTGGCAG AGGCTCAGAGCCTTCTTCTGACCTCA ACAAGAG (SEQ ID GTCTGAGG (SEQ GACGGCTCTGAGCC NO: 758)ID NO: 759) TTATTTCTCTGGAA GCGGCTAAGGGAC GGTT (SEQ ID NO: 757) FUT8NM_004480.3 GACATCATGAAAG ATTGTTCACTAAT CTTTTCCTCTTCA GATTCTGATGGCAAGAGACAGTAATT CAGTAGTAGGTT TTACTGTCTCATTA GCCATCAGAATC GTGCTAATACAAGTGAACAATAAAA CTTTCATGATGTC CAATTTTTCTTTT GAAAAATTGTTGTA(SEQ ID NO: 761) (SEQ ID NO: 762) TTAGCACAACCTAC TACTGTGAAGAGGAAAAG (SEQ ID NO: 760) FYB NM_001465.3 ATGTAAAGTCCCTC CTCTGTCGGGTTGGATGAGTTTGGC ATGGCGAAATATA CCCCCCGTGTTAT CCTGTGACTCTG ACACGGGGGGCAAATTTCGCCATGAG AAGGGTCGGCTA CCCGACAGAGGAT GGACTTTACAT TTGACTGAGACAGTCTCAGTCAATAG (SEQ ID NO: 764) TC (SEQ ID NO: CCGACCCTTCAGAG 765)TCACAGGGCCAAA CTCATC (SEQ ID NO: 763) GAD2 NM_000818.2 TGTATGCCATGATGCTCCTTGACTTCT TTCAGACGTGAA ATCGCACGCTTTAA GGGAACATCTTA GGCAATGAGCCTGATGTTCCCAGAAG AAGCGTGCGATC GGGAAGAGCAG TCAAGGAGAAAGG ATCATGGCATACCCATTCCTTT AATGGCTGCTCTTC A (SEQ ID NO: 767) (SEQ ID NO: 768)CCAGGCTCATTGCC TTCACGTCTGAACA TAG (SEQ ID NO: 766) GATA1 NM_002049.2TGCGGAAGGATGG CCCTTTTCCAGAT CTCCTGTGCCTC TATTCAGACTCGAA GCCTTGCGGTTTCCCAGACTGGAGC ACCGCAAGGCATCT GAGTCTGAATAC CCCGTTTCTTTTT GGAAAAGGGAAAACATCCTTCCGCA (SEQ ID NO: 771) AGAAACGGGGCTC (SEQ ID NO: 770)CAGTCTGGGAGGC ACAGGAGCAGCCG AAGGACC (SEQ ID NO: 769) GATA2 NM_032638.3GAAGAAGGAAGGG TGGACTTGTTGGA CATGCACTTTGA ATCCAGACTCGGAA CATCTTCCGGTTCCAGCTCCTCGAA CCGGAAGATGTCCA CGAGTCTGGATC GCACTCCGCCCC ACAAGTCCAAGAACCTTCCTTCTTC TTTCTTGCTCTTC GAGCAAGAAAGGG (SEQ ID NO: 773) T (SEQ ID NO:GCGGAGTGCTTCGA 774) GGAGCTGTCAAAGT GCATG (SEQ ID NO: 772) GBP1NM_002053.1 CCAGATGACCAGC TTTACCTAAGACT TGGGACATTGTA AGTAGACAAATGGCTGCTCAGTATCC GACTTGGCCAGA ATACTGAGCAGAGT ATTTGTCTACTGC CCAATGCCCAAACTTAGGTAAAAGTC TGGTCATCTGG TATTTCCCAAGA TTGGGAAATATTTG (SEQ ID NO: 776)CT (SEQ ID NO: GGCATTGGTCTGGC 777) CAAGTCTACAATGT CCCA (SEQ ID NO: 775)GBP4 NM_052941.4 TTCTACAAGATATG TTAAGAAGCCTG GGAGCACAGCTT CCATGGGCCTTTTCTGTCCCCTGTGAA TGTAAATAAAGG ACAGGGGACACAG AAGGCCCATGGC ACATAGGGTGAGGCTTCTTAAAACAA ATATCTTGTAGAA GAAGCCGGGTTG CCCGGCTTCCTCAC(SEQ ID NO: 779) TT (SEQ ID NO: CCTATGTCCTTTAT 780) TTACAAAGCTGTGCTCC (SEQ ID NO: 778) GCET2 NM_001008756.1 GGAAAGGAGTCAC GGCAAATCATAACACCCTTCAGCG CTTAACAAAGCTGC GGTTGATTTCTGC ATATGGTGATCC AGAAATCAACCTTAAGCTTTGTTAAGG CAGCATCTAAAA TGATTTGCCATCTC TGACTCCTTTCC TACCCAAGAGAGTCTTGGGTATTTTA (SEQ ID NO: 782) AT (SEQ ID NO: GATGCTGGGATCAC 783)CATATCGCTGAAGG GTG (SEQ ID NO: 781) GGT1 NM_001032365.2 CTCAGCAAGGCAAACTGAACTGTCC TCTCCAGTTGAA GTGAGGTGCTGCCG AGCCTGGATGAC CTCTGCTGTGGGTCATCCAGGCTGGA GGCAGCACCTCA GCCTCAGGCAAA CAGTTCAGTGATTT CTTG (SEQ ID NO:TC (SEQ ID NO: GCCTGAGGCCCCAC 785) 786) AGCAGAGTTCAACT GGAGACAGAGAAACCAG (SEQ ID NO: 784) GHR NM_000163.2 TTCATATAGTACAG CAAGGCAGTCGCTCTGTGCTCACA TCCCCACAGGGCCT ATTGAGTATGAG TAGCCACATGAT CATACTCAATGCGAGCCCTGTGGGGA GAGAGAAACTCT CTGCCTTGCCCTTG CTGTACTATATGA TTGTCAGGCAAGCCTGACAAAGAGTT A (SEQ ID NO: 788) GG (SEQ ID NO: TCTCTCATCATGTG 789)GCTATGTGAGCACA GA (SEQ ID NO: 787) GIT2 NM_057169.2 CAGATTTTACAGGCGTGCCTGGGTCTG GCCCTCCTTGCC TGAATTATTGGCAG CTCCATATACTGC TTGCATAATCAATATATGGAGCAGAC CAATAATTCAGC CGGGAGTTTTCC CCAGGCACACAGG CTGTAAAATCTGCACTAGAATCCT ATTCTAGTGGGAAA (SEQ ID NO: 791) GT (SEQ ID NO:ACTCCCGTTGATTA 792) TGCAAGGCAAGGA GGGC (SEQ ID NO: 790) GLDC NM_000170.2AAAGCTTGGTGAG ATCTCTTGTTACC TGTTGCTCCCTG AATGATGCCTGGAA CCCACCATTCTTCGTTTGAAGAGCA GAATGGTGGGGGT CAGGCATCATTCT AGACGATACACT AACAAGAGATGCCCACCAAGCTTT TCTTTCCCAGTG ACTGGGAAAGAAG (SEQ ID NO: 794) GC (SEQ ID NO:TGTATCGTCTTGCT 795) CTTCAAACCAGGGA GCAACA (SEQ ID NO: 793) GLRXNM_002064.2 ATCCCATCCCACCT AAGGTGGAGAAC GTGACCTTTCAC TGAAAATCACTGCTACTGGTTCAGAG AGAATTGTTGAA CTGAACCAGTGTTC CAGTGATTTTCAA CATTTCCTATGATCCACCTTGTCCTC GGTGGGATGGGA GATCTGTGGAGG CACAGATCTCATAGT (SEQ ID NO: 797) AC (SEQ ID NO: GAAATGTTCAACAA 798) TTCTGTGAAAGGTCAC (SEQ ID NO: 796) GNA13 NM_006572.4 TTTTCTTACAATAT GCCGCTGTCTGCCACAGATTCACCC CTTCCTGCTATAAG CATAATGCTCTTA AGTTGAAATTCT AGCATTATGGGCAGTAGCAGGAAGAT CGACGCCGGTCA ACAGCGGCATACA ATTGTAAGAAAA TAGGCATTCTGTGAATGCCTATGACC (SEQ ID NO: 800) AT (SEQ ID NO: GGCGTCGAGAATTT 801)CAACTGGGTGAATC TGT (SEQ ID NO: 799) GNB4 NM_021629.3 TGCCATCAGCAAGGAAAAATGAGGCC TAGGGAGGAAC ATATCTCCTCCACT TGTCCATTAAAGT CTTGGATATTCATTAATGGACAGGCC GGAGGAGATATC GTCTACATCTCA TCATTTTTGGCAGC CTTGCTGATGGCAAACAGCATAGCT TATGCTGTTTGAGA (SEQ ID NO: 803) GCC (SEQ ID NO:TGTAGACTGAATAT 804) CCAAGGTTCCTCCC TA (SEQ ID NO: 802) GNG10NM_001017998.2 AACTTTTAGAGATA TTGGCTATAGGA CCTTCACCCAGT TTTCAGCCCTTTCCCCAGGCCACAGG TTTCTCACTCAA TGTGGCCTGGTCCT AAAGGGCTGAAA GTAGAAACTCATATAGCCAAAATCAC TATCTCTAAAAGT GAATATCTGTGA AGATATTCATGAGTT (SEQ ID NO: 806) TT (SEQ ID NO: TTCTACTTGAGTGA 807) GAAAACTGGGTGAAGG (SEQ ID NO: 805) GNG4 NM_004485.2 AATGAAAGAGGGC TGGCTTGGGAGATGTCCATACAGG ATGTCTAATAACAG TGCTAGTGGTGCT CTTCCATCTTTA CACCACTAGCATCTGTTATTAGACATG GCTGCTCCACAG CCCAAGCCAGGAA CCCTCTTTCATT CTTTCC (SEQ IDAGCTGTGGAGCAG (SEQ ID NO: 809) NO: 810) CTAAAGATGGAAG CCTGTATGGACAGGGTCAAG (SEQ ID NO: 808) GNL3 NM_014366.4 CATTCAGAAGTGAA AAGAAGTTTCCACCAATTACTCCA GTCTGCTTTGGGAA AAGGCCCTCTTTC ACCCGAATGGCT AGAGGGCCTTTGGACCAAAGCAGACT TTGCTGCAAGTT AACTTCTTGGAGGT TCACTTCTGAATG TCCTGAAAACCTTTTCAGGAAACTTG (SEQ ID NO: 812) CC (SEQ ID NO: CAGCAAAGCCATTC 813)GGGTTGGAGTAATT GG (SEQ ID NO: 811) GORASP1 NM_031899.2 GGCCAGCTTCCCTTGGGCAACTTTGG GGGAAGGGAAA AACTCTGTAGCCTG GTCAGACTGCCA GTAAAAGTGAGGCAGTCTGACCCAA GGCTACAGAGTT GGAGGGAAGAG AGTTGCCCTCACCC AAGG (SEQ ID NO:CCAGAACCTTTG AAAGGTTCTGGCTC 815) GGTGA (SEQ ID TTCCCTCCCTCACT NO: 816)TTTACTTTCCCTTCC C (SEQ ID NO: 814) GPR116 NM_015234.3 TATGTTGGGGTGGGACAACTAGACAG GCATATAAGAAG CTTTTCCATCTTGA GCTGCCAAGCTC TCCGATTCTTGGGCTTGGCAGCCTGT AAGATGGAAAAG TCACCGATTTCC CTAGTTGTGGAAGC CCCACCCCAACAACACCACAGCTT TGTGGTGTGGAAAT TA (SEQ ID NO: CC (SEQ ID NO: CGGTGACCAAGAA818) 819) TCGGACTTCTTATA TGC (SEQ ID NO: 817) GPR176 NM_007223.1AGTATTCTGCTCTG TGTCCAAAGCAA CTTGGCATCAGA TGACCATCCTCAGC TAGCAGGGAAGCTATTTTCCTCTCC TTCCCTGCTATTGC TGAGGATGGTCA AGTGGATAGAG TTTGGACAGGTACTCAGAGCAGAATA GACTGAGTAGTA ACTCAGTCCTCTAT CT (SEQ ID NO: CC (SEQ ID NO:CCACTGGAGAGGA 821) 822) AAATATCTGATGCC AAG (SEQ ID NO: 820) GPR183NM_004951.3 ACTGGAGAATCGG GTAAAACACTAG CGGTCAATACTC AGATGCCTTGTGTACGCAGTTATCCTA AGGCAGGTCATA GGATAACTGCGCTA CACAAGGCATCT AAGTTCACACCTGTGTTTTACATCAA CCGATTCTCCAGT GCATATGTGTTG CACATATGCAGGTG(SEQ ID NO: 824) AT (SEQ ID NO: TGAACTTTATGACC 825) TGCCTGAGTATTGACCG (SEQ ID NO: 823) GRAMD1B NM_020716.1 TTCCGCTGGGAAAC ATGGAACAGATGTGCAAACTTGGA TCTGCTGACAGTCC TCTTTCAAACGGA TGGCATTGGGAA GTTTGAAAGACATCCTGTCAGCAGAG TGAGGCGAGCTG TGTTCCATGACTAA TTTCCCAGCGGA TTTTTTCTTTAGTAGAAAAAACAGCT A (SEQ ID NO: 827) C (SEQ ID NO: CGCCTCATTCCCAA 828)TGCCATCCAAGTTT GCA (SEQ ID NO: 826) GRB10 NM_005311.4 CCTTTGCCACGTCCAAATGGCCACTC TGTCGCCTGTCA CCTTAGCTTAGTGA TCACACCTGATCA AAGGAGTCCTTTTCAGGTGTGAGAGT CTAAGCTAAGGG CTGCTTTACAGG GGCCATTTCCTTAC GACGTGGCAAAGGATCAAAGGTAA CTTTGATCCCTGTA G (SEQ ID NO: 830) GG (SEQ ID NO:AAGCAGAAAGGAC 831) TCCTTTGACAGGCG ACA (SEQ ID NO: 829) GRSF1NM_001098477.1 CTTTCTAAGCCTTG TAAGTAGATAGG CAGGGAGGGAC TGCTAAAGGCGTATCACCACCGTTATA AGTTTAGACAAC AACGGTGGTGCCTA CGCCTTTAGCACA TTTTAAGTTAAGTCTACTTAAGGGGG AGGCTTAGAAAG ACTAGAATGCCC CATTCTAGTCTTAA (SEQ ID NO: 833)CCT (SEQ ID NO: CTTAAAAGTTGTCT 834) AAACTGTCCCTCCC TG (SEQ ID NO: 832)GSK3B NM_002093.2 ACTGATTATACCTC GCCAACACACAG GATCCACACCACTAGTATAGATGTAT CCAGCAGACCAT TATCCCCTGGAA GGTCTGCTGGCTGT ACATCTATACTAGATATTGGTTGTC GTGTTGGCTGAGCT AGGTATAATCAG CTAGTAACAGCT GTTACTAGGACAACT (SEQ ID NO: 836) CA (SEQ ID NO: CAATATTTCCAGGG 837) GATAGTGGTGTGGATC (SEQ ID NO: 835) GTSE1 NM_016426.5 GATGAAGTCTTCTT GCAGCAATACATATGTGGGCAACG CGGACCCTTTGGAC CTTTCTTTATGTC GAGGCTGTTCGG ATAAAGAAAGATGCAAAGGGTCCGA GAACCGGATTAT TATTGCTGCCAGCT AGAAGACTTCAT TTAATTCCAAGCTGGAATTAAATAAT C (SEQ ID NO: 839) TG (SEQ ID NO: CCGGTTCCCGAACA 840)GCCTCCGTTGCCCA CAT (SEQ ID NO: 838) GXYLT2 NM_001080393.1 GTCATGCTCAAATCTGGAATTGGATCT GGCGTAACTGCT AGCTGTGCTTTTTA TCCTGTGGCTAAA TATCAAACTCGGGCCACAGGAAGAT AAGCACAGCTGA GCTTCAGAGAGT CCAATTCCACATCT TTTGAGCATGACCTTCAGTGAAGA TCACTGAAGACTCT (SEQ ID NO: 842) TG (SEQ ID NO:CTGAAGCCCGAGTT 843) TGATAAGCAGTTAC GCC (SEQ ID NO: 841) GYG2NM_001184704.1 CTCTTGGCTTGGTC CACTAAGTTATTG AATTCTCTGGAA TCTACCCTCACTACAGAACTGAGGTA AGAGCTGAGTGG CTCAGTTCTCAATA GTGAGGGTAGAG AAATGGCTTTGAACTTAGTGAATCAC ACCAAGCCAAGA GGAGGGCAGTG TGCCCTCCTCAAAGG (SEQ ID NO: 845) ATT (SEQ ID NO: CCATTTCCACTCAG 846) CTCTTTCCAGAGAATT (SEQ ID NO: 844) GYPC NM_016815.2 AGTACTTTATTTGA GGGGGAGGCATTCAGGGGTGCTGG GGGACAACAGACT CAGGGAAGTGAA GCGATGGGGTGT TCACTTCCCTGAATGTCTGTTGTCCCT ATTTTTCCTGAT GCCTCCCCCATCTC CAAATAAAGTAC GGAGAT (SEQ IDCATCAGGAAAAAT T (SEQ ID NO: 848) NO: 849) ACACCCCATCGCCC AGCACCCCTGCTGATACC (SEQ ID NO: 847) H1FOO NM_153833.1 GGCTCCTGGGAGCG CTGTGGAAGTCGGCCTGGCTTTTC TCACCAGCGACATC AGGAGGGTGAGA AGATTCAGGAGA TCACCCTCCTCGACTGTCGCTGGTGAC CCTGGATGATCC TTCCACAGCAGGAT GCT (SEQ ID NO: TG (SEQ ID NO:CATCCAGGTCTCCT 851) 852) GAATCTGAAAAGC CAGGCCCGAGCCA CGGC (SEQ ID NO:850) H2AFV NM_138635.3 ATGGCTTGTGTTAC GAATTACAAAGC AGATCTGAACCCAAGTAGAGAGCAG CCAACTCTCCACT AGGTAGATAGG TGGAGAGTTGGGCT GCTCTCTACTTGTACTCCAGAACTA TTGTAATTCTTTCA AACACAAGCCAT CAATCACCCTTG AGGGTGATTGTAGT(SEQ ID NO: 854) AAA (SEQ ID NO: TCTGGAGTCCTATC 855) TACCTGGGTTCAGATCT (SEQ ID NO: 853) H2AFX NM_002105.2 CCGCCCCATTTCCC CTAGGTGCTTGGCAACGGAGGCTC TTCCAGCAAACTCA ATTGCCGAGTTG AGTCCAGACAGG ACTCGGCAATCCAAAGTTTGCTGGAA GATTAACCGACT GCACCTAGATACCA GGGAAATGGGGC TGTGCTGGTATGCACAAGTCGGTTA GG (SEQ ID NO: (SEQ ID NO: 858) ATCCCTGTCTGGAC 857)TGAGCCTCCGTTGG CT (SEQ ID NO: 856) HARBI1 NM_173811.3 TGCAGCAGTCTTCCATCTTTGTGCATA GTCATGAGCCAG CTCAGTAGTCAGTT CCCGCTTCAAACT GTTCGAAGAAAGTGAAGCGGGTATGC GACTACTGAGGG AAGGAACTGTCA ACAAAGATAGCTG AAGACTGCTGCACCCAGAAGCCAG GCTTCTGGGTGACA (SEQ ID NO: 860) CT (SEQ ID NO:GTTCCTTCTTTCTTC 861) GAACCTGGCTCATG AC (SEQ ID NO: 859) HCK NM_002110.2CCAGGTCGGAGGC GTGGGCTGGCGC CTTGATGGTGGA AATACATTCTCAAA TGGTTTCAGTTTTTGTGGGATCCGG AACTGAAACCAGC TGAGAATGTATT CACGTACACAGG GCCAGCCCACACTGGCCTCCGACCTG ACAGT (SEQ ID TCCTGTGTACGTGC G (SEQ ID NO: 863) NO: 864)CGGATCCCACATCC ACCATCAAGCCGG GGCCT (SEQ ID NO: 862) HDAC1 NM_004964.2CAAGCCGGTCATGT CCACCGCACTAG AACCTAACCGAT CCAAAGTAATGGA GCTGGAACATCTCCCCAGATAGGG GATGTTCCAGCCTA CCATTACTTTGGA AGTCTGAGCCAC GTGCGGTGGTCTTACATGACCGGCTT ACTGTAAGA CAGTGTGGCTCAGA G (SEQ ID NO: 866)(SEQ ID NO: 867) CTCCCTATCTGGGG ATCGGTTAGGTTGC TTC (SEQ ID NO: 865)HDAC2 NM_001527.1 AAGCCTATTATCTC ACCACAGCACTA TGAAACAACCCA AAAGGTGATGGAGGGTTGATACATCT GTCTATCACCAG ATGTATCAACCTAG CCATCACCTTTGA ATAATGAGTCTGTGCTGTGGTATTAC GATAATAGGCTT CACCACACTGTA AGTGTGGTGCAGAC (SEQ ID NO: 869)AT (SEQ ID NO: TCATTATCTGGTGA 870) TAGACTGGGTTGTT TCA (SEQ ID NO: 868)HDGF NM_004494.2 TCATCAAGAGAATT TCTCAGGTCCTTG GGACAGATGCTCTGGGGCTTCCAAGT GCCCGAACAACT AACACTCCCACC TGTTCGGGCCAAGG TGGAAGCCCCAACAAATGGGTAAA ACCTGAGACCTGAA ATTCTCTTGATGA GTCAACCCTTCA GGGTTGACTTTACC(SEQ ID NO: 872) GG (SEQ ID NO: CATTTGGGTGGGAG 873) TGTTGAGCATCTGTCC (SEQ ID NO: 871) HEG1 NM_020733.1 GAAGTAACATCTCA CTCAGTAGAAGGTTAATGGTGGGT TCCTATGACGGGGA CTGAGCATATTCC GTGTAGGACGGA ATATGCTCAGCCTTCCGTCATAGGAT AGGTTGGATGTA CTACTGAGTCGCCA GAGATGTTACTTC TGCAGAACTGGCGTTCTGCATACATC (SEQ ID NO: 875) GA (SEQ ID NO: CAACCTTCCGTCCT 876)ACACACCCACCATT AA (SEQ ID NO: 874) HHIP NM_022475.1 GATTTGTATACCGGCACGTAGCTTCCA GTCACAGGACTT GGCTGCCAGTCAGA TACAATCTTTCTG TGCTGGAGAGTTAAGATTGTATGGAA ACTGGCAGCCCC AGGAAATTCCCA GCTACGTGTTTGGA GGTATACAAATCTTACGATCTCCA GATCGTAATGGGA (SEQ ID NO: 878) AA (SEQ ID NO:ATTTCCTAACTCTC 879) CAGCAAAGTCCTGT GAC (SEQ ID NO: 877) HJURPNM_018410.3  AACAATACGACAG GGATTTCAATCTC AGGCTGGTTCCT GGCCATGGAGAGACCTCTGACGGTTC GGGACTCAGGCA ACCGTCAGAGGGA TCTCCATGGCC ATATTCCCGATGGATTGAAATCCGAT (SEQ ID NO: 881) AAGCTGATCAAA TTGATCAGCTTCATTC (SEQ ID NO: CGGGAATATTGCCT 882) GAGTCCCAGGAAC CAGCCT (SEQ ID NO: 880)HLA-A NM_002116.5 GGAAGAGCTCAGA ACTGCTTGCAGCC TCTCACACTTTA TAGAAAAGGAGGGTGAGTGTAACTCC CAAGCTGTGAGG AGTTACACTCAGGC CTCCTTTTCTATC GACACATCAGAGTGCAAGCAGTGAC TGAGCTCTTCC CCCTGGGCACTG AGTGCCCAGGGCTC (SEQ ID NO: 884)TC (SEQ ID NO: TGATGTGTCCCTCA 885) CAGCTTGTAAAGTG TGAGA (SEQ ID NO: 883)HLA-B NM_005514.6 TGAATGTGTCTGCG CTGTCTCTCCACC GAAACACAGGTCTCCCTGTTAGCATA TCCTCACATTATG AGCATGGGAAC ATGTGAGGAGGTG CTAACAGGGACGAGGGGTCACAGT GAGAGACAGCCCA CAGACACATT GGACACAAGGG CCCTTGTGTCCACT(SEQ ID NO: 887) TGGG (SEQ ID GTGACCCCTGTTCC NO: 888) CATGCTGACCTGTGTTTC (SEQ ID NO: 886) HLA-C NM_002117.4 AGCTGGGAGCCATC GCAACGATGCCCCACAGCTCCAAG TTCCCAGCCCACCA ATGATGGGGATG GACAGCTAGGAC TCCCCATCATGGGCGTGGGCTGGGAA AACCAGGACAG ATCGTTGCTGGCCT GATGGCTC (SEQ CCAGGCCA (SEQGGCTGTCCTGGTTG ID NO: 890) ID NO: 891) TCCTAGCTGTCCTT GGAGCTGTGGTCACCG (SEQ ID NO: 889) HLA-DMA NM_006120.3 TTATTTGACAAAGA TTTGGCCCTATTTACACTTCAGCGA GTTCTGCGAGTGGA GCTGGATCATCC TAGGAAACCCTC TGATCCAGCAAATAACTCGCAGAACT TGGACACCGGGA GGGCCAAAACTTG CTTTGTCAAATAA TTTTCCCATCAAATGGGAAAATCCC (SEQ ID NO: 893) GT (SEQ ID NO: GGTGTCCAGAGGGT 894)TTCCTATCGCTGAA GTGT (SEQ ID NO: 892) HLA-DPA1 NM_033554.2  GGAGAGATCTGAAAAGAAAAGCTGA AAGGGTCAGCA CTCCAGCTGCCCTA GATGGAGTTTGT ATTCAGTCAGCCCAAACTCCATCTCA AGGGCAGCTGGA ACTGGAGTAGTT GCTTTTCTTCTCACT GTTCAGATCTCTCTTCACATGAAGT TCATGTGAAAACTA C (SEQ ID NO: 896) GAG (SEQ ID NO:CTCCAGTGGCTGAC 897) TGAATTGCTGACCC TT (SEQ ID NO: 895) HLA-DPB1NM_002121.4 TCCAAATTGGATAC GATAGAAACTGA TGGTTGGAGGCC TGCTGCCAAGAAGTCTTCAGAGCAAC CAGTGAGAGAA TGCTCTGAAGTCAG TTCTTGGCAGCAG ACAGTGCTTTGATTTCTATCATTCTG TATCCAATTTGGA ATCAAAGAGCA CTCTTTGATTCAAA (SEQ ID NO: 899)GAAT (SEQ ID GCACTGTTTCTCTC NO: 900) ACTGGGCCTCCAAC CA (SEQ ID NO: 898)HLA-DRA NM_019111.3 GGCCAACATAGCTG AGCGCTTTGTCAT CGTGAGCACAGTTGGACAAAGCCAA GATTTCCAGGTTG TACCTCTGGAGG CCTGGAAATCATGA GCTTTGTCCACAGTACATTGGTGAT CAAAGCGCTCCAAC CTATGTTGGCC CGGAGTATAGTT TATACTCCGATCAC(SEQ ID NO: 902) GG (SEQ ID NO: CAATGTACCTCCAG 903) AGGTAACTGTGCTCACG (SEQ ID NO: 901) HLA-E NM_005516.4 TGTCTTAGGGGACT GACAGATTCAGATGGACTGTTTCT CTGGCTTCTCTTTTT GGCCCTTGCAAA CTACCTCCTCAC GCAAGGGCCTCTGAAAGAGAAGCCAG ATTGTGCTAACA ATCTGTCTGTGTCC AGTCCCCTAAGA GGGACACA (SEQCTGTTAGCACAATG CA (SEQ ID NO: ID NO: 906) TGAGGAGGTAGAG 905)AAACAGTCCACCTC TG (SEQ ID NO: 904) HLA-F NM_001098479.1 CCATTGGGCGTCGCGGAACTGCGGCG CGTCTGGGAAAA GTTTCTAGAGAAGC ACACTGATTGGCT ATATGAGTCCCGCAATCAGTGTCGCC TCTCTAGAAACG CGGGGTGCGTGG GCAGTTCCCAGGTT CGACGCCCAATGGACTTTAGAACC CTAAAGTCCCACGC G (SEQ ID NO: 908) TG (SEQ ID NO:ACCCCGCGGGACTC 909) ATATTTTTCCCAGA CG (SEQ ID NO: 907) HOMER2NM_004839.2 TGGAAGACAAAGT GTATTTGCTCTCC AG GAAG CTCTTC GCGTTCCTTAAAGATCAATGTCTGTCT AACTCCACCTTC CAGACATTGAGGA TTAAGGAACGCA AGGTGGCGCTGTGAGCAAATACCGA CTTTGTCTTCCA CG (SEQ ID NO: CAGCGCCACCTGAA(SEQ ID NO: 911) 912) GGTGGAGTTGAAG AGCTTCCTGGAGGT GCTGGA (SEQ IDNO: 910) HOPX NM_001145460.1 AACAATAGGAAGC CCAGTGAAGCCA ACACCATCTGTCTATGTGTATCTTCT CTGCTTTACACAG ATCATGACTCAA GTGTAAAGCAGTG AAGATACACATAAGGGAAATGCTA GCTTCACTGGAAAA GCTTCCTATTGTT GCCACACCATTT ATGGTGTGGCTAGC(SEQ ID NO: 914) TT (SEQ ID NO: ATTTCCCTTTGAGT 915) CATGATGACAGATGGTGT (SEQ ID NO: 913) HPCAL1 NM_134421.1 CTGTTTCTAAGGAA ATGGGAGGATCAAATCAACAGGG ATGCATGTGTGCCC TCACGGCTCAGG AGGACAGACCA TGAGCCGTGATGATGCACACATGCAT GACACAAATGCC CCTCCCATCCGTGT TTCCTTAGAAACA TGTGCTCACAACTGTGAGCACAGGC G (SEQ ID NO: 917) ACGG (SEQ ID ATTTGTGTCTGGTC NO: 918)TGTCCTCCCTGTTG ATT (SEQ ID NO: 916) HSP90AA1 NM_005348.3 GGTGGCGCGTCAGTGGACCAACGGCA TCTGGGTTTCCT TGCTTCAGCGTCCC CAGCCACACCGG CAGGCATCTTGGGGTGTGGCTGTGCC GACGCTGAAGCA CTAAGTGACCGC GTTGGTCCTGTGCG ACTGACG (SEQ IDACA (SEQ ID NO: GTCACTTAGCCAAG NO: 920) 921) ATGCCTGAGGAAA CCCAGACCCAAGACCAA (SEQ ID NO: 919) HSP90B1 NM_003299.1 TCAGAGCTGACGAT CAGATCCTCTTCTTCTCTCTGTACT GAAGTTGATGTGGA ACTGTACCATCCA ACTTCATCATCC TGGTACAGTAGAACATCAACTTCATC GTCCTTGATCCT GAGGATCTGGGTA GTCAGCT (SEQ ID TCTCTACTTTTACAAAGTAGAGAAGG NO: 923) C (SEQ ID NO: ATCAAGGACGGAT 924) GATGAAGTAGTACAGAGAGA (SEQ ID NO: 922) HSPA12B NM_052970.4 GAAAGGGCAGTAG TCCACCACAATATTCCCAGACGGG ATCTCTAATGTGGA ATGTTCCCACCTC TGTTTTGTCTCG GGTGGGAACATTATCACATTAGAGAT AAAGAAATGCTA TGTGGTGGAGGCA CTACTGCC (SEQ CCCTCATAATTGATTATGAGGGTAGC ID NO: 926) CC (SEQ ID NO: ATTTCTTTCGAGAC 927)AAAACACCCGTCTG GGAA (SEQ ID NO: 925) HSPA9 NM_004134.4 TTCAAGAGAGAGATGAAGTGCCATG CAGATGAGGAG CAGGGGTTGATTTG TTGTCTTTAGTCA AGTTCACATTTAACTAAAGACAACA AATCAACCCCTGT GCCTTTTCAGCA TGGCACTTCAGAGG CTCTCTCTTGAAGCTTCCCGTACC GTACGGGAAGCTG (SEQ ID NO: 929) CTC (SEQ ID NO:CTGAAAAGGCTAA 930) ATGTGAACTCTCCT CATCTG (SEQ ID NO: 928) HSPB8NM_014365.2 CAGATTTAGTGCAA GGTCAGTCCTCAC TTGCGCTATCCT GTAAAATGTTAGAGCCCCGCACCCTCT GTGGAGAAATCT GGTGCGGGGGTGA AACATTTTACTTG ACCACTACACTAGGACTGACCACAG CACTAAATCTG TCCAGGGAATCT ATTCCCTGGATAGT (SEQ ID NO: 932)GT (SEQ ID NO: GTAGTGGTAGATTT 933) CTCCACAGGATAGC GCAA (SEQ ID NO: 931)HTRA1 NM_002775.4 TTGCAATCCCATCT GTCATGGGACTC ATACCAATATAC GATAAGATTAAAACGTGAGGAACTT TTCTTCTTGGTG AGTTCCTCACGGAG TTTAATCTTATCA ATGGCTTTTCCTTCCCATGACCGACA GATGGGATTGCA TTGGCCTGTCG GGCCAAAGGAAAA A (SEQ ID NO: 935)(SEQ ID NO: 936) GCCATCACCAAGA AGAAGTATATTGGT ATCCG (SEQ ID NO: 934)HYOU1 NM_006389.3 CAGGTTGCTGGGGA GGAGGGAAGGAA CAGACACTGGCCGTTTCCACTCTTCT CAATCACCAGAG TGAAAGGATGCT CTGGTGATTGTTCC AAGAGTGGAAACCATCGCATGGTG TTCCCTCCCTTCCTC TCCCCAGCAACCT GGAGAGGAAG TCCCACCATGCGATG (SEQ ID NO: 938) (SEQ ID NO: 939) GAGCATCCTTTCAG GCCAGTGTCTGCAGA (SEQ ID NO: 937) ICAM1 NM_000201.1 GAAATACTGAAACT TAAGTCTGTGGGGGCCTTTGTGTT TGCTGCCTATTGGG CCTCAGCATACCC TTGATGCTACAC TATGCTGAGGCCCAAATAGGCAGCAA ATGTCTATGGAG CAGACTTACAGAA GTTTCAGTATTTC GGCCACTTCTTCGAAGTGGCCCTCCA (SEQ ID NO: 941) TG (SEQ ID NO: TAGACATGTGTAGC 942)ATCAAAACACAAA GGCC (SEQ ID NO: 940) ID1 NM_002165.2 CTGCCCCAGAACCGATGACGTGCTGG CAACTTCGGATT CAAGGTGAGCAAG AGAATCTCCACCT CCGAGTTCAGCTGTGGAGATTCTCCA TGCTCACCTTGCG CCAACTGAAGGT GCACGTCATCGACT GTTCTG (SEQ IDCCCTGATGTAGT ACATCAGGGACCTT NO: 944) CG (SEQ ID NO: CAGTTGGAGCTGAA 945)CTCGGAATCCGAAG TTG (SEQ ID NO: 943) ID2 NM_002166.4 CGGATATCAGCATCTAACTCAGAAGG TCATGAACACCG CTGTCCTTGCAGGC GAATTCAGAAGC CTTATTCAGCCATTCTGAATTCCCTT CTGCAAGGACAG CACAGTGCTTTG CTGAGTTAATGTCA GATGCTGATATCCCTGTCATTTGAC AATGACAGCAAAG G (SEQ ID NO: 947) AT (SEQ ID NO:CACTGTGTGGCTGA 948) ATAAGCGGTGTTCA TGA (SEQ ID NO: 946) ID3 NM_002167.3AGGAAGCCTGTTTG CCGCCGGCCCTG CCTCTTTATTCA CAATTTAAGCGGGC GGCGTTCACAGCAAATGGCCCGCC TGTGAACGCCCAGG CCGCTTAAATTGC TCGGCCCTGCCC GCCGGCGGGGGCAAAACAG (SEQ ID (SEQ ID NO: 951) GGGCCGAGGCGGG NO: 950) CCATTTTGAATAAAGAGGCGTGCCTTCC AGGC (SEQ ID NO: 949) IDS NM_000202.4 GGGAAGACGTCCAAGGAATTGGACC TATGACACAGAG AGCCTTAAACATCA ATACGGCACACT GCAAAGTAGCTCGTGTGCCGTATGGT GATGTTTAAGGCT TGGCGGATTTTC CCAATTCCTGTGGA TGGACGTCTTCCCCGCTGAAAGTCC CTTTCAGCGGAAAA (SEQ ID NO: 953) AC (SEQ ID NO:TCCGCCAGAGCTAC 954) TTTGCCTCTGTGTC ATA (SEQ ID NO: 952) IER3 NM_003897.2TCAACTCCGTCTGT TCATTCCTAATGG CGTAGCCACCCT CTACTGTGTGAGAC TCCGCCGAAGTCTAAAGGCGACTTC TTCGGCGGACCATT CACACAGTAGAC AAGAAGATGGA AGGAATGAGATCCAGACGGAGTTGA AGGATCTCACGG GTGAGATCCTTCCA (SEQ ID NO: 956)ATC (SEQ ID NO: TCTTCTTGAAGTCG 957) CCTTTAGGGTGGCT ACG (SEQ ID NO: 955)IF135 NM_005533.3 TGCCCTCTGCTTGC ACTTTGGGGTCAT TTGATCGTGTGCGGGCTCTGCTCTGA CAAAGGTGATCA TCCTTTTGTTGC TCACCTTTGATGAC GAGCAGAGCCCGAGCACCTGCTCA CCCAAAGTGGCTGA CAAGCAGAG GCC (SEQ ID NO: GCAGGTGCTGCAAC(SEQ ID NO: 959) 960) AAAAGGAGCACAC GATCAACATGGAG GAGT (SEQ ID NO: 958)IF144L NM_006820.2 ATCTCTGCCATTTA CTTCTGCCCCATC CATACAACCTTTTGTTGTGTGACACT TAGCCCCATAGT TAAGATGTGGGG ATGGGGCTAGATG GTCACACAACATAATGTCATCCAT GGGCAGAAGGAGC AAATGGCAGAGA GCACAGTCCTGC AGGACTGTGCATGGT (SEQ ID NO: 962) TC (SEQ ID NO: ATGACATTCCCCAC 963) ATCTTAAAAGGTTGTATG (SEQ ID NO: 961) IFI6 NM_002038.3 GGGGTGGAGGCAG GAGCCGCTGTCCCGACGGCCATGA GTAAGAAAAAGTG GAGCTCTCCGAG AGGTCAGGGCCT CTCGGAGAGCTCGGCACTTTTTCTTAC TCCAGAACCCG ACAGCGGCTCCGG CTG (SEQ ID NO: (SEQ ID NO: 966)GTTCTGGAAGGCCC 965) TGACCTTCATGGCC GTCGGAGGAGGAC TCGCAG (SEQ ID NO: 964)IFIH1 NM_022168.2 GCTTGGGAGAACCC ACCCATTCGACAT CCTGGCCCTGAATCTCCCTTCTCTGA CTTTCTTTCTCAG GCACGAGATGA GAAAGAAAGATGT AGAAGGGAGAGGGATAGCGGAAAT CGAATGGGTATTCC GTTCTCCCAAGC TCTCGTCTGTGG ACAGACGAGAATTT(SEQ ID NO: 968) AAT (SEQ ID NO: CCGCTATCTCATCT 969) CGTGCTTCAGGGCCAGG (SEQ ID NO: 967) IFIT1 NM_001548.3 GAGAAAGGCATTA TGTAGACGAACCCAGGGCCCGCTC GATCTGGAAAGCTT CAAGGAGGCTCA ATAGTACTCCAG GAGCCTCCTTGGGTAGCTTTCCAGATC GGCTTCATTCAT TCGTCTACAAATTG TAATGCCTTTCTC ATTTCCTTCCAAGAAGGAAATATGA (SEQ ID NO: 971) TT (SEQ ID NO: ATGAAGCCCTGGA 972)GTACTATGAGCGGG CCCTG (SEQ ID NO: 970) IFIT2 NM_001547.4 TGCATCCCATAGAGATGAACTTAGCA GCGATGGGGGAT GTTAGTCCTGCATA CATTACTGGCTAT ACTGAGCCCTATGCCAGTAATGTGCT GCAGGACTAACC TTAGACTTTGGT AAGTTCATCCAAAA TCTATGGGATGCCCGCCAGCTTTT GCTGGCGGACCAA A (SEQ ID NO: 974) GG (SEQ ID NO:AGTCTAAATAGGGC 975) TCAGTATCCCCCAT CGC (SEQ ID NO: 973) IFIT3NM_001549.4 GAAGAACAAATCA CTGTGTCTCTGCT GATTTTCTCCAG GCCTGGTCACCAGCGTTCCGAAAAGC GGAATTCTTGGT TTTTCGGAACAGCA TGGTGACCAGGC GACCTCACTCATGAGACACAGAGGG TGATTTGT (SEQ GACTGCCCT CAGTCATGAGTGAG ID NO: 977)(SEQ ID NO: 978) GTCACCAAGAATTC CCTGGAGAAAATCC TTCC (SEQ ID NO: 976)IFITM1 NM_003641.3 CCTGTTACTGGTAT TCTGTAACATAAT AAGGTTGCAGGCTCGGCTCTGTGACA ATGGTAGACTGT TATGGGCGGCTA GTCTACCATATTAT CACAGAGCCGAACTAGTAACCCCG GTTACAGATAATAC TACCAGTAACAG TTTTTCCTGTATT AGGAAAAACGGGGG (SEQ ID NO: 980) A (SEQ ID NO: TTACTAGTAGCCGC 981) CCATAGCCTGCAACCTT (SEQ ID NO: 979) IGFBP5 NM_000599.3 AATGGGTTGCAAA TCCCTGGCTCTGCTCTTCCTATCTG ATAGAAATGAGCTT GGCCTGGATTAA GCTTCTAAAGTC AATCCAGGCCGCAGCTCATTTCTATT TAGCACCCTCCT GAGCCAGGGAAGG TTGCAACCCATT AAAGTTACTCACTGAGTAACTTTAGG (SEQ ID NO: 983) CT (SEQ ID NO: AGGGTGCTAGACTT 984)TAGAAGCCAGATA GGAAGA (SEQ ID NO: 982) IGSF3 NM_001542.2 AGTGGCTGTGAGACAGAAGACTAAAG CATTGTAGACAT CTCATTGCGCATTG CTCCAGTAGACA AGATGAATCCAGTCTACTGGAGCTTT ATGCGCAATGAG AGTATTCAGCAG AGTCTTCTGAGACG GTCTCACAGCCATTTTCCTCCGTCT GAGGAAAACTGCT CT (SEQ ID NO: C (SEQ ID NO: GAATACTCTGGATT986) 987) CATCTATGTCTACA ATG (SEQ ID NO: 985) IK NM_006083.3GTCCAAATTCTTGG AGCCTTTCACCAA CTCTTTGCTGGC GTGGTGACATGGA ATGGGTGTGTTCCAATCTCAGCTCG ACACACCCATTTGG ATGTCACCACCC TACCTTTTGAAG TGAAAGGCTTGGATAAGAATTTGGAC CAGAGCAAAATC TTTGCTCTGCTTCA (SEQ ID NO: 989) CA (SEQ ID NO:AAAGGTACGAGCT 990) GAGATTGCCAGCA AAGAG (SEQ ID NO: 988) IL10 NM_000572.2AAGGATCAGCTGG AAGTCCTCCAGC GGTAAAACTGGA ACAACTTGTTGTTA AAGGACTCCTTTATCATCTCAGACA AAGGAGTCCTTGCT ACAACAAGTTGT AGGCTTGGCAAC GGAGGACTTTAAGCCAGCTGATCCTT CCAGGTAACCCT GGTTACCTGGGTTG (SEQ ID NO: 992)TA (SEQ ID NO: CCAAGCCTTGTCTG 993) AGATGATCCAGTTT TACC (SEQ ID NO: 991)IL12A NM_000882.2 CTTTCTAGATCAAA GGGCCTGCATCA CGGTTCTTCAAGACATGCTGGCAGTT GCTCATCAATAA GGAGGATTTTTG ATTGATGAGCTGAT CTGCCAGCATGTTTGGCACAGTCTC GCAGGCCCTGAATT TTGATCTAGAAA ACTGTTGAAATT TCAACAGTGAGACTG (SEQ ID NO: 995) CA (SEQ ID NO: GTGCCACAAAAATC 996) CTCCCTTGAAGAACCG (SEQ ID NO: 994) IL13RA1 NM_001560.2 TCTGCACTGGAAGA TTTCCTCCTTGGTCCATCACTGAGA AGTACGACATCTAT TTGCTTCTCATAG GGCTTTCTTCAG GAGAAGCAAACCAATGTCGTACTTCT GTTTTCTATCAG AGGAGGAAACCGA TCCAGTGCAGA CACTACAGAGTCCTCTGTAGTGCTGA (SEQ ID NO: 998) GG (SEQ ID NO: TAGAAAACCTGAA 999)GAAAGCCTCTCAGT GATGG (SEQ ID NO: 997) IL16 NM_004513.4 GGCATCTCCAACATCAGAACCATTTG CAGCTCTGAAAG CATCATCCAACGAA CAGCTGAGTCTTC GTTGAGCGAGAAGACTCAGCTGCAAA GTTGGATGATGA CCCTGTGTCCAA TGGTTCTGCTGAAA TGTTGGAGATGCGGCAGATGTTTC CATCTGCCTTGGAC C (SEQ ID NO: AG (SEQ ID NO: ACAGGGTTCTCGCT1001) 1002) CAACCTTTCAGAGC TG  (SEQ ID NO: 1000) IL17RB NM_018725.3TCAATTTTGATGAA CGGATGCTGGCA ACTGGAAGTTGC TGTAAGCTGGGTAC TCTGCCCGGAGTTTTTGCCCGTCA TCCGGGCAGATGCC ACCCAGCTTACAT CACAAATCTTGG AGCATCCGCTTGTTTCATCAAAATTG TGGCCTTCAACA GAAGGCCACCAAG A (SEQ ID NO: AG (SEQ ID NO:ATTTGTGTGACGGG 1004) 1005) CAAAAGCAACTTCC AGT (SEQ ID NO: 1003) IL411NM_172374.1 CAAGGGCACCACT CGGAATCAAGGT CTTTATGGTTAG AACAAGGACAAAGGAATGATGGTGG CCCAGGACAGA CCACCATCATTCAC CTTTGTCCTTGTT AGTCATCGTTGGCTTGATTCCGCACA AGTGGTGC (SEQ GCATGTG (SEQ TGCCCAACGATGAC ID NO: 1007)ID NO: 1008) TTCTGTCCTGGGCT AACCATAAAGGCC ATGGG (SEQ ID NO: 1006) IL6NM_000600.1 TGACAAACAAATTC CCTTTCTCAGGGC TGCCAGTGCCTC GGTACATCCTCGACTGAGATGCCGTC TTTGCTGCTTTC GGCATCTCAGCCCT GAGGATGTACCG ACACATGTTACTGAGAAAGGAGACA AATTTGTTTGTCA CTTGTTACATGT TGTAACAAGAGTA (SEQ ID NO: 1010)CT (SEQ ID NO: ACATGTGTGAAAGC 1011) AGCAAAGAGGCAC TGGCA (SEQ ID NO:1009) ING1 NM_198219.1 TTGGAAGTGCAGTC CATAATTGTGAC TTCACGTAACATAGCAGATGCTGTTG ATTAGCTTCACAA TTTTACAGCTCA TGAAGCTAATGTCA CAGCATCTGCTGCATACAGCAGGA CAATTATGTGCAAA ACTGCACTTCCAA AGCACACCTTTG GGTGTGCTTCCTGC(SEQ ID NO: 1013) CA (SEQ ID NO: TGTATGTGAGCTGT 1014) AAAAATGTTACGTGAA (SEQ ID NO: 1012) INPP5D NM_005541.3 ATAATGGCCACATG TTAGCACAGCACGAGCCTCAGCTC GATCGAACACTCAT TTGGCACATCATG TCGAGGTCATCC GATGTGCCAAGTGCAGTGTTCGATCCA TGATATGACGAA TGTGCTAAGTGCTT TGTGGCCATTAT TGTTCGTAAAGCTACGAACATTCGTC (SEQ ID NO: 1016) AC (SEQ ID NO: ATATCAGGATGACC 1017)TCGAGAGCTGAGG CTC (SEQ ID NO: 1015) IRAK1 NM_001569.3 CACAGCCGTGGAACTGACGACGATG CATCTTCTGTCG GGACTGGCCCTTGG ATGCAGAGCTGC GGCAGGGTTGATCAGCTCTGCATCAT CAAGGGCCAGTC GATAATCTGCGG CGTCGTCAGAGCCA(SEQ ID NO: 1019) TGGCT (SEQ ID CCGCAGATTATCAT NO: 1020) CAACCCTGCCCGACAGAAGATGGTCCA GAAG (SEQ ID NO: 1018) IRAK2 NM_001570.3 GTGTTGGCCGAGGTCTTCGGTTGTTAT CGGTGCTGCTTG CCTCACGGGCATCC CCATTGCAGGGA GAATATCACTGACTGCAATGGATAAC TGCCCGTGAGGA GGAGTAAGTCCT AACCGAAGCCCGG CCTCGG (SEQ IDTCAGGTAAACCG TTTACCTGAAGGAC NO: 1022) GG (SEQ ID NO: TTACTCCTCAGTGA1023) TATTCCAAGCAGCA CCG (SEQ ID NO: 1021) IRAK3 NM_007199.1AGGTAAATATAGAT GCTCCTGCAAGA TCATATTCATCC CCTTCTTCAGAAGC ATGCCCTGGAGCCAGGAAAATTTG TCCAGGGCATTCTT TTCTGAAGAAGG GAGGAACAGCT GCAGGAGCAGGCCATCTATATTTACC GCTCTCCACTGG AGTGGAGAGCAGC T (SEQ ID NO: CCT (SEQ ID NO:TGTTCCTCCAAATT 1025) 1026) TTCCTGGGATGAAT ATGA (SEQ ID NO: 1024) IRAK4NM_016123.1 GAATTCTCCTTGTA AGCCAATGTGGC CTGACAACTGGA AGCCTTGAAGAAGTCCTCTCACATACT AGGTAGGTCTCA ATGTGAGAGGGCC TCTTCAAGGCTTA TCTCCTAGAGGCACATTGGCTAAAAC CAAGGAGAATTC CACCTTTAGGTT CTAAAGGTGGCCTC(SEQ ID NO: 1028) TT (SEQ ID NO: TAGGAGATGAGAC 1029) CTACCTTCCAGTTGTCAG (SEQ ID NO: 1027) IRF1 NM_002198.1 CTGTGCGAGTGTAC TTTTCTCTGGTTCTTCCTCTTGGCC CGGATGCTTCCACC TTGGTGAGAGGT TTGCTCTTAGCA TCTCACCAAGAACCGGAAGCATCCGG TCTCGGCTGGAC AGAGAAAAGAAAG TACACTCGCACA TTCGACTTTCTTTAAAGTCGAAGTCC G (SEQ ID NO: C (SEQ ID NO: AGCCGAGATGCTA 1031) 1032)AGAGCAAGGCCAA GAGGAA (SEQ ID NO: 1030) IRF4 NM_002460.1 GGGCACTGTTTAAAAGGGTCCGGCTT TTGTTCAAAGCG GGAAAGTTCCGAG GTCGATGCCTTCT CACCGCAGGCGCAAGGCATCGACAA CGGAACTTTCCTT GTCTTCCAGGTG GCCGGACCCTCCCA TAAACAGTGCCCGG (SEQ ID NO: CCTGGAAGACGCG (SEQ ID NO: 1034) 1035) CCTGCGGTGCGCTTTGAACAAGAGCAA TGACTT (SEQ ID NO: 1033) ISG15 NM_005101.3 CCCGGCAGCACGGTCTCAGAGGTTCGT TGCTGCTGCGGC CCTGCTGGTGGTGG CGCATTTGTCCAC CCTTGTTATTCCTACAAATGCGACGA CACCAGCAGGAC CACCAGGATG ACCTCTGAGCATCC (SEQ ID NO: 1037)(SEQ ID NO: 1038) TGGTGAGGAATAA CAAGGGCCGCAGC AGCACCTACGAGGTACGGC (SEQ ID NO: 1036) ISY1 NM_020701.2 GGCAAAACATCAG GCTCACAGGAACCCCCTGTCCAAG TGTCTGTGGGTAGT TGAAGATTCCAA AAACTCCACAGG TGGAATCTTCAGTTCTACCCACAGAC CCCAGAAGACGC CCTGTGAGCGTCGG ACTGATGTTTTGC CGAC (SEQ IDCGTCTTCTGGGCCT C (SEQ ID NO: NO: 1041) GTGGAGTTTCTTGG 1040)ACAGGGGCCGCGG GGCT (SEQ ID NO: 1039) ITGA9 NM_002207.2 CATGTCTCCAACCTAGTTGGCTGCGTC GGTGATATTGAT CCTTTGTATATGGC CACGGACTCGCC GGGCTGAAAGTGGAGTCCGTGGACGC ATATACAAAGGA ACACTCCAGGTC AGCCAACTTCATTC GGTTGGAGACATATCCAGCTGAAT AGCTGGATGACCTG G (SEQ ID NO: GA (SEQ ID NO: GAGTGTCACTTTCA1043) 1044) GCCCATCAATATCA CC (SEQ ID NO: 1042) ITGAV NM_002210.2TTTCTTCCGATTCC TCTTCAGTCTCAG GACCATTGTTTC AAACTGGGAGCAC GGTTCTCCTTGTGTCAGCTCATAGA AAGGAGAACCCTG CTCCCAGTTTGGA TGTGCTGAACAA AGACTGAAGAAGAATCGGAAGAAA CTGGCCCAACAT TGTTGGGCCAGTTG (SEQ ID NO: 1046) CT (SEQ ID NO:TTCAGCACATCTAT 1047) GAGCTGAGAAACA ATGGTC (SEQ ID NO: 1045) ITGAXNM_000887.3 CCCCTCAGCCTGTT GTGTATGTAAAC CATATGAGGCAT GGCTTCTGTTCACCCCTTGCAGCTGGT GGAACAATCGGT AGCTGCAAGGGTTT GAACAGAAGCCA GCACGACATTTTACATACACGGCCAC ACAGGCTGAGGG GGATGGCGGTGG CGCCATCCAAAATG(SEQ ID NO: 1049) CC (SEQ ID NO: TCGTGCACCGATTG 1050) TTCCATGCCTCATATG (SEQ ID NO: 1048) ITGB2 NM_000211.2 CATCGACCTGTACT GGTCATCAAGCACGGAGCAGGTCG ATCTGATGGACCTC TGGAGTAGGAGA CCACCTAGCTTC TCCTACTCCATGCTGGTCCATCAGAT TTGACATTCCTG TGATGACCTCAGGA AGTAC (SEQ ID A (SEQ ID NO:ATGTCAAGAAGCTA NO: 1052) 1053) GGTGGCGACCTGCT CCGGGCCCTCAACGAG (SEQ ID NO: 1051) ITPKB NM_002221.3 GTGGCCTCCTGGCA GGCAGTAAGGCTCCTACAAGATAC TCATTTGTTATTGC TGTTTCAGAGGC CCACACTACATT CTCTGAAACAAGCCAATAACAAATGA GGAGAAGCAGG TTACTGCCTGGAGG TGCCAGGAGGCC AATCTAAGCCCTGCTTAGATTCCTGC AC (SEQ ID NO: CCA (SEQ ID NO: TTCTCCAATGTAGT 1055) 1056)GTGGGTATCTTGTA GG (SEQ ID NO: 1054) JAK1 NM_002227.1 GAGAACACCAAGCTCATCAACGGTG AATTGGTGAAAT TCTGGTATGCTCCA ATGGTGCGATTTG AGAACCTCATCCAATCGCACCATCAC GAGCATACCAGA GGTAGTGGAGCC CGTTGATGACAAGA GCTTGGTGTTCTCGGAGGGACATCT TGTCCCTCCGGCTC (SEQ ID NO: 1058) TG (SEQ ID NO:CACTACCGGATGAG 1059) GTTCTATTTCACCA ATT (SEQ ID NO: 1057) JAK2NM_004972.2 CTCCTCCCGCGACG GCCATTCCCATGC GATATATAGAAG GCAAATGTTCTGAAAGAGTCTTTTTCA AGGTGGATGTTC AAAGACTCTGCATG GAACATTTGCCGT CCTCCATTTCTGGGAATGGCCTGCCT CGCGGGAGGAG TCATCGTAAGGC TACGATGACAGAA (SEQ ID NO: 1061)AG (SEQ ID NO: ATGGAGGGAACAT 1062) CCACCTCTTCTATA TATC (SEQ ID NO: 1060)JAK3 NM_000215.2 GTGCTGCTGAAGGT AATGACTCCATG CGGTACGACACT CATGGATGCCAAGCCAGTTCTTGTGCT TGGCTCATCAAG ACAAGAACTGCAT TGGCATCCATGA CTCGCTGCTTCCGGAGTCATTCCTGG CCTTCAGCAG AGG (SEQ ID NO: AAGCAGCGAGCTT(SEQ ID NO: 1064) 1065) GATGAGCCAAGTGT CGTACCGGCATCTC GTGC (SEQ ID NO:1063) KCNJ1 NM_153766.1 GGAGGTGCTTTGGG CCTTTGTCTTGGA CACTTCCACTGTGCTACCGTTTTGCT TACTATGGGAGC CTTGCTAAAGTT CCCATAGTATCCAA AAAACGGTAGCCATGGAAATCCAC GACAAAGGAAGGG CCAAAGCACCTC TCGGTATTTCCC AAATACCGAGTGGC (SEQ ID NO: TT (SEQ ID NO: ATTTCCATAACTTT 1067) 1068) AGCAAGACAGTGGAAGTG (SEQ ID NO: 1066) KCNK12 NM_022055.1 CCAGGGGCTCTACC ACACGCCGAGCACACCTGCTTGAT GCCTGGGCAACTTC GGATGAAGAGGA GAGGATGGAGA CTCTTCATCCTGCTAGTTGCCCAGGC TGACGTTGAAGA CGGCGTGTGCTGCA GGTA (SEQ ID NO: GCGAGTAAATGCTTTACTCGCTCTTC 1070) AGC (SEQ ID NO: AACGTCATCTCCAT 1071) CCTCATCAAGCAGGTG (SEQ ID NO: 1069) KCNMA1 NM_001014797.1 TATTGAGTACCTCA CTTTGGGGAAGTTGACAGCCCTTAA AGCGGGAATGGGA ATGAAGCGTCTC ATCAGCCCGACT GACGCTTCATAACTCCATTCCCGCTTG TAATGGCGTACC TCCCCAAAGTGTCC AGGTACTCAATA AGGCAATATGGAATATTGCCTGGTAC (SEQ ID NO: 1073) CA (SEQ ID NO: GCCATTAAGTCGGG 1074)CTGATTTAAGGGCT GTC (SEQ ID NO: 1072) KCNQ3 NM_004519.2 GTATGAGACTGTCTTAGCAAATGTCTC ACATCCAGCAGC CGGGAGACTGGCTT CAGTAACAGAAG CCAGATCCTCAACTGTTACTGGAGAC CCAGTCTCCCGA AGCAAACTCGGC ATTTGCTATTTTCA GACAGTCTCATATCCAAAGATGAA TCTTTGGAGCCGAG C (SEQ ID NO: AA (SEQ ID NO: TTTGCTTTGAGGAT1076) 1077) CTGGGCTGCTGGAT GT (SEQ ID NO: 1075) KCP NM_001135914.1TATGCCAATGGGCA CAGGCATGGCAA CAGTCAACCAAG GAACTTCACGGATG GGGCTGTCTGCATGAGCATGTCACA CAGACAGCCCTTGC CCGTGAAGTTCTG GTTCCATCCTGA CATGCCTGCCACTG(SEQ ID NO: 1079) CAGTGG (SEQ ID TCAGGATGGAACTG NO: 1080) TGACATGCTCCTTGGTTGACTGCCCTCC CA (SEQ ID NO: 1078) KDM4C NM_015061.2 ATTCTCCACCCAATAATAAGGAGACT GGAATACCATAA GCCTTCCTTGAAGA TGTTCCATCCTCT CAACTTGCATGAGGATGGAACAAGT TCAAGGAAGGCA ACCCGTACGCAG CTCCTTATTTCCTGT TTGGGTGGAGAACACTTTGCACAG GCAAAGTGCTGCGT T (SEQ ID NO: GA (SEQ ID NO: ACGGGTTCATGCAA1082) 1083) GTTGTTATGGTATT CC (SEQ ID NO: 1081) KDR NM_002253.2CAATCACACAATTA CACTCACTTCCAT CTTTGAAATGGG AAGCGGGGCATGT AATCGTCAGTACATTGGTAAGGAT ACTGACGATTATGG ATGCCCCGCTTTA GACAGTGTAATT AAGTGAGTGAAAGATTGTGTGATTG TCCTGTGTCTCTT AGACACAGGAAAT (SEQ ID NO: 1085) T (SEQ ID NO:TACACTGTCATCCT 1086) TACCAATCCCATTT CAAAG (SEQ ID NO: 1084) KIAA1147NM_001080392.1 CCAGGTGGGAGTG TTTTGCATGGATA TGCTGAGCCTAC GAATTCAGGTTTGGCCAACGAGCCCC AGAATTGAAAAT GGCTCGTTGGTATC AAACCTGAATTC GCCCTCTTGAACCATGCAAAATATGA CACTCCCACCTGG AGGCCTTTGTCA CAAAGGCCTGTTCA(SEQ ID NO: 1088) TA (SEQ ID NO: AGAGGGCATTTTCA 1089) ATTCTGTAGGCTCAGCA (SEQ ID NO: 1087) KIAA1274 NM_014431.2 AGGAAAG CCTGTCT TTTTTTTTTCCTGACTTCGGCCTCC TTGGTTAGGCTCGT CAGAAGTACACG TCCCCTTTTCAA GTACTTCTGCAGGAAGCCTAACCAAA ATATCATGACCA AAAAAAAAAAAGG GACAGGCTTTCCT ATGACACATCCTATGTGTCATTGGTC (SEQ ID NO: 1091) TT (SEQ ID NO: ATGATATTTGAAAA 1092)GGGGAGGAGGCCG AAGT (SEQ ID NO: 1090) KIF11 NM_004523.3 CAGACCATTTAATTCTACTATTGAATG AGCCAATCCTCC TGGCAGAGCGGAA GGCGCTAGCTTTC AGTTCGTACACTAGCTAGCGCCCATT CGCTCTGCCAAAT AACTTCTTTTCG CAATAGTAGAATGT TAAATGGTCTGTACAGGATCACA GATCCTGTACGAAA (SEQ ID NO: 1094) TT (SEQ ID NO:AGAAGTTAGTGTAC 1095) GAACTGGAGGATT GGCT (SEQ ID NO: 1093) KIF14NM_014875.2 TGATCGAGCAATCC GCTCAAAAGCAC GGTACAAGGCA AGTCACTTACTATTATGCAGTCTGAA GTAAATCACTCA CAGACTGCATGTGC TAGTAAGTGACT GCCAGTGTTTCATTTTGAGCAGCTAG GGATTGCTCGATC TTAGCACTACTA TAGTGCTAATGAAA A (SEQ ID NO:GCT (SEQ ID NO: CACTGGCTGAGTGA 1097) 1098) TTTACTGCCTTGTACC (SEQ ID NO: 1096) KIF15 NM_020242.2 AACCACCTCAAGTT TCACAGGGTGTAAGTTGATTCAAA TCTGATGAACATTC TATGGATGCAGA GCCTTGAAGTAG TGCATCCATATACAATGTTCATCAGA GCCACTTAATAG CCCTGTGACAGTCA AACTTGAGGTGG CAGACTGCTGACGCAGTCTGCTATTA TT (SEQ ID NO: TG (SEQ ID NO: AGTGGCCTACTTCA 1100) 1101)AGGCTTTGAATCAA CT (SEQ ID NO: 1099) KIF18A NM_031217.3 CATAGACTTGCAATCTCCTTTTCTCCA CACGATGGAGCC GTTGAAAACTCGTC GGTAGGAGCGAC AATTAGTATTCTGCTCCTACCTGGAG GAGTTTTCAACAT CATCAAATTGCT AAAAGGAGGGAGG TGCAAGTCTATGTCAATTCCTCCT AGGAATTGAAGCA (SEQ ID NO: 1103) CC (SEQ ID NO:ATTTGATGAGAATA 1104) CTAATTGGCTCCAT CGTG (SEQ ID NO: 1102) KIF18BNM_001080443.1 TCCAAGCAGCCAAC GGTCTCAAACTCT CCAGGCTCAATT CTCCTGACGCCCGAGTGATCATGTCG TTTTCCTCTTGCA CATGATCACAGAGT GGCGTCAGGAGG CCAGCTGCTGTATTGAGACCCTACAG TTGG (SEQ ID NO: G (SEQ ID NO: CAGCTGGTGCAAG 1106) 1107)AGGAAAAAATTGA GCCTGGGGCAGAG GCCTT (SEQ ID NO: 1105) KIF20A NM_005733.2GCAGGCTTCCCTAT TTTTAAATTACGC CGCAGAGCACA CTGATTGGCCGAAC GCTGCGTTCGTTCACTCCGCCCACG GAACGCAGCGCGT GGCCAATCAGAT AGGTGCAGCTTT AATTTAAAATATTGAGGGAAGCCTGC GTTACAGATACA TATCTGTAACAAAG (SEQ ID NO: 1109)ATA (SEQ ID NO: CTGCACCTCGTGGG 1110) CGGAGTTGTGCTCT GCG (SEQ ID NO:1108) KIF23 NM_138555.1 TGTGTGGATGATTT ATGACCTGGAAG TATGATGTAGCTCTCGAAAGCCATGC ACTGCTTCTGGCA GAGGTCCGTGAT CAGAAGCAGTCTTC TGGCTTTCGAGATTTCAACAAAGC CAGGTCATCTTGTA AATCATCCACAC TGGAGTTCTACA GAACTCCAGCTTTGA (SEQ ID NO: AG (SEQ ID NO: TTGAAAATCACGGA 1112) 1113) CCTCAGCTACATCATA (SEQ ID NO: 1111) KIF2C NM_006845.3 CCTGCTCTAACGGG CTCCTCTTCCTTGCTGATCTGAGTC GCGCTGATTCCAGG GATAAATTGCCT ATGGCTTCGTTA CAATTTATCCAAGGGGAATCAGCGCC AAGCTGGACATC AAGAGGAGGAACT CCGTTAGAGCAG TGGGAAGACAGTGTCTTCCCAGATGT G (SEQ ID NO: TC (SEQ ID NO: CCAGCTTTAACGAA 1115) 1116)GCCATGACTCAGAT CAG (SEQ ID NO: 1114) KIF4A NM_012310.3 GGAGCAAAGCATGCAGAATGCTCTG CCCTCATCATCA GACATCGAGGATCT AACAATATTTTAG TCACCATCACCAAAAATATTGTTCAG ATCCTCGATGTCC TCCTCATGCTCA AGCATTCTGTGAAT ATGCTTTGCTCCTTCA (SEQ ID NO: GAGCATGAGGATG (SEQ ID NO: 1118) 1119) GTGATGGTGATGATGATGAGGGGGATG ACGAG (SEQ ID NO: 1117) KIF6 NM_145027.4 GGACTTCAGCATTTCTATTTTCTTGTG GAAGATTTCAAA TGGGGAAAAGATC GAGCAAACTGGA AGCCTCCTGGCACAGTTTGCTCCACA TCTTTTCCCCAAA TCCTAATGACAT AGAAAATAGGAAT ATGCTGAAGTCCTTCCTCTCTCATT GAGAGAGGAAATG (SEQ ID NO: 1121) C (SEQ ID NO:TCATTAGGATGCCA 1122) GGAGGCTTTTGAAA TCTTC (SEQ ID NO: 1120) KLHL5NM_015990.4 GTGGGGAGAGATT ACATTTTCATCAC TTGAGTACCTTC GCTAAAAAGGAGTCCTAGAAGGAAA ACCATGTTGTGC TTCCTTCTAGGGTG CTCCTTTTTAGCA AATCATCCCCAAATGAAAATGTTCTG ATCTCTCCCCAC TAAGTAGTTCCA GAACTACTTATTGG(SEQ ID NO: 1124) GA (SEQ ID NO: GGATGATTGCACAA 1125) CATGGTGAAGGTACTCAA (SEQ ID NO: 1123) KPNA2 NM_002266.2 TGATGATCCAGAAG TAAGGTAGGAAACACAACTCCTGT TATTAGCAGATACC TAGCCCAGCAGG TTTCACCACCAT TGCTGGGCTATTTCTATCTGCTAATAC GCCAATTCGTTC CTACCTTACTGATG TTCTGGATCATCA ATTTGGACCATCGTCCAAATGAACG (SEQ ID NO: 1127) AG (SEQ ID NO: AATTGGCATGGTGG 1128)TGAAAACAGGAGT TGTG (SEQ ID NO: 1126) KRAS NM_033360.2 CATGGACTGTGTCCGACTAACCAATG AGATTGTATCTT CCACGGTCATCCAG CATGACAACACT GTTGAGCTATCCTGTTGTCATGCATT GGATGACCGTGG AAACTGCCCTAG GGTTAGTCAAAATG GGACACAGTCCATCCCTCCCCATT GGGAGGGACTAGG TG (SEQ ID NO: TT (SEQ ID NO: GCAGTTTGGATAGC1130) 1131) TCAACAAGATACA ATCT (SEQ ID NO: 1129) KYNU NM_003937.2TAAGTGGGCCAAA AAGGACGCTTCC TCCTACAATGTC ATAGCAGCCTATGG CCACTTCATGACCCTTCATAAGGCC TCATGAAGTGGGG ATAGGCTGCTATT TACAATACTCTC AAGCGTCCTTGGATTTGGCCCACTTA ATCTCCTGTAAT TACAGGAGATGAG (SEQ ID NO: 1133) CC (SEQ ID NO:AGTATTGTAGGCCT 1134) TATGAAGGACATTG TAGGA (SEQ ID NO: 1132) LAMB1NM_002291.2 TTGCCAGGAGCTGC AACACAGGCAAG TATCCTGAGGCA TACCAAGATCCTGTCTGTAAAGTAAC CAGTCGTCACAT TACTTTACAGCTTG AGGATCTTGGTA CTGGAACCAATGCCTGTGTTTGTGAT GCAGCTCCTGGC TATCCAGGATCA CCTGGATACATTGG AA (SEQ ID NO:CA (SEQ ID NO: TTCCAGATGTGACG 1136) 1137) ACTGTGCCTCAGGATA (SEQ ID NO: 1135) LAMP3 NM_014398.3 GGTCTCTGCCTTAT TGACACCTTAGGTATTTTCATTCCC GGGTATGGGTGTCT CGGATTTTATAGA CCCGGGCAACAA ATAAAATCCGCCTACACCCATACCCAT TTAGATTCTCTG AGGTGTCAATCATC AAGGCAGAGACC GTATCCAGATGATGGATACCAGAGA (SEQ ID NO: 1139) T (SEQ ID NO: ATCTAATTGTTGCC 1140)CGGGGGGAATGAA AATA (SEQ ID NO: 1138) LANCL1 NM_006055.1 AATGCCTATGCCTTTACTTCATGTCCT GTTCTCCATACT CCTGACACTCTACA GTGTGAGGTTGT CTAAGCACCATTACCTCACACAGGAC AGAGTGTCAGGA CAGCAAACTTAC ATGAAGTACCTGTA AGGCATAG (SEQAGGCCCTATACA TAGGGCCTGTAAGT ID NO: 1142) GG (SEQ ID NO: TTGCTGAATGGTGC1143) TTAGAGTATGGAGA AC (SEQ ID NO: 1141) LAT NM_001014987.1TGTGTAATAGAATA ACAGACGCACGC CACACAGAGAC AAGGCCTGCGTGTG TCAACACAGACAATCTCCAAATCT TCTGTGTTGAGCGT CACGCAGGCCTTT CTGACTCAGACT GCGTCTGTGTGTGCATTCTATTACACA CGCACACAGGCA CTGTGTGCGAGTCT (SEQ ID NO: 1145)CAC (SEQ ID NO: GAGTCAGAGATTTG 1146) GAGATGTCTCTGTG TG (SEQ ID NO: 1144)LAT2 NM_014146.3 TGCAGAGCTGATTA CCCCAGCTCTTCC GAGATACTTTTTAACAGTGTTGTGAC CATGAGACAGTC CTGGCAACATTT TGTCTCATGGGAAG ACAACACTGTTTACTGACTCAAGGT AGCTGGGGCCCAG ATCAG (SEQ ID CCCTCTGGG AGGGACCTTGAGTCNO: 1148) (SEQ ID NO: 1149) AGAAATGTTGCCAG AAAAAGTATCTCCTCCA (SEQ ID NO: 1147) LDHA NM_005566.1 CAGAATGGAATCTC TCTTCCTCAGAAGGCTCCTTTTGGA AGACCTTGTGAAGG TCAGAGTCACCTT TCCCCCAAAGTG TGACTCTGACTTCTCACAAGGTCTGA TATCTGCACTCT GAGGAAGAGGCCC GATTCCATTCTG TCTTCAAACGGGGTTTGAAGAAGAGT (SEQ ID NO: 1151) CC (SEQ ID NO: GCAGATACACTTTG 1152)GGGGATCCAAAAG GAGC (SEQ ID NO: 1150) LHFPL3 NM_199000.2 TGTGCTTGGCTGTATTACTTCATCTGA CCAAGAGTGTAC TGATTTTCCCTGAT GTCCCAGCCATC TTGTCTGTCTTTTGGCTGGGACTCAG AGGGAAAATCAT CTCCACACATCC ATGAAGTAAAACG ACAGCCAAGCACGTT (SEQ ID NO: GATGTGTGGAGAA A (SEQ ID NO: 1155) AAGACAGACAAGT 1154)ACACTCTTGGGGCT TGCTCA (SEQ ID NO: 1153) LHX2 NM_004789.3 TAGAGGCTTTGAGCTTTCCAGGCGAG ACACCGCTGCAT AACTAACTAACCAC ATCCTAAAATGT TAGCCGGGCGCAATTTTAGGATCTCG GGTTAGTTAGTTG CACTTCTTTTTTT CCTGGAAACAGAG CTCAAAGCCTCTATACCTCTG (SEQ GTAAAAAAAAGAA (SEQ ID NO: 1157) ID NO: 1158)GTGTGCGCCCGGCT AATGCAGCGGTGTG GACC (SEQ ID NO: 1156) LIMA1NM_001113547.1 AACTACATCCTGAA AAAGTGCTCTGTT AGATCTCTCTAA CTCGACGTCCTGAGGTATTATACCTCA GCACCGAAGAGT GTATAATACAACAG GGACGTCGAGTT GTAGGTTGGTTTAGCACTTTTTGAGG CAGGATGTAGTT TTCAATTGCCTC CAATTGAAAAACC (SEQ ID NO: 1160)AA (SEQ ID NO: AACCTACACTCTTC 1161) GGTGCTTAGAGAG ATCT (SEQ ID NO: 1159)LIMD1 NM_014240.2 AAGGCAAGTCTCA TAAAAACAGGTG TCTCTCAGTATG GGAACCCATGCAGCAAGCGATGTAC CGGGCAGCTCTT GTACATCGCTTGCA CTGCATGGGTTCC CCCAAAAG C CC GCCTGTTTTTAGCTT TGAGACTTGCCTT TCATTAAATAAG ATTTAATGACGGGC(SEQ ID NO: 1163) C (SEQ ID NO: TTTTGGGAAGAGCT 1164) GCCCGCATACTGAGAGAC (SEQ ID NO: 1162) LMAN2 NM_006816.2 CTTTTGTTGTTGGG TCACTGTTGCCGTCCTTGGTAGGGC GTCTGTGACTGCGG CAGTTATATCCGC TTAATGAGCGAA ATATAACTGACGGCAGTCACAGACCC TGCTCCCGCTTG AACAGTGAACATCT CAACAACAAAAG AGATGT (SEQ IDCAAGCGGGAGCAT (SEQ ID NO: 1166) NO: 1167) TCGCTCATTAAGCC CTACCAAGGGGTCGGTT (SEQ ID NO: 1165) LMO2 NM_005574.3 AAGCATTTCTGTGT ACTATGTCAGAGCCTATATCATCC AGGTGACAGATAC TTGATGAGGAGG CATTGATCTTAG CTCCTCATCAACTCTATCTGTCACCTA TCCACTCGTAGA TGACATAGTGTGCG CACAGAAATGCT TGTCCTGTTCGCAACAGGACATCTAC T (SEQ ID NO: AC (SEQ ID NO: GAGTGGACTAAGA 1169) 1170)TCAATGGGATGATA TAGG (SEQ ID NO: 1168) LOC643529 XR_041961.1CCATTATGTCTCCA ACTTTCTGTGTCA CGCCTTCCTGCG TATCAGACTCTGTT CTTGTACCCAACACTTTTGTGTTTCA GGGTACAAGTGAC GAGTCTGATATG GCTAGTTTGAGA ACAGAAAGTCATCTGAGACATAATGG TG (SEQ ID NO: CAAACTAGCTGAA (SEQ ID NO: 1172) 1173)ACACAAAAGCGCA GGAAGGCGGAAGG GAAGGC (SEQ ID NO: 1171) LOXL2 NM_002318.2GGTTTGCCATCCTC CGCGTTTACTCTT TGGAGAAAGCA CTCTAGTTAAAAGT TTCCCCCTTACTTAGCACCAAGCGT AAGGGGGAAAAGA TTAACTAGAGGA AGGTAGCCGCGC GTAAACGCGCGACTGGATGGCAAACC GCTGGAGTCG CCAGCGCGCGGCTA (SEQ ID NO: 1175)(SEQ ID NO: 1176) CCTACGCTTGGTGC TTGCTTTCTCCAGC CAT (SEQ ID NO: 1174)LPCAT3 NM_005768.5 TGCCACCGGCAACT TCAGAACACAAT ATCTTTCCCTCCACGATATCAAGTGG GTGGCATTGTCCA GTCAAAGTAGTC ACAATGCCACATTG CTTGATATCGTAGAACAGCCAAACC TGTTCTGACTTTGA TTGCCGGTGGCA AATCAGCTTCAA AGCTGATTGGTTTG(SEQ ID NO: 1178) AG (SEQ ID NO: GCTGTTGACTACTT 1179) TGACGGAGGGAAAGAT (SEQ ID NO: 1177) LRMP NM_006152.2 TCCATCAGAAAGGC ACAATGAATGCAACTTCTGGAATA TAATAAGGCCCTCT ATAGAGAGCCAG ATTGGCCTGTGA GGCTCTCTATTGCAAGGGCCTTATTA GGAAGCTCATCA TTCATTGTACTGTT GCCTTTCTGATGG AAGCTGCAAACATGCAGCTTTGATGA A (SEQ ID NO: GT (SEQ ID NO: GCTTCCTCACAGGC 1181) 1182)CAATTATTCCAGAA GT (SEQ ID NO: 1180) LRP3 NM_002333.3 GCCAGGAGGCCTTCGATGAAGGCAGG CTGGAGGCGTCT CGCCTCTGTGGCTC TGGGATGGCGGA GAGTGGAAGAACGCCATCCCACCTG GCCACAGAGGCG AATCCAGACATG CCTTCATCTCTGCC GAAG (SEQ ID NO:GTCGCGGGCAGA CGCGACCATGTCTG 1184) (SEQ ID NO: 1185) GATTTTCTTCCACTCAGACGCCTCCAGC TC (SEQ ID NO: 1183) LRPPRC NM_133259.3 AAAATGTGAGTGTGGGCTAGATAAGG GATATTTGAACA GTACAGAGGAAAT GGGTCTTACCTAT GCTAGTCCTTTGAGGTAAGACCCCCT TTCCTCTGTACCA TAACACCCCCCC TATCTAGCCCTCTC CACTCACATTTTGCTGCTGCCGAG GGCAGCAGCGGGG (SEQ ID NO: 1187) AG (SEQ ID NO:GGGTGTTACAAAG 1188) GACTAGCTGTTCAA ATATC (SEQ ID NO: 1186) LRRC15NM_001135057.2 CTGCCTTCTCTGGC TCTTGAGCGCCAT AAACTGGGCCAG TTTCCTGCTATACAGTGAATATGTGT TTGTCCAGAGAA CATATTCACATGGC ATAGCAGGAAAG AGACACACGTTGGCTCAAGAAGTTAG CCAGAGAAGGCA CCATGAGCCTAA GCTCATGGCAACGT G (SEQ ID NO:CT (SEQ ID NO: GTGTCTTTCTCTGG 1190) 1191) ACAACTGGCCCAGTTT (SEQ ID NO: 1189) LRRC33 NM_198565.1 GTGTGCCAAGACTC CAGAGAAAGTGTGAAACTTCAATT GAAATTCGGTCCGC CCTGTTGTGTGCG CGTCAGACTTGG ACACAACAGGACAGACCGAATTTCG CCTCTGCATCAC CTTTCTCTGCCAGC AGTCTTGGCACA ATCTTGAAAGCTTTTCAAGATGTGAT C (SEQ ID NO: GG (SEQ ID NO: GCAGAGGCCAAGT 1193) 1194)CTGACGAATTGAAG TTTC (SEQ ID NO: 1192) LTBP2 NM_000428.2 CATCTCTCCCAGCTATGGAGGCAATG CGGTGGCTGAAG TAGCCTCTGGCTGT ACCGAAGCTTAC CATTAAAGCGATAAGCTTCGGTCATT AGCCAGAGGCTA TGGTGGTGCTTG GCCTCCATGCCCTT AGCTGGGAGAGAAGCCAAGCAAG GCTTGGCTCAAGCA TG (SEQ ID NO: GGC (SEQ ID NO: CCACCAATCGCTTT1196) 1197) AATGCTTCAGCCAC CG (SEQ ID NO: 1195) LYPD6B NM_177964.3AAACTGTGTGAACG ACCAAGTGCAAG AAGCAAACCACT GTGAACTTTGGAGT ATTGATCTTCACTGGCTTTCGCCTT GAAGATCAATCTTG CCAAAGTTCACC GAGGTCCAATGT CACTTGGTGAAGAGGTTCACACAGTTT GCACTCTTC (SEQ TGCACATTGGACCT (SEQ ID NO: 1199)ID NO: 1200) CAAGGCGAAAGCC AGTGGTTTGCTTGG ATA (SEQ ID NO: 1198) LYZNM_000239.2 ATGATGGCAAAAC ACTGCAGGATAA ACC CTCTTTGCA CCCAGGAGCAGTTAATGACAGGCATT CAAGCTACAGCA ATGCCTGTCATTTA AACTGCTCCTGG TCAGCGATGTTATCCTGCAGTGCTTT GGTTTTGCCATCA TCTTGCAGCAAA GCTGCAAGATAAC T (SEQ ID NO:GC (SEQ ID NO: ATCGCTGATGCTGT 1202) 1203) AGCTTGTGCAAAGAGGGT (SEQ ID NO: 1201) MACROD2 NM_080676.5 CTATAGAGGTGACA CGGCATTGACTATTCTATGAATACA TCACATTGCTAGAG AGCATCTACCTCT GCCATCCACACC GTAGATGCTATAGTAGCAATGTGATG TCCTCCTCCAAG CAATGCCGCAAATG TCACCTCTATAG AAGACTGGCATTCCAGTCTTCTTGGA (SEQ ID NO: 1205) TG (SEQ ID NO: GGAGGAGGTGTGG 1206)ATGGCTGTATTCAT AGA (SEQ ID NO: 1204) MAL NM_002371.2 GCCTTCGCGTCCGGACAGCAGTTGGA CGAACAAGAAG GTTGGGAGCTTGCT GGTTAGACACAG GTCCCCTTTCACGTGTCTAACCTCCA CAAGCTCCCAAC AAACAGGAGGT ACTGCTGTGCTGTC CCGGACGCGAAGGACCCTAGCAGA TGCTAGGGTCACCT (SEQ ID NO: 1208) CAGC (SEQ IDCCTGTTTGTGAAAG NO: 1209) GGGACCTTCTTGTT CG (SEQ ID NO: 1207) MALT1NM_006785.2 AGTGTTGATGGCGT GTTGGTTCAACAC CAGCAACACACT CTCTGAATCCAAGTAGATTTGCAACTT GTAAAACCAATG TGCAAATCTGTGTT GGATTCAGAGAC TGCTGCCTGGCAGAACCAACTTCCCA GCCATCAACACT TCAGCTTTTGGG AAAGCTGATGCCA (SEQ ID NO: 1211)AA (SEQ ID NO: GGCAGCACATTGGT 1212) TTTACAGTGTGTTG CTG (SEQ ID NO: 1210)MAML3 NM_018717.4 TGGAAGCCATCAAC AGAAGCTGAAGG CCACTGTTCTGCAATTTGCCCAGTAA CAGTGGCATGTT AAGGGCAAAGA CATGCCACTGCCTT ACTGGGCAAATTAGGTTTCAGGTC CAGCTTCTCCTCTT GTTGATGGCTTCC AAGTTGGTGAAG CACCAACTTGACCTA (SEQ ID NO: AGG (SEQ ID NO: GAAACCTTCTTTGC 1214) 1215) CCTTGCAGAACAGTGG (SEQ ID NO: 1213) MAP3K1 NM_005921.1 ACTTCAGAGACTTC CACATTTGACTAGTTCCAACAGTGT TCCAGCCAGTTGTA GATGGTGTCTAC TGATATGGACAG GACACCATCCTAGTAACTGGCTGGAG CTGACTTGTGCG CAAATGTGCAGATG AAGTCTCTGAAG GCTATTGGCATCCCAATAGCCGCACA T (SEQ ID NO: TG (SEQ ID NO: AGTCAGCTGTCCAT 1217) 1218)ATCAACACTGTTGG AA (SEQ ID NO: 1216) MAP3K8 NM_005204.2 CTGGCTACTTCAATTCAGCCATATTCA AGCCTCCAGGAG CTTGTTCGGGGACC AGCGTTGGTGGT ATCAATGCTGTCACCAACGCTTGAAT CCCCGAACAAGA TTAATTTAGAGC ATGGCTGAAGGAT TTGAAGTAGCCAAAACATGGCATC GCCATGTTTGCTCT G (SEQ ID NO: CT (SEQ ID NO: AAATTAAGACAGC1220) 1221) ATTGATCTCCTGGA GGCT (SEQ ID NO: 1219) MAP4K4 NM_004834.3GATGCCTACATCAG CCCAGCCCATTGT CAAGTGACCAGT TAGCATATATTCGA CTGATTGGATCGTTCCACAGATCG TCCAATCAGACAAT AATATATGCTACT GATCTCTATGGC GGGCTGGGGAGAGGATGTAGGCATC CTTCTCTC (SEQ AAGGCCATAGAGA (SEQ ID NO: 1223) ID NO: 1224)TCCGATCTGTGGAA ACTGGTCACTTGGA TGGT (SEQ ID NO: 1222) MAPK10 NM_002753.2GTATTCATACAGCA CTGAGGACACTG ACATGAAATGGA CTACTTACTTAGAG ACAGTAGCATCTCCATGTGGTACC ATGCTACTGTCAGT CTAAGTAAGTAG CCAGTGCATTAT GTCCTCAGGGCTCTTGCTGTATGAATA GTCTTGGTAGAG ACCAAGACATAAT C (SEQ ID NO: CC (SEQ ID NO:GCACTGGGGTACCA 1226) 1227) CATGGTCCATTTCA TGT (SEQ ID NO: 1225) MAPKAPK5NM_003668.2 GCGAAGAAAGATC TCCACTCTTCCTC GACCTTCAGGAG ATGACAGGCAGTTTTGGGAACTCAAA CTTCCTCACAAC TGAGTTCCCAGAGG ACTGCCTGTCATG ATCTTTGGCCATAAGAGTGGAGTCA ATCTTTCTTCGC CTCTGAGATCTG GATCTCAGAGATGG (SEQ ID NO: 1229)AC (SEQ ID NO: CCAAAGATGTTGTG 1230) AGGAAGCTCCTGA AGGTC (SEQ ID NO:1228) MARCKS NM_002356.5 CCACCACCCCCACC CAACAGCGGCAG TGTAACGACGGGCCCCTCCCTCCGGT CGGCACACACAC GCGAGCAGCAG GTGTGTGCCGCTGC CGGAGGGAGGGCAGCGGCGGCG CGCTGTTGCCGCCG (SEQ ID NO: 1232) G (SEQ ID NO:CCGCTGCTGCTGCT 1233) CGCCCCGTCGTTAC ACCAACCCGAGGCT CT (SEQ ID NO: 1231)MARCKSL1 NM_023009.5 CAGCTTCCCAAGTT AGGGCCAGGGAC GAAGAAAACCAAGGTTAGTGATGTG AGGAGCATTTCA ACAACTGCCTTA AAATGCTCCTGTCC CATCACTAACCTATGCAGGGGTGGG CTGGCCCTACCTCC ACTTGGGAAGCT GACAGGGAAGG TTCCCTGTCCCCACG (SEQ ID NO: AGGT (SEQ ID CCCTGCATAAGGCA 1235) NO: 1236)GTTGTTGGTTTTCTT C (SEQ ID NO: 1234) MAST2 NM_015112.1 ATGCTCCTCACAGGCAGCTGTAGGCT ATCTGGTACGCT AAAAGCTGCATCA GGAAAGGCAACT CTCTGTGCTGAAGTTGCCTTTCCAGC GATGCAGCTTTTC ATGCTTCGTCAA CTACAGCTGATGAG CTGTGAGGAGCAAAAGTGCAGCTC CTGCACTTTTTGAC T (SEQ ID NO: AT (SEQ ID NO: GAAGCATTTCAG CA1238) 1239) CAGAGAGCGTACC AGAT (SEQ ID NO: 1237) MATR3 NM_001194954.1AAGGAGTGGAGTC TGGCATCGACGA GTCCTGTATCAT AACATATCAATGGA CTGTGACTTGCTCTGTCAGGATTCC GCAAGTCACAGTCG CATTGATATGTTG ATTCTGGGTAGA TCGATGCCAGCTTCACTCCACTC (SEQ TTTCAAGAAGAA TTCTTGAAATCTAC ID NO: 1241) GC (SEQ ID NO:CCAGAATGGAATCC 1242) TGACAATGATACAG GAC (SEQ ID NO: 1240) MCL1NM_021960.3 GCTGTAACTTCCTA ACTTGCTTTTCTG GGGAGCACTCTT GAGTTGCACCCTAGGCTAGGTTGCTA CCCATGTATTTA CAACCTAGCCAGA GGGTGCAACTCT TTCTTGTTAGCCAAAGCAAGTGGCA AGGAAGTTACAG ATAATCCTCTTG AGAGGATTATGGCT C (SEQ ID NO:CC (SEQ ID NO: AACAAGAATAAAT 1244) 1245) ACATGGGAAGAGT GCTCCC (SEQ IDNO: 1243) MCM10 NM_018518.3 AATAACTTCTTGAC AGCTCATCAAAT CATCATCAGCCTGCGGGAAAATGGC GCGTCGGGCTCG CTTCTGTATAAG GAGCCCGACGCATT CCATTTTCCCGCGATTCACCGTCGC TGATGAGCTCTTTG TCAAGAAGTTATT CGTCGGCATCAA ATGCCGACGGCGA(SEQ ID NO: 1247) AG (SEQ ID NO: CGGTGAATCTTATA 1248) CAGAAGAGGCTGATGATG (SEQ ID NO: 1246) MCM1 NM_182776.1 TGGGAAATATCCCT TGTGTTCTCTCCTCAAGAAAATACC CGTAGTATCACGGT TCTACCAGCACC AGTGACGCTGAC GCTGGTAGAAGGAGTGATACTACGA GTGGTCTCCAGG GAGAACACAAGGA GGGATATT (SEQ CTGGGCAATCCTTTGCCCAGCCTGGA ID NO: 1250) (SEQ ID NO: 1251) GACCACGTCAGCGTCACTGGTATTTTCT TGCC (SEQ ID NO: 1249) MDFIC NM_199072.2 CAATAGCCACTTCATTCCCCAAATGG CTGAGGCAAGCG CACATGGAGAGAT ACTGGTCTTGCAT CTGAGGTTGGGTGCAAGACCAGTCC CTCTCCATGTGTG TCTAATGAGTTC ATTTGGGGAAATCC AAGTGGCTATTGACCATCCGAAGG TTCGGATGGTGAAC (SEQ ID NO: 1253) AT (SEQ ID NO:TCATTAGAACCCAA 1254) CCTCAGCGCTTGCC TCAG (SEQ ID NO: 1252) MDM2NM_002392.2 GATCTACAGGAACT CTGAGTCCGATG TTGATCACTCCC TGGTAGTAGTCAATATTCCTGCTGATT ACCTTCAAGGTG CAGCAGGAATCATC GACTACTACCAA ACACCTGTTCTCGGACTCAGGTACAT GTTCCTGTAGATC ACTCACAGATGT CTGTGAGTGAGAAC(SEQ ID NO: 1256) AC (SEQ ID NO: AGGTGTCACCTTGA 1257) AGGTGGGAGTGATCAA (SEQ ID NO: 1255) MFAP5 NM_003480.2 CTCATCTCATTGTT CTCCCTGGAAAGTCCTCTTACGCT TCAGCGGAGGCCA GACTTCAGATTTG GTTCCTACTTTG AATCTGAAGTCCTTGCCTCCGCTGAA GCTGGCGAATAA TCCAGGGAGTGGCT ACAATGAGATGA GATGAACAGAGCTGTTCATCTTATT G (SEQ ID NO: CCA (SEQ ID NO: CGCCAGCCAAAGT 1259) 1260)AGGAACAGCGTAA GAGGA (SEQ ID NO: 1258) MFNG NM_002405.2 CGAACAGGACCAGCATCTGGGCCCC AAATGAGCAAA ATTTTGTTTGGAGC GGCATGCTGAGG AAGGATCATCACCTCAGCATGCCGGG CTCCAAACAAAA AATTGGCTGGGA GCCCAGATGATGG TCTGGTCCT (SEQCCCGTTATGCTC AGCATAACGGGTCC ID NO: 1262) CAT (SEQ ID NO: CAGCCAATTGTGAT1263) GATCCTTTTTGCTC ATTT (SEQ ID NO: 1261) MFSD2A NM_001136493.1GTTGGGATCTCATC TCCATGAGGGCC CACTGATGCCAG AGCAGTGCCATTTC ACCAAGATGAGACTGCCACAGCTA TCATCTTGGTGGCC AATGGCACTGCT CCGCATATGTAA CTCATGGAGAGTAAGATGAGATCCCA TGATGAGGTTAC CCTCATCATTACAT AC (SEQ ID NO: TC (SEQ ID NO:ATGCGGTAGCTGTG 1265) 1266) GCAGCTGGCATCAG TG (SEQ ID NO: 1264) MGC87042NM_001164460.1 CAGGCTATACTGAC GTGGCCTGAAAG GAAATTTGGTGT TGGAAGCCTGGTAGTTGCACAAAGCT GCCTACCAGTTG CTTTGTGCAACTTT ACCAGGCTTCCA TGTCTTGGCCAGCAGGCCACTAAACT GTCA (SEQ ID NO: TTTA (SEQ ID NO: GGCCAAGACACAA 1268)1269) CTGGTAGGCACACC AAATTTCTGGCAGG AGC (SEQ ID NO: 1267) MIR17HGNR_027349.1 TGGACCTAACTGCA TTCCTTTTCAGCA CATTTTCCTCCTC CCAGTAGCTTTTCTAGTATTCTCAGA TTCTGGCTTCCA GAGAATACTTGCTG AAAGCTACTGGT CTTAGCAAATACAAAAGGAAGTTTTC GCAGTTAGGTCC CATTCCAGAAAA TGGAATGGTATTTG A (SEQ ID NO:C (SEQ ID NO: CTAAGTGGAAGCC 1271) 1272) AGAAGAGGAGGAA AATG (SEQ ID NO:1270) MKI67 NM_002417.2 AGCAGATGTAGAG CTGATGGCATTA GTCTTTCTCTTCAGGAGAACTCTTAGC GATTCCTGCACGC CCTACTGATGGT GTGCAGGAATCTAA TAAGAGTTCTCCCTTAGGCGTGTGC TGCCATCAGCAGGC TCTACATCTG ATGGCTTTGCCT AAAGCCATGCACA(SEQ ID NO: 1274) G (SEQ ID NO: CGCCTAAACCATCA 1275) GTAGGTGAAGAGAAAGAC (SEQ ID NO: 1273) MLL2 NM_003482.3 CCAACATTAATTTT GCTTGACCAGTCTCAGCTGCTGGAA CCTAATCTCAAGCA GGGTAGTCTTGCT CCTTTCTCCAGA AGACTACCCAGACTTGAGATTAGGAA GCTTCATGATTT GGTCAAGCCGTTGC AATTAATGTTGG GTTTGCAACGAAACAAATCATGA (SEQ ID NO: 1277) (SEQ ID NO: 1278) AGCTCTGGAGAAAGGTTCCAGCAGCTG ACAA (SEQ ID NO: 1276) MLLT10 NM_004641.2 CTGAGCGGCAAAGTCCAGTGACACG AAACGCAACAG CCCGAATGGTCTCT GGCCGGTCGCTA CCTCCAATCATCAGCGACCGGCCCGT GAGACCATTCG TCCTTCATACTA GTCACTGGAGGAC (SEQ ID NO: 1280)TGGGAGACCTCG GAGGTCTCCCATAG TCC (SEQ ID NO: TATGAAGGAGATG 1281)ATTGGAGGCTGTTG CGTTT (SEQ ID NO: 1279) MME NM_000902.2 GGATTGTAGGTGCATAGGGCTGGAAC CCAAAGGAATAT AGCTGTCCAGAGA AAGGACTCTTTTC TGCAAATACCCAAAAGAGTCCTTGTT TCTGGACAGCTTG AGGTCACCCTGT CCAGCCCTATTCTG CACCTACAATCCCAGGAGTGGCA CCACTCCTGACAGG (SEQ ID NO: 1283) GAA (SEQ ID NO:GTGACCTTGGGTAT 1284) TTGCAATATTCCTT TGG (SEQ ID NO: 1282) MMP1NM_002421.2 CAACTTACATCGTG AGAGTCCAAGAG ACTGAAGGTGTA TTGCGGCTCATGAAAATGGCCGAGTT GCTAGGGTACAT CTCGGCCATTCTCT CATGAGCCGCAA CAAAGCCCCGATTGGACTCTCCCATT CACGATGTAAGT ATCAGTAGAATG CTACTGATATCGGG TG (SEQ ID NO:GG (SEQ ID NO: GCTTTGATGTACCC 1286) 1287) TAGCTACACCTTCAGT (SEQ ID NO: 1285) MMP2 NM_004530.2 CCCGGAGGGGCCT AATGCTGATTAGCACCGGGAGGA GGCAGCCGTGCCTT CTGTAGAGCTGA GCCACTCTCTGG CAGCTCTACAGCTAAGGCACGGCTGC AATCTTAAATTA ATCAGCATTCTCAC CAGG (SEQ ID NO: CCAGGTAGGAGTTCCTACCTGGTAAT 1289) GAG (SEQ ID NO: TTAAGATTCCAGAG 1290) AGTGGCTCCTCCCGGTG (SEQ ID NO: 1288) MMP9 NM_004994.2 CACTACTGTGCCTT AGATGTTCACGTTCCCATCCTTGAA TGAGTCCGGTGGAC GCAGGCATCGTC CAAATACAGCTG GATGCCTGCAACGTCACCGGACTCAA GTTCCCAATCTC GAACATCTTCGACG AGGCACAG (SEQ CGCGATGGCGTCCCATCGCGGAGATT ID NO: 1292) GA (SEQ ID NO: GGGAACCAGCTGT 1293)ATTTGTTCAAGGAT GGG (SEQ ID NO: 1291) MMRN2 NM_024756.2 GCCAAGGATGGGCTTTCCAGGGAAG CATGTGGTTACA TGGAGGTCATTCAG AGACAGACCAAC GGGAAGCCACGTTTGGTCTGTCTCTT TGAATGACCTCC ACACCACACCAT CCCTGGAAACCTTC AGCCCATCC (SEQCTTTGCAGAAGG TGCAAAGATGGTGT ID NO: 1295) (SEQ ID NO: 1296)GGTGTACGTGGCTT CCCTGTAACCACAT GGG (SEQ ID NO: 1294) MNDA NM_002432.1CCAACGGCAGGTG TCACTGGGTCGTT TTCTGGGGACTC GATGCAAGAAGAA TTGGGGAACATTTGTATTTAAATGG ATGTTCCCCAAAAC CTTCTTGCATCCA CGCTGTTGCTTT GACCCAGTGACAGTCCTGCCGTTGG CAGTACCACCAC GGTGGTACTGAAA (SEQ ID NO: 1298) TG (SEQ ID NO:GCAACAGCGCCATT 1299) TAAATACGAGTCCC CAGAA (SEQ ID NO: 1297) MOBKL2CNM_145279.4 TTCTCTTACCCAGA GCAGAGGGATGA TCTCCAACCCCC GATGCCCATGAGCTGTAAAATGTCAG AGGAGGACACG GACATTTTACTCAT CTCATGGGCATCT TATAATACAGGCCCCTCTGCCTCCAA CTGGGTAAGAGA CTTCTTGGAG GAAGGCCTGTATTA A (SEQ ID NO:(SEQ ID NO: 1302) TACGTGTCCTCCTG 1301) GGGGTTGGAGATG ATC (SEQ ID NO:1300) MPEG1 XM_937323.1 GCTGTGAAGCGCTA AGATCTGTGCAG CGCAGGAGCCATTTATACATTCAACA CCAGGGTAGGTG CATCCGTGTTGG CCTACCCTGGCTGC TTGAATGTATAATCCTGAAAATTGA ACAGATCTCAATTC AGCGCTTCA (SEQ AGTTGGGAGAAT TCCCAACTTCAATTID NO: 1304) TG (SEQ ID NO: TTCAGGCCAACACG 1305) GATGATGGCTCCTGCG (SEQ ID NO: 1303) MS4A1 NM_152866.2 CTTCTGATGATCCC CACACAGTCACACCAGGAGTGATC AGCAGGGATCTATG CAGATGGGTGCA CGGAAATAATAT CACCCATCTGTGTGTAGATCCCTGC ACATAATGCCTC ACTGTGTGGTACCC (SEQ ID NO: 1307) CCCAGAGAGGGTTCTCTGGGGAGGCA AC (SEQ ID NO: TTATGTATATTATTT 1308) CCGGATCACTCCTGG (SEQ ID NO: 1306) MST1R NM_002447.1 CCACTTTGGAGTTG GATTCTGGGCCTGCTGCTGCATCTC TCTACCACGGAGAA GTCTATGTATTCT TGTGATGCGACT TACATAGACCAGGCCCGTGGTAGACA TAGTGACTTGAT CCAGAATCGAATCC ACTCCAAAGTG GGCACATTGGATAATGTGCCATCAAG (SEQ ID NO: 1310) TC (SEQ ID NO: TCACTAAGTCGCAT 1311)CACAGAGATGCAG CAG (SEQ ID NO: 1309) MSX2 NM_002449.4 GCCGCTGCCGGGTTTGCCCTACGTAGC GTCGGGCGAAA GCCAGCGGAGTCG TCCCGACGCGCG ACAAGTCATTGCCGCGTCGGGAGCTA ACTCCGCTGGCA CTTTGGACGGAG CGTAGGGCAGAGA ACCCG (SEQ IDAAGCCATGACTT AGTCATGGCTTCTC NO: 1313) CTC (SEQ ID NO: CGTCCAAAGGCAAT1314) GACTTGTTTTCGCC CGAC (SEQ ID NO: 1312) MTHFD2 NM_006636.3TGGAGGTGTTGGCC TAATGGTATTCTT AGACTTCAGCAC CCATGACAGTGGCA CATTAGCATTGCCTTCTCGCTCTTC ATGCTAATGAAGA ACTGTCATGGGG AAGCCTCAGCAC ATACCATTATTGCTCCAACACCTCCA CTTTTTTGCAGC GCAAAAAAGGTGC (SEQ ID NO: 1316) AA (SEQ ID NO:TGAGGCTTGAAGA 1317) GCGAGAAGTGCTG AAGTCT (SEQ ID NO: 1315) MTUS2NM_001033602.2 AACCTGCAAACAC GGTTCCTAATTCG GAAGTCAGTATT AAATTCAGTTACAGGACAGCTAAGCT GCTGTGTAACTG CTTAGCTGTCCGAA GTAACTGAATTTG CATTTAGCAGGTTTAGGAACCGCTTA TGTTTGCAGGTT GCGGCTATGTAA CATAGCCGCACCTG(SEQ ID NO: 1319) GC (SEQ ID NO: CTAAATGCAGTTAC 1320) ACAGCAATACTGACTTC (SEQ ID NO: 1318) MUC16 NM_024690.2 TCTTCTAGACACAG ATATGGCTGGGGCTGCAGAGCTTC GTTTTCCCAGGTCA TCCCCGCATTTGA TGAGCTCCCTGA AATGCGGGGACCCCCTGGGAAAACC AACTCCAAAATT CAGCCATATCTCCC TGTGTCTAGAAG TCTCAGGGTGGGACCCTGAGAAATTT A (SEQ ID NO: AG (SEQ ID NO: TGGAGTTTCAGGGA 1322) 1323)GCTCAGAAGCTCTG CAG (SEQ ID NO: 1321) MYB NM_005375.2 AACTGTTGCATGGAACCACAGTTTCTG AGTGCTGGCCAT TCCTGTGTTTGCAA TCTCCCCAGTTGC CTTGCATCAAATCTGGGGAGACAGA AAACACAGGATC GTTCTTAAGGCA AACTGTGGTTGATA CATGCAACAGTTGTGACTGGCTAT GCCAGTCACTGCCT (SEQ ID NO: 1325) CA (SEQ ID NO:TAAGAACATTTGAT 1326) GCAAGATGGCCAG CACT (SEQ ID NO: 1324) MYBL1XM_034274.14 GGCAAACGCTGTGT TCTCTGCAAATTC ACTGGTAACGTC TATCCTCTTTGCAGTGGGATGGTCTG ACTCCATGCTAC ACCATCCCAGAATT CAAAGAGGATAA AGGATCAGATTCTGCAGAGACTCTAG CACAGCGTTTGCC AATAAGTTCTAG AACTTATTGAATCT(SEQ ID NO: 1328) AG (SEQ ID NO: GATCCTGTAGCATG 1329) GAGTGACGTTACCAGT (SEQ ID NO: 1327) MYC NM_002467.3 TCGGACACCGAGG CGCTCCAAGACGTCTGGTCACGCA AGAATGTCAAGAG TTGTGTGTTCGCC GGGCAAAAAAG GCGAACACACAACTCTTGACATTCTC CTCCGTTTTAGC GTCTTGGAGCGCCA CTCGGTG (SEQ ID TCGTTCCTCCTCTGAGGAGGAACGAG NO: 1331) GG (SEQ ID NO: CTAAAACGGAGCTT 1332)TTTTGCCCTGCGTG ACCAGA (SEQ ID NO: 1330) MYD88 NM_002468.3 ACGTTTTTCTAGGTATGGGACTTTCCC TAGATGAGTGCC ACAGCTCCCAGGA ACCTAGCTGTTCC CAATTTTTGTTCACAGCTAGGTGGG TGGGAGCTGTAC AGGGACATGGTT AAAGTCCCATCACT CTAGAAAAACGTAGGCTCCCTCAG GAGGGAGCCTAAC (SEQ ID NO: 1334) TG (SEQ ID NO:CATGTCCCTGAACA 1335) AAAATTGGGCACTC ATCTA (SEQ ID NO: 1333) MYO7ANM_001127180.1 CGACGCCTTCGTAA CCACAATCCACA TCACATCCTGGG AGGGGATCTACGGCGAACAGCCGCC AGGGAGGCTTGT GCGGCTGTTCGTGT CGTAGATCCCCTT AAATTGCTGCGTGGATTGTGGACAA TACGAAGG (SEQ TGATCTTGT (SEQ GATCAACGCAGCA ID NO: 1337)ID NO: 1338) ATTTACAAGCCTCC CTCCCAGGATGTGA AGAAC (SEQ ID NO: 1336) MZT2BNM_025029.3 TTGAAAGAGGCATT CCAGCCCAGTGC TGATAGACTGCA TACCGAGCGCCCAACAGGCATACATT TTGGTCGTGCTC TGTATGCCTGGCAC GGGCGCTCGGTA GCTTAGGTGGCATGGGCTGGGTGCTG AATG (SEQ ID NO: GCAC (SEQ ID CCACCTAAGCGAGC 1340)NO: 1341) ACGACCAATGCAGT CTATCAGGGAGGCC CA (SEQ ID NO: 1339) NAIF1NM_197956.3 GATTGGCCTTGGCC TTATTAAAGAGG CAGGAGCCCAAC TTAGACCGGCCACGGAGCTGTGCACG AAATTCCTCTTC TGCACAGCTCCCTC TGGCCGGTCTAA TCAAAAACAGTGTTTAATAAACGCTT GGCCAAGG (SEQ CAACCCCTAAGC AGGGGTTGCACTGT ID NO: 1343)GT (SEQ ID NO: TTTTGAGAAGAGGA 1344) ATTTGTTGGGCTCC TG (SEQ ID NO: 1342)NANS NM_018946.3 TTCCTTATCTGGAA GGAGATCACCAT TTCACGATCTGA AAGACAGCCAAAATGGGCGACCTTTT TAAACTTGCTTC AAGGTCGCCCAATG TTGGCTGTCTTTT ATGGTGTCCATTGTGATCTCCAGTGG CCAGATAAGGAA GACTGCATCCCA GATGCAGTCAATGG(SEQ ID NO: 1346) CT (SEQ ID NO: ACACCATGAAGCA 1347) AGTTTATCAGATCGTGAA (SEQ ID NO: 1345) NASP NM_172164.1 TTTGGCTGTGAGCC ACTAGGTGGATACAGGTTTTCAGA AGGCCTAGGATGGT TAGGACAAGAAC GTTCTTTTTCCA TCTTGTCCTATATCCATCCTAGGCCTG GGACAGAATTAT CACCTAGTCTTCAC GCTCACAGCCAA AGCCCCAGGTGACTGGGGCTATAATT A (SEQ ID NO: AG (SEQ ID NO: CTGTCCTGGAAAAA 1349) 1350)GAACTCTGAAAACC TG (SEQ ID NO: 1348) NBN NM_002485.4 GACTACAAAGAATTTTAATCCTGTACT TTCATCAACTGA ACTGTGATCCTCAG GGGATGGCCCTG CACGCCTTGTGAGGCCATCCCAGTAC AGGATCACAGTA AAGGCTTGGTCC AGGATTAAAGACA ATTCTTTGTAGTCTGGAGTTGTTGT ACAACTCCAGGACC (SEQ ID NO: 1352) CT (SEQ ID NO:AAGCCTTTCACAAG 1353) GCGTGTCAGTTGAT GAA (SEQ ID NO: 1351) NCAPGNM_022346.3 GTATTGCACCATCA CTTGGTGCGCCCT TTTTCAGCTAAA GCAAAGACTTTGCCACAATTTTTGGCA ACCTGATAAGCC AAAAATTGTAGGG AAGTCTTTGCTGA AGCTTTCTGACACGCACCAAGGATGT TGGTGCAATAC GCCTCTTTCACA GAAAGAGGCTGTC (SEQ ID NO: 1355)TC (SEQ ID NO: AGAAAGCTGGCTTA 1356) TCAGGTTTTAGCTG AAAA (SEQ ID NO:1354) NCAPH NM_015341.3 TGCTACTATTCTGA TAGCTCTCCAATT AAGCTGGACCAGCCAAGTCCACTTTG CTGGTTCTCCAAA AGTGTCAACATT GAGAACCAGAATT GTGGACTTGGTCGTAGTTGAAATC GGAGAGCTACCAC AGAATAGTAGCA TGTAGGAAGGGT CCTTCCTACAGATT(SEQ ID NO: 1358) GG (SEQ ID NO: TCAACTACAATGTT 1359) GACACTCTGGTCCAGCTT (SEQ ID NO: 1357) NCF2 NM_000433.2 GCCACTAAGGCAG AGAGAGAAGACAAGGGACATGATT CCCTGCTAGGGGAG GGTTGGAGCGTC AGGTAGAAACTA ACGCTCCAACCTGTTCCCCTAGCAG GGAGGCCAAGA CTTCTCTCTGTCTCC (SEQ ID NO: 1361) GAGCTGCCAGGATGGCAGCTCTCTTG GAC (SEQ ID NO: GCCTCCTAGTTTCT 1362) ACCTAATCATGTCCCT (SEQ ID NO: 1360) NCRNA00158 NR_024027.2 AGTAGGATCCAGA TGCTCATCCTTAATGATCTGCACAT GCCATTTTGGAACT TCCTTGGTAAAGT GGCCTCCAAAGT TTACCAAGGATTAATCCAAAATGGCT GATATTTAGACT GGATGAGCACAGA CTGGATCCTACT CTTGATGTGATCTCACATCAAGAGTC (SEQ ID NO: 1364) TG (SEQ ID NO: TAAATATCACTTTG 1365)GAGGCCATGTGCA GATCA (SEQ ID NO: 1363) NDST4 NM_022569.1 GGCTCCATCTGACTATCCAGGTACTA CTGAGAAGTAGC TAAAAACTTTGCAG GGCATCTTCTCTG AAAGTAAGTTAGAGAAGATGCCTAGT CAAAGTTTTTAAG CCATCTTTCTAT ACCTGGATGGTATG TCAGATGGAGCGTGGACTGCATA CAGTCCACATAGAA (SEQ ID NO: 1367) CC (SEQ ID NO:AGATGGCTAACTTA 1368) CTTTGCTACTTCTC AG (SEQ ID NO: 1366) NEBLNM_006393.1 GGGGTGGCATTCAC TTTCGGTTTTGTC CAGATATCCCCA TTAGGGTCTGACTTATAGCTGTGAAG AGACCCGTACAT CACAGCTATGACAA TCAGACCCTAAG CTTAGCACTTCCAACCGAAAAAGCA TGAATGCCACCC TCGCAGTTTTGC AAACTGCGAGGAA C (SEQ ID NO:TT (SEQ ID NO: GTGCTAAGATGTAC 1370) 1371) GGGTCTTGGGGATATCTG (SEQ ID NO: 1369) NECAP2 NM_018090.4 CTCTCCTCTCCTCCT GCCAAACATGCCGGTTGCATACTT TGTCTGGCTCTGTT CGGTTTGTCAACA GAATCCCAGGAA GACAAACCGGGCAGAGCCAGACAAG ACAGTGTGACAC TGTTTGGCAGTAAA GAGGAGAGGAGA GGTGCCAATTTATTGGCACCGTGTCA G (SEQ ID NO: CT (SEQ ID NO: CACTGTTTCCTGGG 1373) 1374)ATTCAAGTATGCAA CC (SEQ ID NO: 1372) NEIL1 NM_024608.2 TTAGCAGGAGGCTCGGCAAGACAATA TGCACCTTCAGA TCCTTGCTTGCACT AGAAAGGGTGAG TATTGCCTGCTCCACCCTTTCTTATT TGCAAGCAAGGA CCAAAAATTCAG GTCTTGCCCTGCAT GAGCCTCCTGCTAACCCCCAGATGC CTGGGGGTCTGAAT A (SEQ ID NO: AG (SEQ ID NO: TTTTGGGAGCAGGC1376) 1377) AATATCTGAAGGTG CA (SEQ ID NO: 1375) NEK6 NM_014397.3GCATCGGGAAGCA AGAAGATGGCCC ATTCAAGGAGGT GGAGCATCTTCTTG AGCCTGGCTGCCGACGAAGTTCCT GCAGCCAGGCTGG AAGAAGATGCT GGTACACAGCAG GCCATCTTCTCCTG(SEQ ID NO: 1379) GTGTCCAGG GACACCTGCTGTGT (SEQ ID NO: 1380)ACCAGGAACTTCGT CACCTCCTTGAATG CTGG (SEQ ID NO: 1378) NEU3 NM_006656.5TGGTTCTAAGATTT CAGGCACTATGC TTGACATCAGAG CTCATCTTCTCATC TTGTCCTAGGGATTCCTTTATGCAG CCTAGGACAAGCAT GAGAAGATGAGA CCAGGACTTACT AGTGCCTGCATGCTAATCTTAGAACC GATCATGAAGCA TCATGATCAGTAAG A (SEQ ID NO: TG (SEQ ID NO:TCCTGGCTGCATAA 1382) 1383) AGGACTCTGATGTC AA (SEQ ID NO: 1381) NFATC1NM_172390.1 CCAGTACCAGCGTT GAAAGATGGCGT GCGTCTTTAGAA TCACCTACCTTCCCTACCGTTGGCGG AAAGCACCCCAC GCCAACGGTAACG GAAGGTAGGTGA GCGCTCATGTTCCCATCTTTCTAACC AACGCTGGTACT ACGGCTTACGGT GTAAGCCGTGAAC GG (SEQ ID NO:TA (SEQ ID NO: ATGAGCGCGTGGG 1385) 1386) GTGCTTTTTCTAAAGACGC (SEQ ID NO: 1384) NFIL3 NM_005384.2 CCTTTCTTTCTCCTC CTCCTTCGTTATCTCTACCGTCTGG GCCGGCCCGAGAG GTGTTCCTGCTCT GATAAATCCGTC CAGGAACACGATACGGGCCGGCGAG AGGCTCCTTATT ACGAAGGAGGCCC GAGAAAGAAAGG GAATGAAGTTGGAACTTCATTCAATA (SEQ ID NO: 1388) GC (SEQ ID NO: AGGAGCCTGACGG 1389)ATTTATCCCAGACG GTAGA (SEQ ID NO: 1387) NFKBIA NM_020529.1 GGATGAGGAGAGCCCTCTGTGAACTC GCCTCCAAACAC TATGACACAGAGTC CGTGAACTCTGA ACAGTCATCATAAGAGTTCACGGAGT CTCTGTGTCATAG GGGCAGCTCGT TCACAGAGGACGA C (SEQ ID NO:(SEQ ID NO: 1392) GCTGCCCTATGATG 1391) ACTGTGTGTTTGGA GGCCAGCGTCTGACGTTA (SEQ ID NO: 1390) NFKBIZ NM_001005474.1 ATTTGGTTCCCGATCTTCAGGATACGT CCAAGCTAATGG GGCCCTGTGGGAG CGGATCTGTTCTC AGCTAATACGGTAACAGATCCGACGT CCACAGGGCCAT GGAGCTCTCTGC ATCCTGAAGGGAA CGGGAACCAAATTGAATGGACTTT AGTCCATTCAGCAG (SEQ ID NO: 1394) CC (SEQ ID NO:AGAGCTCCACCGTA 1395) TTAGCTCCATTAGC TTGG (SEQ ID NO: 1393) NHLH2NM_005599.3 CTCTGGCTCTCCCA ACAGTGACAAGG TtGGAGATGCTT CCCTCTTCCCGTCTAAGCAGAGAAAG GGAGAAAGGTT TTCTCTGCTTCCTTG ACGGGAAGAGGG GGTGAAAAGTGTCACTGTTACTCCA TGGGAGAGCCAG AACGTCTCCTGG GGAGACGTTCACTT AG (SEQ ID NO:AGTA (SEQ ID TTCACCAACCTTTC 1397) NO: 1398) TCCAAGCATCTCCAA (SEQ ID NO: 1396) NIPA2 NM_001008860.1 AACGATTTCTCAGG GCTCAGAGGAAGGCAGGATGTGCT TTGAGATGATCACC CCGGATTCACGG GGCTTGATGAGG GTGAATCCGGCTTCTGATCATCTCAAC TGCTAAGGCCAT CTCTGAGCATTCGA CTGAGAAATCGT CGAAT (SEQ IDTGGCCTTAGCACCT T (SEQ ID NO: NO: 1401) CATCAAGCCAGCAC 1400)ATCCTGCCTGCTGT TG (SEQ ID NO: 1399) NOC3L NM_022451.9 GTTGAGATTGTACTTTTCTGCGCTTAG GGGTACAAAGG CCAGTGCCTTGATG TTAGCATGACATC CGTTTGATGAAGTCATGCTAACTAAG AAGGCACTGGAG GCAAGAGCTCGC CGCAGAAAGCAAG TACAATCTCAACTGCTGAGAAACT TTTCTCAGCAGCGA (SEQ ID NO: 1403) TGC (SEQ ID NO:GCTCTTGCCTTCAT 1404) CAAACGCCTTTGTA CCC (SEQ ID NO: 1402) NOP14NM_003703.1 CTGATCCACAAACA CGGATTTCTCGAA TTCCATGATTTC CAAGCGTGAATTTACGGCCCCTTTAAA TGAGAGTTGCAT AAGGGGCCGTTCG TTCACGCTTGTGT CCTCGCCAGGAAAGAAATCCGCAAG TTGTGGATCAG CTGATTGTCCTT GACAATCAGTTCCT (SEQ ID NO: 1406)G (SEQ ID NO: GGCGAGGATGCAA 1407) CTCTCAGAAATCAT GGAAC (SEQ ID NO: 1405)NOP56 NM_006392.2 TTCTCTATGCGTGT ACCAGCTCCGGA CAATAAACTGGG CAGGGAGTGGTACAAGTGATACCCG CAAGACGGCAGT GGGTATCACTTTCC TACCACTCCCTGA ATGTGGCATTGTGGAGCTGGTGAAG CACGCATAGAGA CGTTGATGATCT ATCATCAACGACAA A (SEQ ID NO:TC (SEQ ID NO: TGCCACATACTGCC 1409) 1410) GTCTTGCCCAGTTTATTG (SEQ ID NO: 1408) NOTCH1 NM_017617.3 CTGCCAGGCTTCAC GGACAATCGTCGTCCACACAGGCA CGGCCAGAACTGTG ATATTTTCCTCAC CCCCCGTTCTTG AGGAAAATATCGAAGTTCTGGCCGGT CAGTTGTTTCCT CGATTGTCCAGGAA GAAGCCTGGCAG (SEQ ID NO: 1413)ACAACTGCAAGAA (SEQ ID NO: 1412) CGGGGGTGCCTGTG TGGACGGCGTGAACACCT (SEQ ID NO: 1411) NOTCH2 NM_024408.2 TCCTGGTGAACAAG TTTCCAGAAAGACGTGTTCTTGAA AACAGGAGGTGGC CTTTAGAGCCAG GCAGTGGTCTGA TGGCTCTAAAGTCTCCACCTCCTGTTC GTCTTGAACACA TTCTGGAAATTGAC TTGTTCACCAGGA CTGGCGGTTGTCAACCGCCAGTGTGT (SEQ ID NO: 1415) AA (SEQ ID NO: TCAAGACTCAGACC 1416)ACTGCTTCAAGAAC ACG (SEQ ID NO: 1414) NRG1 NM_004495.2 TACATCTACATCCATCTCCGCACATTT GTCTTTCACCAT CCACTGGGACAAG TACAAGATGGCT GAAGCACTCCCCCCATCTTGTAAAAT TGTCCCAGTGGTG TCCATTCACACA GTGCGGAGAAGGA GATGTAGATGTAGAAAGTTTTCTC GAAAACTTTCTGTG (SEQ ID NO: 1418) CT (SEQ ID NO:TGAATGGAGGGGA 1419) GTGCTTCATGGTGA AAGAC (SEQ ID NO: 1417) NUF2NM_145697.2 GACTTCCAGTAG GA AAACGTCAACCG AGGAAGACGGC GGCGGCAAGTTTGATCATCACTTTTCA GAGTTCGGGGAG AAAGTGATGACGG AACTTGCCGCCTC CAGCTACAAGCATTGACGTTTGCTGA CTACTGGAAGTC AAGTCAAAAATC TTTTTGACTTTGCTT(SEQ ID NO: 1421) AGC (SEQ ID NO: GTAGCTGCTCCCCG 1422) AACTCGCCGTCTTCCT (SEQ ID NO: 1420) NUP62 NM_016553.3 GGCACTGCAAAGA GAGAAAGAAAACCTGGTTGGAAGG CGGCAACAACCAC CCTGTAGCAGGT GAGCCCCAAAAT ACCTGCTACAGGGTGTGGTTGTTGCCG TAAACCCTCCAG TTTCTTTCTCCACCT TCTTTGCAGTGCC TGCCAGAGGTGCTGGCACTGGAGG (SEQ ID NO: 1424) (SEQ ID NO: 1425) GTTTAATTTTGGGGCTCCCTTCCAACCA GCCA (SEQ ID NO: 1423) NUSAP1 NM_018454.6 TCAAGCGCTCTGCTAGCTGAAAACCT CTGGCTGGAGTC ATCTCTGCAGCTAA GACACCCGTTTTA TTGGTCAGTGAAAACGGGTGTCAGGT GCTGCAGAGATA CGCTTATGCTCA TTTCAGCTGCTACT GCAGAGCGCTTGTTATCTTTAGTA AAAGATAATGAGC A (SEQ ID NO: GC (SEQ ID NO: ATAAGCGTTCACTG1427) 1428) ACCAAGACTCCAGC CAG (SEQ ID NO: 1426) OAS2 NM_016817.2AAGCAAAGGAATG GTTTCCAGTCCCA CCACAACTTCCT GTTATCCTCTCCCT TCCTTGAAGCAGGGTGTCTGCATT GCTTCAAGGATGGG GGAGAGGATAAC GTCGGCACTTTC ACTGGAAACCCAATCATTCCTTTGCTT CAAGGTGGTATT ACCACCTTGGAAAG (SEQ ID NO: 1430)GG (SEQ ID NO: TGCCGACAATGCAG 1431) ACACCAGGAAGTT GTGG (SEQ ID NO: 1429)OAS3 NM_006187.2 GAGTGCCTTAGACA AGGTAAGTTTTA CAATAATGAGGG GCCTGACTCTCCACACAGTGGTTTGTG AAGGCTCTTCCC AAACCACTGTTAAA GAGAGTCAGGCT ATCCCATTCAATACTTACCTGCTAGG GTCTAAGGCACT CTAGCATTCCTA AATGCTAGATTGAA C (SEQ ID NO:GC (SEQ ID NO: TGGGATGGGAAGA 1433) 1434) GCCTTCCCTCATTA TM (SEQ ID NO:1432) OPA1 NM_130837.1 CTGAGACCATATCC CACCATCCTCTGT GGAGCCATGCCTTTAAATGTAAAAGG AGTCCAGGGCCT GATGTCACAGTA CCCTGGACTACAGA TTTACATTTAAGGTTAATCACACCT GGATGGTGCTTGTT ATATGGTCTCAG GGTAAGTCAACA GACTTACCAGGTGT(SEQ ID NO: 1436) AG (SEQ ID NO: GATTAATACTGTGA 1437) CATCAGGCATGGCTCC (SEQ ID NO: 1435) OPN3 NM_014322.2 ACTCACCTCCTCCT AGGGACACCAGCCAGCCGTTCCTC GGTCAACATCAGCC AGGTCGCTGAGG AGGCAGGACAC TCAGCGACCTGCTGCTGATGTTGAC GAAGGTAAAGG GTGTCCCTCTTCGG (SEQ ID NO: 1439) TGACCCCGAAGGGTCACCTTTACCT (SEQ ID NO: 1440) TCGTGTCCTGCCTG AGGAACGGCTGGGTGT (SEQ ID NO: 1438) OSBPL3 NM_145320.1 AGAGGATTGAACA ATTTTCTTCTAAGCAAGAGTCATCG ACTGCAGAGAGAA ACCCGCCGCCTTT TCGGATTTCCTG AGGCGGCGGGTCTTCTCTCTGCAGTTG AAAAACCGAGG AGAAGAAAATCAT TTCAATCCTCT CTGGTGCTCCACGTGGAGCACCAGC (SEQ ID NO: 1442) ATG (SEQ ID NO: CTCGGTTTTTCAGG 1443)AAATCCGACGATG ACTCTTG (SEQ ID NO: 1441) PA2G4 NM_006191.2 TGGATTGCTGGGGGCCAGAGGTACTG TTTAAAAACCTC TTTGTAGAGAAAGG AAATTTGTCACCT ATAAGTTAGTGGTGACAAATTTCAGT TTCTCTACAAACC GAGCCCTAGTTT ACCTCTGGCATGCT CCCAGCAATCCACCTGGGACAGCA GTCCCAGGAAACTA (SEQ ID NO: 1445) TG (SEQ ID NO:GGGCTCCCACTAAC 1446) TTATGAGGTTTTTA AA (SEQ ID NO: 1444) PAG1NM_018440.3 TCACATGATGGGGT GTGTAAGATGAC GCTGTAAGGTGC TCTTTAGTACATGGATGGCTGTTACCA CTATAAAGGATG TAACAGCCATGTCA TGTACTAAAGAA TCACTACAGCATTCTTACACACCTAG CCCCATCATGTGA TCACAATGCTAG CATTGTGAATGCTG(SEQ ID NO: 1448) GT (SEQ ID NO: TAGTGACATCCTTT 1449) ATAGGCACCTTACAGC (SEQ ID NO: 1447) PARM1 NM_015393.3 GACCATGCCTGGTG CATCCTTTCATCTTAATCTCCTGAT CCACAGCCATGGTT AGAAATGGAAAC TCTGATCCAAGA TCCATTTCTAGATGCATGGCTGTGGC GTCTTTGAGACC AAAGGATGGCCTA ACCAGGCATGGT TATGTCCTAGGCGGACATAGGTCTCA C (SEQ ID NO: (SEQ ID NO: 1452) AAGACTCTTGGATC 1451)AGAATCAGGAGAT TAGG (SEQ ID NO: 1450) PAX6 NM_001604.4 CTTTAACTAGGGGCTCCACTCTCACAA GGATTCCACGGG GCGCAGATGTGTGA TAAAAGGCCTCA GCTCGAATATGGGGCCTTTTATTGTG CACATCTGCGCG GGCTCTGAAATC AGAGTGGACAGAC CCCCTAGTTAAATCGGATGTCTG ATCCGAGATTTCAG G (SEQ ID NO: (SEQ ID NO: 1455)AGCCCCATATTCGA 1454) GCCCCGTGGAATCC CGC (SEQ ID NO: 1453) PCNANM_002592.2 GGTGTTGGAGGCAC TAATATCCCAGC CGAGTCCATGCT TCAAGGACCTCATCAGGCCTCGTTGAT CTGCAGGTTTAC AACGAGGCCTGCTG GAGGTCCTTGAG ACCGCTGGAGCGGATATTAGCTCCA TG (SEQ ID NO: (SEQ ID NO: 1458) GCGGTGTAAACCTG 1457)CAGAGCATGGACTC GTCCCACGTCTCTT TG (SEQ ID NO: 1456) PDCDILG2 NM_025239.3TGTGGAGCTGTGGC GAGGAAGATCAT AATAAAGCTGCT AAGTCCTCATATCA GTTCTGTATTTGAATCTGGTGAAGC AATACAGAACATG TATGAGGACTTG TGCAATTCCAGG ATCTTCCTCCTGCTCCACAGCTCCAC CTCAACATTAGC AATGTTGAGCCTGG A (SEQ ID NO: AG (SEQ ID NO:AATTGCAGCTTCAC 1460) 1461) CAGATAGCAGCTTT ATT (SEQ ID NO: 1459) PDE4DIPNM_001002810.2 AGGAGAACTTCAG CATGCGCTCCTCC TAGATGTCCTCC CCTCAAGCTGCGCAAGGAAGTAGATG CGGCTGGCCTCA TCTACTTCCTGGAG CGCAGCTTGAG TACTTCTGTTGGAGCGCATGCAAC (SEQ ID NO: 1463) (SEQ ID NO: 1464) AGAAGTATGAGGCCAGCCGGGAGGAC ATCTACAAGCGGA ACATTGA (SEQ ID NO: 1462) PDE9ANM_001001567.1 CAGCAGGACCAAC TCTTGTGGTTATC GCAGGTACTTGG TGCCCCTGTAAGTACAAAAAACTGTA GGTAAGTGGGA CAGTTTTTTGGATA CTTACAGGGGCA ACATCGCGTCGAACCACAAGAAGTT GTTGGTCCTGCTG GGAGTCAACT GACTCCTCGACGCG (SEQ ID NO: 1466)(SEQ ID NO: 1467) ATGTTCCCACTTAC CCCAAGTACCTGCT CTCT (SEQ ID NO: 1465)PDGFRA NM_006206.3 TAGTGCTTGGTCGG TTCAACCACCTTC ACTGCAACTTTCGTCTTGGGGTCTGG CCAAACGCTCCA ATGACAGGTTGG AGCGTTTGGGAAG GACCCCAAGACCGACCGGCTTAAT GTGGTTGAAGGAA CGACCAAGCACT CCATAGGCTGTT CAGCCTATGGATTAA (SEQ ID NO: CC (SEQ ID NO: AGCCGGTCCCAACC 1469) 1470) TGTCATGAAAGTTGCAGT (SEQ ID NO: 1468) PDIA4 NM_004911.4 TGAAGCCAGTCATC GGGTCCCTTGTTGTTGGGGTCCATC AAATCCCAGCCAGT TTCTTGGGCACTG ACAATGGAGTCA GCCCAAGAACAACGCTGGGATTTGAT AAGGTCTTTCCC AAGGGACCCGTCA GACTGG (SEQ ID ACCACGACCTTGAGGTCGTGGTGGG NO: 1472) AC (SEQ ID NO: AAAGACCTTTGACT 1473)CCATTGTGATGGAC CCCAA (SEQ ID NO: 1471) PDIA5 NM_006810.2 GCTACCCCACTTTCATACTTTTCTGCG CGGAGGGCTCGA CACTACTACCACTA AACTTCCCATAGT ATATAATTGGTATGGGAAGTTCGCAG GGTAGTAGTGGA AATCCCAATTCT AAAAGTATGACAG AAGTGGGGTAGCGTGCGGTCGCTG CGACCGCACAGAA (SEQ ID NO: 1475) TC (SEQ ID NO:TTGGGATTTACCAA 1476) TTATATTCGAGCCC TCCG (SEQ ID NO: 1474) PDK4NM_002612.3 AATCAGAACACTG CCTGGGTCACAG AAATAAGGAGCT ATCCAATGAGGAATAAACAAGCTCCA GGCCATCTGTTA GGAGCTTGTTTCTG TTCCTCATTGGAT ACTCCTGTAGTCTGACCCAGGAGAA CAGTGTTCTGATT TTGCACTAAGTT CTTAGTGCAAGACT(SEQ ID NO: 1478) CT (SEQ ID NO: ACAGGAGTTAACA 1479) GATGGCCAGCTCCTTATTT (SEQ ID NO: 1477) PDLIM1 NM_020992.2 GGATCCCAACAAG TAGTGACAGGAGTTTGTCACACAT CCCTCAGGATTCAG CTTTAACACTTCT AGGCAACTTCTG AAGTGTTAAAGCTCGAATCCTGAGGG AGCATTTCCAAT CTGTCACTAAAGTG CTTGTTGGGATC CGACGCAGCCACGCTGCGTCGATTGG (SEQ ID NO: 1481) TT (SEQ ID NO: AAATGCTCAGAAGT 1482)TGCCTATGTGTGAC AAA (SEQ ID NO: 1480) PDLIM3 NM_001114107.2CTTTGGGACAGAGT CTTTAATCCTGTC TAAGTGAGTTTC CCATGACTCATGCT CTGCGCATCAGCTCCCCTGTCAAT GATGCGCAGGACA ATGAGTCATGGA TTTGAGACACAG GGATTAAAGCAGCCTCTG (SEQ ID CTGGTGAGCTGC AGCTCACCAGCTGT NO: 1484) TG (SEQ ID NO:GTCTCAAAATTGAC 1485) AGGGGAGAAACTC ACTTA (SEQ ID NO: 1483) PDPNNM_006474.4 CTCCAGGAACCAGC CACCAGAGTTGT GTTGGCAGATCC GAAGACCGCTATACAAGCCAGACTT TCGATGCGAATG AGTCTGGCTTGACA ATAGCGGTCTTCG CCTGTTACACTGACTCTGGTGGCAAC CTGGTTCC (SEQ TTGACACTTGTT AAGTGTCAACAGTG ID NO: 1487)GC (SEQ ID NO: TAACAGGCATTCGC 1488) ATCGAGGATCTGCC AAC (SEQ ID NO: 1486)PECAM1 NM_000442.3 ATCTGCACTGCAGG TGGACTGTGTTGC GGGCATCATAAGTATTGACAAAGTGG TTTTCTTGACCAC AAATCCTGGGCT TCAAGAAAAGCAA TTTGTCAATACCTGGGAGAGCATTT CACAGTCCAGATAG GCAGTG (SEQ ID CACATACGACTA TCGTATGTGAAATGNO: 1490) TC (SEQ ID NO: CTCTCCCAGCCCAG 1491) GATTTCTTATGATGCCC (SEQ ID NO: 1489) PECR NM_018441.5 CATTGTCCCTACTA CAGCTCCAGAATGGCCCATTCCAA AAGCTGGATTTCCA GCACAGCTAATG AGCTAAAGATTT TTAGCTGTGCATTCGAAATCCAGCTTT GGTGAGGTTGTA TGGAGCTGCAAGA AGTAGGGACAAT AACACCTGCTCTGCAGGTGTTTACAA G (SEQ ID NO: TG (SEQ ID NO: CCTCACCAAATCTT 1493) 1494)TAGCTTTGGAATGG GCC (SEQ ID NO: 1492) PGAM1 NM_002629.2 ATGGAAAAGCTCCCAACCCAAGTCAC GCTTAGCATGGT CTTATCCAACAGAG TACTTTTAAACTC TCCTCCCCAAAGTTTAAAAGTAGTGA TGTTGGATAAGG TCCTTAGTAAAC CTTGGGTTTTTGCG GGAGCTTTTCCATAAAGCACTCGCA AGTGCTTTGTTTAC (SEQ ID NO: 1496) AA (SEQ ID NO:TAAGGACTTTGGGG 1497) AGGAACCATGCTA AGC (SEQ ID NO: 1495) PHAXNM_032177.3 GAAAAAAACATTC ACATAAGGTAAG ATGAGCCACTGC CCAGTGGCAGCCTGACAGTCTTAGGC GCCGGCATATGT CCTAAGACTGTCTT AGGCTGCCACTG AACATTTTAAATACCTTATGTTAAGG GGAATGTTTTTTT ACCTGACTTCCT AAGTCAGGTATTTA C (SEQ ID NO:TA (SEQ ID NO: AAATGTTACATATG 1499) 1500) CCGGCGCAGTGGCT CAT (SEQ ID NO:1498) PHC3 NM_024947.3 CTACATCTCCCACA CGTTTGGGACAT GAACGGCTTATTGGAAGTGTCACAC ACTTGACTGCTGT AACTGTGCAGGT AGCAGTCAAGTATG GTGACACTTCCTGGTAGGAGAAGT TCCCAAACGTCTAT TGGGAGA (SEQ ID GGAGAGGTTGAT CAACCTCTCCACTTNO: 1502) AGA (SEQ ID NO: CTCCTACACCTGCA 1503) CAGTTAATAAGCCGTTC (SEQ ID NO: 1501) PHF16 NM_014735.3 GTAGCCTTTGTCCC TTGCTTTTCCTCCTCTCCCAATGGC TTCATGCCTTTCAA CACTCAGAATTG ATTACATATGGA TTCTGAGTGGGAGGAAAGGCATGAAG ATTTGGCTGAAG AAAAGCAAACATC GGACAAAGGCTA CACTGTTTTGATAAAACAGTGCTTCA C (SEQ ID NO: GT (SEQ ID NO: GCCAAATTCCATAT 1505) 1506)GTAATGCCATTGGG AGA (SEQ ID NO: 1504) PHF23 NM_024297.2 CTGTCTGTGTCCCGTGATGGTGGCAG TTATAGACAACT ACACATAATCTCTG GTCCAAGAGACA GTCCCATTCCATTCTCTTGGACCTGC GAGATTATGTGTC CCCAATTCCAAT CACCATCACTTTCT GGGACACAGACACCTGACCCAGAA GGGTCAGGATTGG G (SEQ ID NO: AG (SEQ ID NO: AATTGGGATGGAAT1508) 1509) GGGACAGTTGTCTA TAA (SEQ ID NO: 1507) PIK3CA NM_006218.2CCTCAGGCTTGAAG ACAGTGGCCTTTT GTTCTGAAACAG AGTGTCGAATTATG TGCAGAGGACATTAACTCTGACAT TCCTCTGCAAAAAG AATTCGACACTCT GATGTCTGGGTT GCCACTGTGGTTGATCAAGCCTGAGG CTCCCAATTCAA ATTGGGAGAACCC (SEQ ID NO: 1511) CC (SEQ ID NO:AGACATCATGTCAG 1512) AGTTACTGTTTCAG AAC (SEQ ID NO: 1510) PIK3CDNM_005026.3 TGACACTCATTGAT AGCCCCCTCCGCC TTCCCAGATGAC TCTAAAGCATCTTTTGGCAGATTAAA AGTTGTCCTCTC AATCTGCCAGGCGG GATGCTTTAGAAT TGGAATAGTCCAAGGGGGCTTTGCTG CAATGAGTG (SEQ AGAAAGACCAG GTCTTTCTTGGACT ID NO: 1514)CAA (SEQ ID NO: ATTCCAGAGAGGA 1515) CAACTGTCATCTGG GAA (SEQ ID NO: 1513)PIM1 NM_002648.2 CTTCATCATGAGTT TTTCCCCCCTACC AGAGGTGACAG CTGCTGAATGCCGCTGACCCATCGCG GGACTTAAAATG GATGGGTCAGGTA GCATTCAGCAGA GTGCTAGTCCTAGGGGGGAAACAGG ACTCATGATGAA TCCCATCCCAAC TTGGGATGGGATAG G (SEQ ID NO:CTG (SEQ ID NO: GACTAGCACCATTT 1517) 1518) TAAGTCCCTGTCACCTCT (SEQ ID NO: 1516) PIM2 NM_006875.2 GCCATCCAGCACTG TCCTTGATGTCACAATCAATGAGTT CCATTCCCGTGGAG GATGGACAACTC TGGCACAGCCAC TTGTCCATCGTGACCACGGGAATGGC GGCGTAGGTCTA ATCAAGGATGAGA AGTGCTGGATG TCAGGATGTTCTACATCCTGATAGAC (SEQ ID NO: 1520) CA (SEQ ID NO: CTACGCCGTGGCTG 1521)TGCCAAACTCATTG ATT (SEQ ID NO: 1519) PLAU NM_002658.2 TTCATTGATTACCCGAGCGACCCAGG GGTTTTCCACCT AAAGAAGGAGGAC TAGACGATGTAG CAAACTTCATCTTACATCGTCTACCT TCCTCCTTCTTTG CCCCTTGCGTGT GGGTCGCTCAAGGC GGTAATCAATGATGGAGTTAAGCC TTAACTCCAACACG A (SEQ ID NO: TT (SEQ ID NO: CAAGGGGAGATGA1523) 1524) AGTTTGAGGTGGAA AACC (SEQ ID NO: 1522) PLEK NM_002664.2AAATGATATTGCGT GAGCTGCTGCTA AGATCACTCTGG TCGTGCCTCAGCTT CTTGTGCTTAAAGTTAATCATAGGG TAAGCACAAGTAG CTGAGGCACGAA CCATGATGCCCT CAGCAGCTCCTGCTCGCAATATCATTT CAGAACTCAAGC TGAGTTCTGAGGGC (SEQ ID NO: 1526)AG (SEQ ID NO: ATCATGGCCCTATG 1527) ATTAACCAGAGTGA TCT (SEQ ID NO: 1525)PLEKHF2 NM_024613.2 ATCGTCGCCACCAT GCAGGGCCCACA ATCCGCACAGGCTGCCGCAAATGTGG GACAACAAAACC TTAGAGGACTGG TTTTGTTGTCTGTG ACATTTGCGGCACTGGGAAGAAG GGCCCTGCTCTGAA ATGGTGGCGACG AAATCTCTTTTC AAGAGATTTCTTCTAT (SEQ ID NO: AGA (SEQ ID NO: TCCCAGCCAGTCCT 1529) 1530) CTAAGCCTGTGCGGAT (SEQ ID NO: 1528) PLEKHG4B NM_052909.3 CGGTTTCAGCAGGT GACCTAACTCAACTCTGGGCTCCT CCCATGTAGTTAGC GTGCTGTCCTGCT TACAGGAAATGC AGGACAGCACTTGAACTACATGGGA CATGACAAACAG AGTTAGGTCTGAGA CCTGCTGAAACC GCGTTCTTTCTCAAGAACGCCTGTTT G (SEQ ID NO: A (SEQ ID NO: GTCATGGCATTTCC 1532) 1533)TGTAAGGAGCCCA GAGC (SEQ ID NO: 1531) PLXNB1 NM_001130082.1CCAACAGCTTGCCT CTGCGGGTTTTTT ACAAGGAGCAC CTGAGGTTCTGGAT ATTATATTGATCCCGCATCCATGTT CAATATAATAAAA AGAACCTCAGAG ATCAGATGTTTG AACCCGCAGTTTGTGCAAGCTGTTGG CACGTCGAACAC GTTCGACGTGCAAA (SEQ ID NO: 1535)AAA (SEQ ID NO: CATCTGATAACATG 1536) GATGCGGTGCTCCT TGT (SEQ ID NO:1534) PMCHL1 NM_031887.2 CGGGGGAAAGCCC GTCTACTTTGCGG TCTCTGGAGCCCATCCGTACTACCAG ATCCAGTCTCCTG AGCAGTGGCTTC GAGACTGGATCCGC GTAGTACGGATGATGAGACCAAGT AAAGTAGACACTTG GG (SEQ ID NO: (SEQ ID NO: 1539)GTCTCATGAAGCCA 1538) CTGCTGGGCTCCAG AGAGAAGGGAAAA CTAA (SEQ ID NO: 1537)PMEPA1 NM_020182.3 GCTGAGACAGTCCT CAACGAGACCCA CCCCTTTCTCACCATATCCTCTTGAG AACAGTTTGGCTC GCAAAGCCATTC CCAAACTGTTTGGG AAGAGGATATGACCACAAATCCAG TCTCGTTGCTTCAT GGACTGTCTCAG ACCATACCATGA GGTATGGTCTGGATC (SEQ ID NO: AG (SEQ ID NO: TTGTGGGAATGGCT 1541) 1542) TTGCGTGAGAAAGGGG (SEQ ID NO: 1540) PMP22 NM_000304.2 GTCTAGGCTGTTCT CAATACAAGTCAAGTCTTAGCATC GTGCCTCCAAGGAC TTGCCAGACAGT AGAAGGGCACC TGTCTGGCAATGACCCTTGGAGGCAC ATATATACATCT TTGTATTGGCCACC AGAACAGCCTAG ACAGTTGGTGGCAACTGTAGATGTAT AC (SEQ ID NO: (SEQ ID NO: 1545) ATATGGTGCCCTTC 1544)TGATGCTAAGACTC CA (SEQ ID NO: 1543) PNLIP NM_000936.2 GAAAACAGTTCAACAGAACTTCCTCC CAATTCATTGGT CTTCTGTAGTCCAG CTGACGGTTTCTG CAAATAACAGTAAAACCGTCAGGGA GACTACAGAAGT GTCTCCTAACAC GGAAGTTCTGCTCA TGAACTGTTTTCGGTGTGAGGGTG CCCTCACACCGTGT (SEQ ID NO: 1547) AG (SEQ ID NO:TAGGAGACTACTGT 1548) TATTTGACCAATGA ATTG (SEQ ID NO: 1546) PNPNM_000270.3 CGCTGTTGGCATGA CACAGTGCCGTG ATCCATGATGAC GTACAGTACCAGACAACGATAACTT CTTGTTAGTGAT AGTTATCGTTGCAC CTGGTACTGTACT GAGTGAGAAGCGGCACTGTGGACTT CATGCCAACAGC CAAAGACTCGAA CGAGTCTTTGGCTT G (SEQ ID NO:GTC (SEQ ID NO: CTCACTCATCACTA 1550) 1551) ACAAGGTCATCATGGAT (SEQ ID NO: 1549) POU2AF1 NM_006235.2 CCCTGATGCCAGAG ACAAAGGAGCAATGAGATTTTGCT TCCTTGAGCTGTCA CTGTGGGAACTG GCCTGGACTGTA GTTCCCACAGTTGCACAGCTCAAGGA AATCTGGCCGAG TCCTTTGTTTGCTCT CTCTGGCATCAG GCTGAGAAGAGTCTCAGCCTCGGCC GG (SEQ ID NO: CAA (SEQ ID NO: AGATTTACAGTCCA 1553) 1554)GGCAGCAAAATCTC A (SEQ ID NO: 1552) POU2F1 NM_002697.2 GCTATGGGGAAACTCGAGAGATGGTA GTGGCTTCAACT ATATGGAAATGACT GTTTGGCTGAAGT TGCACATGTTCTTCAGCCAAACTACC CATTTCCATATAG TAAAGCTGAGGT ATCTCTCGATTTGA TTTCCCCATAGCTCAAGGCTTCAA AGCCTTGAACCTCA (SEQ ID NO: 1556) AT (SEQ ID NO:GCTTTAAGAACATG 1557) TGCAAGTTGAAGCC AC (SEQ ID NO: 1555) POU2F2NM_002698.2 ATGGGGCCTGGCAC GAGATGCTTACA TAAACATGGACA CTCGTCTACCCAACTTCCGGTGAGGTT AACTCAGAGGTA CTCACCGGAATGTA GGGTAGACGAGG GGGTAAGGGCAAGCATCTCCGCTGA TGCCAGG (SEQ ID GGGAGTCGTTCA ACGACTCCCTGCCC NO: 1559)GCG (SEQ ID NO: TTACCCTACCTCTG 1560) AGTTTGTCCATGTT TA (SEQ ID NO: 1558)PPA1 NM_021129.3 ATACTGGCTGTTGT TCCAATTTCACAC ATGCCTAGAACTGGTGACAATGACCC ACATCAATTGGG TTCACGCCAATT AATTGATGTGTGTG TCATTGTCACCACATTTCACCTCTT AAATTGGAAGCAA AACAGCCAGTAT GCACATACCTTG GGTATGTGCAAGA(SEQ ID NO: 1562) CT (SEQ ID NO: GGTGAAATAATTGG 1563) CGTGAAAGTTCTAGGCAT (SEQ ID NO: 1561) PPP2R3B NM_199326.1 CCCTGACATGCATC CTGCCTCTAGATCAAAACCAGACA TTCGTCTCTCCATC GAAAGCCAGGAT AAGTCGGCATAG CTGGCTTTCGATCTGGAGAGACGAAG CTGATCTTCCCT AGAGGCAGAAAAG ATGCATGTCAGG TCCTTCTGCACTTGCAGAAGGAAGG G (SEQ ID NO: TTT (SEQ ID NO: GAAGATCAGCTATG 1565) 1566)CCGACTTTGTCTGG TTTT (SEQ ID NO: 1564) PPP3CC NM_005605.3 AGCAGAAGGAAGCTGATCTTATTCCT ACTTTCTTGCCG ACTACAGTTCGTAA GATGATCTCCTTA AAGAATTGAAAGGAGATCATCAGG CGAACTGTAGTG AGACCCGTGCCA AATAAGATCAGAG CTTCCTTCTGTCTTCCCAATGG CCATTGGGAAGATG (SEQ ID NO: 1568) CTC (SEQ ID NO:GCACGGGTCTTTTC 1569) AATTCTTCGGCAAG AAAGT (SEQ ID NO: 1567) PPPDE2NM_015704.2 CAAGACCCACTGAT TCTGCTCTAATCT GCCCAATTCTGC TTGCCAGTGTGCATATTATTTCCATGC TAGTAGATCACG GGAAATAATAGATT ACACTGGCAAAT ATTATACAACAGAGAGCAGAAACTA CAGTGGGTCTTG TCCCTGCTAGTT GCAGGGACTGTTGT (SEQ ID NO: 1571)(SEQ ID NO: 1572) ATAATCGTGATCTA CTAGCAGAATTGGG CCC (SEQ ID NO: 1570)PRDM1 NM_182907.1 CATCCCTGCCAACC CTGCAAAGTCCC TGTGAGATTCATAGGAACTTCTTGTG GACAATACCACA CATTGTCAGCTC TGGTATTGTCGGGA CAAGAAGTTCCTTCCGGGATAAGG CTTTGCAGAAAGGC GGTTGGCAGGGA GTAGTGAAGCCT TTCACTACCCTTATTG (SEQ ID NO: TT (SEQ ID NO: CCCGGAGAGCTGA 1574) 1575) CAATGATGAATCTCACA (SEQ ID NO: 1573) PRDM12 NM_021619.2 CCACACTTCCCTCG CGCGCACGGCCCACGGGAATCCTG GTCCCTGCCCGTTT GAATTTGAGGAA GTAAATGACTGC CCTCAAATTCGGGCACGGGCAGGGAC AAAGTGTGAGA CGTGCGCGCCCTCT CGAGGGAAGTG GGCGACACCAGGGTGTCGCCTCTCA (SEQ ID NO: 1577) AGGG (SEQ ID CACTTTGCAGTCAT NO: 1578)TTACCAGGATTCCC GT (SEQ ID NO: 1576) PRDX2 NM_005809.4 GCATGGGGAAGTTTTAATCGTGTCACT AGCCTAATTGTG GTCCCGCTGGCTGG GCCAGGCTTCCA TTTGGAGAAATAAAGCCTGGCAGTG GCCAGCGGGACA TTCCTTGCTGTC ACACGATTAAGCCC AAC (SEQ ID NO:ATCCACGTTGGG AACGTGGATGACA 1580) CT (SEQ ID NO: GCAAGGAATATTTC 1581)TCCAAACACAATTA GGCT (SEQ ID NO: 1579) PRDX4 NM_006406.1 AGGAGGACTTGGGGATGGGTCAAAT CCTGAGTCCTCT CCAATAAGGATTCC CTGAAAGAAGTG AGGTATACACCAACTTCTTTCAGATT GAATCCTTATTGG TAGTCCTTTGAG TGACCCATCAGATC CCCAAGTCCTCCTATCT (SEQ ID NO: TCAAAGGACTATGG (SEQ ID NO: 1583) 1584) TGTATACCTAGAGGACTCAGGCCACACT TTTT (SEQ ID NO: 1582) PRICKLE1 NM_153026.1AGTTTCCTGGCCTC CAATTTTCGAGA AATTCTTCACTG TCAGGCAATGCTGA AAGGGTGTCATCGCAAAACTTGTT TGACACCCTTTCTC AGCATTGCCTGA CCTTGTCTGGAG GAAAATTGGATGATGAGGCCAGGAAA AGACTCAGATCA CTGAGTCTCTCCAG CT (SEQ ID NO: TC (SEQ ID NO:ACAAGGAACAAGT 1586) 1587) TTTGCCAGTGAAGA ATT (SEQ ID NO: 1585) PRKCBNM_212535.1 GCATTTGGAGTCCT TCAAAGGGTGCC CTACGTTGTGTT GCTGTATGAAATGTTGCCCAGCCAAC CCATGATGGATT TGGCTGGGCAGGC ATTTCATACAGCA GGAAGAGTTCATACCCTTTGAAGGGG GGACTCCAAATG CTTCATCCTCCC AGGATGAAGATGA C (SEQ ID NO:CT (SEQ ID NO: ACTCTTCCAATCCA 1589) 1590) TCATGGAACACAACGTAG (SEQ ID NO: 1588) PRMT1 NM_198319.2 ACTGCATCATGGAG GAGGCTCATCCCGCAGACACAGG AATTTTGTAGCCAC ATTAGCCAAGGT GAAGGGCAAAG CTTGGCTAATGGGAGGCTACAAAATT GGGGGTTACTTC TGAGCCTCCAGCCG CTCCATGATGCA TTCAAGAGGCGGCCTCTTGAAGAAGT GT (SEQ ID NO: CTG (SEQ ID NO: AACCCCCCTTTGCC 1592) 1593)CTTCCCTGTGTCTG CC (SEQ ID NO: 1591) PRPSAP2 NM_002767.2 AGACCTCTTGTGCCGTAAGGAAAGTA AGCAATTTAGAG AAGAGCATCATTGG GGGTATCACGCC ACAATGGAGCCTCGTGATACCCTACT AATGATGCTCTTG CTTTTTCTCATCT TTCCTTACAGCAAG GCACAAGAGGTCTGCACTGCTTGC CAGTGCAAGATGA T (SEQ ID NO: T (SEQ ID NO: GAAAAAGAGGCTC1595) 1596) CATTGTCTCTAAAT TGCT (SEQ ID NO: 1594) PRSS1 NM_002769.3GTAATCAACGCCCG GCTGGAGGGGCG TTGCCCCAGCCA CGTGTCCACCATCT GTGGGCAGAGAGGAGATGAGGCA CTCTGCCCACCGCC ATGGTGGACACG CTTCGTGCCAGT CCTCCAGCCACTGGCGG (SEQ ID NO: G (SEQ ID NO: CACGAAGTGCCTCA 1598) 1599) TCTCTGGCTGGGGCAACACTGCGAGCTC TG (SEQ ID NO: 1597) PSMG1 NM_003720.2 AAAATCCAATCCCTCTGCAACATAGC CCTTGGACAAGA CGGTTTTTCTCTGT AACTGCACTGAC GCCAAAAACCTTCAGTGCAGTTGCTA AGAGAAAAACCG TTCCAGCCACTG TGTTGCAGAAGATC AGGGATTGGATTATACTGTTGATC AACAGTATCAGTGG TT (SEQ ID NO: TT (SEQ ID NO: CTGGAAAAGGTTTT1601) 1602) TGGCTCTTGTCCAA GG (SEQ ID NO: 1600) PTEN NM_000314.3TGTGGTCTGCCAGC TGGGTCCTGAATT AGGTAACGGCTG TAAAGGTGAAGAT GGAGGAATATATAGGGAACTCAA ATATTCCTCCAATT CTTCACCTTTAGC AGTACATGAACT CAGGACCCACACGTGGCAGACCACA TGTCTTCCCGTC ACGGGAAGACAAG (SEQ ID NO: 1604)GTG (SEQ ID NO: TTCATGTACTTTGA 1605) GTTCCCTCAGCCGT TACCT (SEQ ID NO:1603) PTENP1 NR_023917.1 ACCACAATGAGAT TTTTTAATAATCA TCAATGTGTGAGGACACTACACATTT TCATTCTGGCAAA GTTCCAGTTTTTT GCCAGAATGATGAT TGTGTAGTGTCATCACATCCTCTCC TATTAAAAAAGACC CTCATTGTGGT AATACTTGGTCT AAGTATTGGAGAG(SEQ ID NO: 1607) (SEQ ID NO: 1608) GATGTGAAAAAAC TGGAACCTCACACATTGAC (SEQ ID NO: 1606) PTGER4 NM_000958.2 CGCGGGCGCCGAG CCAGGGAGGTGGCTGGTTGACGAA ATCCAGATGGTCAT CAATGAGTAAGA TACTCGCACCAC CTTACTCATTGCCATGACCATCTGGAT GAGCGGGATGG CCTCCCTGGTGGTG CTCGG (SEQ ID AGCAGATGAGCCTCATCTGCTCCAT NO: 1610) ACCA (SEQ ID CCCGCTCGTGGTGC NO: 1611)GAGTATTCGTCAAC CAG (SEQ ID NO: 1609) PTGIR NM_000960.3 CTGACATTTCAAGCCTGTCGCCCGAA CGCAGCCATCAG TGACCCTGTGATCT GACAGGGCAGAG CCATGTCCCTGACTGCCCTGTCTTCG ATCACAGGGTCA TTTTCTGGCTC GGCGACAGGAGCC GCTTGAAATG(SEQ ID NO: 1614) AGAAAATCAGGGA (SEQ ID NO: 1613) CATGGCTGATGGCTGCGGATGCTGGAA CCTTG (SEQ ID NO: 1612) PTK2 NM_005607.3 GGTTCAAGCTGGATCCTTCTTCTGGGC AGTCAGCAAGAT TATTTCAGTGGAAC CGATTGCCAGTTC GTGTGGGATTGCTGGCAATCGGCCCA CACTGAAATAAT AGCCCTTGTCCG GAAGAAGGAATCA CCAGCTTGAACCTTAGGTAACTGA GTTACCTAACGGAC (SEQ ID NO: 1616) TT (SEQ ID NO:AAGGGCTGCAATCC 1617) CACACATCTTGCTG ACT (SEQ ID NO: 1615) PTPN1NM_002827.2 AGTGACTTCCCATG TTTCGGTTTTTGT GATGTAGTTTAA TAGAGTGGCCAAGTCTTAGGAAGCTT TCCGACTATGGT CTTCCTAAGAACAA GGCCACTCTACAT CAAAGGGACTGAAACCGAAATAGG GGGAAGT (SEQ ID ACGTCTCTGTAC TACAGAGACGTCA NO: 1619)CTA (SEQ ID NO: GTCCCTTTGACCAT 1620) AGTCGGATTAAACT ACATC (SEQ ID NO:1618) PTPN21 NM_007039.3 ATTGGAGCGTGTCT TGCCTTCCATTCT ACTTGTTGTGGGTGAAGGTATCTTTG TGTGTTTCACAAA ACATGTTGGCAA TGAAACACAAGAA GATACCTTCAAGTGTCATGCCACC TGGAAGGCATCCTG ACACGCTCCAAT TAAATACCACAG TGGTATTTAGGTGG(SEQ ID NO: 1622) GA (SEQ ID NO: CATGACATTGCCAA 1623) CATGTCCCACAACAAGT (SEQ ID NO: 1621) PTPRB NM_002837.3 CTTGTAAATACCGC CGGCCTGGTGTTACTGACTGCTGTA AACCGAGTATCGAT GGGAAGTAAATC CATCCCCGCTAA TTACTTCCCTAACAGATACTCGGTTGC TCGTCAAGACAA CCAGGCCGCCAATA GGTATTTACAAG GAATTTTGTATTCAAAATTCTTGTCT (SEQ ID NO: 1625) GG (SEQ ID NO: TGACGATTAGCGGG 1626)GATGTACAGCAGTC AG (SEQ ID NO: 1624) PTRH1 NM_001002913.1 CCCGGCGCACCCTGGGGAGAAGCAGC ATCCAGCAACAG AGGCGGTTCAGGCC CCAGCACATGGG AGGCAGCAGCTCCATGTGCTGGGCTG CCTGAACCGCC CTGCTCAGCAG CTTCTCCCCTGCTG (SEQ ID NO: 1628)(SEQ ID NO: 1629) AGCAGGAGCTGCT GCCTCTGTTGCTGG ATCGAGCCACCGACCTG (SEQ ID NO: 1627) PVRL1 NM_002855.4 GTTAAGCGGGGCCT AATGTAAAACCACGCGTCAGAGCT TGGGCAGTGTTTTC CCCTCAGCAGGA AGGCCAACTCCA CTGCTGAGGGTGGTAAACACTGCCCA CTCTCTGTGGGC TTTACATTTTTTTTC AGGCCCCGCTTA CAATGAGGAAACTCATTGGCCCACA AC (SEQ ID NO: AAA (SEQ ID NO: GAGAGTGGAGTTG 1631) 1632)GCCTAGCTCTGACG CG (SEQ ID NO: 1630) PXDN NM_012293.1 GCGACTGTTGACAGCTGTCAAACAAA CCCTCGGATACC AGCTATAAACTCAA TGTGTTCGGGTTG GGAACAAGGCCCCCGAACACATTTG AGTTTATAGCTCT AGCAAATCATTT TTTGACAGCCGTCC GTCAACAGTCGCGGAGAACGAGG TCGTTCTCCAAATG (SEQ ID NO: 1634) ACGG (SEQ ID ATTTGCTGGCCTTGNO: 1635) TTCCGGTATCCGAG GG (SEQ ID NO: 1633) QSOX1 NM_002826.4TAGGGCAGCTCAGT GCTGAAAAACAG AAGCAGGAGAG CCCTGGCCTCTTAG GAATGTGGTGCTACTGAGGCTCCA CACCACATTCCTGT AAGAGGCCAGGG GTGAGAATGAG TTTTCAGCTTATTTACTGAGCTGCCCT GCAGGACTTCAA GAAGTCCTGCCTCA A (SEQ ID NO: ATAA (SEQ IDTTCTCACTGGAGCC 1637) NO: 1638) TCAGTCTCTCCTGC TT (SEQ ID NO: 1636)R3HDM1 NM_015361.2 CCTGTGTTCCCAAG CCTCGTCTTGGAG ATCTTTATTAACAGAATTACATTATT TCTTTTGTCAATA TCTAAATATCTG GACAAAAGACTCC ATGTAATTCTCTTGCGCCTCTGCTG AAGACGAGGATGC GGGAACACAGG GGTACTACTGGC CAGTAGTACCCAGC(SEQ ID NO: 1640) AT (SEQ ID NO: AGAGGCGCCAGAT 1641) ATTTAGAGTTAATAAAGAT (SEQ ID NO: 1639) RAB20 NM_017817.1 AGACCGGCTACAAT CACCAGGTCAAAGACGGCCTCTCA GTGGACCTCCTGTT GAGGGTCTCAAA GCTCTCTGCTGT TGAGACCCTCTTTGCAGGAGGTCCAC AAGATCATTGGC ACCTGGTGGTGCCA ATTGTAGCCGG AC (SEQ ID NO:ATGATCTTACAGCA (SEQ ID NO: 1643) 1644) GAGAGCTGAGAGG CCGTCACACACAGTGGA (SEQ ID NO: 1642) RAB31 NM_006868.3 TTTTGTAAAGAGCT CTTGTATGTGCAACTACAGAATAGA TCCATCTGGGCTGG GAACTGGGTCCA ATACATGGCGGA ACCCAGTTCTTGCAGCCCAGATGGAA AAGGTCCTAGCT CATACAAGACACC GCTCT1TACAAAA GACTGCAGCGGTGCTGCAGTCAGCTA (SEQ ID NO: 1646) GT (SEQ ID NO: GGACCTTTCCGCCA 1647)TGTATTCTATTCTG TAG (SEQ ID NO: 1645) RAB33A NM_004794.2 GGGAGAAGACCGTCCACACCTGAAC TAGTAATGCTCG GGAAATCGAGGGC CTTGATCTTCTCG ACCATGCTTTTGGAGAAGATCAAGG CCCTCGATTTCCA CGGAAACGTTCC TTCAGGTGTGGGAC CG (SEQ ID NO:TGACCTGCTGTG ACAGCAGGTCAGG 1649) TC (SEQ ID NO: AACGTTTCCGCAAA 1650)AGCATGGTCGAGC ATTACTA (SEQ ID NO: 1648) RAB3A NM_002866.4 CGCCACAGACTCGCCGAAGTTCTGATC CGTCTTGCCCAC GCTATGGGCAGAA CGAGGACTCCTTC GCTGCTGTTGCCGGAGTCCTCGGATC TGCCCATAGCGC GATGATGAGAAT AGAACTTCGACTAC GA (SEQ ID NO:CTTGAACATGTA ATGTTCAAGATTCT 1652) GT (SEQ ID NO: CATCATCGGCAACA 1653)GCAGCGTGGGCAA GACG (SEQ ID NO: 1651) RAB7L1 NM_001135664.1CATTTGAATTGTCT AGTGACAATGGG CTAATCCAGGAG CCTGACTACTGTCC CCTCCTTACTGGAATGCAGAAATGC AGTAAGGAGGCCC CAGTAGTCAGGA ACATGGGTTCCA ATTGTCACTTAGAAGACAATTCAAAT GGTGTCTTTTCT AAGACACCTGGAA G (SEQ ID NO: A (SEQ ID NO:CCCATGTGCATTTC 1655) 1656) TGCATCTCCTGGAT TAGC (SEQ ID NO: 1654) RANBP9NM_005493.2 TTGAAGGATGCATT GGGCTGTTCCAG TGAGCACACAGG CAGTCTACTAGCATGGATCTGAATAT TTCTCTCTGAAT ATTCAGATCCCTGG GCTAGTAGACTG CGGGTCAAGCTGAACAGCCCAGTTGG AATGCATCCTTCA ATTTCCAACT AAATCAGCTTGACC A (SEQ ID NO:(SEQ ID NO: 1659) CGATTCAGAGAGA 1658) ACCTGTGTGCTCAG CTC (SEQ ID NO:1657) RAPGEF5 NM_012294.3 GCATTTTGCGTACC CTGTCATTCCATA TGCTAAGTGCTTTCATACAGGCTCCT GTGTGGGCAAGG CACTCATTAAAT TGCCCACACTATGG AGCCTGTATGAGGTCACTTAACCT AATGACAGCAGCC GTACGCAAAATG CCCTGCACTGGC AGTGCAGGGAGGTC (SEQ ID NO: TG (SEQ ID NO: TAAGTGACATTTAA 1661) 1662) TGAGTGAAGCACTTAGCA (SEQ ID NO: 1660) RARRES2 NM_002889.3 GAAACCCGAGTGC CCAGGCATTTCCGCAACCGGCCCAG AAAGTCAGGCCCA TTTCCTCCCATTG AACTTTGTCCTC ATGGGAGGAAACGGGCCTGACTTTGC AGAGCCCAGTTT GAAATGCCTGGCCT ACTCGGGTTTC GATGCAGG (SEQGCATCAAACTGGGC (SEQ ID NO: 1664) ID NO: 1665) TCTGAGGACAAAGTTCTGGGCCGGTTGG TCCAC (SEQ ID NO: 1663) RASGRP3 NM_015376.2GCTGACTTGCATGA GAGACATTTTCA TTCCCAAGGCCA TTATGGAGATGGTC GCATCAGATAGACTTGATCCCATG TATCTGATGCTGAA CCATCTCCATAAT GTTATTTAGCCG AATGTCTCTAGTTTCATGCAAGTCAG TTGTCAAAAAAC TTTGACAACGGCTA C (SEQ ID NO: TA (SEQ ID NO:AATAACCATGGGAT 1667) 1668) CAAGTGGCCTTGGG AA (SEQ ID NO: 1666) RASSF4NM_032023.3 TGAAGGAAGACTG CTTGCTGTCACTG TAGCAGTTGTAG TCTGCCGAGTTCTCATGGGCACGTGA GTTTTCAGCAGG ACGTGCCCATCAGT GAACTCGGCAGA CCTAAGAGCTCCGACAGCAAGTCCAT CAGTCTT (SEQ ID GACTTCTGAATG TCAGAAGTCGGAG NO: 1670)GA (SEQ ID NO: CTCTTAGGCCTGCT 1671) GAAAACCTACAACT GCTA (SEQ ID NO:1669) RC3H2 NM_018835.2 AGATCCAATAATTC CACCCCATTTTGA CTGGACAGGATCCCTTTAGTGATGGA GATGATGGGTCC TGTGGTATGGTA CCCATCATCTCAAA ATCACTAAAGGGACCTGTACGGGA ATGGGGTGCGATTT AATTATTGGATCT AGATCTGGAAAT CCAGATCTTCCCGT(SEQ ID NO: 1673) CG (SEQ ID NO: ACAGGTTACCATAC 1674) CACAGATCCTGTCCAG (SEQ ID NO: 1672) RCL1 NM_005772.3 TGGTGAATCATTTG CTCCGGGAGGCAGGGCTTCAAGAC AACTGAAGATTGTG TTCCCCGTCGCAC CTTCCTCACAGG CGACGGGGAATGCAATCTTCAGTTCA ACATGAGAAAA CTCCCGGAGGAGG AATGATTCACCA CCACTTCGCCTCAGGCGAAGTGGTTT (SEQ ID NO: 1676) CTC (SEQ ID NO: TCTCATGTCCTGTG 1677)AGGAAGGTCTTGA AGCCC (SEQ ID NO: 1675) REL NM_002908.2 TGGCCTCCGGTGCGCCTGGGTTGTTCA CTGCCTGCTGAT TATAACCCGTATAT ATTATCTCTATAT CGCCCTTCACATAGAGATAATTGAA ACGGGTTATACG TTGTATCTAAAA CAACCCAGGCAGA CACCGGAGGCCACGCATTCCCCTC GGGGAATGCGTTTT (SEQ ID NO: 1679) TG (SEQ ID NO:AGATACAAATGTG 1680) AAGGGCGATCAGC AGGCAG (SEQ ID NO: 1678) RETNLBNM_032579.2 TGACCTGACAGGG TACTGTCATGGTC ATGAAGTGGGAC AGGAGGCTGAGAAACAAAACTGAGT GTTTGAGTTAGA CTCAGTTTTGTGAC TCTCAGCCTCCTC TTTCTTGGTTGGCATGACAGTAATGA CC (SEQ ID NO: GACCCTGGTTTC AACCAGGGTCCCA 1682)AT (SEQ ID NO: ACCAAGAAATCTA 1683) ACTCAAACGTCCCA CTTCAT (SEQ ID NO:1681) RFTN1 NM_015150.1 AGAGCCATCCTGAT TGAAGATCAGTTT GGTGGTCTAAGGCAAGAAAACCGAC TCTGAGATCTGTC AGGAACAGCAA AGATCTCAGAAAA GGTTTTCTTGATCTCTAATTCCAAG CTGATCTTCACAAT AGGATGGCTCT ATGTAGCCTTCA GAAGGCTACATCTT(SEQ ID NO: 1685) TTG (SEQ ID NO: GGAATTAGATTGCT 1686) GTTCCTCCTTAGACCACC (SEQ ID NO: 1684) RGL1 NM_015149.3 AGCCATGTGAATTC CCGCAAATCTCTAAAAGACCAAAG CACAAGAAGCACC AACTTTCCCTGGT GAAATTGGAGG AGGGAAAGTTTAGGCTTCTTGTGGAA ACTTCCTGGCCC AGATTTGCGGCAAT TTCACATGGCT GTTCTTCGGTCCGGACCGAAGAACG (SEQ ID NO: 1688) ATTG (SEQ ID NO: GGCCAGGAAGTCCT 1689)CCAATTTCCTTTGG TCTTT (SEQ ID NO: 1687) RGS9 NM_003835.1 GGATCACCGATGACTTCCACCAATTTG AATTCGCTGAAG ACCCAGTTCTGGGA GCATTTAAGTCCC TTGAAGGCCCATCTTAAATGCCAAAT AGAACTGGGTGT CGTTCCACTCGC TGGTGGAAATCCCA CATCGGTGATCCATCTTGGTTGGG ACCAAGATGCGAG (SEQ ID NO: 1691) AT (SEQ ID NO:TGGAACGATGGGC 1692) CTTCAACTTCAGCG AATT (SEQ ID NO: 1690) RHCENM_020485.4 GACAACTTCCTCTC CATGAGCGTTTCT TCAAATCTGTCT ACTGTTGCCTGCATCACGTACAAATG CTGACCTTGTTT TTGTACGTGAGAAA CAGGCAACAGTG CATTATACATAACGCTCATGACAGCA AGAGGAAGTTGT GGAGACTTTGCT AAGTCTCCTTATGT C (SEQ ID NO:GT (SEQ ID NO: ATAATGAAACAAG 1694) 1695) GTCAGAGACAGATT TGA (SEQ ID NO:1693) RHEBL1 NM_144593.1 GAAGACATCTTTGG AGCCTTCCGAGA TTTGCCAAGAGTCACATCAATTTGTG ACTCGCCTTCCAC CACTATCTTGCT GAAGGCGAGTTCTC AAATTGATGTGCGTAAGTATTCTC GGAAGGCTACGAT CAAAGATGTCTTC CACTGTAGGATC CCTACAGTGGAGA(SEQ ID NO: 1697) GT (SEQ ID NO: ATACTTACAGCAAG 1698) ATAGTGACTCTTGGCAAA (SEQ ID NO: 1696) RHOF NM_019034.2 CTGCGGCAAGACCT CGGGGAAGGAGCTGGCCGTGTACT CGCTGCTCATGGTG CCTGGCTGTACAC TCTCGAACACCG TACAGCCAGGGCTCCATGAGCAGCGA ATGGGGCGTAGT CTTCCCCGAGCACT G (SEQ ID NO: GCT (SEQ ID NO:ACGCCCCATCGGTG 1700) 1701) TTCGAGAAGTACAC GGCCAGCGTGACC GTT (SEQ ID NO:1699) RHOXF1 NM_139282.1 CGCCAATGAACTAC CCACGACGATGT AACCCATCTCCAGTGCTGACCCAGAC AGACACAGTCGT AACTAGCTCCTG GACTGTGTCTACAT CTGGGTCAGCACAAGAAGGATGG CGTCGTGGACTAGC GTAGTTCAT (SEQ CATTCTAGGGCT CCTAGAATGCCATCID NO: 1703) AGT (SEQ ID NO: CTTCTTCAGGAGCT 1704) AGTTTGGAGATGGGTT (SEQ ID NO: 1702) RNASEH2B NM_001142279.1 CAGTTCCCGGGTAC TGGAAGCTTGGTGTCAGATATCAG AGTCAACTGCATTT CACCAGAGAAAA ACCATGGGCATA TTCTCTGGTGACCAATGCAGTTGACT ACGAATATAATC AGCTTCCACTGACA GTACCCGGGAAC CTCTTCCTTGTCAGGAAGAGGATTA TG (SEQ ID NO: AG (SEQ ID NO: TATTCGTTATGCCC 1706) 1707)ATGGTCTGATATCT GAC (SEQ ID NO: 1705) RNF214 NM_207343.2 AAGCTTGGATTTCCCTCCTTCAACCCC AGAAAGCTTCAG GACCTGTAGTGTCT ATTTGCTGGAGA GGAAGAGCTATCCCAGCAAATGGGG CACTACAGGTCG TTGATCATCATC TTGAAGGAGTCCGA GAAATCCAAGCTCTGATCCACTCG GTGGATCAGGATG T (SEQ ID NO: GA (SEQ ID NO: ATGATCAAGATAGC1709) 1710) TCTTCCCTGAAGCT TTCT (SEQ ID NO: 1708) RNGTT NM_003800.3CCTTTTTGGTG GAG AGTAGCAACTGC TCCTTCAAATAA AAAATGGATTGGA TGCTTCGATACTCTCACCCTTGTAG GTATCGAAGCAGC CAATCCATTTTCT ATTCCTGGTGGT AGTTGCTACTTTTGCCACCAAAAAGG CTGGCTTGGGCA CCCAAGCCAGACC (SEQ ID NO: 1712) AA (SEQ ID NO:ACCAGGAATCTACA 1713) AGGGTGATTATTTG AAGGA (SEQ ID NO: 1711) ROB01NM_002941.2 TGAACCACAAAAA AATGAACAAGTT GTTCCCTTAGTA AAAAGGCTGGTGTTTGGTTTTGGTGAA CTGCACGCCTTT CACCAAAACCAAA CACCAGCCTTTTT TCTATGGAACTTCTTGTTCATTTAGA TTTTGTGGTTCA TTTCAAATTATC TAATTTGAAAAAGT(SEQ ID NO: 1715) TA (SEQ ID NO: TCCATAGAAAAGG 1716) CGTGCAGTACTAAGGGAAC (SEQ ID NO: 1714) ROBO4 NM_019055.5 CCTGACTCTCAGAT GGCATACGACAGCAGGGACACGGT CTCTTCCCAGAGAA TGGAGCTGACTTC TCAGGAGTAATC GTCAGCTCCACTGTTCTGGGAAGAGA TACAGGAGAAG CGTATGCCCAAGGC TCTGAGAG (SEQ CACCAGCCTTGTGGTGCTTCTCCTG ID NO: 1718) (SEQ ID NO: 1719) TAGATTACTCCTGAACCGTGTCCCTGAG AC (SEQ ID NO: 1717) RPN2 NM_001135771.1 AGATGCCACTTTGATGACCACATCAG AAGGTTCTGGGA AGAACCCAATCCTC CCACATTCCAGA CAAGACAGTCGATGGAATGTGGCTGA GGATTGGGTTCTT GGGAGCTTCTTC TGTGGTCATCAAGT CAAAGTGGCATCCTCAGGGAACTT TCCCTGAGGAAGA T (SEQ ID NO: GA (SEQ ID NO: AGCTCCCTCGACTG1721) 1722) TCTTGTCCCAGAAC CTT (SEQ ID NO: 1720) RPS6KA5 NM_004755.2GTGGAACTATTGAA TGAATCTCCCCCT TCATACATTAGA TACATGGCACCAGA CTGACAATATCTGACACCCAAACTC TATTGTCAGAGGGG GTGCCATGTATTC CACCAGTCAACT GAGATTCAGGACATAATAGTTCCAC GCCTTGTCATGT GACAAGGCAGTTG (SEQ ID NO: 1724) ACTGGTGGAGTTTG1725) GGTGTTCTAATGTA TGA (SEQ ID NO: 1723) RRP1B NM_015056.2CAACAGGAAGCGC CAGAAAGGTCTT ATCAGCAGAAAT CTCTCCAAACTCAT GGAATTTCTTGATGTCCTCCGCAAA CAAGAAATTCCAA GAGTTTGGAGAG ACTGAGTTGAGA GACCTTTCTGAAGGGCGCTTCCTGTTG TATACTGCTTCC AAGCAGTATATCTC (SEQ ID NO: 1727)TT (SEQ ID NO: AACTCAGTTTTGCG 1728) GAGGACATTTCTGC TGAT (SEQ ID NO:1726) RSAD2 NM_080657.4 AG GAAG CTG GTAT AAGAAATGGCTC TCTACTTTGCAGGGAGAAGATCAAC TCCACCTGAAAA AACCTCACCAAC TTTTCAGGTGGAGA GTTGATCTTCTCCTTGCCCAGGTAT GCCATTTCTTCAAG ATACCAGCTTCCT TCTCCCCGGTCT ACCGGGGAGAATA(SEQ ID NO: 1730) TG (SEQ ID NO: CCTGGGCAAGTTGG 1731) TGAGGTTCTGCAAAGTAGA (SEQ ID NO: 1729) RTCD1 NM_001130841.1 AGCGTGGCTGTGTG AACACCAGCAACATGCATCTAACT ACTAAGATATATGG GAAAGCTCTTCC GCTGCCGCTGCC AAGAGCTTTCGTTGATATATCTTAGTC ATATCTTTTGCT CTGGTGTTTTGCCA ACACAGCCACGC ACTTTAAATGGCTTTAAAGTAGCAAA T (SEQ ID NO: AA (SEQ ID NO: AGATATGGCAGCG 1733) 1734)GCAGCAGTTAGATG CAT (SEQ ID NO: 1732) RUNDC2B XM_001714307.1CCTGCGTGCCCGGG CCTCGCCACTATA TGCTGTGTCCTG CCTGTCCCTCCTGA ATCCTGGGGTCAGCTCAATCCGCT CCCCAGGATTATAG GGAGGGACAGGC TGGCTAACACCC TGGCGAGGCAGGG(SEQ ID NO: 1736) TG (SEQ ID NO: TGTTAGCCAAGCGG 1737) ATTGAGCCAGGACACAGCACCGCGGA GCCCT (SEQ ID NO: 1735) RXRA NM_002957.4 TACAAATGTAATTTCCTCCCCCCGCCA GACGAAGCTTTC TATCCCTCATGTAT TATCCAAGTATAC ACCTCAATCTCTACTTGGATATGGCG ATGAGGGATAAA AGAAGCAGAAA GGGGGAGGGCTGG ATTACATTTGTACGAAACAGTCCC GACTGTTTCGTTTC (SEQ ID NO: 1739) AGC (SEQ ID NO:TGCTTCTAGAGATT 1740) GAGGTGAAAGCTTC GTC (SEQ ID NO: 1738) S100ZNM_130772.3 GGGGTCTGCCTGGA CAAGCCAAAGGC ACCTAATTTATG ATAGCACTGAATGTACTACTAAACAC AGCATGGGAAG GTTTAGTAGTGCCT ATTCAGTGCTATT GGCTCAAGCAGCTTGGCTTGGGGGCT CCAGGCAGACCC TTTCTCCAAAGC TTGGAGAAAGCTGC C (SEQ ID NO:CCC (SEQ ID NO: TTGAGCCCTTCCCA 1742) 1743) TGCTCATAAATTAGGT (SEQ ID NO: 1741) S1PR2 NM_004230.2 TCCCGCCAGGTGGC ACAATGGCGCAAGGAACTTGCTGT CTCGGCCTTCATCG CAGAGGATGACG TTCGGGCCACCG TCATCCTCTUFTGCATGAAGGCCGAG CAATGAGCACCA GCCATTGTGGTGGA GCCACCTGG (SEQ GAAGGTTTTCCAAAACCTTCTGGTGC ID NO: 1745) CC (SEQ ID NO: TCATTGCGGTGGCC 1746)CGAAACAGCAAGT TCC (SEQ ID NO: 1744) SAA1 NM_199161.1 AGCTTCTTTTCGTTCACATGTCCCGA ATTTGTCTGAGC CCTTGGCGAGGCTT GCCCCATCAAAA CGATGTAATTGGTTGATGGGGCTCGG GCCTCGCCAAGG CTTCTCTCATGT GACATGTGGAGAG AACGAAAAGAAGCAGAGTAGGCTC CCTACTCTGACATG CT (SEQ ID NO: TC (SEQ ID NO: AGAGAAGCCAATT1748) 1749) ACATCGGCTCAGAC AAAT (SEQ ID NO: 1747) SACS NM_014363.4TTGAGTCTTTTAGG ACTTTTCAGAAA TTTCTCTGTTCCG GCAGATGCAGACA GAGCAGCACTGTTCAGCCTCTCGG CAGTGCTGCTCTTT GTCTGCATCTGCC ACATATAAGGAA CTGAAAAGTGTGCACTAAAAGACTCA ACATCCTGCAC GGATGTTTCCTTAT A (SEQ ID NO: (SEQ ID NO: 1752)ATGTCCGAGAGGCT 1751) GACGGAACAGAGA AACT (SEQ ID NO: 1750) SAE1NM_005500.2 CTACCAGTTGCCTT AGGAGGAATCTC AACTCTTGCTGC TTCAGACCTGAGGCTTGAGTTAGAGC ATCACCCAGAAA TCTAACTCAAGAGA CTCAGGTCTGAA AAATGGTGGCAGTTCCTCCTCTCCCTC AAGGCAACTGGT GAATGGTGAGG ACCATTCCTGCCAC AG (SEQ ID NO:GAG (SEQ ID NO: CATTTTTTCTGGGT 1754) 1755) GATGCAGCAAGAGTT (SEQ ID NO: 1753) SAMSN1 NM_022136.3 ATTCAGGACCATTC TGGCGTGAAATCTCTATGATGTCT TGTGGCCGTGCCAG CGTATGCACTCTG CCTTTCTTGATTT AGTGCATACGGATTGCACGGCCACAG TGAGGGAGTCAG TCACGCCAAGTCCC AATGGTCCTGAA TGTCATAGGGACTATGACACTGACTC T (SEQ ID NO: T (SEQ ID NO: CCTCAAAATCAAGA 1757) 1758)AAGGAGACATCAT AGA (SEQ ID NO: 1756) SAP30 NM_003864.3 ACAAGTAAATACATGGTTGGTAGCTT AAAGTGGCAACC CTTAGGAGATACAA GAAGTGTCTTTTG AACTATCTCAACAAGACACTTCAAGC TATCTCCTAAGTG AAGTTGTGCTTT TACCAACCAGACCA TATTTACTTGTATTAAGTCCTGG GGACTTAATAAAGC (SEQ ID NO: 1760) TC (SEQ ID NO:ACAACTTGTTGAGA 1761) TAGTTGGTTGCCAC TTT (SEQ ID NO: 1759) SCARA5NM_173833.4 CAGCCTTACCTCCA TTGCAGTCTAGGT AGACAATAAGTT GGTAGCACTTAATTGAATGGACCAAT CAGGTGGGCACA GGTCCATTCACCTA TAAGTGCTACCTG CGGTCTCAGTCAGACTGCAAGTAAG GAGGTAAGGCTG TTTTGTCTTCTTA AAGACAAAATGAC (SEQ ID NO: 1763)C (SEQ ID NO: TGAGACCGTGTGCC 1764) CACCTGAACTTATT GTCT (SEQ ID NO: 1762)SDC1 NM_002997.4 TGAAATTCTCCTGG TCAGCCTTATAAA TTTGCCATTTAGAGGTCGGTAGGTTC ACCTTGGCTGAA AAGATGGGGCTT AGCCAAGGTTTTAT CCTACCGACCTCCGGAGCTTGGCAA AAGGCTGATGTCAA AGGAGAATTTCA CACAGAAATTGA TTTCTGTGTTGCCA(SEQ ID NO: 1766) CA (SEQ ID NO: AGCTCCAAGCCCCA 1767) TCTTCTAAATGGCAAA (SEQ ID NO: 1765) SDCCAG8 NM_006642.2 CCGGAAACATGCA CACCCCAGAATCTTGCCAAAATCT CAATTCTTGGATTA TTCACCTGTTGTA GCATTGTCATGG CAACAGGTGAAGAATCCAAGAATTG GAAAATGGTCTT TTCTGGGGTGGGCG TGCATGTTTCCGG TTGGAGGTTTCGAAACCTCCAAAAG (SEQ ID NO: 1769) CC (SEQ ID NO: ACCATTTTCCCATG 1770)ACAATGCAGATTTT GGCAA (SEQ ID NO: 1768) SEL1L3 NM_015187.3 TACTCCATTATTGCGTCAACAAAGTA TAGCCCTCTTCC AAGGCCAACCTCTG CAGAATCCCACA GTAAGAAATACATGGGATTCTGTACT GAGGTTGGCCTT GAAGGTGTGCCG TTGTTGACTCTAAT GCAATAATGGAGTACATCTCATTA GAGATGTACGGCA TA (SEQ ID NO: GA (SEQ ID NO: CACCTTCTGTATTT1772) 1773) CTTACGGAAGAGG GCTA (SEQ ID NO: 1771) SEMA7A NM_001146029.1CCCACAGTTCATCA CATCGTAAGCCT TCAGGATTCTTG AAGCCACCATCGTG GGTCTTGGTGCACTCAGGATTGTCC CACCAAGACCAGG GATGGTGGCTTTG TCTCGGAAGAAG CTTACGATGACAAGATGAACTG (SEQ TAGTAGATCTTG ATCTACTACTTCTT ID NO: 1775) T (SEQ ID NO:CCGAGAGGACAAT 1776) CCTGACAAGAATCC TGAG (SEQ ID NO: 1774) SEPHS1NM_001195602.1 TGCCCATCTTCGTG GCACCAGAAATG TTGGCAAGAAGT AGAGAAAAAGCAGGGCAGGATGTGC CAGTTTACATGT CACATCCTGCCCAT TGCTTTTTCTCTC GCAGCTTTGGTGTTCTGGTGCTTTCT ACGAAGATGG CCTGTGAGCAGA GCTCACAGGCACCA (SEQ ID NO: 1778)AA (SEQ ID NO: AAGCTGCACATGTA 1779) AACTGACTTCTTGC CAA (SEQ ID NO: 1777)SERBP1 NM_001018068.1 CCAAAGGGCGCTG CAAAAATTAAAA AGTGCTGCTGTTGTTGGTAGGGTGAG TACTCCCCCACCT CCAACCTTACAA GTGGGGGAGTATTT CACCCTACCAACAGTAAAGCTGTC TAATTTTTGGAATT CAGCGCCCTTTGG TGCTTCCCAAAT TGGGAAGCAGACA(SEQ ID NO: 1781) TC (SEQ ID NO: GCTTTACTTTGTAA 1782) GGTTGGAACAGCAGCACT (SEQ ID NO: 1780) SERPINA9 NM_001042518.1 CCACTAAATCCTAGTAGCAATGTGCC ATGCACCCTCAG GTGGGAAATGGCCT ATCAGTTAACAG AACAGAAAGAGGTTAACTGATGGCA GCCATTTCCCACC GGATGTGGTTTG CATTGCTAATGCAC TAGGATTTAGTTATTTCTTGTGC AAGAAATAACAAA (SEQ ID NO: 1784) AT (SEQ ID NO:CCACATCCCTCTTT 1785) CTGTTCTGAGGGTG CAT (SEQ ID NO: 1783) SERPINB1NM_030666.2 TTACACTCTCAACT TAAAGAGATCCT AAAAATATCTCT CCGACCTCGCCCGCGCACACCTAGGC GGCTCCTGACAT CTAGGTGTGCAGGA GGGCGAGGTCGG GCCAGACAGATCTCTCTTTAACAGTA AGTTGAG (SEQ ID AGCCTTGCTACT GCAAGGCTGATCTG NO: 1787)GT (SEQ ID NO: TCTGGCATGTCAGG 1788) AGCCAGAGATATTT TT (SEQ ID NO: 1786)SFN NM_006142.3 TGGGCCTGGCCCTG GCTGTTGGCGATC TCGAAAGTGGTC AACTTTTCCGTCTTTCGTAGTGGAAG TTGGCCAGAGAG CCACTACGAGATCG ACGGAAAAGTTC ATGGCCTCCTCGCCAACAGCCCCGA AGGGCCAGGC GG (SEQ ID NO: GGAGGCCATCTCTC (SEQ ID NO: 1790)1791) TGGCCAAGACCACT TTCGACGAGGCCAT GGC (SEQ ID NO: 1789) SFPQNM_005066.2 GGAGGTGGTGGTG GCTGGTGGAACG CAAAGCGCTCAG GCATAGGTTATGAACCAGGATTAGCTT TACGCATGTCAC GCTAATCCTGGCGT CATAACCTATGCC TTCCCATCATGGTCCACCAGCAACCA ACCACC (SEQ ID AACCACTCATGG TGAGTGGTTCCATG NO: 1793)TT (SEQ ID NO: ATGGGAAGTGACA 1794) TGCGTACTGAGCGC TTTG (SEQ ID NO: 1792)SGK1 NM_005627.2 GTGTGAACCGTCGT ACAAAATCCATC AACAATGTCCCA GTGAGTGTGGTATGTGTGATCAGGCA CGTTGTAGTGTC CCTGATCACAGATG TACCACACTCAC CTGCAAGTGTCAGATTTTGTTATAAG ACGACGGTTCAC CATTGATGCTTA CATCAATGTGACAC AC (SEQ ID NO:TA (SEQ ID NO: TTGCAGGACACTAC 1796) 1797) AACGTGGGACATTGTT (SEQ ID NO: 1795) SGOL2 NM_152524.5 AGACCTCCATAGAT TATTCTTTCCATTTCCTTATCAGCT CCTTCTCCAGAGAG ACTTCATGGCTCT TGTTCAGATACA CCATGAAGTAATGGCTGGAGAAGGAT GTAGACTTTCCC AAAGAATACTTGAC CTATGGAGGT TGAACGCTGTCAAGCGTTCAGGGAA (SEQ ID NO: 1799) AG (SEQ ID NO: AGTCTACTGTATCT 1800)GAACAAGCTGATA AGGA (SEQ ID NO: 1798) SH2D1A NM_002351.4  GCTGTATCACGGTTCTGTTTCTGTCTG CCGGAAATATCT ACATTTATACATAC GGACACTCGGTA TTTATGTACCCCCGAGTGTCCCAGAC TGTATAAATGTA AGGTGCTGTCTC AGAAACAGGTTCTT ACCGTGATACAGAGCACTCCAAGA GGAGTGCTGAGAC C (SEQ ID NO: AC (SEQ ID NO: AGCACCTGGGGTAC1802) 1803) ATAAAAGATATTTC CGG (SEQ ID NO: 1801) SH3BP5 NM_001018009.2AGCTCTTGGGCTGG ACAGTCTACCCA TTCCACAATGCC TTTTTCAGAGCAGA CAACAAGAACTCGTTATACGGAAT GTTCTTGTTGTGGG TGCTCTGAAAAA GTTCCACAAAGG TAGACTGTGACTAGCCAGCCCAAGAG CTGTGAACCTAG GTTCACAGCCTTTG CT (SEQ ID NO: TC (SEQ ID NO:TGGAACATTCCGTA 1805) 1806) TAACGGCATTGTGG AA (SEQ ID NO: 1804) SIDT1M4017699.2 GGTCATCATGGTCA ATACGTCATTTTT GGCTAGCGAGGC CCGTCCTTGGAGTGTCCAAACACCAC CAGAACGTGGAT GTGTTTGGAAAAAA TCCAAGGACGGT TGCAGAGAAGATTGACGTATGGTTCT GACCATGATGAC GACCCAGAACC GGGTCATCTTCTCT C (SEQ ID NO:(SEQ ID NO: 1809) GCAATCCACGTTCT 1808) GGCCTCGCTAGCCCTC (SEQ ID NO: 1807) SIRPA NM_080792.2 CCAGGGCAAGCAG GTTATAGTGAAGGCATCCCAAGGC ATGTCGCAAGCCCT ACTGAATAAATA CAGGAGTCATGA ATTTATTCAGTCTTGGGCTTGCGACA ACATTAGCGTCT CACTATAACTCTTA TCTGCTTGCCCTG CAACTCTAAGAGAGTTGAGACGCTA G (SEQ ID NO: (SEQ ID NO: 1812) ATGTTCATGACTCC 1811)TGGCCTTGGGATGC CCA (SEQ ID NO: 1810) SIRPB1 NM_006065.2 ACAATTGGTTTTCACTCTGAGGTTTCC GACAGGGAGGG GGGCCCAGTCCAA AGCAGCAGGCTT GTGGTGGAGGTGGCCTGCTGCTGGAA GGACTGGGCCCT AGAGGTGTGGA ACCTCAGAGTTAAA GAAAACCAATTGGAATAGGGATTT TCCCTATTCTCCAC T (SEQ ID NO: AA (SEQ ID NO: ACCTCTCACCTCCA1814) 1815) CCACCCCTCCCTGT CCC (SEQ ID NO: 1813) SLA NM_001045556.2GTGTGATTTCTGAT AGTGCTAAGAGA CCATGGTAAACT GAAGGGGGCTGGT AATAGCTTTCCACCTGGCCACACAT GGAAAGCTATTTCT CAGCCCCCTTCAT ATTCCAGGGATG CTTAGCACTGGTCGCAGAAATCACAC TAACTCTCTCGA AGAGAGTTACATCC (SEQ ID NO: 1817)CC (SEQ ID NO: CTGGAATATGTGTG 1818) GCCAGAGTTTACCA TGG (SEQ ID NO: 1816)SLAMF1 NM_003037.2 GTGTCTCTTGATCC CGATCTCCTAGAT TCCTGCTTTCCCATCCGAAGCAGGC AACGTGGAGGGC GTATCCCCAGGG CCTCCACGTTATCT CTGCTTCGGATGGTGAGATTCTCCA AGGAGATCGCTAC ATCAAGAGACAC GATAAAACTTGT AAGTTTTATCTGGA(SEQ ID NO: 1820) AG (SEQ ID NO: GAATCTCACCCTGG 1821) GGATACGGGAAAGCAGGA (SEQ ID NO: 1819) SLC12A8 NM_024628.5 GAACAACACGCTG AGACAGTGAAAACATGTTGAAGCC CCCGATTACAGCCC AAGATTCCCCCG GGCCATGACTCC GGGGGAATCTTTTTGGCTGTAATCGG TGTAGCCGCTGG TCACTGTCTTTGGG GCAGCGTGTTGTT GAAGAAAACCCGTTTTCTTCCCAGC C (SEQ ID NO: CAA (SEQ ID NO: GGCTACAGGAGTC 1823) 1824)ATGGCCGGCTTCAA CATG (SEQ ID NO: 1822) SLC16A9 NM_194298.2 TTACCTCACTGAAGACAGTTGCTCAGT TTCTCCATTTGG TACTCGCATGTTGT GGGTACCAAACA AGTTCACCCACATTGGTACCCACTGA ACATGCGAGTAC TCTCAGCAAATA GCAACTGTTTCAGT TTCAGTGAGGTACCTTAGGAACTG TCCTAAGGTATTTG A (SEQ ID NO: AA (SEQ ID NO: CTGAGATGTGGGTG1826) 1827) AACTCCAAATGGA GAA (SEQ ID NO: 1825) SLC1A4 NM_003038.4TTTTTCCAATTACC ATCTTCCCCTTCA CCTGTTACATCA TGCTGACACGGTTC CTTAGCTTAGAACCGAATATGCATC TAAGCTAAGTGAA CGTGTCAGCAGG AACAGCCACAA GGGGAAGATCTGATAATTGGAAAAA ACAGCACGCTCT GAGCGTGCTGTTTG (SEQ ID NO: 1829)CAG (SEQ ID NO: TGGCTGTTGATGCA 1830) TATTCGTGATGTAA CAGG (SEQ ID NO:1828) SLC31A1 NM_001859.3 TTGACATCAAACTC ACAACTTCCCACT GAGGAGCAAGATATGGCGTGGCCTT GCAATCGATAAG AGGGATGATTGG ATCGATTGCAGTGG GCCACGCCATAGAGCAGGAATCAC GAAGTTGTTGAAGA AGTTTGATGTCAA GTCTTCAAGTCT CTTGAAGACGTGAT(SEQ ID NO: 1832) TCA (SEQ ID NO: TCCTGCTCCAATCA 1833) TCCCTTCTTGCTCCTC (SEQ ID NO: 1831) SLC35E2B NM_001110781.1 CGGTGACTTTCAGC CCAGATGGACAACCAACGGCCGAC GTCGCCAGCACCGT GGCATGTTTCACG AAGCTGGTGATC GAAACATGCCTTGTGTGCTGGCGACG TTGTTGCCGAAA CCATCTGGCTCAGC CTGAAAGTCACC ACGATTACGCTGGTAATCGTTTTCGG G (SEQ ID NO: AG (SEQ ID NO: CAACAAGATCACC 1835) 1836)AGCTTGTCGGCCGT TGG (SEQ ID NO: 1834) SLC38A5 NM_033518.2 ACGACATGTGGCCACAAGGACATTGA GGTGGACCCGAT TAGCTCTGATCCTG CCAAAACAAGCA AACTCCAAAGATCTTGTTTTGGTCAA GGATCAGAGCTA ATCCCGGATGGT TGTCCTTGTCATCT TGGCCACATGTCTGGCACACAGAT GTGTGCCAACCATC GT (SEQ ID NO: GA (SEQ ID NO: CGGGATATCTTTGG1838) 1839) AGTTATCGGGTCCA CC (SEQ ID NO: 1837) SMAD1 NM_005900.2CCTTGCATGTACTT GTCAGTTCTCAAT TCTGAATCCAAC GAAGGATGGATGA CGTGTCTGACTCAAGTTGGTCACAG GTCAGACACGATTG TCCATCCTTCAAG AGGTCAAGTATT AGAACTGACAAAGTACATG (SEQ ID ATCAAGGCTCCT GAGCCTTGATAATA NO: 1841) TT (SEQ ID NO:CTTGACCTCTGTGA 1842) CCAACTGTTGGATT CAGA (SEQ ID NO: 1840) SMAD7NM_005904.2 AGCAGAAATCCAA ATGACCGCCCCC CACACACAGCCG GCACCACCAAACACTTCATACACTGT CACACTCACACT CAGTGTATGAAGG GTTTGGTGGTGCT CACACACACTCCGGGGCGGTCATCAT TGGATTTCTG TGACAAGTGAAA TTCACTTGTCAGGA (SEQ ID NO: 1844)TG (SEQ ID NO: GTGTGTGTGAGTGT 1845) GAGTGTGCGGCTGT GTGTG (SEQ ID NO:1843) SMARCA4 NM_003072.3 GCCCTGTCCTGGCA CTTTAAGACAGTT AAGAAAAACAGTCAGTAGCATCTGT AATGCTGTTACA GTATCGTGTGTT AACAGCATTAACTG GATGCTACTGATCCCCAATTCGGA TCTTAAAGAGAGA GCCAGGACAGGG ATTCTCTCTCTCT GAGAGAGAATTCCC (SEQ ID NO: CT (SEQ ID NO: GAATTGGGGAACA 1847) 1848) CACGATACCTGTTTTTCTT (SEQ ID NO: 1846) SNAP23 NM_003825.2 GTTGAGGGAAGGA GAAGGTTTTTACTCAACTAGATCTT CAAGAGATAAGAG GAGGTAACAACC CGTTGTGGCTAT GTTGTTACCTCAGTTCTTATCTCTTGT GCAACTTTTTGC AAAAACCTTCAGGC CCTTCCCTCAAC TTTGTGGCCTCACAAAGCAAAAA (SEQ ID NO: 1850) (SEQ ID NO: 1851) GTTGCATAGCCACAACGAAGATCTAGTT GGATA (SEQ ID NO: 1849) SNN NM_003498.4 GGCAGGGGTCTCTCCTCACTTCCTTGA CAAGCACCCCAA ATGTGTGTCCATCT CATACACGCAGA CTGGTCAGCCTCGCGTGTATGTCAAG TGGACACACATG AAGACCCCAAAT GAAGTGAGATGCC AGAGACCCCTGCTGGCAT (SEQ ID AATTTGGGGTCTTG C (SEQ ID NO: NO: 1854) AGGCTGACCAGTTG1853) GGGTGCTTGGGTGA TCT (SEQ ID NO: 1852) SNX11 NM_152244.1TGGGAGGAGATCA AACTGTTTCTAAC CGCATCTTCTCT TGCTGTGCCTTTGG TGACCAGGGTCCGACCATCTCAGA ACCCTGGTCAGTTA AAAGGCACAGCA GCAGAACCCAG GAAACAGTTTTGGATGATCTCCTCC AGCTCACTTTTC AAAGTGAGCTCTGG (SEQ ID NO: 1856)CAA (SEQ ID NO: GTTCTGCTCTGAGA 1857) TGGTCAGAGAAGA TGCG (SEQ ID NO:1855) SNX22 NM_024798.2 AGGACTTAATTACC GAGCCTTGAGTG AAGAGCATACACAGTGCCCAGTTGT GGAATGTGGCAC AATTCTACCACC GCCACATTCCCACT AACTGGGCACTGTCCAGCTACCAA CAAGGCTCAGAACT GGTAATTAAGT TGCGAGCCAAGT TGGCTCGCATTGGT(SEQ ID NO: 1859) TCT (SEQ ID NO: AGCTGGAGGTGGT 1860) AGAATTTGTATGCTCTT (SEQ ID NO: 1858) SNX29 NM_001080530.2 ACTGCATTTTCCAC TGAGCTGTGACACATCACTAATGG CAACAGTCATTAGA GTGCCAGGTGTCT CTCCTTGCCAAA CACCTGGCACTGTCAATGACTGTTGGT GCCACAGGAATA ACAGCTCACTTTTC GGAAAATGCAGT TCCCTCTGGAAACAGAGGGATATTCC (SEQ ID NO: 1862) AG (SEQ ID NO: TGTGGCTTTGGCAA 1863)GGAGCCATTAGTGA TG (SEQ ID NO: 1861) SOCS1 NM_003745.1 TTAACTGTATCTGGATGAAGAGGTAG GACCCTCCCCCA AGCCAGGACCTGA GAGGTGCGAGTT ACCCCTGGTTTGACTCGCACCTCCTA CAGGTCCTGGC TGCAAAGATACT CCTCTTCATGTTTA (SEQ ID NO: 1865)GGGTATATGTAA CATATACCCAGTAT AC (SEQ ID NO: CTTTGCACAAACCA 1866)GGGGTTGGGGGAG GGTC (SEQ ID NO: 1864) SOCS2 NM_003877.3 GGAACGGCACTGTTTGCTGACGTGTA GCACCGGTACAT CACCTTTATCTGAC GAGCGGTTTGGT TTGTTAATGGTGCAAACCGCTCTACA CAGATAAAGGTG AGCCTACAGAGA CGTCAGCACCATCT AACAGTGCCGTTTGCTGCAGAGAT CTGCAGCATCTCTG CC (SEQ ID NO: GG (SEQ ID NO: TAGGCTCACCATTA1868) 1869) ACAAATGTACCGGT GC (SEQ ID NO: 1867) SOCS3 NM_003955.3GGAGGATGGAGGA TTCTCTACCAGGA ACATAGTCAGGA GACGGGACATCTTT GCCTGAGGTGAAGGCACAGAGTA CACCTCAGGCTCCT AGATGTCCCGTC GAATCCCCTGTC GGTAGAGAAGACA(SEQ ID NO: 1871) (SEQ ID NO: 1872) GGGGATTCTACTCT GTGCCTCCTGACTATGTCTGGCTAAGAG ATTC (SEQ ID NO: 1870) SORBS1 NM_001034956.1CCTCTCTTAGATCC GCAGGGAATGGG TTCATFTTCCTGT TGAGTGAGACAAA TCATTTCTGTATTGTCAGTCTCCCC TACAGAAATGACCC TGTCTCACTCAGG AATCACCTCTGA ATTCCCTGCCCACCATCTAAGAGAGG GTTTCTGGTGG AGAAACTCAGAGG (SEQ ID NO: 1874)(SEQ ID NO: 1875) TGATTGGGGAGACT GACACAGGAAAAT GAACT (SEQ ID NO: 1873)SOX11 NM_003108.3 CTAAGCATTGACAG CCACCCGCCACC TATAATAAACAGAATATCTTAAAATG CCCAGGTTACCAT CAGGATCCCCAC GTAACCTGGGGGTG TTTAAGATATTCTTGGCTAGGCTGC GCGGGTGGGTGCTG GTCAATGCTTAG CGTGCACACAGC TGTGCACGGCAGCC(SEQ ID NO: 1877) AC (SEQ ID NO: TAGCCAGTGGGGAT 1878) CCTGCTGTTTATTATA (SEQ ID NO: 1876) SOX5 NM_152989.2 TAGCCATGCAATGA CACTTCCATCAGATACCACGCCCTC TGGATTTCAATCTG ATCTCCACTCAGA GGGATTCCCTAT AGTGGAGATTCTGATTGAAATCCATCA AAATTCTTGACT TGGAAGTGCTGGA TTGCATGGCTA CTGAGACTCCAGGTCTCAGAGTCAAG (SEQ ID NO: 1880) (SEQ ID NO: 1881) AATTTATAGGGAATCCCGAGGGCGTGGT AGC (SEQ ID NO: 1879) SPAG5 NM_006461.3 AACAAGACATGATGTTTGTCTCTGCC TCCTCTCTCACC ATTTGAGGCCCGTT ATGGTATCTAAA AGATCGTCTGTTTAGATACCATGGCA CGGGCCTCAAAT CTCAAAGGTCCA GAGACAAACAGCA ATCATGTCTTGTTTTTAAAGATATG TATCTTTAAATGGA (SEQ ID NO: 1883) CT (SEQ ID NO:CCTTTGAGAACAGA 1884) CGATCTGGTGAGAG AGGA (SEQ ID NO: 1882) SPARCNM_003118.2 TTTTCGAGACCTGT CTCATCCAGGGC CGATATCCTTCT GACCTGGACAATGGATGTACTTGTCA GCTTGATGCCGA ACAAGTACATCGCC TTGTCCAGGTCAC AGCAGCCGGCCCCTGGATGAGTGGGC AGGTCTCGAAAA A (SEQ ID NO: CGGCTGCTTCGGCA(SEQ ID NO: 1886) 1887) TCAAGCAGAAGGA TATCGACAAGGATC TTGT (SEQ ID NO:1885) SPARCL1 NM_004684.4 TTGACCAACACCCT AGGAGCAAGTTC TCAAAGAAACGATGGATAGAGTCTT AGAATGTGTCAA GGTTATGCAGTG GACACATTCTGAAC GACTCTATCCATATTCCATGGGCAC TTGCTCCTCTGCGA GGGTGTTGGTCA CAGAGATGCTCG GCATCTCTGGTGCCA (SEQ ID NO: CAG (SEQ ID NO: CATGGAACACTGCA 1889) 1890) TAACCCGTTTCTTTGA (SEQ ID NO: 1888) SPATA6 NM_019073.2 GTCCAAACCAAATG CATGGTAACCTGGTAGAAAATTCC TCTGGACACCATGA GCGGTTTGAATC AGCCTTGGAGCA TTCAAACCGCCAGGATGGTGTCCAGA TTTCCTCGAAGG TTACCATGAGGAGG CATTTGGTTTGGA CCAGAAATCCTCATTTCTGGCCTTCG C (SEQ ID NO: CT (SEQ ID NO: AGGAAATGCTCCA 1892) 1893)AGGCTGGAATTTTC TAC (SEQ ID NO: 1891) SPATS1 NM_145026.3 CCACTTGAGCCTCTTCCTTCACCCAGA TCAAGCTCCTCA TCCACAAATTCCCA AAGGCAAGTTGG ACCTCTTGTATCACTTGCCTTTCTGG GAATTTGTGGAA TCATTTTTCAAA GTGAAGGAGAAGG GAGGCTCAAGTGCTGTTGGCCTTC CCAACAGTTTGAAA G (SEQ ID NO: (SEQ ID NO: 1896)AATGAGATACAAG 1895) AGGTTGAGGAGCTT GACA (SEQ ID NO: 1894) SPIBNM_003121.3 CTTTGTCATGTACA GTCCTGTCACCCA AAGAACTGCTAC GACTCCCTGGGATCAAACATGAGGAT CCTGCCTCCCCG CTCATGTTTTGGGT CCCAGGGAGTCT AGTATAGTGGTCGACAGGACCTATG GTACATGACAAA CATAG (SEQ ID GACCACTATACTCG G (SEQ ID NO:NO: 1899) GGGAGGCAGGGTA 1898) GCAGTTCTTCCAGA ATCC (SEQ ID NO: 1897)SPINK2 NM_021114.2 CCTGGCAGTCACCT AAAACAGACCAA GGGACATCCTGGTCGCAGCCTCTCTG ATTGAGGGATCA TAATCTATACTG ATCCCTCAATTTGG GAGAGGCTGCGAAGAGCAGTTTGG TCTGTTTTCAAAAT AGGTGACTGCCA CGTTCTATATTTT ATAGAACGCCAAAGG (SEQ ID NO: G (SEQ ID NO: CTGCTCTCAGTATA 1901) 1902) GATTACCAGGATGTCCC (SEQ ID NO: 1900) SPINT2 NM_021102.2 CAGATGCCGGGCCT ATCCGTCAGTGAGTAATTATTGCT CCATGCCTAGGTGG CATTGTACCACCA GTTTCCGTCACA TGGTACAATGTCACCCTAGGCATGGA GCCCCCATACAC TGACGGATCCTGCC GGC (SEQ ID NO: AAACAGCTGGCAAGCTGTTTGTGTAT 1904) GG (SEQ ID NO: GGGGGCTGTGACG 1905) GAAACAGCAATAATTAC (SEQ ID NO: 1903) SPON1 NM_0061082 GATTCCACATTTGA GCACAG CAGTCTTCTCGGACCAAT TGGGGTGACTGACA AAGATGGGTTTG TCCCATAAAATG AACCCATCTTAGACTCAGTCACCCCAT TGAGTCTGTACT TGCTGTGCCTGCGG CAAATGTGGAAT TGGCAGTTCCGCAACTGCCAAGTACA C (SEQ ID NO: AG (SEQ ID NO: GACTCACATTTTAT 1907) 1908)GGGAATTGGTCCGA GA (SEQ ID NO: 1906) SPRED2 NM_181784.2 TGTCGCTAGCAAGCTCATCATTCTCAC ACCTCCTATACA ATCTGGTTCAGCGG ATCCCATTTCCGC TAATAACTGACTAAATGGGATGTGA TGAACCAGATGC GCAGGCTGAGAT GAATGATGAAACC TTGCTAGCGACAACTTCTGTCGGG CGACAGAAGTATCT (SEQ ID NO: 1910) TT (SEQ ID NO:CAGCCTGCAGTCAG 1911) TTATTATGTATAGG AGGT (SEQ ID NO: 1909) SPRY1NM_005841.1 GGATGACTTGAAG TGAACTTGTGCTG CTGGGAGCAGTG GGTTCCTTGAAAGATGTCAGGTCCTCT CATTCTCCACAC GGACCTGACACAG TTCAAGGAACCC TTGCACTTCCCACACAAGTTCATTTG TTCAAGTCATCC CACTGTTCACAA TGAACAGTGTGGG (SEQ ID NO: 1913)A (SEQ ID NO: AAGTGCAAGTGTG 1914) GAGAATGCACTGCT CCCAGG (SEQ IDNO: 1912) SRPK1 NM_003137.3 GGGCCTTTTTGAGG CCTCTTCCTGCGA CAGGGATCAGCTTTCTAGTGGAGAAG CCACTCATACTTC CCAACATGGGCA TATGAGTGGTCGCA TCCACTAGAACCTGTAAGAAATCTG GGAAGAGGCAGCT CAAAAAGGCCC TGAAGCCAGCTG GGCTTCACAGATTT(SEQ ID NO: 1916) (SEQ ID NO: 1917) CTTACTGCCCATGT TGGAGCTGATCCCTGAG (SEQ ID NO: 1915) SRPX NM_006307.2 GTATGGTGCTAGTG GGAGACATAGCGCTCAAGGGAAA GATAAGCATGGCAT CTCTTTGTCCATG AGTGTCAATCAG GGACAAAGAGCGCCCATGCTTATCCA GTTGAACAGGGC TATGTCTCCCTGGT CTAG (SEQ ID NO: CACAGGCATCACGATGCCTGTGGCCC 1919) CAG (SEQ ID NO: TGTTCAACCTGATT 1920) GACACTTTTCCCTTGAG (SEQ ID NO: 1918) SRSF1 NM_006924.4 GAGAGGGCTCACT TTTGAATCCAATGCGCTCCATGAAT GGATCCCAATCCTT ATCCAGCTCCAA CCTGGTAATTCA GGAGCTGGATCATTGGATTGGGATCC TCCTCCCTATCC GGATTCAAATCATA AGTGAGCCCTCTC TATCCACATTATATGTGGATAGGATA (SEQ ID NO: 1922) GA (SEQ ID NO: GGGAGGATGAATT 1923)ACCAGGATTCATGG AGCG (SEQ ID NO: 1921) SSBP2 NM_012446.2 GGATCCAACTCGACTCTGCATTGGCCC TGGTCCTAAGGG AACAAGGACATCC ACCCATATTTGGA CACCATTCCTCTAAATATGGGTGGG TGTCCTTGTTGTC TGGAGGAGTCAT CCAATGCAGAGAA GAGTTGGATCCTC (SEQ ID NO: TGACTCCTCCAAGA (SEQ ID NO: 1925) 1926) GGAATGGTGCCCTTAGGACCACAGAAC TATGGA (SEQ ID NO: 1924) SSPN NM_005086.4 TCTCCTCTAAACCAGAAGAGGAGGAG TTCCCCGTCTTTC CGAAAGAGTAAGA GGTTGCACAAAT CAAAGTCTTGATTTTGTGCAACCCTC CTTACTCTTTCGT TCATTTAATTCT CTCCTCTTCCACCT GGTTTAGAGGAGCCTGAAGGAGGT CCTTCAGGAGAATT A (SEQ ID NO: G (SEQ ID NO: AAATGAATCAAGA1928) 1929) CTTTGGAAAGACGG GGAA (SEQ ID NO: 1927) STAG3 NM_012447.2AGGGACTCAAACC TCAGCTAACAAA CTCTTCTTCACA ATACCTCAGAGGG GAGTCGCCATTCCTTGCGATTCAAG GAATGGCGACTCTT CCTCTGAGGTATG CTGTCTTCAAAG TGTTAGCTGATGAAGTTTGAG (SEQ ID TCAGTGTCTTCA GACACTGACTTTGA NO: 1931) (SEQ ID NO: 1932)AGACAGCTTGAATC GCAATGTGAAGAA GAGAG (SEQ ID NO: 1930) STAMBPL1NM_020799.2 ATGCTGGCATGCTT TGGATGAAAGCC TTTACCAACACA GAGGTTTCTGCTTGCTTTTTTTTACAA TGTTTGCATATA TAAAAAAAAGGGC GCAGAAACCTCA CTGAACAGCCTGTTTCATCCACACAC AGCATGCCAGCA GGCTCCTTGGTG CAAGGAGCCCAGG T (SEQ ID NO:TG (SEQ ID NO: CTGTTCAGTATATG 1934) 1935) CAAACATGTGTTGGTAAA (SEQ ID NO: 1933) STAP1 NM_012108.2 GAACCCTTCTTTGG TTCTACTGTCACTGTGCTTGATTCT GAAATATGATCCTG ACCAGGCCTCAG TGGAATGTCTAT AGGCCTGGTAGTGAGATCATATTTCCC CTCCTGCCGAAT CAGTAGAAACTACT AAAGAAGGGTTC AGTGATGGAGTACCATCACTATTCGG (SEQ ID NO: 1937) GT (SEQ ID NO: CAGGAGATAGACA 1938)TTCCAAGAATCAAG CAC (SEQ ID NO: 1936) STAT1 NM_007315.2 TTTGCTGTATGCCACAGAGTGCGAAC AGCAGCTACGCA TCCTCGAGAGCTGT GTTAACCTAGAC CAGCACGTTAGGCTAGGTTAACGTTC AGCTCTCGAGGA TGCCAAGACTGT GCACTCTGTGTATA TGGCATACAGCACGAGGTTATATA TAACCTCGACAGTC AA (SEQ ID NO: CA (SEQ ID NO: TTGGCACCTAACGT1940) 1941) GCTGTGCGTAGCTG CT (SEQ ID NO: 1939) STAT3 NM_139276.2AGACTTGGGCTTAC ACCCTCGCCCTAG TGCTACCTAAGG CATTGGGTTTAAAT GTCCCTATGATTTCCATGAACTTGA CATAGGGACCTAG AAACCCAATGGT CAATATCTGCTC GGCGAGGGTTCAGAAGCCCAAG (SEQ CAGAGAAGCCCT GGCTTCTCTGGAGC ID NO: 1943) GA (SEQ ID NO:AGATATTGTCAAGT 1944) TCATGGCCTTAGGT AGCA (SEQ ID NO: 1942) STEAP1NM_012449.2 GATGCCTGGATTGA AGAGACACATAA GAATAGATGTCA GCATGATGTTTGGAATCTCCATTCTCC CAGCCAACAGA GAATGGAGATTTAT AAACATCATGCT GCCAGTATTGCCGTGTCTCTGGGAAT CAATCCAGGCAT AATCCCACAATT TGTGGGATTGGCAA C (SEQ ID NO:CCC (SEQ ID NO: TACTGGCTCTGTTG 1946) 1947) GCTGTGACATCTATTC (SEQ ID NO: 1945) STK17A NM_004760.1 CTTTCAGGATGGAA ACCTTCTTGGAGGTCCTCGGTTTCT AAGGCACTAGAAG GCATTTGCTTCTT GATTTGTCGGTA AAGCAAATGCCCTCCTAGTGCCTTTTC TCCGAATTAATT CAAGAAGGTCATTC CATCCTGAAAG TCAGGCACAGAATGTGCCTGAAATTA (SEQ ID NO: 1949) TG (SEQ ID NO: ATTCGGATACCGAC 1950)AAATCAGAAACCG AGGA (SEQ ID NO: 1948) STK38L NM_015000.1 CCAGACTTGGCTTGTCCTCTTCCTATA TAGATATGGCCT GATGACTTTGAGTC ACTTTCAGAGACT GTATCTTTCTTCTTCTGAAAGTTATAG CAAAGTCATCCA GGACCAACCGCA GAAGAGGAGCTTTT AGCCAAGTCTGGCCTCTCCAAAAG GGAGAGGTGCGGT (SEQ ID NO: 1952) C (SEQ ID NO: TGGTCCAGAAGAA1953) AGATACAGGCCAT ATCTA (SEQ ID NO: 1951) STMN1 NM_203401.1CGTGGGTGGCGGC TGTATTCTGCACA ACCTGGATATCA AGGACTTTCCTTAT ATCAACTGGGATGAAGAAGCCAT CCCAGTTGATTGTG AAGGAAAGTCCT GGTGAATAGAA CAGAATACACTGCCGCCGCCACCCAC GACAAGCGACA TGTCGCTTGTCTTC G (SEQ ID NO: GGCAG (SEQ IDTATTCACCATGGCT 1955) NO: 1956) TCTTCTGATATCCA GGT (SEQ ID NO: 1954) STSNM_000351.4 GACCCAGCTGTAGT TGAAGCAGGCCA CTGCACCAGTGG GAGGTTGCAGTGATATCCTACTCAATC GAGTTTAATAAG TGAGTAGGATTGGC ACTGCAACCTCA CATATTCCCATGCTGCTTCAAAGCAG CTACAGCTGG AGAAACCTCTGC AGGTTTCTCATGGG (SEQ ID NO: 1958)TT (SEQ ID NO: AATATGCTTATTAA 1959) ACTCCCACTGGTGC AG (SEQ ID NO: 1957)STX11 NM_003764.3 TGACACCTTGCACT TTCAGTTCCTTAC TTTATTAGGAGGCTTACCGTCTTGAC TTGGCTTCTGTCA CAGGCCTCAGAC AGAAGCCAAGTAA AGACGGTAAGAGATTCACCCTACA GGAACTGAAGTTGT TGCAAGGTG (SEQ GTCAGATACAAC ATCTGACTGTAGGGID NO: 1961) (SEQ ID NO: 1962) TGAATGTCTGAGGC CTGCCTCCTAATAAAGA (SEQ ID NO: 1960) SUFU NM_016169.2 GGTGCCTCTTCCTG CCTTGGAGCACTAAAAATGCTCTA CCCGTATCTTTCTC GCCCTTGGAAGA GCCCTTTTAGAC TTCCAAGGGCAGTGGAAAGATACGGG TCTCCCCTTGGC CTCCAAGGCAGGG CAGGAAGAGGCA TTCTCCAGTCCCACTGGAGAAGCCA CC (SEQ ID NO: TG (SEQ ID NO: AGGGGAGAGTCTA 1964) 1965)AAAGGGCTAGAGC ATTTTT (SEQ ID NO: 1963) SULF1 NM_015170.2 TCCAGAAATCAGGGGTCCAATGTTGC TGCCCAGGACAG AGACGGAGACATTT AAAACTGACAAA CCAAAACCAGATGTCAGTTTTGCAA ATGTCTCCGTCTC GCACAGCAAGA CATTGGACCAAATA CTGATTTCTGGAATACTTCATTGT CAATGAAGTATTCT (SEQ ID NO: 1967) ATTT (SEQ ID NO:TGCTGTGCTCTGGT 1968) TTTGGCTGTCCTGG GCA (SEQ ID NO: 1966) SUNSNM_080675.3 GATGGAAGCCATGT TCTTCATTATTTT TATAGACTTCAG CCGATGAGCAAAACTGGGCCATTTTT GGCAAAGTCTGG AATGGCCCAGAAA TGCTCATCGGAC CTTTTCGATGTAATAATGAAGATGAT ATGGCTT (SEQ ID ATCTCCGTGTAT ACACGGAGATTAC NO: 1970)CA (SEQ ID NO: ATCGAAAAGCCAG 1971) ACTTTGCCCTGAAG TCTATA (SEQ ID NO:1969) SYCP1 NM_003176.2 GCATTGTTCGTACC TTCACCGCAGAC ATTTGTTGAAACACCGAGATCAAGC ACCTGACTGCTGC TCTTGAAGAAAG AGCAGTCAGGTGTC TTGATCTCGGTGGTGGAATCGCCTC TGCGGTGAAACCTC TACGAACAATG CCAGGGTCTGAG AGACCCTGGGAGG(SEQ ID NO: 1973) GT (SEQ ID NO: CGATTCCACTTTCT 1974) TCAAGAGTTTCAACAAAT (SEQ ID NO: 1972) SYK NM_003177.3 CGGACTCTCCAAAG TCTGGGCCTTGTAGTAGTTGATGCA CACTGCGTGCTGAT GTAGTTTTCATCA TTCCGGAGCGTA GAAAACTACTACAGCACGCAGTGCT CCACTTGACAGG AGGCCCAGACCCAT TTGGAGAGTCCG CCACTTTCCATGGGAAAGTGGCCTGT (SEQ ID NO: 1976) GG (SEQ ID NO: CAAGTGGTACGCTC 1977)CGGAATGCATCAAC TAC (SEQ ID NO: 1975) SYPL1 NM_182715.1 GGTCCTCGAGTGGAAACCTCCACAGG CTCAGTAACTGC TTGCTTCTATCTTTG TGGCAAAAGCAA AGGAGGACAATTCTTTTGCCACCTGT AGATAGAAGCAA CACTTGAATTTC GGAGGTTTTAAGGG TCCACTCGAGGATGTTTGGCCCTT CCAAACAGAAATTC CC (SEQ ID NO: AA (SEQ ID NO: AAGTGAATTGTCCT1979) 1980) CCTGCAGTTACTGA G (SEQ ID NO: 1978) SYT17 NM_016524.2CTGCTCCTGACCGT ATGACACAGTGG CCGCCCTTGACC GGTGGATTTTGATA CGGGAGAACTTAAGGTCAACTTCA AGTTCTCCCGCCAC TCAAAATCCACC CACAAAGGCAC TGTGTCATTGGGAAACGGTCAGGAGC AGAAACTTTCCC AGTTTCTGTGCCTT AG (SEQ ID NO: A (SEQ ID NO:TGTGTGAAGTTGAC 1982) 1983) CTGGTCAAGGGCG GGC (SEQ ID NO: 1981) SYTL4NM_001129896.1 GCCGGAGCTGGGTT GTTTCAAGGGAG CAACAGGTGCCT GCGATCTTCCCGGAGGTCTCCGGCTCC CCAGAGATCGAG GCCGGAGACCCTCC GGGAAGATCGCA AAGTCCCAGTGCCTTGAAACCGGCAC AC (SEQ ID NO: CG (SEQ ID NO: TGGGACTTCTCGAT 1985) 1986)CTCTGGAGGCACCT GTTGCAAGTGACAG AG (SEQ ID NO: 1984) TARS NM_152295.3CCCTCGCCAGGTAA CATATTCATCACA AATGTCTGCCAT TGGTAGTTCCAGTG GGTTGGTCCCACTGAATTTGGCATC GGACCAACCTGTGA GGAACTACCATT GTGGAATTGTTG TGAATATGCCCAAAACCTGGCG (SEQ TCGTACCTTTTG AGGTACGACAACA ID NO: 1988) GG (SEQ ID NO:ATTCCACGATGCCA 1989) AATTCATGGCAGAC ATT (SEQ ID NO: 1987) TAX1BP1NM_006024.4 AAAAAACCACACC AGCATCCGCTCTA CCAAACTCAAAG TAAAATAGACCACTTGGTCTCCTCAGT TAGCTCCTGGTC GAGGAGACCATAG GGTCTATTTTAGG AGAAAGTGCAGTAGCGGATGCTTTCA TGTGGTTTTTT AAAGGGTGCATG TGCACCCTTTACTG (SEQ ID NO: 1991)AA (SEQ ID NO: CACTTTCTGACCAG 1992) GAGCTACTTTGAGT TTGG (SEQ ID NO:1990) TBC1D27 XM_002343481.2 TGAGCTGCATTTTT CTTGCACCAGCTT TACAATTGCACTTGGAGAGGCGGCC TGGGGACAGGGG GCAAGGCACTGG CCTGTCCCCAAAGC CCGCCTCTCCAAACCTGCTACACCC TGGTGCAAGCCCTG AAATGCAG (SEQ AGGG (SEQ ID GGTGTAGCAGGCCID NO: 1994) NO: 1995) AGTGCCTTGCAGTG CAATTGTACCTGAG GACC (SEQ ID NO:1993) TBC1D9 NM_015130.2 ACCAATAAAGACA AGCAAGGAGTGG TGATGAGTCTAAGCACACTGCCTCCC AGGTGAGGAATG AGATGTCTACCT ATTCCTCACCTCCA GGAGGCAGTGTGCAGGGTAAGGTT CTCCTTGCTCAGCG CTGTCTTTATTG CCACATCATCGC ATGATGTGGAACCT(SEQ ID NO: 1997) TG (SEQ ID NO: TACCCTGAGGTAGA 1998) CATCTTTAGACTCATCA (SEQ ID NO: 1996) TCF3 NM_003200.2 ATACGTGTCAACAC GAGGGTCGTTTTAATTGCTACAGTG AGCTGGCTGGATGA AAGTCCCAATCA CTGTTATATACA TTGGGACTTTAAAATCCAGCCAGCTGT GGACAGGTCTCT CGACCCTCTTTCAG GTTGACACGTAT GAATCCACCTGAGTGGATTCAGAGAC (SEQ ID NO: 2000) AA (SEQ ID NO: CTGTCCTGTATATA 2001)ACAGCACTGTAGCA AT (SEQ ID NO: 1999) TCF4 NM_001083962.1 TTAGGGGAAGCTCGCATCAGGACGTTT CCATCTGTTCCT GCTGCCCTAGTAAC GCTGGTYTTGTTA CCTACCCTAAGGAAAACCAGCAAAC CTAGGGCAGCCG AATGGCTAATGT GTCCTGATGACAAC AGCTTCCCCTAACATCACTTCGTT GAAGTGATGACATT (SEQ ID NO: 2003) GT (SEQ ID NO:AGCCATTCCTTAGG 2004) GTAGGAGGAACAG ATGG (SEQ ID NO: 2002) TCTN3NM_015631.5 AGGTATTGTGGGCA TACATGAGCTTGC TGCTGAGAATCC TATGTAGGTCTCCTGGGTTGGACAGG TGTATAGACTGG GTCCAACCCGCAAG AGACCTACATAT CACTGGTATAGGCTCATGTATCAGGA GCCCACAATACC AATCGAACTCCT GTTCGATTCCTATA T (SEQ ID NO:GA (SEQ ID NO: CCAGTGCCAGTCTA 2006) 2007) TACAGGATTCTCAG CA (SEQ ID NO:2005) TEAD1 NM_021961.5 CCAGAAGAGGGCT AGACTGTGCTTTC TCACCTCCCCTCAAGATACGTTTTCT AGCTCAAGACAG TGGCCTCAACTT GTCTTGAGCTGAAA AAAACGTATCTTTCTCATCGACAA GCACAGTCTACTCT AGCCCTCTTCTGG AACGAAGGAGA CCTTCGTTTTGTCG(SEQ ID NO: 2009) GT (SEQ ID NO: ATGAGAAAGTTGA 2010) GGCCAGAGGGGAGGTGAC (SEQ ID NO: 2008) TEK NM_000459.2 CGAGTTCGAGGAG TGTTGACGCATCTTATCTCCCTTGT AGGCAATCAGGAT TCATGGTTCGTAT CCACAGTCATAG ACGAACCATGAAGCCTGATTGCCTCT TTAAAGTAGCTG ATGCGTCAACAAGC CCTCGAACTCG GTAGGAAGGAATTCCTTCCTACCAG (SEQ ID NO: 2012) GCT (SEQ ID NO: CTACTTTAACTATG 2013)ACTGTGGACAAGG GAGATA (SEQ ID NO: 2011) TERT NM_198253.1 GGCTTCAAGGCTGGCGCAAGACCCCA TCTGGAGGCTGT GAGGAACATGCGT AAGAGTTTGCGA TCACCTGCAAATCGCAAACTCTTTGG CGCATGTTCCTCC CCAGAAACAGG GGTCTTGCGGCTGA CAGCCTTGAAGCCTGTGACACTTC AGTGTCACAGCCTG C (SEQ ID NO: AGC (SEQ ID NO: TTTCTGGATTTGCA2015) 2016) GGTGAACAGCCTCC AGA (SEQ ID NO: 2014) TEX9 NM_198524.1ACCTGGACCCGACC CATTTAAACGCTT TATTTCCTTAGC TCCTCGCCTTGGAG ATATTCTTCCTCCTTGTTGAACCAC GAAGAATATAAGC AAGGCGAGGAGG GTCAGCTGTTTT GTTTAAATGCAGAATCGGGTCCAG TGCCTGCAATTC TTGCAGGCAAAAA (SEQ ID NO: 2018) TG (SEQ ID NO:CAGCTGACGTGGTT 2019) CAACAAGCTAAGG AAATA (SEQ ID NO: 2017) TFDP2NM_006286.3 GACCTTCTTGGTTA AACTGATTGGGT TTTACACTTGAC AATCAGGGACTACTAGAGTTCAGAAG TGGGGTAAGGTG TCTGAACTCTACCC TAGTCCCTGATTT GCACCAGTGGTCAATCAGTTTCAAAT AACCAAGAAGGT AGGTCTAAATTT TTAGACCTGACCAC C (SEQ ID NO:GA (SEQ ID NO: TGGTGCCACCTTAC 2021) 2022) CCCAGTCAAGTGTA AA (SEQ ID NO:2020) TFPI2 NM_006528.2  TTTAATCCAAGATA CCACAGCCAGTA CACATGCACGTTCAGAACCTGTGATG TAGGTGAAAGCA TGCAATCCTCCC CTTTCACCTATACT TCACAGGTTCTGTTGCTAACAAAGT GGCTGTGGAGGGA ATCTTGGATTAAA TATTGTCATTCC ATGACAATAACTTT(SEQ ID NO: 2024) CT (SEQ ID NO: GTTAGCAGGGAGG 2025) ATTGCAAACGTGCATGTG (SEQ ID NO: 2023) TGFBR1 NM_004612.2 GGGGAAATACGAC CAGAAAGGATGGAGGGACCAGCA TTAGTGAGGCATAG ACCAGGGATGTC AGCAGGAGAGC ACATCCCTGGTCCATATGCCTCACTAA AGGTTCCAAGAA TCCTTTCTGTCTCC GTCGTATTTCCCC ACAGCTGGAGAAGCTGTTTCTTGGA (SEQ ID NO: 2027) (SEQ ID NO: 2028) ACCTGCTCTCCTGCTTGCTGGTCCCTGA CGC (SEQ ID NO: 2026) THBS2 NM_003247.2 AAACATCCTTGCAATTGCCAAATCCAC CAGCTAAAGCAC ATGGGTGTGACGCG ATCTGGAACCGC CGCACTTTGCTCGTTCCAGATGTGGA GTCACACCCATTT TGCTAACCTTTT TTTGGCAAAACCTC GCAAGGATGTTTACTTAAATGAGG ATTTAAGTAAAAGG (SEQ ID NO: 2030) TT (SEQ ID NO:TTAGCAGAGCAAA 2031) GTGCGGTGCTTTAG CTG (SEQ ID NO: 2029) TH005NM_001002878.1 CCTGGGGATCATGG AACTGATACTGA GACCTAGCTCAA AAAGAAAACTCCGTTGGCTGGATTCG GTACATAGTCGC AATCCAGCCAATCA GAGTTTTCTTTCC TCAAAGTCAGGAGTATCAGTTTGATA ATGATCCCCAGG TGCCAACTTTAT AAGTTGGCATCCTG(SEQ ID NO: 2033) CA (SEQ ID NO: ACTTTGAGCGACTA 2034) TGTACTTGAGCTAGGTC (SEQ ID NO: 2032) THY1 NM_006288.2 CCTGCCTAGTGGAC GGTATTCTCATGGTTCTTTGTCTCAC CAGAGCCTTCGTCT CGGCAGTCCAGA GGGTCAGGCTGA GGACTGCCGCCATGCGAAGGCTCT ACTCGTACTGGA AGAATACCAGCAG (SEQ ID NO: 2036) TGGGTGAACTGCTTCACCCATCCAGT T (SEQ ID NO: ACGAGTTCAGCCTG 2037) ACCCGTGAGACAAAGAA (SEQ ID NO: 2035) TIAM2 NM_001010927.2 TTGCCTGGGGATGA TTGGGAGATGTGTCAAAGAAACCT GAGGGAGAGACAA TAAGACACACGT GCTCCCTCTGGG CGTGTGTCTTACACTGTCTCTCCCTCT AGAACGGATCAC ATCTCCCAACAGCC CATCC (SEQ ID ATCTAAGTCGGCGACTTAGATGTGAT NO: 2039) TG (SEQ ID NO: CCGTTCTCCCAGAG 2040)GGAGCAGGTTTCTT TGA (SEQ ID NO: 2038) TICAM2 NM_021649.4 TATTCCCCACTTGTAAGATGTGTGCA TGCTCCTCATAG ATATCCCCTACCAG GATCCCGGTACT AACGTTTTGGTTTACCGGGATCTGCA GGTAGGGGATAT CATGGCTATGAA CACATCTTTTTGCA ACAAGTGGGGAAGAGGTAACTGCA GTTACCTCTTCATA TA (SEQ ID NO: AA (SEQ ID NO: GCCATGAACCAAA2042) 2043) ACGTTCTATGAGGA GCA (SEQ ID NO: 2041) TJP2 NM_004817.2AGCCAATGATAGCT GCTGATGCTGAA ATCATCCATCCC GGTTTGGCAGCTTA TAGTGTCCTTTAATTCCATCTTTCCT AAGGACACTATTCA GCTGCCAAACCA TCAGAGACCCAA GCATCAGCAAGGAGCTATCATTGGCT ACCGCTTCTCCT GAAGCGGTTTGGGT (SEQ ID NO: 2045)T (SEQ ID NO: CTCTGAAGGAAAG 2046) ATGGAAGGGATGG ATGAT (SEQ ID NO: 2044)TK1 NM_003258.1 GGATGGCCTGGATT AAGGGCTTTGAG TCTTGGTGAAAG CACGCCCTCTTGTTCCCAAAAGGAAA ATGCTGTTGTTC TCCTTTTGGGCTCA CAAGAGGGCGTG CTGTGGAAACCAAAGCCCTTCCTACC AATCCAGGCCAT TCACCAGAGGTA TCTGGTGATGGTTT CC (SEQ ID NO:GG (SEQ ID NO: CCACAGGAACAAC 2048) 2049) AGCATCTTTCACCA AGA (SEQ ID NO:2047) TLE4 NM_007005.3 AAAACAAGGACAG TGTTTTTCAGAGG CCGGAGGTAAACAGAGGAGGGTTT GAGGTCTCTGCA GAAAGCAAGTCC GCAGAGACCTCCCT AACCCTCCTCTGCTCATCCCAGGAG CTGAAAAACACAA TGTCCTTGTTTT AGAGTCCATTCT AGAATGGACTCTCT(SEQ ID NO: 2051) TTG (SEQ ID NO: CCTGGGATGAGGA 2052) CTTGCTTTCTTTACCTCCGG (SEQ ID NO: 2050) TLK1 NM_012290.3 CCACGCGTCCGCGG CTACTTTGGACACTGGGACCAAGAT GTTCCCAGAAAGTA TCATCAAGCTACT GGCGGCCCCTCC GCTTGATGAGTGTCTTCTGGGAACCC AAACTTCCACTG CAAAGTAGCAGTG GCGGACGCGTGG (SEQ ID NO: 2055)GAAGTTTGGAGGG (SEQ ID NO: 2054) GCCGCCATCTTGGT CCCAGCTCTCCACGTCTC (SEQ ID NO: 2053) TLR7 NM_016562.3 TGTGGGCACCACAC GAAAAAGAGCAGGTGTCTTTCTTTC AGGTGGTTGCTGCT GAAGCACTGAAG TTACTGTTTCCCT TCAGTGCTTCCTGCCAGCAACCACCT ATGGAACCCAGA TCTTTTTCCTTGGG GTGTGGTGCCCA AGCAGGCCCAACCTGCTTCTGGGTT CA (SEQ ID NO: G (SEQ ID NO: CCATAGGGAAACA 2057) 2058)GTAAGAAAGAAAG ACAC (SEQ ID NO: 2056) TM4SF1 NM_014220.2 AATCGCAGTATTTAAGCAAACACCAC AGCTCAGTGATA AGAGGTAGCAGGA TCTCAGCCCATTC CCCCAAATTAGAATGGGCTGAGAGT CTGCTACCTCTTA TGAAAGTGTGCC GGTGTTTGCTTTCT AATACTGCGATTCTTCTGGTGGAG CCACCAGAAGGGC (SEQ ID NO: 2060) AA (SEQ ID NO:ACACTTTCATCTAA 2061) TTTGGGGTATCACT GAGCT (SEQ ID NO: 2059) TMBIM6NM_003217.2 GGCCCTTCCTTCCT GTCCCACAGGAA GTTAACAATGGG CATTGTTGTTTGGTCTGTGCGCATACC ACCACTGAACTT ATGCGCACAGTTCC AAACAACAATGA CTTTCCAATGGATGTGGGACTGGGCC GGAAGGAAGGGC AAACTCACGGCC GTGAGTTTTCCATT C (SEQ ID NO:CA (SEQ ID NO: GGAAAGAAGTTCA 2063) 2064) GTGGTCCCATTGTT AAC (SEQ ID NO:2062) TMEM109 NM_024092.2 TAGGGGCCACTTTT AGAGAAGGACAT GAACAGTAAGACCTTTGAGGCTCTA CCACCTCCACTAG ATTGGGCATTTA GTGGAGGTGGATGT AGCCTCAAAGGATTCTTCACATCA CCTTCTCTGCCAGG AAAGTGGCCCCT TGTGCCAAGCCT CTTGGCACATGATGA (SEQ ID NO: GGC (SEQ ID NO: TGAAGAATAAATG 2066) 2067) CCCAATTCTTACTGTTC (SEQ ID NO: 2065) TMEM119 NM_181724.2 GTCACAGGTCATTT GCTCCCTTGATGGCACCTTGGCGTC GTGGGGCAAACAT AAAAGCAGTGAT TCTCATCCAAAC CACTGCTTTTCCATGTTTGCCCCACAA TCTTCCAAAACT CAAGGGAGCAAAG ATGACCTGTGAC CCCACTTATTCTAATAAGTGGGAGTT (SEQ ID NO: 2069) TT (SEQ ID NO: TTGGAAGAGTTTGG 2070)ATGAGAGACGCCA AGGTG (SEQ ID NO: 2068) TMOD1 NM_003275.2 AGATGCTCAAGGAGTTGGATTCCACA TTGTATGGGAGG GAACAAGGTGTTG TTCAGTGTCTTCA GCTTCTACCAGGAAGACACTGAATGT ACACCTTGTTCTC CGCAGAATCCCA GGAATCCAACTTCA CTTGAGCATCTGCTCCAGAAATG TTTCTGGAGCTGGG (SEQ ID NO: 2072) AA (SEQ ID NO:ATTCTGCGCCTGGT 2073) AGAAGCCCTCCCAT ACAA (SEQ ID NO: 2071) TMPRSS6NM_153609.2 CCCGAGGGCCTAGT AATGCAGCTATG GCCCACGTAGCT GATCCTGGAAGCCATCTTTCACACTGG GTAGCGGTAACA GTGTGAAAGACAT CTTCCAGGATCAC ACCCAGCGTGGAAGCTGCATTGAATT TAGG (SEQ ID NO: ATTC (SEQ ID NO: CCACGCTGGGTTGT 2075)2076) TACCGCTACAGCTA CGTGGGCCAGGGC CAGG (SEQ ID NO: 2074) TNFNM_000594.2 AGCAACAAGACCA CAGGCCACACAT TTCTGGAGGCCC CCACTTCGAAACCTTCCTGAATCCCAG CAGTTTGAATTC GGGATTCAGGAAT GTTTCGAAGTGGT TTAGTGGTTGCCGTGTGGCCTGCACA GGTCTTGTTGCT AGCACTTCACTG GTGAAGTGCTGGCA(SEQ ID NO: 2078) TG (SEQ ID NO: ACCACTAAGAATTC 2079) AAACTGGGGCCTCCAGAA (SEQ ID NO: 2077) TNFAIP2 NM_006291.2 GTCACTGTACCCGG TGTGATCATAAGCAGCTGACCTGA CCTGCTCTACCGCT CGTCCTTAAAAG AAATAGAAAGA TTTAAGGACGCTTACGGTAGAGCAGG CGACCTGGGTTC TGATCACATTGCGC CCGGGTACAGTG TCTGGGTAGGCGCTACCCAGAGAACC AC (SEQ ID NO: CAA (SEQ ID NO: CAGGTCGTCTTTCT 2081) 2082)ATTTTCAGGTCAGC TG (SEQ ID NO: 2080) TNFAIP3 NM_006290.2 CAAAGCCCTCATCGTCTTCTGGCTTTC GTTCGTMCAG ACAGAAACATCCA CAGGGTGGCCTG CGCCACAAGCTTGGCCACCCTGGAA GATGTTTCTGTCG CCGGACTTCTCG AGCCAGAAGAAAC ATGAG (SEQ IDACACCAGTTGAG TCAACTGGTGTCGA NO: 2084) TT (SEQ ID NO: GAAGTCCGGAAGC 2085)TTGTGGCGCTGAAA ACGAAC (SEQ ID NO: 2083) TNFRSF13B NM_012452.2TGCAAAACCATTTG CAGAAGGCTGCA TCATAGAACTTG CAACCATCAGAGCC CAGGTGCGCTGGCCTTGCTCCTTG AGCGCACCTGTGCA CTCTGATGGTTGC CGGCAGCTGAGT GCCTTCTGCAGGTCAAATGGTTTTGCA GACCTG (SEQ ID ACTCAGCTGCCGCA (SEQ ID NO: 2087) NO: 2088)AGGAGCAAGGCAA GTTCTATGACCATC TCC (SEQ ID NO: 2086) TNERSF14 NM_003820.2CTCAGGGAGCCTCG TGATTAGGCCAA GACGATCACCTT TCATCGTCATTGTT CTGTGGAGCAAAGACTACATCACC TGCTCCACAGTTGG CAATGACGATGA CCTTGGCTTTCTT CCTAATCATATGTGCGAGGCTCCCTG CTTTTCACACAT TGAAAAGAAGAAA AG (SEQ ID NO: A (SEQ ID NO:GCCAAGGGGTGAT 2090) 2091) GTAGTCAAGGTGAT CGTC (SEQ ID NO: 2089) TNFRSF17NM_001192.2 TCTGACCATTGCTT AGAATGGTTGCG TCAAAGCAGCTG TCCACTCCCAGCTACCTTCCTCCATAG GCAGGCTCTTGC TGGAGGAAGGCGC CTGGGAGTGGAA AATAGTCATTCGAACCATTCTTGTCA AGCAATGGT (SEQ TTTTCGTGGTGA CCACGAAAACGAA ID NO: 2093)CA (SEQ ID NO: TGACTATTGCAAGA 2094) GCCTGCCAGCTGCT TTGA (SEQ ID NO:2092) TNFRSF19 NM_018647.2 TGAATCAGGAGACT AGTTTCCAGACC TTAGACAACTCCGTAGACAGCAAGA GATCCCTGAATTC ATGCCTGGCCCA ATTCAGGGATCGGT TTGCTGTCTACAGCACTGGTTGCAG CTGGAAACTGTGTT TCTCCTGATTCA GGAACAC (SEQ CCCTGCAACCAGTG(SEQ ID NO: 2096) ID NO: 2097) TGGGCCAGGCATG GAGTTGTCTAAGGAATGT (SEQ ID NO: 2095) TNFSF10 NM_003810.2 GGGGGGACCCAGC CTGTGAAGATCAGTTGGTAAAGTA CTGGGACAGACCTG CGATCAGCACGC CACGTAAGTTAC CGTGCTGATCGTGAAGGTCTGTCCC AGCCACACAGA TCTTCACAGTGCTC (SEQ ID NO: 2099) GAGACTGCAGGCTGCAGTCTCTCTG AGCA (SEQ ID TGTGGCTGTAACTT NO: 2100) ACGTGTACTTTACCAAC (SEQ ID NO: 2098) TNFSF4 NM_003326.2 GAAGGTCAGGTCTG CTTTGTAAGTCAGGAAGTCATCCAG TCAACTCCTTGATG AGAGGCCACCAT GGAGGTATTGTC GTGGCCTCTCTGACCAAGGAGTTGAC AGTGGTCACATT TTACAAAGACAAA AGACCTGACCTTC CAAGTAGACTTTGTCTACTTGAATGT (SEQ ID NO: 2102) GT (SEQ ID NO: GACCACTGACAATA 2103)CCTCCCTGGATGAC TTC (SEQ ID NO: 2101) TNXB NM_019105.5 CAGGTGGTACCTGTAGTGAGGAGACA TCTTGTTCGCAA GGAAGGGCCCGAG ACAAATGAACGC TTCCAAACAGAGCGTTCATTTGTTGT TCGGGCCCTTCCA TGAATCTGTACT CTCCTCACTGGACC CAGGTACCACCTTGTGGTCAGGGT CTGACCACAAGTAC G (SEQ ID NO: CC (SEQ ID NO: AGATTCACTCTGTT2105) 2106) TGGAATTGCGAACA AGA (SEQ ID NO: 2104) TOP2A NM_001067.2TTTCAGCTCTTGAC GGGAGATTCAGA TCCCCGAGTCTT CTGTCCCCTCTGGC CTCAGAGGCAGCCTGCAATCCAGT TGCCTCTGAGTCTG CAGAGGGGACA CCTCTTAGAAAT AATCTCCCAAAGAG(SEQ ID NO: 2108) TGGTTTCTCTCTT AGAAACCAATTTCT T (SEQ ID NO:AAGAGGACTGGAT 2109) TGCAGAAGACTCG GGGA (SEQ ID NO: 2107) TOX NM_014729.2AATGAGCAGCTTTG GCACTGTGCTTTC ACTCTCTACCCT ACTTTGACAGGCGG CTGCACAAACCGGGTCGCACAGCT TTTGTGCAGGAAAG CCTGTCAAAGTC GCTCTAGAAAAG CACAGTGCCGTGTTAAAGCTGC (SEQ CTGTAAACAACA GTTTACAGCTTTTC ID NO: 2111) CG (SEQ ID NO:TAGAGCAGCTGTGC 2112) GACCAGGGTAGAG AGT (SEQ ID NO: 2110) TP53NM_000546.2 GGGGAGCAGGGCT TAGACTGACCCTT GTCTGAGTCAGG CACTCCAGCCACCTTTTGGACTTCAGG CCCTTCTGTCTT GAAGTCCAAAAAG TGGCTGGAGTGA GAACATGAGTTTGGTCAGTCTACCTC GCCCTG (SEQ ID TTTATGGCGGGA CCGCCATAAAAAA NO: 2114)GG (SEQ ID NO: CTCATGTTCAAGAC 2115) AGAAGGGCCTGAC TCAGAC (SEQ IDNO: 2113) TP73 NM_005427.1 CAAGCCGGGGGAA GTCCATGCTGGA CATGACAGATGTTAATGAGGTGGTGG ATCCGTTCCGCCC AGTCATGCCCTC GCGGAACGGATTCC ACCACCTCATTATCAGGTGGAAGA AGCATGGACGTCTT T (SEQ ID NO: C (SEQ ID NO: CCACCTGGAGGGC2117) 2118) ATGACTACATCTGT CATGGCCCAGTTCA ATCT (SEQ ID NO: 2116) TPM1NM_000366.5 CCTCTCTGAGCTCT GAGAGAACCAGG GTACAATAGAAA GCATTTGTCTATTCGTCAGCTGGAGA GCACAGTGTGTG TCCAGCTGACCCTG ATAGACAAATGC CCTGGCTCTAAGGTTCTCTCTCTTAG AGAGCTCAGAGA GCAGGATGCTAA CATCCTGCCTTAGA GG (SEQ ID NO:GA (SEQ ID NO: GCCAGGCACACACT 2120) 2121) GTGCTTTCTATTGT AC (SEQ ID NO:2119) TPX2 NM_012112.4 TGGGACCTGCTCTT CCAATGACAAAG TTCTCAGGCACGAACCTCAAACCTAG CAAGACGGTCCT GGTAGGTAAAA GACCGTCTTGCTTT AGGTTTGAGGTTGTCTGGAGAAAT GTCATTGGGCATGG AAGAGCAGGTCC GGGTTCTCTCCA AGAGAACCCATTTCCA (SEQ ID NO: TGC (SEQ ID NO: TCCAGACTTTTACC 2123) 2124) TACCCGTGCCTGAGAA (SEQ ID NO: 2122) TRAF1 NM_005658.3 CGAGTGATGGGTCT CAAGAGGTTATTTTGTTCTACAAA AGGCCCTGAAACTG GCTAGGACATCA TCCCCCCTTGGG ATGTCCTAGCAATAGTTTCAGGGCCTA CTCAACACTCGG ACCTCTTGATCCCT GACCCATCACTC TGAGTAGGGATACTCACCGAGTGTT G (SEQ ID NO: (SEQ ID NO: 2127) GAGCCCAAGGGGG 2126)GATTTGTAGAACAA GCC (SEQ ID NO: 2125) TRAF3 NM_145725.1 ATATGATGCCCTGCGCATGAGTGTCA GCTTGAATGCAT TTCCTTGGCCGTTT CTTTCTGCTTAAA CTCCCAAATGACAAGCAGAAAGTGA CGGCCAAGGAAG GTCGAGAGGACC CACTCATGCTGATG CAGGGCATCATACCTGATCCATCA GATCAGGGGTCCTC T (SEQ ID NO: (SEQ ID NO: 2130)TCGACGTCATTTGG 2129) GAGATGCATTCAAG CCC (SEQ ID NO: 2128) TRIM56NM_030961.1 GTGGAGGCCGAGG TTGAAAAGTTGC CCTATTCTCACA ACATTTTCCTGAAGCAACCCCTGCCCT CACTAGAAGACG GGCAGGGGTTGGC TCAGGAAAATGT GGTTAGCAGTTTAACTTTTCAACATG CCTCGGCCT (SEQ GGCACTCCATG GAGTGCCAAACTGC ID NO: 2132)(SEQ ID NO: 2133) TAACCCGTCTTCTA GTGTGTGAGAATAG GGAC (SEQ ID NO: 2131)TRIM6- NM_001003819.3 AAGGATGCTGCGA CCCAGTAGCTTTG CTCTCCTCTCTCT TRIM34GTGTGTAGAGAGCT GACATCTGTCAG TCTGGTTAAAGA GACAGATGTCCAA CTCTCTACACACCCCCTGGATGG AGCTACTGGGCCAT (SEQ ID NO: 2135) (SEQ ID NO: 2136)CCAGGGGTCTTTAA CCAGAAGAGAGAG GAGAGCCTCAGGA GTTAGG (SEQ ID NO: 2134)TRIM62 NM_018207.2 GATTTACTACCTGG TCCAGCTCTTCCA ATGATGAATCTGCCCCTGGTGGCTTG ACAATTTTGCAA GCGCTGGGAGTT CAAAATTGTTGGAA GCCACCAGGGGCCCTGGAAATTCA GAGCTGGAGAAGC CAGGTAGTAAAT GCAGAGTCTGCT AGACTCTGCTGAATC (SEQ ID NO: TC (SEQ ID NO: TTCCAGGAACTCCC 2138) 2139) AGCGCCAGATTCATCAT (SEQ ID NO: 2137) TRIP13 NM_004237.2 AAGAGACAGAAAA AGCTGCAGGTAGGATTTGACTTCC CATAATTGCAGCAA AACCCAGTGATTT ACATCGTATACC ATCACTGGGTTCTAGCTGCAATTATGT AAGCTGTCCCAA CCTGCAGCTGAATT TTTCTGT (SEQ ID AGCCCATGGAATCCATGGGCTTTGGG NO: 2141) TC (SEQ ID NO: ACAGCTTGGTATAC 2142)GATGTGGAAGTCA AATC (SEQ ID NO: 2140) TTC9 NM_015351.1 AGCATCGTATAGGCTATTTACACTGAA GGGCTGCTTCCA TAGGGGATTGAACT TCAGTCCACAGTT ACAGAACTGACAGTGGACTGATTCAG CAATCCCCTAGCC GGAACTACTACC TGTAAATAAAAAC TATACGATGCTTGTTAATTTGTTT AAATTAACAGGTA (SEQ ID NO: 2144) T (SEQ ID NO:GTAGTTCCTGTCAG 2145) TTCTGTTGGAAGCA GCCC (SEQ ID NO: 2143) TUBB2CNM_006088.5 TGGCGGAGCGTCG ACAGCAGCAGAA GCGGCGGCGGC GTTGTAGCACTCTGGAGCGGGCGCGC GGGGAAGCAGG CGCGCCCGCTCTTC AGAGTGCTACAA AGGAAGTAGACTGCTGCTGTTTGTC (SEQ ID NO: 2147) AA (SEQ ID NO: TACTTCCTCCTGCT 2148)TCCCCGCCGCCGCC GCCGCCATCATGAG GGA (SEQ ID NO: 2146) TUBG1 NM_001070.4CCCCTCAGAGCACA ATGTATATGAGA TAGTCTCATAAG GATCAGGGACCTCA AAGAGATGCGTGAGGAGAAGTAA CGCATCTCTTTCTC AGGTCCCTGATCT ATGTGTTTGCAG ATATACATGGACTCGTGCTCTGAGGG GCCAACAGAGA TCTGTTGGCCTGCA G (SEQ ID NO: GTCC (SEQ ID NO:AACACATTTACTTC 2150) 2151) TCCTCTTATGAGAC TA (SEQ ID NO: 2149) TXNNM_003329.2 CAGCCAAGATGGT GGCTTCCTGAAA CACGTGGCTGAG GAAGCAGATCGAGAGCAGTCTTGCTC AAGTCAACTACT AGCAAGACTGCTTT TCGATCTGCTTCA ACAAGTTTATCATCAGGAAGCCTTGG CCATCTTGG (SEQ CCTGCAGCGTCC ACGCTGCAGGTGAT ID NO: 2153)AA (SEQ ID NO: AAACTTGTAGTAGT 2154) TGACTTCTCAGCCA CGTG (SEQ ID NO:2152) TXNDC5 NM_030810.2 AGCAGATTGAAAT GGCCGTGAAGGT TAACCTCTCACAGCAAAAACCCACA ATCTTCCAGAGGT CTGAGAGAAGTA CCTCTGGAAGATAC GTGGGTTTTTGCATTCACAGCAACA CTTCACGGCCGCTG TTTCAATCTGCT GAAGCTCCAGCA CTGGAGCTTCTGTT(SEQ ID NO: 2156) GC (SEQ ID NO:  GCTGTGAATACTTC 2157) TCTCAGTGTGAGAGGTTA (SEQ ID NO: 2155) TYK2 NM_003331.3 TCATCGCTGACAGC CCAACTTTATGTGGGGCCTGAGCAT TGAGGAAGTCTGCA CAATGTGGATGC CGAAGAGGGCA TCCACATTGCACATAGACTTCCTCAGC AAGAGATTGAA AAAGTTGGTATCAC TGTCAGCGATGA GCAAGGAGGAGTCCTCCTTGCTTCA (SEQ ID NO: 2159) TGATA (SEQ ID ATCTCTTTGCCCTC NO: 2160)TTCGATGCTCAGGC CC (SEQ ID NO: 2158) TYMS NM_001071.1 TCAGATTATTCAGGGTGTCAATCACTC GATTCCAAGCGC ACAGGGAGTTGAC TTTGCAGTTGGTC ACATGATGATTCCAACTGCAAAGAG AACTCCCTGTCCT TTCTGTCGTCAG TGATTGACACCATC GAATAATCTGAGGTTGGTTTTGA AAAACCAACCCTG (SEQ ID NO: 2162) TG (SEQ ID NO:ACGACAGAAGAAT 2163) CATCATGTGCGCTT GGAATC (SEQ ID NO: 2161) UBE2INM_003345.3 CGGCCGCCCGAGG GAGTCTGCTGAG CACGAAACCAA GACTTTGAACATGTGGCGATCCCCGA ATGGGTGGTCTT CGGGGATCGCCCTC CATGTTCAAAGTC TCCTCCATGCTTAGCAGACTCGCCCA (SEQ ID NO: 2165) TCCTCTCCTGGG GGAGAGGAAAGCAC (SEQ ID NO: TGGAGGAAAGACC 2166) ACCCATTTGGTTTC GTGGC (SEQ ID NO: 2164)UBE2S NM_014501.2 CCTCTCCGCCACTT GCTCCCTTCCCCG GACGTCAGCGCGCCCTCGCTTCTGAC CAAACTATGGTC CACGTTCCTTGG CATAGTTTGCGGGG AGAAGCGAGGGATTTTCGACGCGC AAGGGAGCGAGCG AGTGG (SEQ ID TC (SEQ ID NO: CGTCGAAAACCAANO: 2168) 2169) GGAACGTGCGCGCT GACGTCACGGTTGA GGCT (SEQ ID NO: 2167)UBXN4 NM_014607.3 CATCGCGACGGCCA CTGCCACGAACA TTTATCATCTTCCAAAGGAGCGGCGC CCACGAAGACCG CAACTTGCAGCC GGTCTTCGTGGTGT CGCCGCTCCTTTTATCTGTGTAGAC TCGTGGCAGGTGAT GGCCG (SEQ ID TGTTCATCATCA GATGAACAGTCTACNO: 2171) C (SEQ ID NO: ACAGATGGCTGCA 2172) AGTTGGGAAGATGATAAA (SEQ ID NO: 2170) USP12 NM_182488.3 GTTCTTGCGTATAA CATGTAAGAAGGCTCCAACCTTTT GAGTCAACCTAGG CTCTCCTTTTTCC TCTTCTGAGTGG AAAAAGGAGAGCCTAGGTTGACTCTT CTATGCTATGGA TTCTTACATGCTTA ATACGCAAGAAC AGAGATCTGCTAGCAGATCTCTTCCA (SEQ ID NO: 2174) AG (SEQ ID NO: TAGCATAGCCACTC 2175)AGAAGAAAAAGGT TGGAG (SEQ ID NO: 2173) USP18 NM_017414.3 GGAAATGCCCAAAGGAAATGGAAAA TGCTTCTCCTCA ACCTTCAGAGATTG TGACAGCGTGTC TTGCAAAATCTCACACGCTGTCATTT AATCTCTGAAGG TTAGAAGACTCC TCCATTTCCGTTCC TTTTGGGCATTTCGTAGATCCAGGA TGGATCTACGGAGT C (SEQ ID NO: AC (SEQ ID NO: CTTCTAAGAGATTT2177) 2178) TGCAATGAGGAGA AGCA (SEQ ID NO: 2176) USP46 NM_022832.2AATACCAGAGTTAG CCACGGACACTT AGGAGTCTGAGC CTGGGTATAGAGGT CCTTTGAGCCACCCAAAGAAACAG GGCTCAAAGGAAG TCTATACCCAGCT CGCCATTTTGTT TGTCCGTGGGCAGGAACTCTGGTATT CATTCCTCCCCC GGGAGGAATGAAC (SEQ ID NO: 2180)TGC (SEQ ID NO: AAAATGGCGCTGTT 2181) TCTTTGGCTCAGAC TCCT (SEQ ID NO:2179) VAC14 NM_018052.3 CCACCTCAGTGACA TGAGAACTGCAA CGGAACATCTTCCGGCCATTGGGATG TCCTGGTCATCAT CGAGGAGTTTTG ATGACCAGGATTGC CCCAATGGCCGTATGTAGAGGTGG AGTTCTCAAGTGGC GTCACTGA (SEQ TAGAGCCACT TCTACCACCTCTACID NO: 2183) (SEQ ID NO: 2184) ATCAAAACTCCTCG GAAGATGTTCCGGCAC (SEQ ID NO: 2182) VASH2 NM024749.3 TCAAATCCGAATTT CACAGAAACCCTATAGTTGCAGTT AGCCAAGCCATACC CTTGCTGGCCGGT CCTCCTGAAGAT GGCCAGCAAGAGGATGGCTTGGCTA GCTGGGTAAAGT GTTTCTGTGGTGCT AATTCGGATTTGA GCAGAGAGAAGTCTCTCTGCACTTT (SEQ ID NO: 2186) CAC (SEQ ID NO: ACCCAGCATCTTCA 2187)GGAGGAACTGCAA CTAT (SEQ ID NO: 2185) VGLL4 NM_001128220.1 GCGCTTTCTCAGTCACAAAGCGTCTG GTGGAAGCTGAG ACAAGCCATGATG AGTCACCAATTC CCACACACACCCAATTGGTGACTCAG ATCATGGCTTGTG CGGTCTCAAGAA ACGCTTTGTGCTTT ACTGAGAAAGCGGCAAAGGAAAA TTCCTTTGCTTCTTG C (SEQ ID NO: AGC (SEQ ID NO: AGACCGGGGTGTGT2189) 2190) GTGGCTCAGCTTCC AC (SEQ ID NO: 2188) VMP1 NM_030938.3GATGATGAAGAGT GACTCTGCATGTT GTACTAGTTTTT ATCAGGAATTTGAA CCAGCATCTCTTCGAACTGCCAGTT GAGATGCTGGAAC AAATTCCTGATAC TGGCCCGGGAGG ATGCAGAGTCTGCATCTTCATCATC CAAAGTCTTGTG CAAGACTTTGCCTC (SEQ ID NO: 2192) CA (SEQ ID NO:CCGGGCCAAACTG 2193) GCAGTTCAAAAACT AGTAC (SEQ ID NO: 2191) VRK3NM_016440.3 ACAGACAAGAGTG TCCCTGGTCTGGA TGGAGGTGGGTG GGCGACAGTGGAAAGGACTTCAGCTT CAGCTTCATAGA GCTGAAGTCCTTCC CCACTGTCG (SEQ GAATGCCCTGGTAGACCAGGGACAA ID NO: 2195) TG (SEQ ID NO: CCAGGGCATTCTCT 2196)ATGAAGCTGCACCC ACCTCCACCCTCAC CTGTG (SEQ ID NO: 2194) VWF NM_000552.3CACCTGCAACCCCT CACCTGTGTTATT TCCTCTTAGCTG GCCCCCTGGGTTAC TTCTTCCTTGTAAAATGGTGCAAGC AAGGAAGAAAATA CCCAGGGGGCAG CGTAGGCAAACA ACACAGGTGAATGTGGGTTGCAGGTG TCTCCCACAACA TGTGGGAGATGTTT (SEQ ID NO: 2198)TT (SEQ ID NO: GCCTACGGCTTGCA 2199) CCATTCAGCTAAGA GGA (SEQ ID NO: 2197)WAC NM_100486.2 CCTCTGGACTGAAC GACCGCTGAAGC GGGTCCTGAAGT CCCACATCTGCACCAGATGTTGGAGG AAGGGAGGTATT TCCAACATCTGCTT TGCAGATGTGGG GGCGACTGTGGACAGCGGTCCCTGTT GTT (SEQ ID NO: ACAGGAGAAAC TCTCCTGTTCCACA 2201)AGG (SEQ ID NO: GTCGCCAATACCTC 2202) CCTTACTTCAGGAC CC (SEQ ID NO: 2200)WASF1 NM_001024934.1 TGGCCCAGCCTCTC TATGATCCACGTA CTCACTCATCTGATTTTGAAACAAGA TGTCTGAGGTCTT ACTAAATGGCAA CCTCAGACATACGT GTTTCAAAATGAGGCAGAAAGTG GGATCATATGGATG GAGGCTGGGCCA AGTAAGATCCAT GATCTTACTCACTT(SEQ ID NO: 2204) CCA (SEQ ID NO: TCTGCCTTGCCATT 2205) TAGTCAGATGAGTGAG (SEQ ID NO: 2203) WDR25 NM024515.4 GCATCCTCAGTGGT TTCAAGGTCTGTTAAGGTAGTGATT GGCTTTGACTTCGC AGGTGCAGCGCG CTAAAGTCACTT GCTGCACCTAACAGAAGTCAAAGCCA CGACCACTAAAT ACCTTGAAACAGG CCACTGAG (SEQ AGCTGGGTTCCTAACCCAGCTATTTA ID NO: 2207) GT (SEQ ID NO: GTGGTCGAAGTGAC 2208)TTTAGAATCACTAC CTT (SEQ ID NO: 2206) WDR55 NM_017706.4 CTACCTCTTCAATTGGGCAAAGCGGT GACTCTCGGTGA GGAATGGCTTTGGG CACTTGTGGCCCC CTGGAACCATGCGCCACAAGTGACC AAAGCCATTCCA AGTCGATAGATT GCTTTGCCCTGAGA ATTGAAGAG (SEQCAGCTCTCA GCTGAATCTATCGA ID NO: 2210) (SEQ ID NO: 2211) CTGCATGGTTCCAGTCACCGAGAGTCTG CTG (SEQ ID NO: 2209) WFDC9 NM_147198.2 CAGAGTATTGGGATGTATTTGGGTTA AGATGAACATGA AAAGACTTGCCTTC AGTTCTGGCAGA CGAGTAGAAGATGCCAGAACTTAAC AGGCAAGTCTTTT ATCCAGGGCTTC CCAAATACACACA CCCAATACTCTGATGGTGCTCTCT GAGAGCACCATGA (SEQ ID NO: 2213) GTG (SEQ ID NO:AGCCCTGGATTCTT 2214) CTACTCGTCATGTT CATCT (SEQ ID NO: 2212) WHSC1NM_007331.1 AAAAGAGTGCACG TTCTGGGGCGTCA TGTCCTTCTCCTT CCAGTATCACGTACCCAAAGAACTGT CAAAAGCTACGA AGTTCTTTGGTGAC ACGTGATACTGG GGCTCTTCTCAAGCCCCAGAAAGAG CGTGCACTCTTTT ATATCCAAGCTC CTTGGATATTTGAG(SEQ ID NO: 2216) T (SEQ ID NO: AAGAGCCTCGTAGC 2217) TTTTGAAGGAGAAGGACA (SEQ ID NO: 2215) WNT3 NM_030753.3 CCAACTCGCCTGTG ATGTAAGATGAGAAAGAAAGCCC GACGGGGAGGCTC AGAGAGGGAGAG CCTTCTTTAAAA TCCCTCTCTCTCATCCTCCCCGTCCAC ACCACACACCAT CTTACATTTCTCAC AGGCGAGTTGG CCAGAGTAGGGTCCTACTCTGGATGG (SEQ ID NO: 2219) GAGAA (SEQ ID TGTGTGGTTTTTAA NO: 2220)AGAAGGGGGCTTTC TTT (SEQ ID NO: 2218) XAF1 NM_017523.2 TGGTTTGCCCAAGGGGAACCTTTCTTT TCTCCAGGCTGT ACTACAAATAAACC TTTCCCGTTGGTT AGGGCCCAGAGAACGGGAAAAAAG TATTTGTAGTCCT GCTTAATCAGAA AAAGGTTCCAGTTT TGGGCAAAC (SEQTTTTCAGACAAA TGTCTGAAAATTCT ID NO: 2222) ACT (SEQ ID NO: GATTAAGCCTCTGG2223) GCCCTACAGCCTGG AGA (SEQ ID NO: 2221) XBP1 NM_005080.2GGAGTTAAGACAG CCTCCTCTTCAGC CGGCCACTGGCC CGCTTGGGGATGGA AACCAGGGCATCTCACTTCATTCC TGCCCTGGTTGCTG CATCCCCAAG CCTTGGCTTCCG AAGAGGAGGCGGA(SEQ ID NO: 2225) (SEQ ID NO: 2226) AGCCAAGGGGAAT GAAGTGAGGCCAGTGGCCGGGTCTGCT GAGTCC (SEQ ID NO: 2224) YPEL1 NM_013313.3 ATAGAGGGGCCTGTAAATATATGGCA CCCACTCCTGGT GCAATCTCCTAAGG GAAACACAGGCC GGAGGGCAGGTCCTGTGTTTCTGCC TTAGGAGATTGC GGATGAGTGGAT ATATATTTTATTAT ACAGGCCCCTCTTGTAATTTATAA AAATTACAATCCAC AT (SEQ ID NO: TA (SEQ ID NO: TCATCCACCTGCCC2228) 2229) TCCACCAGGAGTGG GC (SEQ ID NO: 2227) ZAP70 NM_001079.3GGAGCTCAAGGAC CTATGAGGAGGT CTGGCGCACTGA AAGAAGCTCTTCCT TATCGCGCTTCAGGCCAAAGTTGCC GAAGCGCGATAAC GAAGAGCTTCTT GCAGCCAAGTTC CTCCTCATAGCTGAGTCCTTGAGCTCC AATGTCAG (SEQ CATTGAACTTGGCT (SEQ ID NO: 2231)ID NO: 2232) GCGGCAACTTTGGC TCAGTGCGCCAGGG CGTG (SEQ ID NO: 2230) ZBTB32NM_014383.1 AGGCCGTCTCGGCC GTGGTGGAGGAA TTCGTTCTTTAAT CTCGACCTCTCCCTGAAGGACAACAG TGGACTCTTGGC GTTGTCCTTCTTCCT GGAGAGGTCGAG TAAGACGCTACCCCACCACCTGACGG GGCCGAGACG GACACCCCGTCA GGTGTCGGTAGCGT (SEQ ID NO: 2234)G (SEQ ID NO: CTTAGCCAAGAGTC 2235) CAATTAAAGAACG AA (SEQ ID NO: 2233)ZBTB37 NM_001122770.1 GAACATACAATTGG GATGGCTCAGGA CACATTGACCACAGATTCCTGACTTC CAGAGTTGCTGA AATATCACAGAG AGCAACTCTGTCCT AGTCAGGAATCTACGGCCCTGCAT GAGCCATCTAAACC CCAATTGTATGTT GCGCAACTGGTT AGTTGCGCATGCAGC (SEQ ID NO: TA (SEQ ID NO: GGCCGTCTCTGTGA 2237) 2238) TATTGTGGTCAATGTG (SEQ ID NO: 2236) ZBTB38 XM_929657.1 CAAGACCTGCGGA CATGTTTCTGTAACTTGTTGCAATA CGGTGCTTTTCGGT GTTTCCTTGCACC CTGACAGACGAA GCAAGGAAACTTAGAAAAGCACCGT CTCCTTCAAGCC CAGAAACATGAAC CCGCAGGTCTTG CAGGTGGATGCGGCATCCACCTGGGC (SEQ ID NO: 2240) TT (SEQ ID NO: TTGAAGGAGTTCGT 2241)CTGTCAGTATTGCA ACAAG (SEQ ID NO: 2239) ZBTB8A NM_001040441.1TGGAGATAAGGATT AGGATCTATTCTC AACCTGTTGGAT CCAGATGGCACTTG ATCTTCACTCAAGGACCAGATCACC AGTGAAGATGAGA TGCCATCTGGAAT AGACCCATCTTC ATAGATCCTATGTGCCTTATCTCCA TACAATCTCCAC GAGATTGTAGAAG (SEQ ID NO: 2243) AT (SEQ ID NO:ATGGGTCTGGTGAT 2244) CTGGTCATCCAACA GGTT (SEQ ID NO: 2242) ZCCHC2NM_017742.4 GGCCAACAGCTTGC AGCCAGTAACTC GCGGGAGTACTA ACTGGAGAATCGGAAGGTGCTTTTCC CTGTGTGGAAGG AAAAGCACCTTGA GATTCTCCAGTGC AAGGTTGATGGAGTTACTGGCTTCCC AAGCTGTTGGC ATAGGTAAAGG CTTTACCTATTCCA (SEQ ID NO: 2246)GGA (SEQ ID NO: TCAACCTTCCTTCC 2247) ACACAGTAGTACTC CCGC (SEQ ID NO:2245) ZCCHC7 NM_032226.2 CTGCTGAAGCTGTT CAGCTAGTGATG AATTCCCTGCCTGTCAGAATCTTCCT TTTTGTCCAAAGG CTTCAGGGCTTC TTGGACAAAACATC AAGATTCTGACAAATGATGACACT ACTAGCTGACTATA ACAGCTTCAGCA TTTGTTTTTATAG AAAACAAAAGTGTG (SEQ ID NO: T (SEQ ID NO: CATCATTGAAGCCC 2249) 2250) TGAAGAGGCAGGGAATT (SEQ ID NO: 2248) ZFP36L1 NM_004926.2 CCACGTGCCCATCT AATCCAGAACCTGTGTGTGTGCCA CAAGACATTCCACT CAAATCTGTGAG GTTCTGTTTACA CACAGATTTGAGGTTGGAATGTCTTGA TTAACATTGGAA TCTGGATTCCAGGT GATGGGCACGTG AACTCCAGACCTCTGGAGTTTTCCAA G (SEQ ID NO: GG (SEQ ID NO: TGTTAATGTAAACA 2252) 2253)GAACTGGCACACA CAC (SEQ ID NO: 2251) ZFP42 NM_174900.3 AAAGAATATGACAGTGCATCCACTCT CATGAATGAGGA GTCTGAGCGCAATC GAGGACAAGCGA GATGCTTTCTCAGCTTGTCCTCAGAG TTGCGCTCAGACT GGGCAGCTCTAT TGGATGCACTAGGA GTCATATTCTTTTCCTCAACTTCC AGTTGAGGAATAG (SEQ ID NO: 2255) TA (SEQ ID NO:AGCTGCCCTGAGAA 2256) AGCATCTCCTCATT CATG (SEQ ID NO: 2254) ZMYND8NM_183047.1 GTTGGGATCGGGA GGAGCCAACGGC CTGGTCCGGAGA GTTTCGGCACAGACTTGATGGGATAG GCTTGCGTTTTA TATCCCATCAAGCC TCTGTGCCGAAA GGAACGTGGTAAGTTGGCTCCTTTCA CTCCCGATC (SEQ CGTAGTAGCTGA GCTACTACGTTACC ID NO: 2258)AA (SEQ ID NO: ACGTTCCTAAAACG 2259) CAAGCTCTCCGGAC CAG (SEQ ID NO: 2257)ZNF135 NM_003436.2 ACTAGACCCAAAGT TCTTCAGAGATGC ACAGACCATCCCCAAACTGTCAGTTC CTTGCTTTAGAAC ACAGGAATCTTT TAAAGCAAGGCAT TGACAGTTTGACTCTACCAAGATGA CTCTGAAGAAATAT TTGGGTCTAGT CACTGTTGGATA CCAACAGTGTCATC(SEQ ID NO: 2261) TT (SEQ ID NO: TTGGTAGAAAGATT 2262) CCTGTGGGATGGTCTGT (SEQ ID NO: 2260) ZNF238 NM_006352.3 GGGACTGGAGCGC AATTTCTCATTAGCTACTATGGTCT TGAAAAGTTGTTCC AGCCTGGTCAGG GGAAACTCCATA TGACCAGGCTCTAAAACAACTTTTCAG CTGTCTTCATAA TGAGAAATTCCTCT CGCTCCAGTCCC CCTGGGGAGAGCTCCCCAGGTTATG (SEQ ID NO: 2264) AGG (SEQ ID NO: AAGACAGTATGGA 2265)GTTTCCAGACCATA GTAG (SEQ ID NO: 2263) ZNF281 NM_012482.3 AGCGTTTGGTTCTCTAAAGGTCATTG TGACACTGAAGT AGTTTAAGTCGGGC GCACCCTGCTGCC CCTTACTCTATGAGCAGGGTGCCAA CGACTTAAACTG GTCCACTTCTCC TGACCTTTATCACT AGAACCAAACGCATTAGAGTTAGT AACTCTAATGGAGA T (SEQ ID NO: GA (SEQ ID NO: AGTGGACCATAGA2267) 2268) GTAAGGACTTCAGT GTCA (SEQ ID NO: 2266) ZNF318 NM_014345.2TCCGACCCAACCTG TGAACATGACTT GACTTAATAGAC CCTATTCCATCCAC GCGGAGTACTGTAGAAAGGTGTTA AGTACTCCGCAAGT GGATGGAATAGG AGAGGAGCTGG CATGTTCAGCCACACAGGTTGGGTCG CTTGCTCATTGT ATGAGCAAGCCAG GA (SEQ ID NO: GGC (SEQ ID NO:CTCCTCTTAACACC 2270) 2271) TTTCTGTCTATTAA GTC (SEQ ID NO: 2269) ZNF385BNM_001113398.1 CTGACAAATCAGA CTGACTGGAACT GGTGTTGTGCCA AGATAAAGGGAAGGCTGGCTTTTAAC GATTTGAGGAGA TTAAAAGCCAGCA TTCCCTTTATCTT AATGAGCCACTTGTTCCAGTCAGCCA CTGATTTGTCAG TCAGAGCTTGAT TCAAGCTCTGAAAG(SEQ ID NO: 2273) GG (SEQ ID NO: TGGCTCATTTCTCC 2274) TCAAATCTGGCACAACACC (SEQ ID NO: 2272) ZNF598 NM_178167.2 TCAGACAGGGCCTG GTCCCGGCAACTACCAGCAGCTCA ATCTCCGCAGCCCA CTTGTAATACTGG TTAAAGACCTTC GTATTACAAGAGTTGCTGCGGAGATC TGGAAATTCTCC GCCGGGACCTGCTG AGG (SEQ ID NO: CCCAGCAG (SEQGGGGAGAATTTCCA 2276) ID NO: 2277) GAAGGTCTTTAATG AGCTGCTGGTCCTGCT (SEQ ID NO: 2275) ZNF608 NM_020747.2 CAGCACAATCATCT GCTGTGGTAATAGCACCGACCTGC CAACTGAAAGAGT GGGAGAATGGGA CCAGGGTGCATG CCCATTCTCCCTATCTCTTTCAGTTGA TAACTTGGAGAA TACCACAGCTATGA GATGATTGTGCTG TAATAAGGATCATCCTTATTATTCTCC (SEQ ID NO: 2279) TA (SEQ ID NO: AAGTTACATGCACC 2280)CTGGGCAGGTCGGT GC (SEQ ID NO: 2278) ZNRF1 NM_032268.4 ATAGCTTTGTCACCAGCAGGAGGTGC TTTGCTGGTGGA ACAAAGGGCACTG TGTGAATAGAAC ATTAAATATAGCTTCTATTCACAGCA AGTGCCCTTTGTG ACAGGGAGACA CCTCCTGCTTCTGC GTGACAAAGCTACAGTTGCCAGGC CTGGCAACTGTGTC T (SEQ ID NO: AGA (SEQ ID NO: TCCCTGTGCTATAT2282) 2283) TTAATTCCACCAGC AAA (SEQ ID NO: 2281) ZPBP2 NM_198844.2TGCAAGTAGTACGT TTCATTTTTTCCA GTCGCAGGACTA CTGGATAGCTGTCG AAGCCTGGTCGACAAACCACACAA ACCAGGCTTTGGAA CAGCTATCCAGA CAGCTAGCGCAA AAAATGAACGTCTACGTACTACTTGCA TTACTGTGTAGA CACAGTAATTGCGC (SEQ ID NO: 2285)CG (SEQ ID NO: TAGCTGTTGTGTGG 2286) TTTGTAGTCCTGCG AC (SEQ ID NO: 2284)ZWINT NM_007057.3 GGAGATGTAAATTT CTTTCTCCATGCT TAATGATGGTTGGCCATGACTTCCTG GCTGTCCTCCAGG GGAGGTGAGGG GAGGACAGCAGCA AAGTCATGGCAAAAGTCAGAGGCC TGGAGAAAGATCCT ATTTACA (SEQ ID TTTTCTAGGAT AGAAAAGGCCTCTNO: 2288) (SEQ ID NO: 2289) GACTTCCCTCACCT CCCAACCATCATTACAGG (SEQ ID NO: 2287) IgG2 NCI_Lih_1_008.1 TCCCCAGGCTCTCG TAGACGGGGTACCTGGGTGCTTTA constant GGGTCGCGCGAGG GTGCCAAGCATC TTTCCATGCTGG regionATGCTTGGCACGTA CTCGCGCGACCC GTGCCCGGGAAG CCCCGTCTACATAC CGAG (SEQ ID NO:TATG (SEQ ID NO: TTCCCGGGCACCCA 2291) 2292) GCATGGAAATAAA GCACCCAGCGCTGCCCTG (SEQ ID NO: 2290) IgG4 NCI_Lih_1_034.1 GATGGCGTGGAGG AACTGCTCCTCCCTGCAGGACGGTG constant TGCATAATGCCAAG GCGGCTTTGTCTT AGGACGCTGACC regionACAAAGCCGCGGG GGCATTATG (SEQ ACACGGTACGTG AGGAGCAGTTCAA ID NO: 2294)CTGTTG (SEQ ID CAGCACGTACCGTG NO: 2295) TGGTCAGCGTCCTC ACCGTCCTGCACCAGGACT (SEQ ID NO: 2293) IgA2 NCI_Lih_1_017.1 GCCGCTGGCCTTCATGGGTTTACCCGC AGGTGCCGTCCA constant CACAGAAGACCAT CAAGCGGTCGATCCTCCGCCATGA region CGACCGCTTGGCGG GGTCTTCTGTGTG CAACAGACACATGTAAACCCACCCAT AAGG (SEQ ID NO: TGACATGGG GTCAATGTGTCTGT 2297)(SEQ ID NO: 2298) TGTCATGGCGGAGG TGGACGGCACCTGC TAC (SEQ ID NO: 2296)IgE NCI_Lih_1_009.1 AAGACCAAGGGCT CTGGTCACCTCCA CACGGCAGATGA constantCCGGCTTCTTCGTC GGCGGCTGAAGA ACTCATCTTTCT region TTCAGCCGCCTGGACGAAGAAGCCGG GCTCCCATTCGG GGTGACCAGGGCC AGC (SEQ ID NO: CC (SEQ ID NO:GAATGGGAGCAGA 2300) 2301) AAGATGAGTTCATC TGCCGTGCAGTCCATGAGG (SEQ ID NO: 2299) EBV LMP1 NCI_Lih_1_001.1 TTGCTTTCCATCTTGTGTGGCTTGGG CAAAGAATGTGT unique GTGCCAATACACAT CTGAATCCAAATCAACAACAGGTG TTGGATTCAGCCCA GTGTATTGGCAC TTCCTGCCTCTG AGCCACACCTAACTAAGATGGAAAGC CTGGCATGAGTT CATGCCAGCAGAG AA (SEQ ID NO: AG (SEQ ID NO:GCAGGAACACCTGT 2303) 2304) TGTTGACACATTCT TTG (SEQ ID NO: 2302) EBV LMP1NCI_Lih_1_025.1 CTGTTTGGACTTTT GGTCGCATGGTG TGAAGGAACGG 3′ endATGCCTGCTCCTCA GCTTCTTAGATGA CGGAGAGTAGC TCTAAGAAGCCACC GGAGCAGGCATAGTAGAATCCAGC ATGCGACCGGGTA AAAGTCCAAACA CAGTGGTCTACC GACCACTGGCTGGAG (SEQ ID NO: C (SEQ ID NO: TTCTACGCTACTCT 2306) 2307) CCGCCGTTCCTTCAGAA (SEQ ID NO: 2305) EBV NCI_Lih_1_043.1 AATTCACACACGGC GACTCCGGTTCATGAGGATACCAAT EBNA2 3′ AACCCCTAACGTTT GTATTGGTGAAA CATCGGGGAAG endCACCAATACATGAA CGTTAGGGGTTG AGAATGGGAGC CCGGAGTCCCATAA CCGTGTGTGAATTCTCTGGGCTATT TAGCCCAGAGGCTC (SEQ ID NO: 2309) ATGG (SEQ IDCCATTCTCTTCCCC NO: 2310) GATGATTGGTATCC TC (SEQ ID NO: 2308) EBVNCI_Lih_1_006.1 AATTGTTGACACGG AGGGAATTACTG TGTTAGTGGAAT EBNA2 longATAGTCTTGGAAAC AGAGTGACGGGT TAATGGAGTGTC CCGTCACTCTCAGT TTCCAAGACTATCTGACAGTTGTTC AATTCCCTCGAATC CGTGTCAACAATT CTGGTAGGGATT CCTACCAGGAACA(SEQ ID NO: 2312) CG (SEQ ID NO: ACTGTCAGACACTC 2313) CATTAATTCCACTAACA (SEQ ID NO: 2311) EBV NCI_Lih_1_024.1 GAGGTTTTGAAGGA GGAGCGGGCTTTAATCTACTCCAT EBNA1 TGCGATTAAGGACC GTCATAACAAGG CGTCAAAGCTGC CDSTTGTTATGACAAAG TCCTTAATCGCAT ACACAGTCACCC CCCGCTCCTACCTG CCTTCAAAACCTCTGATATTGCAGG CAATATCAGGGTGA (SEQ ID NO: 2315) TA (SEQ ID NO:CTGTGTGCAGCTTT 2316) GACGATGGAGTAG ATT (SEQ ID NO: 2314) EBVNCI_Lih_1_004.1 GAGGAAGTATGAA GAGGTAGGGCGC GTACTAACTGAG LPM2ATCCAGTATGCCTGC AACAATTACAGG GCCGTGAAACAC CTGTAATTGTTGCG CAGGCATACTGGGAGGCGGCAAT CCCTACCTCTTTTG ATTCATACTTCCT AGCCGCCAGCCA GCTGGCGGCTATTGC (SEQ ID NO: AAA (SEQ ID NO: CCGCCTCGTGTTTC 2318) 2319) ACGGCCTCAGTTAGTAC (SEQ ID NO: 2317) EBV BZLF1 NCI_Lih_1_027.1 TGCCCAAGCCTGGAAAAACATCTGGT GCAGGCGTGGTT TGTTGACTCCATTA GTCCGGCGGATA TCAATAACGGGATCCGCCGGACACCA ATGGAGTCAACA GTTAGAAATTTA GATGTTTTACACGA TCCAGGCTTGGGAGAGATCCTCGT GGATCTCTTAAATT CA (SEQ ID NO: GT (SEQ ID NO: TCTAACTCCCGTTA2321) 2322) TTGAAACCACGCCT GC (SEQ ID NO: 2320) EBV NCI_Lih_1_020.1CCAACATCAGCTGG GATGGTTAAGAC AGCCTGGCTGAG EBNA3A ATGCTTTGGGGTATCATGGAGTGTAT ATGATATTGGTT ACACTCCATGGTCT ACCCCAAAGCAT AACGGCAGGAGTAACCATCCCGGGG CCAGCTGATGTTG ACACGGGAACCC TTCCCGTGTCTCCT G (SEQ ID NO:CGG (SEQ ID NO: GCCGTTAACCAATA 2324) 2325) TCATCTCAGCCAGGCT (SEQ ID NO: 2323) EBV NCI_Lih_1_022.1 ACAATCGGAAACTT TCATTAGGTGGTGCGTTCTGGATTA EBNA3C TAAGCCATATTACC CATTCCACGGGT CGTGTTCTTTTATCGTGGAATGCACCA AATATGGCTTAA GCCTCTCCGCGC CCTAATGAAAATCC AGTTTCCGATTGTGTGATATGGATT ATATCACGCGCGGA (SEQ ID NO: 2327) T (SEQ ID NO:GAGGCATAAAAGA 2328) ACACGTAATCCAGA ACG (SEQ ID NO: 2326) EBVNCI_Lih_1_003.1 CTCCCGTCGTTATC CAGAGTCTGCTGT CAACATGTCCCT EBNA3BTTGGAGAATGTCGG TGCCCCTGGCCG TTCCTGTTTAGC CCAGGGGCAACAG ACATTCTCCAAGAGTTCCTCCGCA CAGACTCTGGAGTG ATAACGACGGGA CTC (SEQ ID NO: CGGAGGAACTGCTG (SEQ ID NO: 2331) AAACAGGAAAGGG 2330) ACATGTTGGGGCTG GGGGA (SEQ ID NO:2329) HHV8 NCI_Lih_1_040.1 CGGTGTTTGTGGCA GCGCCACCCATTT ACACCAATCGCCT0.7/P6 GTTCATGTCCCGGA AGTAACACATCC AACAGACAAAC TGTGTTACTAAATGGGGACATGAACT GAGTGGTGGTAT GGTGGCGCTGGAG GCCACAAACACC CGCCCCAAGCCTGCTTGGGGCGATAC G (SEQ ID NO: CCA (SEQ ID NO: CACCACTCGTTTGT 2333) 2334)CTGTTGGCGATTGG TGT (SEQ ID NO: 2332) HHV8 T1.1 NCI_Lih_1_007.1AGCAAGTCGATTTG TGACAAATGCCA GCTGCCGCACAC AATGACATAGGCG CCTCACTTTGTCGCACTTTAGTCCA ACAAAGTGAGGTG CCTATGTCATTCA ATGTTCTTACAC GCATTTGTCAGAAGAATCGACTTGCT GACTTTGAAACT TTTCAAAGTCGTGT (SEQ ID NO: 2336)TC (SEQ ID NO: AAGAACATTGGACT 2337) AAAGTGGTGTGCG GCAGC (SEQ ID NO:2335) HHV8 NCI_Lih_1_037.1 CCATAATCTTGCAC GTAATCCACTTCC TTATCTCCTGGTORF73/LAN GGGTCGTCATCCGA ATTTCGTCCTCGG GGGCTACTGGCA A GGACGAAATGGAAATGACGACCCGT ATTTGTTCATGT GTGGATTACCCTGT GCAAGATTATGG GTGCTAACAACATGTTAGCACACATG (SEQ ID NO: 2339) GG (SEQ ID NO: AACAAATTGCCAGT 2340)AGCCCACCAGGAG ATAA (SEQ ID NO: 2338) HHV8 NCI_Lih_1_021.1 TGTTCTCCACGTAGTCAAAGACCTAA GAATGTCTGTGG vFLIP ACGGGGAGCTGTGT TATCCCTCGCACATGTGCTGCGAGA ORF71 GCGAGGGATATTA CAGCTCCCCGTCT CCCTATAGTGTCGGTCTTTGATATTT ACGTGGAGAACA CTTGCTTAAAAA TTAAGCAAGGACA (SEQ ID NO: 2342)TA (SEQ ID NO: CTATAGGGTCTCGC 2343) AGCACACCACAGA CATTC (SEQ ID NO:2341) HHV8 NCI_Lih_1_010.1 ATCACAGGCTTAAT GCCAACATGGCC TGCTCAACCCAA BCL2GCGAGACAAGGAG TCGAATAAAGAC GCTGGTTTATAC homologue TCTTTATTCGAGGCTCCTTGTCTCGCA CGGTGGTGCTGT CATGTTGGCTAATG TTAAGCCTGTGAT GAAATCTCACATTGAGATTTCACAGC (SEQ ID NO: 2345) TA (SEQ ID NO: ACCACCGGTATAAA 2346)CCAGCTTGGGTTGA GCA (SEQ ID NO: 2344) HHV8 NCI_Lih_1_041.1 ATTAGCGCATGCAACCCCACCGGCTTT TCATAGAGAGGA vMIP 1b ATTAGCTTTGCCGA CCGAGAACTTCGCACCGGTCCCAT ORFK4.2 AGTTCTCGGAAAGC GCAAAGCTAATT TTCCCACGGTCC KIE-3CGGTGGGGCGCGCT TGCATGCGCTAAT AAAAATCCAGCG GGATTTTTGGACCG(SEQ ID NO: 2348) CG (SEQ ID NO: TGGGAAATGGGAC 2349) CGGTGTCCTCTCTATGA (SEQ ID NO: 2347) HHV8 vIL6 NCI_Lih_1_026.1 CGTACCGGCATCTGAGATGAAAAATA TAAATCCTATTA CAAGGGTATTCTAG GCAGCGGGCTCT ACCCGCAGTGATAGCCCGCTGCTATT AGAATACCCTTG CAGTATCGTTGA TTTCATCTGAAACT CAGATGCCGGTATGGCTGGTAGTT ACCAGCCATCAACG CG (SEQ ID NO: TC (SEQ ID NO: ATACTGATCACTGC2351) 2352) GGGTTAATAGGATT TA (SEQ ID NO: 2350) HHV8 K1- NCI_Lih_1_01TCGGATTCATCCTT CAAAGCCGAGTA TAAAATTGCAGG 32 BCb K1 5.1 GCCAATATCCTGGTTCGTTGCAATACC TAATGATGTCAA protein ATTGCAACGATACT AGGATATTGGCATAGTGAGTGTTG CGGCTTTGGCGACT AGGATGAATCCG GCTTCGTCAGTC GACGAAGCCAACAA (SEQ ID NO: GC (SEQ ID NO: CTCACTATTGACAT 2354) 2355) CATTACCTGCAATTTTA (SEQ ID NO: 2353) EBV NCI_Lih_1_016.1 TGTAGCCACCCGTC CAGACACCGTCCGCTGGTACTTGA EBER1 CCGGGTACAAGTCC TCACCACCCGGG CCGAAGACGGC CGGGTGGTGAGGAACTTGTACCCG AGAAAGCAGAG CGGTGTCTGTGGTT (SEQ ID NO: 2357) TCTGGGAAGACAGTCTTCCCAGACTC ACCA (SEQ ID TGCTTTCTGCCGTC NO: 2358) TTCGGTCAAGTACCAGC (SEQ ID NO: 2356) EBV NCI_Lih_1_014.1 GTCCCGGGGGAGG TGACTTGCAAATAAAATAGCGGA EBER2 AGAAGAGAGGCTT GCTCTAGGCGGG CAAGCCGAATAC CCCGCCTAGAGCATAAGCCTCTCTTCT CCTTCTCCCAGA TTGCAAGTCAGGAT CCTC (SEQ ID NO:  GGGATTAGAGATCTCTAATCCCTCT 2360) ATCC (SEQ ID NO: GGGAGAAGGGTAT 2361) TCGGCTTGTCCGCTATTTT (SEQ ID NO: 2359) BCL2_1 NCI_Lih_1_013.1 TCTTGATTCTTCAAGAGACTCAGGGC AAACAAAGCTCC AAGCATTCTGAGAA TTATCTCACCTTC TCAGTGGCCAGTGGTGAGATAAGCC TCAGAATGCTTTT GACATCCAGGTT CTGAGTCTCAGCTA GAAGAATCAAGATTTCTTAGGTAG CCTAAGAAAAACCT (SEQ ID NO: 2363) CT (SEQ ID NO:GGATGTCACTGGCC 2364) ACTGAGGAGCTTTG TTT (SEQ ID NO: 2362) BCL2_2NCI_Lih_1_028.1 TGGCCTTCTTTGAG CCGGTTGACGCTC CACAGGGCGATG TTCGGTGGGGTCATTCCACACACATG TTGTCCACCAGG GTGTGTGGAGAGC ACCCCACCGAAC GGCGACATCTCGTCAACCGGGAGA TCAAAGAAGGCC (SEQ ID NO: 2367) TGTCGCCCCTGGTGA (SEQ ID NO: GACAACATCGCCCT 2366) GTGGATGACTGAGT ACCT (SEQ ID NO: 2365)BCL2_3 NCI_Lih_1_038.1 ATTCTGCAACACTG CCATGTAAAGTA AAGTGCCATTATTACACATAAAAAAT TCCTTACCGTATT AGCTAATGGTGG ACGGTAAGGATACT TTTTATGTGTACACCAACTGGAGAC TTACATGGTTAAGG GTGTTGCAGAAT TTACTTTACCTT TAAAGTAAGTCTCC(SEQ ID NO: 2369) AA (SEQ ID NO: AGTTGGCCACCATT 2370) AGCTATAATGGCACTT (SEQ ID NO: 2368) BCL2_4 NCI_Lih_1_035.1 GAACTTGAGGAAG TCTAGCCTTCCTGTCTCCTAAAAGC TGAACATTTCGGTG ATGCGGAAGTCA AGGCACTTGTGG ACTTCCGCATCAGGCCGAAATGTTCA CGGCCTGATGCT AAGGCTAGAGTTAC CTTCCTCAAGTTC CTGGGTAACCCAGAGCATCAGG (SEQ ID NO: 2372) (SEQ ID NO: 2373) CCGCCACAAGTGCCTGCTTTTAGGAGAC CGAA (SEQ ID NO: 2371) BCL2_5 NCI_Lih_1_011.1TCAGGGAGTTGGA GTCCTTCATACCC ATTTGTCACACA AGTTTTCAGAATAA TTAGTTCTGGTTAAGGTTCTTCGCA CCAGAACTAAGGG TTCTGAAAACTTC GAGGCATCACAT TATGAAGGACCTGTCAACTCCCTGA CGACCCCAATAC ATTGGGGTCGATGT (SEQ ID NO: 2375) AG (SEQ ID NO:GATGCCTCTGCGAA 2376) GAACCTTGTGTGAC AAAT (SEQ ID NO: 2374) BCL2_6NCI_Lih_1_032.1 CGGCCCCAGCATGC TCTTCAGAGACA AGGGTGATGCAA GGCCTCTGTTTGATGCCAGGAGAAAT GCTCCCACCAGG TTCTCCTGGCTGTC CAAACAGAGGCC GCCAAACTGAGCTCTGAAGACTCTGC GCATGCTGGGGC AGAG (SEQ ID TCAGTTTGGCCCTG CG (SEQ ID NO:NO: 2379) GTGGGAGCTTGCAT 2378) CACCCTGGGTGCCT AT (SEQ ID NO: 2377)CCND12 NCI_Lih_1_030.1 TGCTAATTTAAAGA CAGCACTGTGAG TGCAAATTCTTTGACTCCAAATCTCA CTGGCTTCATTGA TGGTTCGGCAGC ATGAAGCCAGCTCA GATTTGGAGTCTCTTGCTAGGTGAC CAGTGCTGTGTGCC TTTAAATTAGCA CGGGGCACA CCGGTCACCTAGCA(SEQ ID NO: 2381) (SEQ ID NO: 2382) AGCTGCCGAACCA AAAGAATTTGCACCCCG (SEQ ID NO: 2380) CCND13 NCI_Lih_1_002.1 CGCGCCGGTGTCCC CGCAGGGAAGAGACTACTATGATG CAGAGACCAGGCT AAGAGGGACACA CTACGCCCCCGA GTGTCCCTCTTCTCGCCTGGTCTCTGG TCAGATGAAGTG TTCCCTGCGCCTGT GGACACCG (SEQ CCCAGCATCACAGATGCTGGGCACTT ID NO: 2384) GG (SEQ ID NO: CATCTGATCGGGGG 2385)CGTAGCATCATAGT AGT (SEQ ID NO: 2383) CCND14 NCI_Lih_1_005.1ATTGATTCAGCCTG TGCCTGTCCAATC ATTCATCGGAAC TTTGGCGTTTCCCA AGATGACTCTGGCGAACTTAGGTT GAGTCATCTGATTG GAAACGCCAAAC GAGTACCCTAAT GACAGGCATGGGTAGGCTGAATCAA TTTCCTTGCACC GCAAGGAAAATTA T (SEQ ID NO: CA (SEQ ID NO:GGGTACTCAACCTA 2387) 2388) AGTTCGGTTCCGAT GAAT (SEQ ID NO: 2386) CCND15NCI_Lih_1_029.1 GTTGTGTGTGCAGG GATATTCCCAAA CCACAGTGGCCC GAGGGCAGTTTTCTCCATTCCATTAGA ACACTTGCCTCA AATGGAATGGTTTG AAACTGCCCTCCC AAGTCCTGCTTGGGAATATCCATGTA TGCACACACAAC CAAACAAGTACA CTTGTTTGCAAGCA(SEQ ID NO: 2390) TG (SEQ ID NO: GGACTTTGAGGCAA 2391) GTGTGGGCCACTGTGG (SEQ ID NO: 2389) CCND16 NCI_Lih_1_019.1 TCATGGCTGAAGTC GCACACGGCCACCACTGGATGGTT ACCTCTTGGTTACA GCTACGCTACTGT TGTTGGGGTGGT GTAGCGTAGCGTGGAACCAAGAGGTG GGTCACAGGCGC CCGTGTGCATGTCC ACTTCAGCCATG AAAGGACATTTTGCGCCTGTGAC A (SEQ ID NO: (SEQ ID NO: 2394) CACCACCCCAACAA 2393)ACCATCCAGTGACA AA (SEQ ID NO: 2392) CDKN2A_1 NCI_Lih_1_018.1GCACTCACGCCCTA CGAGGCTCGCAA TCCCTAGTTCAC AGCGCACATTCATG GAAATGCCCACAAAAATGCTTGTC TGGGCATTTCTTGC TGAATGTGCGCTT ATGAAGTCGACA GAGCCTCGCAGCCTAGGGCGTGAGTG GCTTCCGGAGGC CCGGAAGCTGTCGA C (SEQ ID NO: TG (SEQ ID NO:CTTCATGACAAGCA 2396) 2397) TTTTGTGAACTAGG GA (SEQ ID NO: 2395) CDKN2A_2NCI_Lih_1_042.1 AAAGATACCGCGG CCCCCTCCGACCC CCCTCCTCTTTCT TCCCTCCAGAGGATTGTCCCTCAAATC TCCTCCGGTGCT TTGAGGGACAGGG CTCTGGAGG (SEQ GGCGGAAGAGTCGGAGGGGGCTCT ID NO: 2399) (SEQ ID NO: 2400) TCCGCCAGCACCGGAGGAAGAAAGAGG AGGGGCTGGCTGGT CACCA (SEQ ID NO: 2398)

Gene expression signatures based on novel combinations of genes derivedfrom the 800 gene array can be used to diagnose a patient as havingactivated B cell-like diffuse large B cell lymphoma (ABC DLBCL),germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL),primary mediastinal B cell lymphoma (PMBL), Burkitt lymphoma (BL), ormantle cell lymphoma (MCL). For example, a gene expression signaturethat can be used to diagnose a patient as having one of theaforementioned lymphoma types includes at least one, but preferably twoor more of the genes set forth in Table 1 (e.g., 2, 5, 10, 50, 75, 100,125, 150, 175, 200, 225, 250, 275, 300, 400, 500, 600, or 700 genes, ora range defined by any two of the foregoing values). Desirably, the geneexpression signature that can be used to diagnose a patient as havingABC DLBCL, GCB DLBCL, PMBL, BL, or MCL includes 15-200 of the genes setforth in Table 1 (e.g., 15, 30, 50, 75, 100, 125, 150, 175, or 200genes, or a range defined by any two of the foregoing values). In oneembodiment, the gene expression signature used to diagnose a patient ashaving ABC DLBCL, GCB DLBCL, PMBL, BL, or MCL includes the genes setforth in Table 2, or a subset of the genes set forth in Table 2 (e.g.,10, 15, 30, 50, 75, 100, 125, 150, or 190 of the genes set forth inTable 2, or a range defined by any two of the foregoing values).

TABLE 2 Gene GenBank Accession No. ACSL5 NM_016234.3 ADAM12 NM_003474.4AHCYL2 NM_001130723.2 AHR NM_001621.3 AKAP2 NM_001136562.2 AKAP9NM_005751.3 ALOX5 NM_000698.2 ANKRD13A NM_033121.1 ANTXR1 NM_018153.3ARID3A NM_005224.2 ARID3B NM_006465.2 ASB13 NM_024701.3 ATXN7L2NM_153340.4 AUH NM_001698.2 AUTS2 NM_001127231.1 BANK1 NM_001083907.1BATF NM_006399.3 BCAT1 NM_005504.4 BCL2 NM_053056.2 BCL2A1 NM_004049.2BCL2L10 NM_020396.2 BCL6 NM_001706.2 BIRC3 NM_001165.3 BPGM NM_199186.1BPNT1 NM_006085.4 BSPRY NM_017688.2 BUB1B NM_001211.4 C10orf18NM_017782.3 C13orf18 NM_025113.2 C3orf37 NM_020187.2 CALD1 NM_033138.2CARD11 NM_032415.2 CCDC50 NM_174908.3 CCL17 NM_002987.2 CCND1NM_053056.2 CCND2 NM_001759.2 CCR7 NM_001838.2 CD44 NM_000610.3 CDH11NM_001797.2 CDK5RAP2 NM_001011649.1 CDK6 NM_001259.5 CFLAR NM_003879.3CGNL1 NM_032866.3 CHD4 NM_001273.2 CLIP2 NM_003388.4 CPA6 NM_001127445.1CPNE3 NM_003909.2 CR2 NM_001006658.1 CREB3L2 NM_194071.2 CSF2RANM_006140.3 CSTA NM_005213.3 CTHRC1 NM_138455.2 CTSH NM_148979.2 CTSKNM_000396.2 CYB5R2 NM_016229.3 CYP27A1 NM_000784.3 DAZAP2 NM_014764.3DCTD NM_001012732.1 DENND4A NM_005848.3 DNAJB12 NM_017626.4 DNAJC10NM_018981.1 DOCK10 NM_014689.1 DPYSL3 NM_001387.2 E2F2 NM_004091.2 EEPD1NM_030636.2 EFEMP2 NM_016938.3 ELL2 NM_012081.5 EML1 NM_004434.2 ENTPD1NM_001776.4 ERBB2IP NM_018695.2 ERP29 NM_001034025.1 ETV6 NM_001987.4FAM108C1 NM_021214.1 FAM159A NM_001042693.1 FAM171B NM_177454.3 FAM46CNM_017709.3 FAM69A NM_001006605.3 FAP NM_004460.2 FAS NM_000043.3 FBXO41NM_001080410.1 FCER2 NM_002002.4 FKBP11 NM_016594.2 FLJ42418NM_001001695.1 FN1 NM_212482.1 FNDC1 NM_032532.2 FUT8 NM_004480.3 GCET2NM_001008756.1 GIT2 NM_057169.2 GNA13 NM_006572.4 GNL3 NM_014366.4GORASP1 NM_031899.2 GSK3B NM_002093.2 GYPC NM_016815.2 HARBI1NM_173811.3 HCK NM_002110.2 HDAC1 NM_004964.2 HDGF NM_004494.2 HEG1NM_020733.1 HLA-DMA NM_006120.3 HOMER2 NM_004839.2 HOPX NM_001145460.1HPCAL1 NM_134421.1 HSP90AA1 NM_005348.3 HSP90B1 NM_003299.1 HSPA9NM_004134.4 HSPB8 NM_014365.2 HTRA1 NM_002775.4 ICAM1 NM_000201.1 IFIH1NM_022168.2 IGSF3 NM_001542.2 IK NM_006083.3 IL12A NM_000882.2 IL13RA1NM_001560.2 IL16 NM_004513.4 IL17RB NM_018725.3 IRF4 NM_002460.1 ISG15NM_005101.3 ISY1 NM_020701.2 ITGAV NM_002210.2 ITGAX NM_000887.3 ITGB2NM_000211.2 1TPKB NM_002221.3 JAK2 NM_004972.2 JAK3 NM_000215.2 KCNK12NM_022055.1 KIAA0746 NM_015187.3 KIAA1274 NM_014431.2 KLHL5 NM_015990.4KRAS NM_033360.2 KYNU NM_003937.2 LANCL1 NM_006055.1 LDHA NM_005566.1LIMA1 NM_001113547.1 LIMD1 NM_014240.2 LMO2 NM_005574.3 LRMP NM_006152.2LRRC15 NM_001135057.2 LRRC33 NM_198565.1 LTBP2 NM_000428.2 LYPD6BNM_177964.3 LYZ NM_000239.2 MAL NM_002371.2 MAML3 NM_018717.4 MAP3K1NM_005921.1 MAP4K4 NM_004834.3 MAPK10 NM_002753.2 MARCKSL1 NM_023009.5MAST2 NM_015112.1 MDFIC NM_199072.2 MLL2 NM_003482.3 MLLT10 NM_004641.2MME NM_000902.2 MMP2 NM_004530.2 MMP9 NM_004994.2 MOBKL2C NM_145279.4MPEG1 XM_937323.1 MTHFD2 NM_006636.3 MYB NM_005375.2 MYBL1 XM_034274.14MYC NM_002467.3 NAIF1 NM_197956.3 NANS NM_018946.3 NCF2 NM_000433.2NECAP2 NM_018090.4 NEIL1 NM_024608.2 NEK6 NM_014397.3 NEU3 NM_006656.5NFIL3 NM_005384.2 NFKBIZ NM_01005474.1 NEPA2 NM_001008860.1 NOC3LNM_022451.9 NOL5A NM_006392.2 NP NM_000270.3 OPA1 NM_130837.1 OSBPL3NM_145320.1 PAG1 NM_018440.3 PDE9A NM_001001567.1 PDIA5 NM_006810.2PDLIM1 NM_020992.2 PDPN NM_006474.4 PFTK1 NM_012395.2 PHF16 NM_014735.3PHF23 NM_024297.2 PIM1 NM_002648.2 PIM2 NM_006875.2 PLAU NM_002658.2PLEK NM_002664.2 PLEKHF2 NM_024613.2 PMEPA1 NM_020182.3 PPA1 NM_021129.3PPP3CC NM_005605.3 PRDX2 NM_005809.4 PRICKLE1 NM_153026.1 PRKCBNM_212535.1 PRPSAP2 NM_002767.2 PRR6 NM_181716.2 PTGIR NM_000960.3 PTK2NM_005607.3 PTPN1 NM_002827.2 PTRH1 NM_001002913.1 R3HDM1 NM_015361.2RAB20 NM_017817.1 RAB33A NM_004794.2 RAB7L1 NM_001135664.1 RANBP9NM_005493.2 RAPGEF5 NM_012294.3 RARRES2 NM_002889.3 RASGRP3 NM_015376.2RC3H2 NM_018835.2 RCL1 NM_005772.3 REL NM_002908.2 RFTN1 NM_015150.1RGS9 NM_003835.1 RHOF NM_019034.2 RNF214 NM_207343.2 RNUXA NM_032177.3ROBO1 NM_002941.2 RRP1B NM_015056.2 S100Z NM_130772.3 S1PR2 NM_004230.2SACS NM_014363.4 SAMSN1 NM_022136.3 SCARA5 NM_173833.4 SERPINA9NM_001042518.1 SGK1 NM_005627.2 SH3BP5 NM_001018009.2 SIDT1 NM_017699.2SLA NM_001045556.2 SLAMF1 NM_003037.2 SLC38A5 NM_033518.2 SMARCA4NM_003072.3 SNN NM_003498.4 SNX11 NM_152244.1 SNX22 NM_024798.2 SNX29NM_001080530.2 SOX11 NM_003108.3 SPARC NM_003118.2 SPINK2 NM_021114.2SPINT2 NM_021102.2 SPRED2 NM_181784.2 SSBP2 NM_012446.2 STAMBPL1NM_020799.2 STAP1 NM_012108.2 STAT3 NM_139276.2 STK17A NM_004760.1 STSNM_000351.4 STX11 NM_003764.3 SUFU NM_016169.2 SULF1 NM_015170.2 TARSNM_152295.3 TBC1D9 NM_015130.2 TCF3 NM_003200.2 TCF4 NM_001083962.1TCTN3 NM_0115631.5 TERT NM_198253.1 TEX9 NM_198524.1 THBS2 NM_003247.2THOC5 NM_001002878.1 THY1 NM_006288.2 TIAM2 NM_001010927.2 TICAM2NM_021649.4 TLE4 NM_007005.3 TLK1 NM_012290.3 TLR7 NM_016562.3 TMEM119NM_181724.2 TMOD1 NM_003275.2 TNFRSF13B NM_012452.2 TNFRSF17 NM_001192.2TNFSF4 NM_003326.2 TOX NM_014729.2 TPM1 NM_000366.5 TRAF1 NM_005658.3TRIM56 NM_030961.1 TRM62 NM_018207.2 TRIP13 NM_004237.2 TTC9 NM_015351.1TUBB2C NM_006088.5 UBXN4 NM_014607.3 USP12 NM_182488.3 USP46 NM_022832.2VAC14 NM_018052.3 VASH2 NM_024749.3 VGLL4 NM_001128220.1 VRK3NM_016440.3 WAC NM_100486.2 WDR55 NM_017706.4 WNT3 NM_030753.3 XBP1NM_005080.2 ZBTB32 NM_014383.1 ZBTB37 NM_001122770.1 ZBTB8NM_001040441.1 ZCCHC2 NM_017742.4 ZCCHC7 NM_032226.2 ZNF281 NM_012482.3ZNF318 NM_014345.2 ZNF598 NM_178167.2 ZNF608 NM_020747.2

The invention also provides a method for selecting a treatment optionfor a subject who already has been diagnosed with a diffuse large B celllymphoma (DLBCL). The method comprises isolating a gene expressionproduct from a biopsy sample from a DLBCL subject, and obtaining digitalgene expression data from the isolated gene expression product. Themethod comprises isolating a gene expression product from a biopsysample from a DLBCL subject, and obtaining digital gene expression datafrom the isolated gene expression product. Descriptions of the geneexpression product, digital gene expression data, and gene expressionsignature set forth above in connection with other embodiments of theinvention also are applicable to those same aspects of the aforesaidinventive method for selecting a treatment option for a subject whoalready has been diagnosed with a DLBCL.

The invention further provides a method for selecting a GCB DLBCLsubject for treatment with R-CHOP (rituxan, cyclophosphamide,hydroxydaunorubicin, oncovin (vincristine), and prednisone) therapy. Themethod comprises (a) isolating a gene expression product from a biopsysample from a DLBCL subject; (b) obtaining digital gene expression datafrom the isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature(c) generating a weighted average of the expression levels of genes fromthe gene expression signature to thereby obtain a gene expressionsignature value; (d) calculating a predictor score based on the geneexpression signature value; (e) classifying the subject as belonging toABC DLBCL or GCB DLBCL based on the predictor score of (d); (f)selecting a GCB DLBCL subject for R-CHOP therapy; and (g) providingR-CHOP therapy to the GCB DLBCL subject and providing a differenttherapy to an ABC DLBCL subject. Descriptions of the gene expressionproduct, digital gene expression data, and gene expression signature setforth above in connection with other embodiments of the invention alsoare applicable to those same aspects of the aforesaid inventive methodfor selecting a GCB DLBCL subject for treatment with R-CHOP therapy.

The invention provides gene expression signatures that can be used toclassify a DLBCL as belonging to the GCB subtype or the ABC subtype andthen select an appropriate treatment option based on thatclassification. In this respect, the invention provides a novel 20 genearray for the identification and diagnosis of various lymphoma types.The 20 gene array contains 15 genes of interest and 5 housekeepinggenes, and is based on a pilot study described in Lenz et al., N. Engl.J. Med., 359: 2313-2323 (2008) (see also the Example herein). The genesand probe sequences that comprise the 20 gene array are set forth inTable 3. Gene expression signatures based on all or combinations of thegenes from the 20 gene array can be used to diagnose a patient hashaving ABC DLBCL or GCB DLBCL. For example, a gene expression signaturethat can be used to diagnose a patient as having ABC DLBCL or GCB DLBCLincludes at least one, but preferably two or more (e.g., 2, 3, 4, 5, 6,7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, or 20) of the genes setforth in Table 3.

TABLE 3 GenBank Capture Probe Reporter Probe Gene Accession No.Target Sequence Sequence Sequence ASB13 NM_024701.3 GGACACGTAGGCGGTCGGTTTGAATGGC GAATGCCGAGCC ACCACTAAGGTTTTG TCATTACCAAAAC ACGAGAATATACGTAATGAGCCATTCA CTTAGTGGTACCG ACCTTGACACAC AACCGACAGCAGTGT CCTACGTGTCCCTTCACACTGCTG GAAGGTGTGTCAAGG (SEQ ID NO: 2402) T (SEQ ID NO:TGTATATTCTCGTGGC 2403) TCGGCATTC (SEQ ID NO: 2401) CCDC50 NM_174908.3AAACACTTTCCAGAG TAGTAACTATCTG TAGATACAGCTTC TTCCCTGCAACCCGTCATAAGCACGGGT TTICATCACTCYT GCTTATGCAGATAGT TGCAGGGAACTCT GGCTTCATTCCTCTACTATTATGAAGAT GGAAAGTGTTT CATCTTCATAA GGAGGAATGAAGCCA(SEQ ID NO: 2405) (SEQ ID NO: 2406) AGAGTGATGAAAGAA GCTGTATCTA (SEQ IDNO: 2404) CREB3L2 NM_194071.2 ATGCCTGAGGGGATC AAGATGGGGCAGG AGAACTATGGATAGGCTTTTCTACTCCA TTTGCCTGGAGTA GTGTGGGGAACC GGCAAACCTGCCCCAGAAAAGCCTGATC AGGTTGTGGGAG TCTTGTCGCTTTTAGG CCCT (SEQ ID NO:GTCCTAAAAGCG ACCTCCCACAACCTG 2408) AC (SEQ ID NO: GTTCCCCACACATCC 2409)ATAGTTCT (SEQ ID NO: 2407) CYB5R2 NM_016229.3 CCATGTCTTAGGGCTTTTTTGCCAAGAG ATCATCACTGGA TCCTGTAGGTAACTA CTGGACATAGTTA GACAGGGGTGTATGTCCAGCTCTTGGC CCTACAGGAAGCC AGCCCTGACCAC AAAAATCGATAATGA CTAAGACATGGCAATTCATTATCG ATTGGTGGTCAGGGC (SEQ ID NO: 2411) A (SEQ ID NO:TTACACCCCTGTCTCC 2412) AGTGATGAT (SEQ ID NO: 2410) IRF4 NM_002460.1GGGCACTGTTTAAAG AGGGTCCGGCTTG TTGTTCAAAGCGC GAAAGTTCCGAGAAGTCGATGCCTTCTC ACCGCAGGCGCG GCATCGACAAGCCGG GGAACTTTCCTTT TCTTCCAGGTGGGACCCTCCCACCTGGA AAACAGTGCCC (SEQ ID NO: 2415) AGACGCGCCTGCGGT(SEQ ID NO: 2414) GCGCTTTGAACAAGA GCAATGACTT (SEQ ID NO: 2413) ISY1NM_020701.2 GGCAAAACATCAGTG GCTCACAGGAACT CCCCTGTCCAAG TCTGTGGGTAGTTGGGAAGATTCCAACT AAACTCCACAGG AATCTTCAGTTCCTGT ACCCACAGACACT CCCAGAAGACGCGAGCGTCGGCGTCTT GATGTTTTGCC CGAC (SEQ ID NO: CTGGGCCTGTGGAGT(SEQ ID NO: 2417) 2418) TTCTTGGACAGGGGC CGCGGGGCT (SEQ ID NO: 2416)ITPKB NM_002221.3 GTGGCCTCCTGGCAT GGCAGTAAGGCTT CCTACAAGATACCATTTGTTATTGCCTC GTTTCAGAGGCAA CCACACTACATTG TGAAACAAGCCTTACTAACAAATGATGC GAGAAGCAGGAA TGCCTGGAGGGCTTA CAGGAGGCCAC TCTAAGCCCTCCAGATTCCTGCTTCTCCA (SEQ ID NO: 2420) (SEQ ID NO: 2421) ATGTAGTGTGGGTATCTTGTAGG (SEQ ID NO: 2419) LIMD1 NM_014240.2 AAGGCAAGTCTCAGGTAAAAACAGGTGC TCTCTCAGTATGC AACCCATGCAGGTAC AAGCGATGTACCT GGGCAGCTCTTCCATCGCTTGCACCTGTT GCATGGGTTCCTG CAAAAGCCCGTC TTTAGCTTATTTAATG AGACTTGCCTTATTAAATAAGC ACGGGCTTTTGGGAA (SEQ ID NO: 2423) (SEQ ID NO: 2424)GAGCTGCCCGCATAC TGAGAGAC (SEQ ID NO: 2422) MAML3 NM_018717.4TGGAAGCCATCAACA AGAAGCTGAAGGC CCACTGTTCTGCA ATTTGCCCAGTAACAAGTGGCATGTTAC AGGGCAAAGAAG TGCCACTGCCTTCAG TGGGCAAATTGTT GTTTCAGGTCAACTTCTCCTCTTCACCA GATGGCTTCCA GTTGGTGAAGAG ACTTGACCTGAAACC(SEQ ID NO: 2426) G (SEQ ID NO: TTCTTTGCCCTTGCAG 2427) AACAGTGG (SEQ IDNO: 2425) MME NM_000902.2 GGATTGTAGGTGCAA TAGGGCTGGAACA CCAAAGGAATATGCTGTCCAGAGAAAA AGGACTCTTTTCTC TGCAAATACCCA GAGTCCTTGTTCCAGTGGACAGCTTGCA AGGTCACCCTGTC CCCTATTCTGCCACTC CCTACAATCC (SEQAGGAGTGGCAGA CTGACAGGGTGACCT ID NO: 2429) A (SEQ ID NO: TGGGTATTTGCAATA2430) TTCCTTTGG (SEQ ID NO: 2428) MYBL1 XM_034274.14 GGCAAACGCTGTGTTTCTCTGCAAATTCT ACTGGTAACGTC ATCCTCTTTGCAGAC GGGATGGTCTGCA ACTCCATGCTACACATCCCAGAATTTGC AAGAGGATAACAC GGATCAGATTCA AGAGACTCTAGAACTAGCGTTTGCC (SEQ ATAAGTTCTAGA TATTGAATCTGATCCT ID NO: 2432) G (SEQ ID NO:GTAGCATGGAGTGAC 2433) GTTACCAGT (SEQ ID NO: 2431) PIM2 NM_006875.2GCCATCCAGCACTGC TCCTTGATGTCAC AATCAATGAGTTT CATTCCCGTGGAGTTGATGGACAACTCC GGCACAGCCACG GTCCATCGTGACATC ACGGGAATGGCAG GCGTAGGTCTATCAAGGATGAGAACATC TGCTGGATG (SEQ AGGATGTTCTCA CTGATAGACCTACGC ID NO: 2435)(SEQ ID NO: 2436) CGTGGCTGTGCCAAA CTCATTGATT (SEQ ID NO: 2434) R3HDM1NM_015361.2 CCTGTGTTCCCAAGA CCTCGTCTTGGAG ATCTTTATTAACT GAATTACATTATTGATCTTTTGTCAATAA CTAAATATCTGGC CAAAAGACTCCAAGA TGTAATTCTCTTGGGCCTCTGCTGGGT CGAGGATGCCAGTAG GAACACAGG (SEQ ACTACTGGCAT TACCCAGCAGAGGCGID NO: 2438) (SEQ ID NO: 2439) CCAGATATTTAGAGT TAATAAAGAT (SEQID NO: 2437) RAB7L1 NM_001135664.1 CATTTGAATTGTCTCC AGTGACAATGGGCCTAATCCAGGAG TGACTACTGTCCAGT CTCCTTACTGGAC ATGCAGAAATGC AAGGAGGCCCATTGTAGTAGTCAGGAGA ACATGGGTTCCA CACTTAGAAAAGACA CAATTCAAATG GGTGTCTTTTCTACCTGGAACCCATGTG (SEQ ID NO: 2441) (SEQ ID NO: 2442) CATTTCTGCATCTCCTGGATTAGC (SEQ ID NO: 2440) S1PR2 NM_004230.2 TCCCGCCAGGTGGCCACAATGGCGCAAC GGAACTTGCTGTT TCGGCCTTCATCGTC AGAGGATGACGAT TCGGGCCACCGCATCCTCTGTTGCGCC GAAGGCCGAGGCC AATGAGCACCAG ATTGTGGTGGAAAACACCTGG (SEQ ID AAGGTTTTCCACC CTTCTGGTGCTCATTG NO: 2444)(SEQ ID NO: 2445) CGGTGGCCCGAAACA GCAAGTTCC (SEQ ID NO: 2443) SERPINA9NM_001042518.1 CCACTAAATCCTAGG TAGCAATGTGCCA ATGCACCCTCAGTGGGAAATGGCCTGT TCAGTTAACAGGC AACAGAAAGAGG TAACTGATGGCACAT CATTTCCCACCTAGATGTGGTTTGTT TGCTAATGCACAAGA GGATTTAG (SEQ ID ATTTCTTGTGCATAATAACAAACCACAT NO: 2447) (SEQ ID NO: 2448) CCCTCTTTCTGTTCTGAGGGTGCAT (SEQ ID NO: 2446) TNFRSF13B NM_012452.2 TGCAAAACCATTTGCCAGAAGGCTGCAC TCATAGAACTTGC AACCATCAGAGCCAG AGGTGCGCTGGCT CTTGCTCCTTGCGCGCACCTGTGCAGCC CTGATGGTTGCAA GCAGCTGAGTGA TTCTGCAGGTCACTC ATGGTTTTGCACCTG (SEQ ID NO: AGCTGCCGCAAGGAG (SEQ ID NO: 2450) 2451) CAAGGCAAGTTCTATGACCATCTCC (SEQ ID NO: 2449) TRIM56 NM_030961.1 GTGGAGGCCGAGGACTTGAAAAGTTGCC CCTATTCTCACAC ATTTTCCTGAAGGGC AACCCCTGCCCTT ACTAGAAGACGGAGGGGTTGGCAACTT CAGGAAAATGTCC GTTAGCAGTTTGG TTCAACATGGAGTGCTCGGCCT (SEQ ID CACTCCATG (SEQ CAAACTGCTAACCCG NO: 2453) ID NO: 2454)TCTTCTAGTGTGTGA GAATAGGGAC (SEQ ID NO: 2452) UBXN4 NM_014607.3CATCGCGACGGCCAA CTGCCACGAACAC TTTATCATCTTCC AAGGAGCGGCGCGGTCACGAAGACCGCG CAACTTGCAGCC CTTCGTGGTGTTCGTG CCGCTCCTTTTGGC ATCTGTGTAGACTGCAGGTGATGATGAA CG (SEQ ID NO: GTTCATCATCAC CAGTCTACACAGATG 2456)(SEQ ID NO: 2457) GCTGCAAGTTGGGAA GATGATAAA (SEQ ID NO: 2455) WDR55NM_017706.4 CTACCTCTTCAATTGG GGGCAAAGCGGTC GACTCTCGGTGA AATGGCTTTGGGGCCACTTGTGGCCCCA CTGGAACCATGC ACAAGTGACCGCTTT AAGCCATTCCAAT AGTCGATAGATTGCCCTGAGAGCTGAA TGAAGAG (SEQ ID CAGCTCTCA (SEQ TCTATCGACTGCATG NO: 2459)ID NO: 2460) GTTCCAGTCACCGAG AGTCTGCTG (SEQ ID NO: 2458)

In one embodiment, a method used to evaluate the likelihood that aparticular sample belongs to ABC DLBCL, GCB DLBCL, PMBL, BL, or MCLinvolves (1) normalizing and transforming gene expression data from thegene expression signature and performing quality control, (2) formingindividual trinary submodels, and (3) combining submodels into a finalprediction. The gene expression data can be transformed by associatingwith each probe set a value equal to log₂ of the counts reported forthat probe set. A weighted average of the expression levels of genesfrom the gene expression signature can then be generated by multiplyingthe transformed data by their respective normalization weights (as setforth in Table 4) and summed to arrive at a normalization factor. If thenormalization factor is less than 4.5, the sample is excluded as beingof poor quality. Otherwise, the normalization factor can be subtractedfrom each of the log transformed data counts. If a reference array forthe chip batch and a reference gold standard array are available, thenfor each probe set the log₂ of the score for the reference array countsfor that gene is subtracted and the log₂ of the gold standard counts forthat gene is added. These aforementioned steps are summarized in thefollowing equation, which calculates a predictor score y_(i) (the finaloutput signal used for probe set i):

$y_{i} = {{\log_{2}\left( x_{i} \right)} - {\sum\limits_{j}\; {{\log_{2}\left( x_{j} \right)}h_{j}}} - {\log_{2}\left( r_{i} \right)} + {\log_{2}\left( g_{i} \right)}}$

wherein x_(i) is the counts for probe set i on the array of the samplebeing tested, h_(i) is the housekeeping weight for probe set j, r_(i) isthe counts for probe set i on the reference array, and g_(i) is thecounts for probe set i on the gold-standard array.

The final classification of the subject as belonging to (i) ABC DLBCL,(ii) GCB DLBCL, (iii) PMBL, (iv) BL, or (v) MCL is based on acombination of five trinary submodels for each lymphoma type (i.e., MCL,BL non-myc, BL myc, PMBL, ABC DLBCL, and GCB DLBCL), each of whichproduces three possible output values (i.e., −1,0,1) according to thefollowing formula:

${{Submodel}\mspace{14mu} {call}} = \left\{ \begin{matrix}{- 1} & {{{if}\mspace{14mu} {\sum\limits_{i}\; {y_{i}w_{i}}}} \leq {{Lower}\mspace{14mu} {cutpoint}}} \\0 & {{{Lower}\mspace{14mu} {cutpoint}} < {\sum\limits_{i}\; {y_{i}w_{i}}} < {{Upper}\mspace{14mu} {cutpoint}}} \\1 & {{\sum\limits_{i}\; {y_{i}w_{i}}} \geq {{Upper}\mspace{14mu} {cutpoint}}}\end{matrix} \right.$

wherein y_(i) is the predictor score y_(i) assigned to probe set i asdescribed above, w_(i) are the weights associated with that probe setfor the particular model as presented in Table 4, and the upper andlower cutpoints for a particular submodel are set forth in Table 5.

TABLE 4 Normalization ABC/GCB BL non- BL Gene weights weights Mycweights myc weights PMBL Weights MCL Weights ACPP 0 0 0 0 0 0 ACTG2 0 00 0 0 0 ADAM12 0 0 0 0 −2.166433184 0 ADAM28 0 0 0 0 0 0 ADH1B 0 0 0 0 00 ADIPOQ 0 0 0 0 0 0 ADO 0 0 0 0 0 0 AHR 0 0 0 −4.866117918 0 0 AICDA 00 0 0 0 0 AKAP2 0 0 0 0 19.33144328 0 AKR1C2 0 0 0 0 0 0 ALOX5 0−11.14191131 0 0 0 59.14375571 AMIGO2 0 0 0 0 0 0 ANKRD13A 0 −13.11444410 0 0 0 ANLN 0 0 0 0 0 0 ANO3 0 0 0 0 0 0 ANTXR1 0 0 0 0 −2.443912822 0ANUBL1 0 0 0 0 0 0 APOL1 0 0 0 0 0 0 ARID3A 0 16.99118469 0 0 0 0 ARID3B0 12.66080868 0 0 0 0 ARID5A 0 0 0 0 0 0 ARL6IP1 0 0 0 0 0 0 ARNT2 0 0 00 0 0 ARNTL 0 0 0 0 0 0 ASB13 0 −19.64578147 0 0 0 0 ASPM 0 0 0 0 0 0ATF3 0 0 0 0 0 0 ATM 0 0 0 0 0 0 ATP6V0E1 0 0 0 0 0 0 AUH 0 0 0 020.46302485 0 AURKA 0 0 0 0 0 0 AUTS2 0 −15.20513307 0 0 0 0 BANK1 0 0 00 −24.53325693 0 BASP1 0 0 0 0 0 0 BATF 0 17.98245577 0 0 0 0 BATF3 0 00 0 0 0 BCAT1 0 0 0 0 0 −74.11099391 BCL10 0 0 0 0 0 0 BCL2 0 0 0 0 0 0BCL2 0 0 0 0 0 0 BCL2 0 0 0 0 0 0 BCL2 0 0 0 0 0 0 BCL2 0 14.07216258 00 0 0 BCL2 0 0 0 0 0 0 BCL2A1 0 0 0 −5.947560928 0 0 BCL2L10 09.91380548 0 0 0 0 BCL6 0 −17.29479012 0 −5.383296889 0 0 BEST3 0 0 0 00 0 BIRC2 0 0 0 0 0 0 BIRC3 0 0 0 −5.663158028 0 0 BIRC5 0 0 0 0 0 0BMP7 0 0 0 0 0 0 BPGM 0 10.51166906 0 0 0 0 BPNT1 0 −11.94204992 0 0 0 0BSPRY 0 12.55890968 0 0 0 0 BST2 0 0 0 0 0 0 BTBD19 0 0 0 0 0 0 BTG1 0 00 0 0 0 BTG2 0 0 0 0 0 0 BTK 0 0 0 0 0 0 BUB1 0 0 0 0 0 0 BUB1B 0 00.129449175 −6.543666003 0 0 C10orf18 0 −11.23438924 0 0 0 0 C13orf18 014.60869443 0 6.676459404 0 0 C15orf41 0 0 0 0 0 0 C3orf37 0 −13.28923760 0 0 0 C5AR1 0 0 0 0 0 0 C5orf41 0 0 0 0 0 0 C7orf68 0 0 0 0 0 0CACNA1D 0 0 0 0 0 0 CALD1 0 0 0 0 −2.249574505 0 CAMK2B 0 0 0 0 0 0CARD11 0 13.81862222 0 0 −18.72040556 0 CAV1 0 0 0 0 0 0 CAV2 0 0 0 0 00 CCDC50 0 18.68358953 0 5.320661402 0 68.6051667 CCDC75 0 0 0 0 0 0CCL17 0 0 0 0 25.50999568 0 CCNA2 0 0 0 0 0 0 CCNB1 0 0 0 0 0 0 CCNB2 00 0 0 0 0 CCND1 0 0 0 0 0 0 CCND1 0 0 0 0 0 0 CCND1 0 0 0 0 0 0 CCND1 00 0 0 0 0 CCND1 0 0 0 0 0 0 CCND1 0 0 0 0 0 87.99680321 CCND2 013.55862157 0 0 0 0 CCND3 0 0 0 0 0 0 CCR7 0 11.22811168 0 −4.8626126970 0 CD2 0 0 0 0 0 0 CD200 0 0 0 0 0 0 CD22 0 0 0 0 0 0 CD247 0 0 0 0 0 0CD274 0 0 0 0 0 0 CD3D 0 0 0 0 0 0 CD3E 0 0 0 0 0 0 CD3G 0 0 0 0 0 0CD40 0 0 0 0 0 0 CD44 0 13.50378135 0 −5.782231847 0 0 CD47 0 0 0 0 0 0CD5 0 0 0 0 0 0 CD58 0 0 0 0 0 0 CD6 0 0 0 0 0 0 CD74 0 0 0 0 0 0 CD79A0 0 0 0 0 0 CD79B 0 0 0 0 0 0 CD8A 0 0 0 0 0 0 CD8B 0 0 0 0 0 0 CDC20 00 0 0 0 0 CDC25B 0 0 0 0 0 0 CDC25C 0 0 0 0 0 0 CDCA3 0 0 0 0 0 0 CDCA50 0 0 0 0 0 CDCA8 0 0 0 0 0 0 CDH11 0 0 0 0 −2.338738276 0 CDC2 0 0 0 00 0 PFTK1 0 −15.92270263 0 0 0 0 CDK4 0 0 0 0 0 0 CDK6 0 0 0 0 0−65.86959926 CDKN2A 0 0 0 0 0 0 CDKN2A 0 0 0 0 0 0 CDKN3 0 0 0 0 0 0CELSR1 0 0 0 0 0 0 CENPA 0 0 0 0 0 0 CENPE 0 0 0 0 0 0 CENPF 0 0 0 0 0 0CENPN 0 0 0 0 0 0 PRR6 0 0 0 0 22.43680643 0 CEP55 0 0 0 0 0 0 CFLAR 016.61287119 0 −5.100315997 0 0 CGNL1 0 0 0 0 −2.156504887 0 CIITA 0 0 00 0 0 CKS2 0 0 0 0 0 0 CLIP2 0 0 0 0 20.2768953 0 CLMN 0 0 0 0 0 0 CPNE30 −11.49752906 0 0 0 0 CR2 0 −12.2225611 0 −5.465732584 −19.63179827 0CREB3L2 0 19.29029329 0 0 0 0 CREBBP 0 0 0 0 0 0 CSF2RA 0 0 0 0−2.424880636 0 CSTA 0 0 0 0 −2.543864326 0 CTGF 0 0 0 0 0 0 CTH 0 0 0 00 0 CTHRC1 0 0 0 0 −2.518684898 0 CTLA4 0 0 0 0 0 0 CTNNA2 0 0 0 0 0 0CTPS 0 0 0 0 0 0 CTSH 0 0 0 −5.145507824 0 0 CTSK 0 0 0 0 −2.572873829 0CXCL10 0 0 0 0 0 0 CXCL12 0 0 0 0 0 0 CXCL9 0 0 0 0 0 0 CYB5R2 019.12600362 0 0 0 0 CYP27A1 0 0 0 0 −2.635085165 0 CYP2J2 0 0 0 0 0 0CYSLTR1 0 0 0 0 0 0 DCBLD1 0 0 0 0 0 0 DCTD 0 15.98936135 0 0 0 0 DDAH20 0 0 0 0 0 DDX58 0 0 0 0 0 0 DENND4A 0 0 0 0 21.20254474 0 DLC1 0 0 0 00 0 DLEU1 0 0 0 0 0 0 DLGAP5 0 0 0 0 0 0 DNAJA1 0 0 0 0 0 0 DNAJB9 0 0 00 0 0 DNAJC10 0 −12.209423 0 0 0 0 DNMT3A 0 0 0 0 0 0 DOCK10 015.87228876 0 0 17.13938941 0 DPY19L1 0 0 0 0 0 0 DPYSL3 0 0 0 0−2.427210322 0 DRAM 0 0 0 0 0 0 DTX1 0 0 0 0 0 0 E2F2 0 0 0 4.8718530590 0 E2F8 0 0 0 0 0 0 EBV_BZLF1 0 0 0 0 0 0 EBV_EBER1 0 0 0 0 0 0EBV_EBER2 0 0 0 0 0 0 EBV_EBNA1_CDS 0 0 0 0 0 0 EBV_EBNA2_3′_end 0 0 0 00 0 EBV_EBNA2_long 0 0 0 0 0 0 EBV_EBNA3A 0 0 0 0 0 0 EBV_EBNA3B 0 0 0 00 0 EBV_EBNA3C 0 0 0 0 0 0 EBV_LMP1_3′_end 0 0 0 0 0 0 EBV_LMP1_unique 00 0 0 0 0 EBV_LPM2A 0 0 0 0 0 0 EEPD1 0 −14.43898719 0 0 0 0 EFEMP2 0 00 0 −2.309390981 0 EGFL7 0 0 0 0 0 0 EHD2 0 0 0 0 0 0 EIF5AL1 0 0 0 0 00 ELL2 0 12.74051826 0 −5.784944094 0 0 EML1 0 0 0 0 −2.370584039 0 EMR10 0 0 0 0 0 ENO1 0 0 0 0 0 0 ENPP3 0 0 0 0 0 0 ENTPD1 0 12.50562718 0 00 0 EP300 0 0 0 0 0 0 EPHB1 0 0 0 0 0 0 EPSTI1 0 0 0 0 0 0 ERG 0 0 0 0 00 ERP29 0 14.40630514 0 0 0 0 TXNDC4 0 0 0 0 0 0 ESPL1 0 0 0 0 0 0 ETV60 17.10124803 0 0 0 0 EXO1 0 0 0 0 0 0 FABP4 0 0 0 0 0 0 FAM108C1 013.9119712 0 0 0 0 FAM159A 0 0 0 0 −19.09112771 0 FAM171B 0 0 0 020.15840479 0 FAM46C 0 16.04589049 0 0 0 0 FAM69A 0 0 0 0 20.26920874 0FAM83D 0 0 0 0 0 0 FAP 0 0 0 0 −2.448537997 0 FAS 0 0 0 0 19.4917463 0FBP2 0 0 0 0 0 0 FBXO10 0 0 0 0 0 0 FBXO11 0 0 0 0 0 0 FCER2 0 0 0 019.36530173 0 FEZ1 0 0 0 0 0 0 FGL2 0 0 0 0 0 0 FKBP11 0 10.77110305 0 00 0 FKBP2 0 0 0 0 0 0 FLJ42418 0 −13.07282539 0 0 0 0 FLNA 0 0 0 0 0 0FN1 0 0 0 0 −2.515692387 0 FNBP1 0 0 0 0 0 0 FNDC1 0 −9.924277783 0 0−2.337279029 0 FOXM1 0 0 0 0 0 0 FOXO1 0 0 0 0 0 0 FOXP1 0 0 0 0 0 0FSCN1 0 0 0 0 0 0 FUT8 0 12.89311878 0 0 0 0 FYB 0 0 0 0 0 0 GBP1 0 0 00 0 0 GBP4 0 0 0 0 0 0 GCET2 0 0 0 0 17.14715594 0 GGT1 0 0 0 0 0 0 GHR0 0 0 0 0 0 GLDC 0 0 0 0 0 0 GLRX 0 0 0 0 0 0 GNA13 0 −13.98237394 0 0 00 GNB4 0 0 0 0 0 0 GNG10 0 0 0 0 0 0 GNL3 0 13.0455436 0.131002027−6.622162805 0 0 GPR116 0 0 0 0 0 0 GPR176 0 0 0 0 0 0 GPR183 0 0 0 0 00 GRAMD1B 0 0 0 0 0 0 GRB10 0 0 0 0 0 0 GRSF1 0 0 0 0 0 0 GTSE1 0 0 0 00 0 GLT8D4 0 0 0 0 0 0 GYPC 0 0 0 0 17.83003931 0 H2AFV 0 0 0 0 0 0H2AFX 0 0 0 0 0 0 HCK 0 15.54344514 0 −5.412764958 0 0 HDAC1 0−15.02975702 0 0 0 0 HDAC2 0 0 0 0 0 0 HDGF 0 0 0.116000721 −5.8638455810 0 HEG1 0 0 0 0 −2.46106726 0 HHV8_BCL2_homologue 0 0 0 0 0 0HHV8_K1-32_Bcb_K1_protein 0 0 0 0 0 0 HHV8_ORF73-LANA 0 0 0 0 0 0HHV8_T0.7/P6 0 0 0 0 0 0 HHV8_T1.1 0 0 0 0 0 0 HHV8_vFLIP_ORF71 0 0 0 00 0 HHV8_vIL6 0 0 0 0 0 0 HHV8_vMIP1b_ORFK4.2_KIE-3 0 0 0 0 0 0 HJURP 00 0 0 0 0 HLA-A 0 0 0 0 0 0 HLA-B 0 0 0 0 0 0 HLA-C 0 0 0 0 0 0 HLA-DMA0 0 0 −4.825417012 0 0 HLA-DPA1 0 0 0 0 0 0 HLA-DPB1 0 0 0 0 0 0HLA-DQA1 0 0 0 0 0 0 HLA-DRA 0 0 0 0 0 0 HLA-E 0 0 0 0 0 0 HLA-F 0 0 0 00 0 HOMER2 0 0 0 0 19.38721241 0 HOPX 0 −14.01730842 0 0 0 0 HPCAL1 0 00 0 0 59.25326244 HSP90B1 0 15.53130763 0 0 0 0 HSPB8 0 0 0 0−2.192325405 0 HTRA1 0 0 0 0 −2.354416381 0 HYOU1 0 0 0 0 0 0 ICAM1 0 00 −5.307124944 0 0 ID1 0 0 0 0 0 0 ID2 0 0 0 0 0 0 ID3 0 0 0 0 0 0 IDS 00 0 0 0 0 IER3 0 0 0 0 0 0 IFI16 0 0 0 0 0 0 IFI35 0 0 0 0 0 0 IFI44L 00 0 0 0 0 IFI6 0 0 0 0 0 0 IFIH1 0 0 0 0 21.31413442 0 IFIT1 0 0 0 0 0 0IFIT2 0 0 0 0 0 0 IFIT3 0 0 0 0 0 0 IFITM1 0 0 0 0 0 0 IFNAR1 0 0 0 0 00 IFNAR2 0 0 0 0 0 0 IFNB1 0 0 0 0 0 0 IgA2_constant_region 0 0 0 0 0 0IgE_constant_region 0 0 0 0 0 0 IGFBP5 0 0 0 0 0 0 IgG2_constant_region0 0 0 0 0 0 IgG4_constant_region 0 0 0 0 0 0 IGSF3 0 11.04304441 0 018.36718646 0 IL10 0 0 0 0 0 0 IL12A 0 10.87451224 0 0 0 0 IL13 0 0 0 00 0 IL13RA1 0 0 0 −5.477834924 22.21511102 0 IL16 0 15.38015948 0 0 0 0IL17RB 0 10.16999574 0 0 0 0 IL4I1 0 0 0 0 0 0 IL6 0 0 0 0 0 0 ING1 0 00 0 0 0 INPP5D 0 0 0 0 0 0 IRAK1 0 0 0 0 0 0 IRAK2 0 0 0 0 0 0 IRAK3 0 00 0 0 0 IRAK4 0 0 0 0 0 0 IRF1 0 0 0 0 0 0 IRF3 0 0 0 0 0 0 IRF4 021.21696785 0 0 0 0 IRF5 0 0 0 0 0 0 IRF7 0 0 0 0 0 0 ISG15 0 0 0 018.22975543 0 ITGA9 0 0 0 0 0 0 ITGAV 0 0 0 0 −2.502427838 0 ITGAX 0 0 00 −2.527107115 0 ITGB2 0 0 0 −5.354319759 0 0 ITPKB 0 −19.39129721 0 0 00 JAK1 0 0 0 0 0 0 JAK2 0 0 0 0 18.78741327 0 JAK3 0 0 0 −4.911758111 00 KCNJ1 0 0 0 0 0 0 KCNK12 0 −12.19178395 0 0 0 0 KCNMA1 0 0 0 0 0 0JMJD2C 0 0 0 0 0 0 KDR 0 0 0 0 0 0 KIAA1147 0 0 0 0 0 0 KIAA1274 0−11.88673995 0 0 0 0 KIF11 0 0 0 0 0 0 KIF14 0 0 0 0 0 0 KIF15 0 0 0 0 00 KIF18A 0 0 0 0 0 0 KIF18B 0 0 0 0 0 0 KIF20A 0 0 0 0 0 0 KIF23 0 0 0 00 0 KIF2C 0 0 0 0 0 0 KIF4A 0 0 0 0 0 0 KLHL5 0 −10.77233553 0 0 0 0KPNA2 0 0 0 0 0 0 KYNU 0 0 0 0 23.67824397 0 LAMB1 0 0 0 0 0 0 LAMP3 0 00 0 0 0 LANCL1 0 −11.96529389 0 0 0 0 LAT 0 0 0 0 0 0 LAT2 0 0 0 0 0 0LDHA 0 0 0 0 0 −62.43798035 LHFPL3 0 0 0 0 0 0 LHX2 0 0 0 0 0 0 LIMA1 00 0 0 22.38509346 0 LIMD1 0 17.83248768 0 0 0 0 LMAN2 0 0 0 0 0 0 LMO2 0−16.98695863 0 −9.427107802 0 0 LOC643529 0 0 0 0 0 0 LOXL2 0 0 0 0 0 0LPCAT3 0 0 0 0 0 0 LRMP 0 −15.8755653 0 0 0 0 LRPPRC 0 0 0 0 0 0 LRRC150 −12.69088474 0 0 −2.555292482 0 LRRC33 0 15.08028382 0 0 0 0 LTBP2 0 00 0 −2.274436223 0 LYPD6B 0 −12.18942045 0 0 0 0 LYZ 0 0 0 0−2.548310761 0 MACROD2 0 0 0 0 0 0 MAL 0 0 0 0 21.94306064 0 MALT1 0 0 00 0 0 MAML3 0 −17.94799886 0 0 0 0 MAP3K1 0 0 0 0 0 55.17626389 MAP3K8 00 0 0 0 0 MAP4K4 0 −10.29136026 0 0 0 0 MAPK10 0 −14.19048558 0 0 0 0MAPKAPK5 0 0 0 0 0 0 MARCKS 0 0 0 0 0 0 MARCKSL1 0 −16.15992041 0−5.183663919 0 0 MAST2 0 −13.37445723 0 0 0 0 MATR3 0 0 0 0 0 0 MCL1 0 00 0 0 0 MCM10 0 0 0 0 0 0 MCM7 0 0 0 0 0 0 MDFIC 0 0 0 −6.830814658 0 0MDM2 0 0 0 0 0 0 MFAP5 0 0 0 0 0 0 MFNG 0 0 0 0 0 0 MFSD2A 0 0 0 0 0 0MGC87042 0 0 0 0 0 0 MIR17HG 0 0 0 0 0 0 MKI67 0 0 0 0 0 0 MME 0−18.26084621 0 0 0 0 MMP1 0 0 0 0 0 0 MMP2 0 0 0 0 −2.575770684 0 MMP9 00 0 0 −2.62062289 0 MMRN2 0 0 0 0 0 0 MNDA 0 0 0 0 0 0 MOBKL2C 0 0 0 024.05195347 0 MPEG1 0 13.61757622 0 0 0 0 MS4A1 0 0 0 0 0 0 MST1R 0 0 00 0 0 MTHFD2 0 0 0 0 0 −64.88192756 MUC16 0 0 0 0 0 0 MYB 0 0 06.206314452 0 0 MYBL1 0 −19.42564163 0 0 0 0 MYC 0 0 0.129410593−6.541715697 0 0 MYD88 0 0 0 0 0 0 MYO7A 0 0 0 0 0 0 FAM128B 0 0 0 0 0 0NANS 0 0 0 −5.411187191 0 −62.00052085 NASP 0 0 0 0 0 0 NBN 0 0 0 0 0 0NCAPG 0 0 0 0 0 0 NCAPH 0 0 0 0 0 0 NCF2 0 0 0 0 17.12736383 0NCRNA00158 0 0 0 0 0 0 NDST4 0 0 0 0 0 0 NECAP2 0 0 0 0 17.90953211 0NEIL1 0 −16.14074081 0 0 0 0 NEK6 0 −14.536944 0 0 0 0 NFATC1 0 0 0 0 00 NFIL3 0 0 0 0 23.55828096 0 NFKBIA 0 0 0 0 0 0 NFKBIZ 0 14.96909754 00 0 0 NIPA2 0 12.59506241 0 0 0 0 NOC3L 0 11.52493513 0 0 0 0 NOL14 0 00 0 0 0 NOL5A 0 0 0.123010002 −6.218165306 0 0 NOTCH1 0 0 0 0 0 0 NOTCH20 0 0 0 0 0 NUF2 0 0 0 0 0 0 NUP62 0 0 0 0 0 0 NUSAP1 0 0 0 0 0 0 OAS2 00 0 0 0 0 OAS3 0 0 0 0 0 0 OPN3 0 0 0 0 0 0 OSBPL3 0 −13.37500509 0 0 00 PA2G4 0 0 0 0 0 0 PAG1 0 −16.35818989 0 0 0 0 DKFZP564O0823 0 0 0 0 00 PAX6 0 0 0 0 0 0 PCNA 0 0 0 0 0 0 PDCD1LG2 0 0 0 0 0 0 PDE9A 0−12.58569832 0 0 0 0 PDGFRA 0 0 0 0 0 0 PDIA4 0 0 0 0 0 0 PDIA5 011.45635103 0 0 0 0 PDK4 0 0 0 0 0 0 PDLIM1 0 14.15712166 0 0 0 0 PDLIM30 0 0 0 0 0 PDPN 0 0 0 0 −2.469335735 0 PECAM1 0 0 0 0 0 0 PECR 0 0 0 00 0 PGAM1 0 0 0 0 0 0 PHC3 0 0 0 0 0 0 PHF16 0 15.59828263 0 0 0 0PIK3CA 0 0 0 0 0 0 PIK3CD 0 0 0 0 0 0 PIM1 0 13.17752239 0 0 0 0 PIM2 019.17848124 0 0 0 0 PLAU 0 0 0 −4.942137646 −2.638406534 0 PLEK 0 0 0−5.140753466 0 0 PLEKHF2 0 −14.32290025 0 0 0 0 PLEKHG4B 0 0 0 0 0 0PLXNB1 0 0 0 0 0 0 PMEPA1 0 −11.10781933 0 0 −2.5144432 0 PMP22 0 0 0 00 0 NP 0 11.18914667 0 0 0 0 POU2AF1 0 0 0 0 0 0 POU2F1 0 0 0 0 0 0POU2F2 0 0 0 0 0 0 PPA1 0 0 0 0 0 −58.07910524 PPP2R3B 0 0 0 0 0 0FAM152B 0 0 0 0 0 0 PRDM1 0 0 0 0 0 0 PRDM12 0 0 0 0 0 0 PRDX2 0 0 0 0−23.58686384 0 PRDX4 0 0 0 0 0 0 PRICKLE1 0 0 0 0 0 56.2707098 PRKCB 0 00 0 −16.97009784 0 PRMT1 0 0 0 0 0 0 PRPSAP2 0 −12.13413417 0 0 0 0PRSS1 0 0 0 0 0 0 PSMG1 0 0 0 0 0 0 PTEN 0 0 0 0 0 0 PTGER4 0 0 0 0 0 0PTGIR 0 0 0 0 26.72740141 0 PTK2 0 −13.78968685 0 −4.948036735 0 0 PTPN10 13.38225581 0 0 0 0 PTPRB 0 0 0 0 0 0 PVRL1 0 0 0 0 0 0 PXDN 0 0 0 0 00 QSOX1 0 0 0 0 0 0 RAB31 0 0 0 0 0 0 RAB33A 0 0 0 −4.912839787 0 0RAB3A 0 0 0 0 0 0 RAB7L1 0 20.66492996 0 0 0 0 RAPGEF5 0 −14.68045686 00 0 0 RARRES2 0 0 0 0 −2.570678175 0 RASGRP3 0 0 0 −6.000117265 0 0RASSF4 0 0 0 0 0 0 RBCK1 0 0 0 0 0 0 RCL1 0 0 0 0 19.91410729 0 REL 0−10.88675527 0 0 0 0 RFTN1 0 −10.08136072 0 0 0 0 RGL1 0 0 0 0 0 0 RGS90 0 0 0 18.38318043 0 RHEBL1 0 0 0 0 0 0 RHOF 0 0 0 0 19.45176982 0RHOXF1 0 0 0 0 0 0 RNASEH2B 0 0 0 0 0 0 RNF31 0 0 0 0 0 0 RNGTT 0 0 0 00 0 ROBO1 0 0 0 0 −2.163573921 0 ROBO4 0 0 0 0 0 0 RPN2 0 0 0 0 0 0RPS6KA5 0 0 0 0 0 0 RSAD2 0 0 0 0 0 0 RTCD1 0 0 0 0 0 0 RUNDC2B 0 0 0 00 0 RXRA 0 0 0 0 0 0 S100Z 0 −12.22316337 0 0 0 0 S1PR2 0 −21.44566507 00 0 0 SAA1 0 0 0 0 0 0 SACS 0 12.97435391 0 0 0 0 SAE1 0 0 0 0 0 0SAMSN1 0 0 0 −5.803971429 22.68315196 0 SAP30 0 0 0 0 0 0 SCARA5 0 0 0 0−2.335496267 0 SDC1 0 0 0 0 0 0 SDCCAG8 0 0 0 0 0 0 KIAA0746 0−15.04224714 0 0 0 0 SEMA7A 0 0 0 0 0 0 SEPHS1 0 0 0 0 0 0 SERBP1 0 0 00 0 0 SERPINA9 0 −17.70615386 0 −4.937282176 0 0 SERPINB1 0 0 0 0 0 0SFN 0 0 0 0 0 0 SFPQ 0 0 0 0 0 0 SGK1 0 −9.835329752 0 −5.684745402 0 0SGOL2 0 0 0 0 0 0 SH2D1A 0 0 0 0 0 0 SH3BP5 0 17.2475192 0 0 0 0 SHARPIN0 0 0 0 0 0 SIDT1 0 10.70030882 0 0 0 0 SIRPA 0 0 0 0 0 0 SIRPB1 0 0 0 00 0 SLA 0 16.00267223 0 0 0 0 SLAMF1 0 −13.70193031 0 −5.13597013520.7055292 0 SLC12A8 0 0 0 0 0 0 SLC16A9 0 0 0 0 0 0 SLC1A4 0 0 0 0 0 0SLC31A1 0 0 0 0 0 0 SLC35E2B 0 0 0 0 0 0 SLC38A5 0 16.76798547 0 0 0 0SMAD1 0 0 0 0 0 0 SMAD7 0 0 0 0 0 0 SMARCA4 0 −13.90289239 0 5.0371860220 0 SNAP23 0 0 0 0 0 0 SNN 0 0 0 0 0 67.01976847 SNX11 0 0 0 022.05768278 0 SNX22 0 −13.10658722 0 0 0 0 SNX29 0 0 0 0 19.13395502 0SOCS1 0 0 0 0 0 0 SOCS2 0 0 0 0 0 0 SOCS3 0 0 0 0 0 0 SORBS1 0 0 0 0 0 0SOX11 0 0 0 0 0 54.39896926 SOX5 0 0 0 0 0 0 SPAG5 0 0 0 0 0 0 SPARC 0 00 0 −2.470075697 0 SPARCL1 0 0 0 0 0 0 SPIB 0 0 0 0 0 0 SPINK2 0−10.030466 0 0 0 0 SPINT2 0 0 0 0 19.59153543 0 SPON1 0 0 0 0 0 0 SPRED20 −11.78392433 0 0 0 0 SPRY1 0 0 0 0 0 0 SRPK1 0 0 0 0 0 0 SRPX 0 0 0 00 0 SRSF1 0 0 0 0 0 0 SSBP2 0 −16.54355885 0 0 0 0 STAG3 0 0 0 0 0 0STAMBPL1 0 14.49186031 0 0 0 0 STAP1 0 −12.71264348 0 0 0 0 STAT1 0 0 00 0 0 STAT3 0 10.99589419 0 −5.30437752 0 0 STEAP1 0 0 0 0 0 0 STK17A 0−12.60874641 0 0 0 0 STK38L 0 0 0 0 0 0 STMN1 0 0 0 0 0 0 STS 0−9.978596163 0 0 0 0 STX11 0 0 0 −5.423455974 0 0 SULF1 0 0 0 0−2.512044172 0 SYK 0 0 0 0 0 0 SYPL1 0 0 0 0 0 0 SYT17 0 0 0 0 0 0 SYTL40 0 0 0 0 0 TARS 0 13.55653507 0 0 0 0 TAX1BP1 0 0 0 0 0 0 TBC1D27 0 0 00 0 0 TBC1D9 0 0 0 0 0 61.55561013 TCF3 0 0 0 5.046896623 0 0 TCF4 015.61877166 0 0 0 0 TCTN3 0 13.00379932 0 0 0 0 TEAD1 0 0 0 0 0 0 TEK 00 0 0 0 0 TERT 0 0 0.125565268 −6.347334222 0 0 TEX9 0 −12.41661821 0 00 0 TFDP2 0 0 0 0 0 0 TFPI2 0 0 0 0 0 0 TGFBR1 0 0 0 0 0 0 THBS2 0 0 0 0−2.458163143 0 THY1 0 0 0 0 −2.435821946 0 TIAM2 0 −10.50158544 0 0 0 0TICAM2 0 10.36653445 0 −4.996251154 0 0 TJP2 0 0 0 0 0 0 TK1 0 0 0 0 0 0TLE4 0 0 0 0 17.47264051 0 TLK1 0 12.28505922 0 0 0 0 TLR7 0 0 0 019.4679966 0 TM4SF1 0 0 0 0 0 0 TMBIM6 0 0 0 0 0 0 TMEM109 0 0 0 0 0 0TMEM119 0 −10.5658305 0 −5.379086543 −2.658347176 0 TMOD1 0 0 0 019.102924 0 TMPRSS6 0 0 0 0 0 0 TNF 0 0 0 0 0 0 TNFAIP2 0 0 0 0 0 0TNFAIP3 0 0 0 0 0 0 TNFRSF13B 0 19.52210849 0 0 0 0 TNFRSF14 0 0 0 0 0 0TNFRSF17 0 0 0 0 20.07405253 0 TNFRSF19 0 0 0 0 0 0 TNFSF10 0 0 0 0 0 0TNFSF4 0 0 0 0 27.41538607 0 TNIP2 0 0 0 0 0 0 TNXB 0 0 0 0 0 0 TOP2A 00 0 0 0 0 TOX 0 −11.9192864 0 0 0 0 TP53 0 0 0 0 0 0 TP73 0 0 0 0 0 0TPM1 0 0 0 0 −2.197810042 0 TPX2 0 0 0 0 0 0 TRAF1 0 0 0 0 21.57006782 0TRAF3 0 0 0 0 0 0 TRIM25 0 0 0 0 0 0 TRIM6-TRIM34 0 0 0 0 0 0 TRIP13 0 00.122871716 −6.211174921 0 0 TTC9 0 −12.56263701 0 0 0 0 TUBG1 0 0 0 0 00 TXN 0 0 0 0 0 0 TXNDC5 0 0 0 0 0 0 TYK2 0 0 0 0 0 0 TYMS 0 0 0 0 0 0UBE2I 0 0 0 0 0 0 UBE2S 0 0 0 0 0 0 USP12 0 −11.66057366 0 0 0 0 USP18 00 0 0 0 0 USP46 0 13.42760916 0 0 0 0 VASH2 0 0 0 0 20.35631229 0 VGLL40 −12.24069542 0 0 0 0 TMEM49 0 0 0 0 0 0 VWF 0 0 0 0 0 0 WASF1 0 0 0 00 0 WDR25 0 0 0 0 0 0 WHSC1 0 0 0 0 0 0 WNT3 0 0 0 0 0 55.5970345 XAF1 00 0 0 0 0 XBP1 0 10.72031521 0 0 0 0 YPEL1 0 0 0 0 0 0 ZAP70 0 0 0 0 0 0ZBTB32 0 12.89819312 0 0 0 0 ZBTB38 0 0 0 0 0 0 ZBTB8 0 0 0 022.31265521 0 ZCCHC7 0 −10.53054134 0 0 0 0 ZFP36L1 0 0 0 0 0 0 ZMYND8 00 0 0 0 0 ZNF238 0 0 0 0 0 0 ZNF281 0 0 0 0 17.18038245 0 ZNF318 0−14.69750421 0 0 0 0 ZNF385B 0 0 0 0 0 0 ZNF608 0 −12.02764268 0 0 0 0ZNRF1 0 0 0 0 0 0 ZPBP2 0 0 0 0 0 0 ZWINT 0 0 0 0 0 0 A2LD1 0 0 0 0 0 0ABCA12 0 0 0 0 0 0 ACSL5 0.021276596 0 0 0 0 0 AHCYL2 0.021276596 0 0 00 0 AKAP9 0.021276596 0 0 0 0 0 ASCL2 0 0 0 0 0 0 ASMTL-AS1 0 0 0 0 0 0ATOH8 0 0 0 0 0 0 ATXN7L2 0.021276596 0 0 0 0 0 C19orf26 0 0 0 0 0 0C4orf31 0 0 0 0 0 0 CA7 0 0 0 0 0 0 CAMKK1 0 0 0 0 0 0 CDK5RAP20.021276596 0 0 0 0 0 CHD4 0.021276596 0 0 0 0 0 CHST5 0 0 0 0 0 0 CPA60 −10.24419002 0 0 0 0 DAZAP2 0.021276596 0 0 0 0 0 DCLK3 0 0 0 0 0 0DNAJB12 0.021276596 0 0 0 0 0 ERBB2IP 0.021276596 0 0 0 0 0 ERN2 0 0 0 00 0 KIAA0574 0 0 0 0 0 0 FAR2 0 0 0 0 0 0 FARP1 0 0 0 0 0 0 FBXL13 0 0 00 0 0 FBXO36 0 0 0 0 0 0 FBXO41 0.021276596 0 0 0 0 0 FCN2 0 0 0 0 0 0GAD2 0 0 0 0 0 0 GATA1 0 0 0 0 0 0 GATA2 0 0 0 0 0 0 GIT2 0.021276596 00 0 0 0 GNG4 0 0 0 0 0 0 GORASP1 0.021276596 0 0 0 0 0 GSK3B 0.0212765960 0 0 0 0 GYG2 0 0 0 0 0 0 H1FOO 0 0 0 0 0 0 HARBI1 0.021276596 0 0 0 00 HHIP 0 0 0 0 0 0 HSP90AA1 0.021276596 0 0 0 0 0 HSPA12B 0 0 0 0 0 0HSPA9 0.021276596 0 0 0 0 0 IK 0.021276596 0 0 0 0 0 ISY1 0.021276596 00 0 0 0 KCNQ3 0 0 0 0 0 0 KCP 0 0 0 0 0 0 KIF6 0 0 0 0 0 0 KRAS0.021276596 0 0 0 0 0 LRP3 0 0 0 0 0 0 MLL2 0.021276596 0 0 0 0 0 MLLT100.021276596 0 0 0 0 0 MSX2 0 0 0 0 0 0 KIAA0774 0 0 0 0 0 0 NAIF10.021276596 0 0 0 0 0 NEBL 0 0 0 0 0 0 NEU3 0.021276596 0 0 0 0 0 NHLH20 0 0 0 0 0 NRG1 0 0 0 0 0 0 OPA1 0.021276596 0 0 0 0 0 PDE4DIP 0 0 0 00 0 RNUXA 0.021276596 0 0 0 0 0 PHF23 0.021276596 0 0 0 0 0 PMCHL1 0 0 00 0 0 PNLIP 0 0 0 0 0 0 PPP3CC 0.021276596 0 0 0 0 0 PTENP1 0 0 0 0 0 0PTPN21 0 0 0 0 0 0 PTRH1 0.021276596 0 0 0 0 0 R3HDM1 0.021276596 0 0 00 0 RAB20 0.021276596 0 0 0 0 0 RANBP9 0.021276596 0 0 0 0 0 RC3H20.021276596 0 0 0 0 0 RETNLB 0 0 0 0 0 0 RHCE 0 0 0 0 0 0 RNF2140.021276596 0 0 0 0 0 RRP1B 0.021276596 0 0 0 0 0 SPATA6 0 0 0 0 0 0SPATS1 0 0 0 0 0 0 SSPN 0 0 0 0 0 0 SUFU 0.021276596 0 0 0 0 0 SPAG4L 00 0 0 0 0 SYCP1 0 0 0 0 0 0 THOC5 0.021276596 0 0 0 0 0 TRIM560.021276596 0 0 0 0 0 TRIM62 0.021276596 0 0 0 0 0 TUBB2C 0.021276596 00 0 0 0 UBXN4 0.021276596 0 0 0 0 0 VAC14 0.021276596 0 0 0 0 0 VRK30.021276596 0 0 0 0 0 WAC 0.021276596 0 0 0 0 0 WDR55 0.021276596 0 0 00 0 WFDC9 0 0 0 0 0 0 ZBTB37 0.021276596 0 0 0 0 0 ZCCHC2 0.021276596 00 0 0 0 ZFP42 0 0 0 0 0 0 ZNF135 0 0 0 0 0 0 ZNF598 0.021276596 0 0 0 00

TABLE 5 Submodel Lower Cut-point Upper Cut-point ABC/GCB 712.91 1238.61BL Non-Myc −89.39 −60.39 BL Myc 1.11 1.11 PMBL −400.06 −150.06 MCL−51.92 359.08

The five submodels can then be combined according to the logic set forthbelow and summarized in the FIGURE.

-   (1) If the MCL submodel has a value of 1, the sample is called MCL.    -   If the MCL submodel has a value of 0, the sample is called        unclassifiable but borderline MCL.    -   If the MCL submodel has a value of −1, proceed to step 2.-   (2) If the BL non-myc submodel has a value of 1, proceed to step 3.    -   If the BL non-myc submodel has a value of 0, the sample is        called unclassifiable but borderline BL.    -   If the BL non-myc submodel has a value of −1, proceed to step 4.-   (3) If the BL myc submodel has a value of 0 or 1, the sample is    called BL.    -   If the BL myc submodel has a value of −1, the sample is called        unclassifiable but borderline BL.-   (4) If the PMBL submodel has a value of 1, the sample is called    PMBL.    -   If the PMBL submodel has a value of 0, the sample is called        unclassifiable but borderline PMBL.    -   If the PMBL submodel has a value of −1, proceed to step 5.-   (5) If the ABC/GCB submodel has a value of 1, the sample is called    ABC.    -   If the ABC/GCB submodel has a value of 0, the sample is called        unclassified DLBCL.    -   If the ABC/GCB submodel has a value of −1, the sample is called        GCB.

A similar analysis can be performed to predict whether a subject alreadydiagnosed with DLBCL has the germinal center B cell (GCB) subtype or theactivated B cell (ABC) subtype using the 800 gene array. In thisrespect, the sample is assumed to be of non-PMBL DLBCL, so only aABC/GCB submodel is used employing the following logic:

-   -   If the ABC/GCB submodel has a value of 1, the sample is called        ABC    -   If the ABC/GCB submodel has a value of 0, the sample is called        unclassified DLBCL    -   If the ABC/GCB submodel has a value of −1, the sample is called        GCB.

In another embodiment, evaluating the likelihood that a particular DLBCLsample belongs to either the ABC subtype or the GCB subtype can involvecalculating a predictor score using the 20 gene array containing thegenes set forth in Table 3. The predictor score can be calculated usingthe algorithms described above with respect to the classification of ABCDLBCL, GCB DLBCL, PMBL, BL, or MCL, but using a different set of modelweights, housekeeping weights, and cut points. For example, the weights(w₁) associated with the 20 gene probe set for the particular submodelare set forth in Table 6. In this example, the lower cutpoint for theABC/GCB submodel is 1988.2, while the upper cutpoint for the ABC/GCBsubmodel is 2513.9.

TABLE 6 Gene Normalization weights ABC/GCB weights ASB13 0 −66.35 CCDC500 40.54 CREB3L2 0 65.79 CYB5R2 0 67.72 IRF4 0 71.92 ISY1 0.2 0.00 ITPKB0 −67.78 LIMD1 0 61.92 MAML3 0 −58.59 MME 0 −56.55 MYBL1 0 −72.92 PIM2 071.80 R3HDM1 0.2 0.00 RAB7L1 0 70.45 S1PR2 0 −78.74 SERPINA9 0 −61.81TNFRSF13B 0 66.49 TRIM56 0.2 0.00 UBXN4 0.2 0 WDR55 0.2 0

An alternative method to report the likelihood that a particular samplebelongs to ABC DLBCL, GCB DLBCL, PMBL, BL, or MCL avoids assigningdiscrete prediction class labels to each sample and instead provides avector of five confidence values. Each confidence value indicates thelikelihood that the sample is of one of the five lymphoma types. Forexample, linear predictor scores are first created for each submodel

$z = {\sum\limits_{i}\; {y_{i}w_{i}}}$

as described above. However, rather than using discrete cut-points toindicate one of three discrete groups, the following transformation canbe used to define a Bayesian sub-model score:

$B_{submodel} = \frac{\varphi\left( {{{\sum\limits_{i}\; {y_{i}w_{i}}};m_{1}},v_{1}} \right)}{{\varphi\left( {{{\sum\limits_{i}\; {y_{i}w_{i}}};m_{1}},v_{1}} \right)} + {\varphi\left( {{{\sum\limits_{i}\; {y_{i}w_{i}}};m_{1}},v_{1}} \right)}}$

wherein y_(i) is the value assigned probe set i as described above;w_(i) are the weights associated with that probe set for the particularmodel as presented in Table 4; m_(1.) v₁, m₂, and v₂ are valuesassociated with the submodel as set forth in Table 7, and Φ is theGaussian density defined as follows:

${\varphi \left( {{y;m},v} \right)} = {\frac{1}{\sqrt{2\pi \; v}}{^{\frac{- {({y - m})}^{2}}{v^{2}}}.}}$

TABLE 7 Submodel m₁ m₂ v₁ v₂ ABC/GCB 2021.11 −302.89 469.00 596.00 BLnon-myc 78.02 −201.94 47.60 38.88 BL myc 1.88 0.27 0.26 0.47 PMBL 571.94−1080.06 315.00 294.00 MCL 1610.08 −916.92 582.00 412.00

The two Bayesian submodels can then be combined into the followingsingle Bayesian score, B_(BL):

$B_{BL} = \left\{ {\begin{matrix}B_{{BLnon} - {myc}} & {{{if}\mspace{14mu} B_{BLmyc}} > 0.1} \\{\min \left( {B_{{BLnon} - {myc}},0.5} \right)} & {{{if}\mspace{14mu} B_{BLmyc}} \leq 0.1}\end{matrix}.} \right.$

The confidence values of each subtype can then be calculated as follows:

MCL confidence=B _(MCL)

BL confidence=(B _(BL))(1−B _(MCL))

PMBL confidence=(B _(PMBL))(1−B _(BL))(1−B _(MCL))

ABC confidence=(B _(ABC/GCB))(1−B _(PMBL))(1−B _(BL))(1−B _(MCL)

GCB confidence=(1−B _(ABC/GCB))(1−B _(PMBL))(1−B _(BL))(1−B _(MCL)).

A similar confidence value analysis can be performed to predict whethera subject already diagnosed with DLBCL has the germinal center B cell(GCB) subtype or the activated B cell (ABC) subtype using the 800 genearray. In this respect, the sample is assumed to be of non-PMBL DLBCL,so only a ABC/GCB Bayesian submodel is used which employs the followinglogic:

ABC confidence=(B _(ABC/GCB))

GCB confidence=(1−B _(ABC/GCB)).

In another embodiment, evaluating the likelihood that a particular DLBCLsample belongs to either the ABC subtype or the GCB subtype can involvecalculating confidence values using the 20 gene array containing thegenes set forth in Table 3. The confidence values can be calculatedusing the algorithms described above with respect to ABC DLBCL, GCBDLBCL, PMBL, BL, or MCL, but using a different set of model weights,housekeeping weights, and cut points. For example, the weights (w_(i))associated with the 20 gene probe set for the particular submodel areset forth in Table 6. The m₁, m₂, v₁, and v₂ values for this model are,for example, 916.74, −449.76, 294.24, and 343.55, respectively.

The classification of a lymphoproliferative disorder in accordance withembodiments of the invention may be used in combination with any othereffective classification feature or set of features. For example, adisorder may be classified by a method of the invention in conjunctionwith WHO suggested guidelines, morphological properties, histochemicalproperties, chromosomal structure, genetic mutation, cellularproliferation rates, immunoreactivity, clinical presentation, and/orresponse to chemical, biological, or other agents. Embodiments of theinvention may be used in lieu of or in conjunction with other methodsfor lymphoma diagnosis, such as immunohistochemistry, flow cytometry,FISH for translocations, or viral diagnostics.

The inventive methods further comprise selecting a treatment option forthe subject based on the subject's lymphoma classification. Accuratedetermination of lymphoma type in a subject allows for better selectionand application of therapeutic methods. Knowledge about the exactlymphoma affecting a subject allows a clinician to select therapies ortreatments that are most appropriate and useful for that subject, whileavoiding therapies that are nonproductive or even counterproductive. Forexample, central nervous system (CNS) prophylaxis may be useful fortreating BL but not DLBCL, CHOP therapy (cyclophosphamide,hydroxydaunorubicin, oncovin (vincristine), and prednisone) may beuseful for treating DLBCL but not blastic MCL (see, e.g., Fisher et al.,N. Engl. J. Med., 328: 1002-1006 (1993); and Khouri et al., J. Clin.Oncol., 12: 3803-3809 (1998)), and subjects with follicular lymphomafrequently receive treatment while subjects with follicular hyperplasiado not.

The treatment option selected can comprise any suitable therapeuticregimen or pharmaceutical agent that shows efficacy in treating theparticular lymphoma type. For example, the current standard of care forthe treatment of diffuse large B cell lymphoma (DLBCL) includesanthracycline-based chemotherapy regimens such as CHOP in combinationwith the administration of the anti-CD20 monoclonal antibody rituximab(RITUXAN™, Genentech, Inc., South San Francisco, Calif.) (“R-CHOP”),CODOX-M/IVAC therapy (cyclophosphamide, doxorubicin, vincristine,methotrexate/ifosfamide, etoposide, high dose cytarabine), CNSprophylaxis, and radiotherapy. In one embodiment, the inventioncomprises providing R-CHOP therapy to a GCB DLBCL subject, whileproviding a different therapy to an ABC DLBCL subject, as an ABC DLBCLdiagnosis can have a worse prognosis in response to R-CHOP chemotherapyas compared to a GCB DLBCL diagnosis. In this embodiment, the ABC DLBCLsubject can be provided with any of the treatment options describedherein or otherwise known in the art to be effective against lymphoma.

Treatment options for MCL include, for example, chemotherapy (e.g.,CHOP), immune based therapy (e.g., rituximab), radioimmunotherapy, andbiologic agents (e.g., protoesome inhibitors and mTor inhibitors).Treatment options for BL include, for example, R-EPOCH therapy (i.e.,rituximab, etoposide, prednisone, oncovirin(vincristine)-doxorubicin-cyclophosphamide), CODOX-M/IVAC therapy,immunotherapy, bone marrow transplantation, stem cell transplantation,surgery, and radiotherapy. Treatment options for PBML are similar tothose for DLBCL, and also can include high-dose chemotherapy,radiotherapy, and/or stem cell transplantation. Other lymphomatreatments include drugs which target specific pathways that sustainlymphoma survival, such as, e.g., ibrutinib.

The following examples further illustrates the invention but, of course,should not be construed as in any way limiting its scope.

Example 1

This example demonstrates a method for determining subtypes of diffuselarge B-cell lymphoma (DLBCL) using gene expression profiling onformalin-fixed paraffin embedded tissue.

Although the ABC DLBCL and GCB DLBCL subtypes were originally definedusing gene expression profiling (GEP) on snap-frozen tissues (referredto herein as “frozen-GEP”), it has become common practice to use lessprecise but relatively inexpensive and broadly applicableimmunohistochemical (IHC) methods using formalin-fixed paraffin embeddedtissues (FFPET). The inventive method allows for a robust, highlyaccurate, molecular assay for cell-of-origin (COO) distinction using newGEP techniques applicable to FFPET. Studies were performed on centrallyreviewed DLBCL FFPET biopsies from the Lymphoma/Leukemia MolecularProfiling Project (LLMPP) matching cases that had “gold standard” COOassigned by frozen-GEP using GENECHIP™ U133 plus 2.0 microarrays(Affymetrix, Santa Clara, Calif.). The training cohort consisted of 51cases comprising 20 GCB DLBCL, 19 ABC DLBCL and 12 unclassifiable (U)cases. An independent validation cohort, which includes 68 cases (28 GCBDLBCL, 30 ABC DLBCL, and 10 U) drawn from the validation cohortdescribed in Lenz et al., N. Engl. J. Med., 359: 2313-2323 (2008), hadthe typical proportions of COO subtypes seen in DLBCL populations.

Nucleic acids were extracted from 10 μm FFPET scrolls. Digital geneexpression was performed on 200 ng of RNA using the NANOSTRING™ assay(NanoString Technologies, Seattle, Wash.). All FFPET GEP studies wereperformed in parallel at two independent sites (BC Cancer Agency,Vancouver and NCI, Bethesda, Md.) using different FFPET scrolls todetermine inter-site concordance, which assesses the robustness andportability of the assay. To assign COO by IHC, tissue microarrays weremade using 0.6 mm duplicate cores for the validation cohort and stainedfor antibodies for CD10, BCL6, MUM1, FOXP1, GCET1, and LMO2. Twohematopathologists independently assessed the proportion of tumor cellsstained, with consensus on discordant cases reached with a thirdhematopathologist. For the validation studies, those producing andanalyzing the GEP and IHC data were blinded to the “gold standard” COO.

All 119 FFPET biopsies yielded sufficient RNA. A pilot study using thetraining cohort identified 20 genes (i.e., 15 genes of interest and 5housekeeping genes) whose expression, measured using the NANOSTRING™assay, would allow accurate replication of the COO assignment modeldescribed in Lenz et al., supra. The NANOSTRING™ assay was then used toquantify expression of these 20 genes in the training cohort, therebyallowing the COO model to be optimized. Despite the age of the FFPETblocks (6 to 32 years old), 95% (49/51) of the training samples producedgene expression data of sufficient quality. The COO model, includingcoefficients, thresholds, and QC parameters was then “locked” andapplied to the independent validation cohort. Ninety-nine percent(67/68) of the samples from the validation cohort (5 to 12 years old)provided gene expression of adequate quality. When considering the “goldstandard” ABC DLBCL and GCB DLBCL cases, the COO assignments by theNANOSTRING™ assay at the NCI site were 93% concordant, with 5% labeled Uand 1 ABC misclassified as GCB, as shown in Table 8.

TABLE 8 NANOSTRING ™ Hans Tally Choi GEP Assay - NCI Algorithm AlgorithmAlgorithm GCB U ABC GCB Non-GCB GCB ABC GCB ABC Frozen-GEP GCB 28 0 0 210 18 3 19 2 U 7 2 1 5 5 2 8 6 4 ABC 1 3 25 4 22 0 26 6 20

Thus, 119 highly characterized DLBCL cases from the LLMPP, which werepreviously subtyped by a published disease-defining algorithm usingfrozen-GEP, were highly accurately analyzed in accordance with theinventive method. These results demonstrate that the inventive method,which utilized RNA from FFPET that is routinely obtained for diagnosis,provides a desirable alternative to existing techniques for the analysisof DLBCL cases. The 2% rate of misclassification of ABC and GCB cases bythe inventive method compares favorably with the 9%, 6% and 17% ratesfor the Hans, Tally and Choi algorithms, respectively (see Hans et al.Blood, 103(1): 275-82 (2004); Meyer et al., J. Clin. Oncol., 29(2):200-207 (2011); and Choi et al., Clin. Cancer Res., 15(17): 5494-502(2009)). Furthermore, the 100% concordance of COO assignment (95% if“gold standard” U cases also are included) between the NCI and BC CancerAgency sites indicates that, in contrast to the IHC algorithms, theinventive method is robust.

The inventive method exhibits high performance with archival FFPET andallows for rapid turn-around time (<36 hours from FFPET block toresult), which is highly desirable in clinical practice.

Example 2

This example demonstrates a method for determining subtypes ofaggressive B cell non-Hodgkin lymphomas (agg-B-NHL) using geneexpression profiling on formalin-fixed paraffin embedded tissue.

Formalin-fixed, paraffin-embedded tissue (FFPET) biopsies qualified byan expert Hematopathology review panel as having a tumor content of ≧60%and confirmed B cell immunophenotype were evaluated. Diagnosticcategories included diffuse large B cell lymphoma (DLBCL) including theactivated B cell-like (ABC) and germinal center B cell-like (GCB)subtypes, unclassifiable (UNC) DLBCL, primary mediastinal B celllymphoma (PMBCL), Burkitt lymphoma (BL), and mantle cell lymphoma (MCL).Using previous GEP data, diagnostic signatures, the NCOUNTER™ geneexpression assay (NanoString Technologies, Seattle, Wash.), andemploying published procedures (Scott et al, Blood, (January 2014); DOI:10.1182/blood-2013-11-536433), probes to 800 genes (shown in Table 4)were designed with utility in distinguishing between these pathologicalentities.

The training cohort comprised 107 unique cases, whose FFPET biopsieswere independently assayed at the Molecular Characterization Laboratory,Frederick National Laboratory for Cancer Research (Frederick, Md.) andthe Centre for Lymphoid Cancer, BC Cancer Agency (Vancouver, BC). Theresulting algorithm was locked down and applied to an independent cohortof 199 cases. The nucleic acids from FFPET biopsies from these caseswere extracted and run across the two independent laboratories, with 83cases run at both laboratories to assess inter-laboratory performance.The “gold standard” by which the NANOSTRING™ classification was comparedwas based on Affymetrix gene expression profiling of matched frozenbiopsies in the cases of ABC, GCB, and UNC DLBCL (Lenz et al., supra)and on the pathological diagnosis by the Hematopathology review panel inthe cases of BL, MCL, and PMBCL. The use of human tissues and clinicaldata for this study was approved by the University of ArizonaInstitutional Review Board in accordance with the Declaration ofHelsinki.

The final locked algorithm consisted of 297 gene probes (shown in Table2) including 47 housekeeping genes. Thirty-six cases from the trainingcohort were run again on the new lot of NANOSTRING™ code set to allowfor cross code set calibration of the assay. The laboratory procedureand algorithm, together termed the “Lymph5Cx” test, consists of ahierarchical series of pair-wise comparisons. In the independentvalidation set, 257/282 (91.1%) of assays yielded gene expression dataof sufficient quality (total of 185 of the 199 cases). A classificationsummary is given in Table 9.

TABLE 9 Lymphoma # % % % Subtype cases accurate borderline error ABC 2676.9% 23.1% 0.0% GCB 27 88.9% 7.4% 3.7% BL 48 68.8% 19.8% 11.5% PMBL 3080.0% 6.7% 13.3% MCL 34 100.0% 0.0% 0.0%

In this cohort, 136 cases (82%) were correctly assigned while 12 cases(6%) were assigned incorrect diagnoses as follows: 6 BL assigned to GCB,1 GCB labeled a PMBCL, 1 UNC DLBCL called a PMBCL and 4 PMBCL assignedto DLBCL subtypes. The Lymph5Cx test included categories ofindeterminate results between two diagnostic entities and were declaredborderline. The agreement between the two laboratory sites was 71/72(99%) of cases that yielded adequate gene expression data at both sites.

Therefore, the results of this example demonstrate that the Lymph5Cxtest was robust and able to discriminate the often clinically difficultdiagnostic categories of agg-B-NHL using a single methodology for caseswith histologic and immunophenotypic features of an agg-B-NHL.Misclassification errors were low, suggesting that this test would beuseful adjunct to current diagnostic methods. In addition, targetablepathways, as well as genes associated with known prognostic signaturesin DLBCL (stromal) and MCL (proliferation) were quantified.

All references, including publications, patent applications, andpatents, cited herein are hereby incorporated by reference to the sameextent as if each reference were individually and specifically indicatedto be incorporated by reference and were set forth in its entiretyherein.

The use of the terms “a” and “an” and “the” and “at least one” andsimilar referents in the context of describing the invention (especiallyin the context of the following claims) are to be construed to coverboth the singular and the plural, unless otherwise indicated herein orclearly contradicted by context. The use of the term “at least one”followed by a list of one or more items (for example, “at least one of Aand B”) is to be construed to mean one item selected from the listeditems (A or B) or any combination of two or more of the listed items (Aand B), unless otherwise indicated herein or clearly contradicted bycontext. The terms “comprising,” “having,” “including,” and “containing”are to be construed as open-ended terms (i.e., meaning “including, butnot limited to,”) unless otherwise noted. Recitation of ranges of valuesherein are merely intended to serve as a shorthand method of referringindividually to each separate value falling within the range, unlessotherwise indicated herein, and each separate value is incorporated intothe specification as if it were individually recited herein. All methodsdescribed herein can be performed in any suitable order unless otherwiseindicated herein or otherwise clearly contradicted by context. The useof any and all examples, or exemplary language (e.g., “such as”)provided herein, is intended merely to better illuminate the inventionand does not pose a limitation on the scope of the invention unlessotherwise claimed. No language in the specification should be construedas indicating any non-claimed element as essential to the practice ofthe invention.

Preferred embodiments of this invention are described herein, includingthe best mode known to the inventors for carrying out the invention.Variations of those preferred embodiments may become apparent to thoseof ordinary skill in the art upon reading the foregoing description. Theinventors expect skilled artisans to employ such variations asappropriate, and the inventors intend for the invention to be practicedotherwise than as specifically described herein. Accordingly, thisinvention includes all modifications and equivalents of the subjectmatter recited in the claims appended hereto as permitted by applicablelaw. Moreover, any combination of the above-described elements in allpossible variations thereof is encompassed by the invention unlessotherwise indicated herein or otherwise clearly contradicted by context.

1. A method for selecting a treatment option for an activated Bcell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinalcenter B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, aprimary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma(BL) subject, or a mantle cell lymphoma (MCL) subject comprising thesteps of: (a) isolating a gene expression product from a biopsy samplefrom a lymphoma subject; (b) obtaining digital gene expression data fromthe isolated gene expression product, wherein the digital geneexpression data comprises data for genes in a gene expression signature,and wherein the gene expression signature comprises at least one of thegenes listed in Table 2; (c) generating a weighted average of theexpression levels of genes from the gene expression signature to therebyobtain a gene expression signature value; (d) calculating a predictorscore based on the gene expression signature value; (e) classifying thesubject as belonging to one of the following groups based on thepredictor score of (d): (i) ABC DLBCL, (ii) GCB DLBCL, (iii) PMBL, (iv)BL, or (v) MCL; (f) selecting a treatment option for the subject basedon the subject's classification in (e); and (g) providing the treatmentoption to the subject.
 2. A method for selecting a treatment option fora diffuse large B cell lymphoma (DLBCL) subject comprising the steps of:(a) isolating a gene expression product from a biopsy sample from aDLBCL subject; (b) obtaining digital gene expression data from theisolated gene expression product, wherein the digital gene expressiondata comprises data for genes in a gene expression signature, andwherein the gene expression signature comprises at least one of thefollowing genes: ASB13 (GenBank Accession No. NM_024701.3), CCDC50(GenBank Accession No. NM_174908.3), CREB3L2 (GenBank Accession No.NM_194071.2), CYB5R2 (GenBank Accession No. NM_016229.3), IRF4 (GenBankAccession No. NM_002460.1), ISY1 (GenBank Accession No. NM_020701.2),ITPKB (GenBank Accession No. NM_002221.3), LIMD1 (GenBank Accession No.NM_014240.2), MAML3 (GenBank Accession No. NM_018717.4), MME (GenBankAccession No. NM_000902.2), MYBL1 (GenBank Accession No. XM_034274.14),PIM2 (GenBank Accession No. NM_006875.2), R3HDM1 (GenBank Accession No.NM_015361.2), RAB7L1 (GenBank Accession No. NM_001135664.1), S1PR2(GenBank Accession No. NM_004230.2), SERPINA9 (GenBank Accession No.NM_001042518.1), TNFRSF13B (GenBank Accession No. NM_012452.2), TRIM56(GenBank Accession No. NM_030961.1), UBXN4 (GenBank Accession No.NM_014607.3), and WDR55 (GenBank Accession No. NM_017706.4); (c)generating a weighted average of the expression levels of genes from thegene expression signature to thereby obtain a gene expression signaturevalue; (d) calculating a predictor score based on the gene expressionsignature value; (e) classifying the subject as belonging to one of thefollowing groups based on the predictor score of (d): (i) activated Bcell-like diffuse large B cell lymphoma (ABC DLBCL) or (ii) germinalcenter B cell-like diffuse large B cell lymphoma (GCB DLBCL); (f)selecting a treatment option for the subject based on the subject'sclassification in (e); and (g) providing the treatment option to thesubject.
 3. The method of claim 1, wherein the treatment optioncomprises one or more of the following: CHOP therapy, R-CHOP therapy,CODOX-M/IVAC therapy, R-EPOCH therapy CNS prophylaxis, radiotherapy,immunotherapy, bone marrow transplantation, stem cell transplantation,and/or surgery.
 4. A method for selecting a germinal center B cell-likediffuse large B cell lymphoma (GCB DLBCL) subject for treatment withR-CHOP (rituxan, cyclophosphamide, hydroxydaunorubicin, oncovin(vincristine), and prednisone) therapy comprising the steps of: (a)isolating a gene expression product from a biopsy sample from a DLBCLsubject; (b) obtaining digital gene expression data from the isolatedgene expression product, wherein the digital gene expression datacomprises data for genes in a gene expression signature, and wherein thegene expression signature comprises at least one of the following genes:ASB13 (GenBank Accession No. NM_024701.3), CCDC50 (GenBank Accession No.NM_174908.3), CREB3L2 (GenBank Accession No. NM_194071.2), CYB5R2(GenBank Accession No. NM_016229.3), IRF4 (GenBank Accession No.NM_002460.1), ISY1 (GenBank Accession No. NM_020701.2), ITPKB (GenBankAccession No. NM_002221.3), LIMD1 (GenBank Accession No. NM_014240.2),MAML3 (GenBank Accession No. NM_018717.4), MME (GenBank Accession No.NM_000902.2), MYBL1 (GenBank Accession No. XM_034274.14), PIM2 (GenBankAccession No. NM_006875.2), R3HDM1 (GenBank Accession No. NM_015361.2),RAB7L1 (GenBank Accession No. NM_001135664.1), SIPR2 (GenBank AccessionNo. NM_004230.2), SERPINA9 (GenBank Accession No. NM_001042518.1),TNFRSF13B (GenBank Accession No. NM_012452.2), TRIM56 (GenBank AccessionNo. NM_030961.1), UBXN4 (GenBank Accession No. NM_014607.3), and WDR55(GenBank Accession No. NM_017706.4); (c) generating a weighted averageof the expression levels of genes from the gene expression signature tothereby obtain a gene expression signature value; (d) calculating apredictor score based on the gene expression signature value; (e)classifying the subject as belonging to one of the following groupsbased on the predictor score of (d): (i) activated B cell-like diffuselarge B cell lymphoma (ABC DLBCL) or (ii) germinal center B cell-likediffuse large B cell lymphoma (GCB DLBCL); (f) selecting a GCB DLBCLsubject for R-CHOP therapy; and (g) providing R-CHOP therapy to the GCBDLBCL subject and providing a different therapy to an ABC DLBCL subject.5. The method of claim 4, which comprises providing to the ABC DLBCLsubject CODOX-M/IVAC therapy, R-EPOCH therapy CNS prophylaxis,radiotherapy, immunotherapy, bone marrow transplantation, stem celltransplantation, and/or surgery.
 6. The method of claim 4, wherein thestep of calculating a predictor score comprises using an equation:$y_{i} = {{\log_{2}\left( x_{i} \right)} - {\sum\limits_{j}\; {{\log_{2}\left( x_{j} \right)}h_{j}}} - {\log_{2}\left( r_{i} \right)} + {\log_{2}\left( g_{i} \right)}}$7. The method of claim 1, wherein the gene expression product isisolated from a formalin-fixed and paraffin-embedded (FFPE) biopsysample from the subject.
 8. The method of claim 7, wherein the digitalgene expression data is obtained using a NANOSTRING™ assay.
 9. Themethod of claim 2, wherein the treatment option comprises one or more ofthe following: CHOP therapy, R-CHOP therapy, CODOX-M/IVAC therapy,R-EPOCH therapy CNS prophylaxis, radiotherapy, immunotherapy, bonemarrow transplantation, stem cell transplantation, and/or surgery. 10.The method of claim 2, wherein the gene expression product is isolatedfrom a formalin-fixed and paraffin-embedded (FFPE) biopsy sample fromthe subject.
 11. The method of claim 10, wherein the digital geneexpression data is obtained using a NANOSTRING™ assay.
 12. The method ofclaim 4, wherein the gene expression product is isolated from aformalin-fixed and paraffin-embedded (FFPE) biopsy sample from thesubject.
 13. The method of claim 12, wherein the digital gene expressiondata is obtained using a NANOSTRING™ assay.
 14. A method for selecting atreatment option for an activated B cell-like diffuse large B celllymphoma (ABC DLBCL) human subject, a germinal center B cell-likediffuse large B cell lymphoma (GCB DLBCL) human subject, a primarymediastinal B cell lymphoma (PMBL) human subject, a Burkitt lymphoma(BL) human subject, or a mantle cell lymphoma (MCL) human subject, themethod comprising: (a) isolating RNA gene expression product from abiopsy sample from a lymphoma human subject; (b) obtaining digital geneexpression data from the isolated gene expression product, wherein thedigital gene expression data comprises data for genes in a geneexpression signature, and wherein the gene expression signaturecomprises the genes listed in Table 2; (c) optionally obtaining digitalgene expression data from a first and second reference array, the secondreference array being a known array for classifying ABC DLBCL, GCBDLBCL, PMBL, BL, or MCL; (d) generating a weighted average of theexpression levels of genes from the gene expression signature to therebyobtain a gene expression signature value and calculating a predictorscore based on the gene expression signature value using an equation:$y_{i} = {{\log_{2}\left( x_{i} \right)} - {\sum\limits_{j}\; {{\log_{2}\left( x_{j} \right)}h_{j}}} - {\log_{2}\left( r_{i} \right)} + {\log_{2}\left( g_{i} \right)}}$wherein y_(i) is a predictor score, x_(i) is the counts for gene i forprobe set i, probe set i is on the array of the sample being tested,x_(j) is the counts for gene j for probe set j, probe set j is the setof normalization genes on the array of the sample being tested, h_(j) isthe normalization weight for probe set j as listed in Table 4, r_(i) isthe counts for gene i for probe set i on the first reference array, andg_(i) is the counts for gene i for probe set i on the second referencearray, the mathematical terms with r_(i) and g_(i) being equal to zeroif no digital gene expression data is obtained from a first and secondreference array; (e) classifying the subject as belonging to one of thefollowing groups based on the predictor score of (d): (i) ABC DLBCL,(ii) GCB DLBCL, (iii) PMBL, (iv) BL, or (v) MCL, using the formula:${{Submodel}\mspace{14mu} {call}} = \left\{ \begin{matrix}{- 1} & {{{if}\mspace{14mu} {\sum\limits_{i}\; {y_{i}w_{i}}}} \leq {{Lower}\mspace{14mu} {cutpoint}}} \\0 & {{{Lower}\mspace{14mu} {cutpoint}} < {\sum\limits_{i}\; {y_{i}w_{i}}} < {{Upper}\mspace{14mu} {cutpoint}}} \\1 & {{\sum\limits_{i}\; {y_{i}w_{i}}} \geq {{Upper}\mspace{14mu} {cutpoint}}}\end{matrix} \right.$ wherein y_(i) is the predictor score, w_(i) arethe weights associated with the probe set as listed in Table 4, and theupper and lower cutpoints are as listed in Table 5, and using the logic:(1) if the MCL submodel has a value of 1, the sample is called MCL, ifthe MCL submodel has a value of 0, the sample is called unclassifiablebut borderline MCL, if the MCL submodel has a value of −1, proceed tostep 2, (2) if the BL non-myc submodel has a value of 1, proceed to step3, if the BL non-myc submodel has a value of 0, the sample is calledunclassifiable but borderline BL, if the BL non-myc submodel has a valueof −1, proceed to step 4, (3) if the BL myc submodel has a value of 0 or1, the sample is called BL, if the BL myc submodel has a value of −1,the sample is called unclassifiable but borderline BL, (4) if the PMBLsubmodel has a value of 1, the sample is called PMBL, if the PMBLsubmodel has a value of 0, the sample is called unclassifiable butborderline PMBL, if the PMBL submodel has a value of −1, proceed to step5, (5) if the ABC/GCB submodel has a value of 1, the sample is calledABC, if the ABC/GCB submodel has a value of 0, the sample is calledunclassified DLBCL, if the ABC/GCB submodel has a value of −1, thesample is called GCB; (f) selecting a treatment option for the subjectbased on the subject's classification in (e); and (g) providing thetreatment option to the subject.
 15. The method of claim 14, wherein thetreatment option comprises one or more of the following: CHOP therapy,R-CHOP therapy, CODOX-M/IVAC therapy, R-EPOCH therapy CNS prophylaxis,radiotherapy, immunotherapy, bone marrow transplantation, stem celltransplantation, and/or surgery.
 16. The method of claim 14, wherein thegene expression product is isolated from a formalin-fixed andparaffin-embedded (FFPE) biopsy sample from the subject.
 17. The methodof claim 16, wherein the digital gene expression data is obtained usinga NANOSTRING™ assay.